Strain Name:
C57BL/6J-MtgxR6238Btlr/Mmmh
Stock Number:
044401-MU
Citation ID:
RRID:MMRRC_044401-MU
Other Names:
R6238 (G1)
Major Collection:

Strain Information

Suz12
Name: SUZ12 polycomb repressive complex 2 subunit
Synonyms: D11Ertd530e, 2610028O16Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 52615
Homologene: 32256
Adcy10
Name: adenylate cyclase 10
Synonyms: soluble adenylyl cyclase, Sacy, 4930431D04Rik, sAC
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 271639
Homologene: 10188
Mef2d
Name: myocyte enhancer factor 2D
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 17261
HGNC: HGNC:6997
Homologene: 4327
Ankrd13a
Name: ankyrin repeat domain 13a
Synonyms: 1100001D10Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 68420
Homologene: 23814
Uhmk1
Name: U2AF homology motif (UHM) kinase 1
Synonyms: C820018A03Rik, Kist, KIS, OTTMUSG00000021542
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16589
Homologene: 7801
Polr2a
Name: polymerase (RNA) II (DNA directed) polypeptide A
Synonyms: Rpo2-1, 220kDa
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20020
HGNC: HGNC:9187
Homologene: 721
Etl4
Name: enhancer trap locus 4
Synonyms: Sickle tail, 6620402G01Rik, Skt, 9430077C05Rik, Etl-4, E330027G05Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 208618
Homologene: 10477
Taf4
Name: TATA-box binding protein associated factor 4
Synonyms: Taf2c1, TAFII130, TAFII135, Taf4a
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228980
Homologene: 55723
Tonsl
Name: tonsoku-like, DNA repair protein
Synonyms: 2810439M11Rik, Nfkbil2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 72749
HGNC: HGNC:7801
Homologene: 22754
Cdc27
Name: cell division cycle 27
Synonyms: APC3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217232
HGNC: HGNC:1728
Homologene: 960
Cc2d2a
Name: coiled-coil and C2 domain containing 2A
Synonyms: 5730509K17Rik, b2b1035Clo
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231214
Homologene: 18159
Casp9
Name: caspase 9
Synonyms: Mch6, ICE-LAP6, Caspase-9
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12371
HGNC: HGNC:1511
Homologene: 31024
Fzd10
Name: frizzled class receptor 10
Synonyms: Fz-10
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 93897
HGNC: HGNC:4039
Homologene: 21411
Car12
Name: carbonic anhydrase 12
Synonyms: 2310047E01Rik, CA XII
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 76459
HGNC: HGNC:1371
Homologene: 20327
Nodal
Name: nodal growth differentiation factor
Synonyms: Tg.413d
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 18119
HGNC: HGNC:7865
Homologene: 8417
Cpsf3
Name: cleavage and polyadenylation specificity factor 3
Synonyms: 73 kDa
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 54451
VEGA: 12
HGNC: HGNC:2326
Homologene: 6499
Ddrgk1
Name: DDRGK domain containing 1
Synonyms: 2600009E05Rik, 1110001I20Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 77006
Homologene: 11400
Zfand2a
Name: zinc finger, AN1-type domain 2A
Synonyms: Airap
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100494
Homologene: 64373
Ttc7b
Name: tetratricopeptide repeat domain 7B
Synonyms: Ttc7l1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 104718
VEGA: 12
Homologene: 14675
Dennd6a
Name: DENN domain containing 6A
Synonyms: Fam116a, A630054L15Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 211922
Homologene: 13503
Plxna2
Name: plexin A2
Synonyms: OCT, Plxn2, 2810428A13Rik, PlexA2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18845
HGNC: HGNC:9100
Homologene: 56427
Cmtr1
Name: cap methyltransferase 1
Synonyms: Ftsjd2, 1300018I05Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 74157
Homologene: 9003
Baiap3
Name: BAI1-associated protein 3
Synonyms: LOC381076
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 545192
HGNC: HGNC:948
Homologene: 20844
Nbas
Name: neuroblastoma amplified sequence
Synonyms: 4933425L03Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 71169
VEGA: 12
Homologene: 41073
Amfr
Name: autocrine motility factor receptor
Synonyms: gp78
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 23802
HGNC: HGNC:463
Homologene: 888
Spata24
Name: spermatogenesis associated 24
Synonyms: TIPT, TIPT2, 5133400G04Rik, 2700012K08Rik, 4930583E11Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 71242
VEGA: 18
Homologene: 32688
Rfx8
Name: regulatory factor X 8
Synonyms: 4933400N17Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 619289
Homologene: 82436
Hydin
Name: HYDIN, axonemal central pair apparatus protein
Synonyms: 4930545D19Rik, hyrh, hy-3, hy3, 1700034M11Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244653
Homologene: 52118
Fbn1
Name: fibrillin 1
Synonyms: Fib-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14118
HGNC: HGNC:3603
Homologene: 30958
Ttn
Name: titin
Synonyms: shru, L56, mdm, connectin, D330041I19Rik, 2310057K23Rik, 2310074I15Rik, 2310036G12Rik, D830007G01Rik, 1100001C23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Dnah10
Name: dynein, axonemal, heavy chain 10
Synonyms: Dnahc10
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 56087
HGNC: HGNC:2941
Homologene: 25816
Zfp990
Name: zinc finger protein 990
Synonyms: Gm13225
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 101056073
2610028H24Rik
Name: RIKEN cDNA 2610028H24 gene
Synonyms: ORF67
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 76964
HGNC: HGNC:1300
Homologene: 50540
Adgrv1
Name: adhesion G protein-coupled receptor V1
Synonyms: Mgr1, Mass1, Gpr98, VLGR1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 110789
Homologene: 19815
Pdzd8
Name: PDZ domain containing 8
Synonyms: Pdzk8, A630041P07Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 107368
VEGA: 19
Homologene: 14879
Dock3
Name: dedicator of cyto-kinesis 3
Synonyms: Moca, PBP
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 208869
HGNC: HGNC:2989
Homologene: 21030
Skint5
Name: selection and upkeep of intraepithelial T cells 5
Synonyms: OTTMUSG00000008560
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242627
Homologene: 135888
Gcc1
Name: golgi coiled coil 1
Synonyms: 4932417P04Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 74375
Homologene: 11567
Lrtm1
Name: leucine-rich repeats and transmembrane domains 1
Synonyms: A930016D02Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 319476
VEGA: 14
Homologene: 49635
Zkscan4
Name: zinc finger with KRAB and SCAN domains 4
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 544922
Homologene: 128718
Plcl2
Name: phospholipase C-like 2
Synonyms: Plce2, PRIP-2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224860
VEGA: 17
HGNC: HGNC:9064
Homologene: 9052
Naalad2
Name: N-acetylated alpha-linked acidic dipeptidase 2
Synonyms: NAALADASE2, GCPIII, D9Ertd285e, GCP3, NAADALASE2, Folh1b
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 72560
Homologene: 3294
Vmn2r74
Name: vomeronasal 2, receptor 74
Synonyms: EG546980
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 546980
Homologene: 115466
Cebpz
Name: CCAAT/enhancer binding protein zeta
Synonyms: Cebpa-rs1, CBF2, Cbf
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12607
VEGA: 17
Homologene: 4210
Tsen54
Name: tRNA splicing endonuclease subunit 54
Synonyms: 0610034P02Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 76265
Homologene: 35476
Ptpre
Name: protein tyrosine phosphatase receptor type E
Synonyms: RPTPepsilon, PTPe, PTPepsilon
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 19267
HGNC: HGNC:9669
Homologene: 31387
Parl
Name: presenilin associated, rhomboid-like
Synonyms: Psarl, D16Ertd607e, PSARL1, PRO2207, PSENIP2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 381038
Homologene: 10239
Vmn2r107
Name: vomeronasal 2, receptor 107
Synonyms: V2r6
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22312
Homologene: 129750
Cenpo
Name: centromere protein O
Synonyms: D12Ertd482e, 2810429O05Rik, 8430427C03Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 52504
Homologene: 49760
Tlr1
Name: toll-like receptor 1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 21897
Homologene: 20694
4933402N03Rik
Name: RIKEN cDNA 4933402N03 gene
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233918
Homologene: 52852
Clca1
Name: chloride channel accessory 1
Synonyms: gob5, gob-5, Clca3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 23844
HGNC: HGNC:2015
Homologene: 984
Wdr20rt
Name: WD repeat domain 20, retrogene
Synonyms: Wdr20b, 4921538B03Rik, 4930427E19Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 70948
VEGA: 12
Rpe
Name: ribulose-5-phosphate-3-epimerase
Synonyms: 5730518J08Rik, 2810429B02Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 66646
Homologene: 12005
Or52ab7
Name: olfactory receptor family 52 subfamily AB member 7
Synonyms: GA_x6K02T2PBJ9-6037823-6038782, MOR23-4P, MOR23-5, Olfr598
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 257975
Homologene: 132401
Chid1
Name: chitinase domain containing 1
Synonyms: 3110023E09Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 68038
Homologene: 12229
Lif
Name: leukemia inhibitory factor
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16878
HGNC: HGNC:6596
Homologene: 1734
Or8b12c
Name: olfactory receptor family 8 subfamily B member 12C
Synonyms: GA_x6K02T2PVTD-31489645-31490577, Olfr876, MOR161-1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258883
Homologene: 74154
Efcab10
Name: EF-hand calcium binding domain 10
Synonyms: 4930504H06Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 75040
VEGA: 12
Homologene: 19147
Pcdha9
Name: protocadherin alpha 9
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 192161
HGNC: HGNC:8664
Homologene: 130700
2610042L04Rik
Name: RIKEN cDNA 2610042L04 gene
Synonyms: takusan, Tksn
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 554327
Raet1e
Name: retinoic acid early transcript 1E
Synonyms: Rae-1 epsilon
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 379043
Homologene: 134115
Ftmt
Name: ferritin mitochondrial
Synonyms: MtF, mitochondrial ferritin, Fth3, 4930447C24Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 67634
VEGA: 18
Homologene: 110661
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 39,670,394 bp
  • T to A, chromosome 1 at 66,701,648 bp
  • C to A, chromosome 1 at 165,575,728 bp
  • T to A, chromosome 1 at 170,199,994 bp
  • T to A, chromosome 1 at 194,790,196 bp
  • T to A, chromosome 2 at 20,801,568 bp
  • A to T, chromosome 2 at 76,811,243 bp
  • T to A, chromosome 2 at 125,324,945 bp
  • G to A, chromosome 2 at 130,654,679 bp
  • T to A, chromosome 2 at 179,932,039 bp
  • T to A, chromosome 3 at 88,159,545 bp
  • C to A, chromosome 3 at 145,008,955 bp
  • A to T, chromosome 4 at 113,942,867 bp
  • G to T, chromosome 4 at 141,807,137 bp
  • T to A, chromosome 4 at 145,537,913 bp
  • T to A, chromosome 5 at 43,671,235 bp
  • G to T, chromosome 5 at 64,927,129 bp
  • T to C, chromosome 5 at 114,786,726 bp
  • A to G, chromosome 5 at 124,743,679 bp
  • T to C, chromosome 5 at 128,602,931 bp
  • T to A, chromosome 5 at 139,481,991 bp
  • T to C, chromosome 6 at 28,420,743 bp
  • C to T, chromosome 7 at 85,952,072 bp
  • A to T, chromosome 7 at 103,328,908 bp
  • T to C, chromosome 7 at 131,146,134 bp
  • C to A, chromosome 7 at 135,671,180 bp
  • A to G, chromosome 7 at 141,496,136 bp
  • A to C, chromosome 8 at 94,000,364 bp
  • A to G, chromosome 8 at 110,392,111 bp
  • T to A, chromosome 9 at 18,385,065 bp
  • A to G, chromosome 9 at 37,804,021 bp
  • C to T, chromosome 9 at 66,753,726 bp
  • G to A, chromosome 9 at 106,912,948 bp
  • T to A, chromosome 10 at 22,180,871 bp
  • T to C, chromosome 10 at 61,423,479 bp
  • A to C, chromosome 10 at 76,449,262 bp
  • A to G, chromosome 11 at 4,268,940 bp
  • G to T, chromosome 11 at 69,747,221 bp
  • G to C, chromosome 11 at 80,002,180 bp
  • T to C, chromosome 11 at 104,528,444 bp
  • G to A, chromosome 11 at 115,820,687 bp
  • T to A, chromosome 12 at 4,231,968 bp
  • T to C, chromosome 12 at 13,482,595 bp
  • G to T, chromosome 12 at 21,300,162 bp
  • T to C, chromosome 12 at 33,398,434 bp
  • C to T, chromosome 12 at 65,226,190 bp
  • A to G, chromosome 12 at 100,495,422 bp
  • A to T, chromosome 13 at 21,484,587 bp
  • G to A, chromosome 13 at 81,466,283 bp
  • A to G, chromosome 14 at 4,348,962 bp
  • T to A, chromosome 14 at 26,616,658 bp
  • C to A, chromosome 14 at 29,027,671 bp
  • T to C, chromosome 15 at 76,636,218 bp
  • G to A, chromosome 16 at 20,302,213 bp
  • A to G, chromosome 17 at 20,345,587 bp
  • A to G, chromosome 17 at 25,245,758 bp
  • A to G, chromosome 17 at 29,682,148 bp
  • T to C, chromosome 17 at 50,606,845 bp
  • A to G, chromosome 17 at 78,936,910 bp
  • C to A, chromosome 18 at 35,660,336 bp
  • G to A, chromosome 18 at 36,998,975 bp
  • G to A, chromosome 18 at 52,332,235 bp
  • A to G, chromosome 19 at 59,300,562 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6238 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044401-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.