Strain Name:
C57BL/6J-MtgxR6312Btlr/Mmmh
Stock Number:
044415-MU
Citation ID:
RRID:MMRRC_044415-MU
Other Names:
R6312 (G1)
Major Collection:

Strain Information

Nudt2
Name: nudix hydrolase 2
Synonyms: 2310051L06Rik, nudix (nucleoside diphosphate linked moiety X)-type motif 2, APAH1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 66401
HGNC: HGNC:8049
Homologene: 896
Gnai2
Name: G protein subunit alpha i2
Synonyms: Gnai-2, Galphai2, Gia
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 14678
HGNC: HGNC:4385
Homologene: 55539
Lrp2
Name: low density lipoprotein receptor-related protein 2
Synonyms: b2b1625.2Clo, D230004K18Rik, Megalin, Gp330
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14725
HGNC: HGNC:6694
Homologene: 20952
Gng3
Name: guanine nucleotide binding protein (G protein), gamma 3
Synonyms: 83
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 14704
VEGA: 19
HGNC: HGNC:4405
Homologene: 22575
Cct2
Name: chaperonin containing TCP1 subunit 2
Synonyms: Cctb
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 12461
VEGA: 10
HGNC: HGNC:1615
Homologene: 4696
Rsf1
Name: remodeling and spacing factor 1
Synonyms: Hbxap, p325, XAP8, C030033M12Rik, 4832420A03Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233532
Homologene: 41142
Slitrk6
Name: SLIT and NTRK-like family, member 6
Synonyms: 4832410J21Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 239250
VEGA: 14
Homologene: 12986
Acadvl
Name: acyl-Coenzyme A dehydrogenase, very long chain
Synonyms: VLCAD
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11370
HGNC: HGNC:92
Homologene: 5
Epg5
Name: ectopic P-granules 5 autophagy tethering factor
Synonyms: 5430411K18Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 100502841
VEGA: 18
Homologene: 14575
Zfp592
Name: zinc finger protein 592
Synonyms: A730014M16Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233410
Homologene: 8759
Lig4
Name: ligase IV, DNA, ATP-dependent
Synonyms: DNA ligase IV, tiny, 5830471N16Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 319583
HGNC: HGNC:6601
Homologene: 1736
Hdc
Name: histidine decarboxylase
Synonyms: Hdc-c, L-histidine decarboxylase, Hdc-s, Hdc-e, Hdc-a
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 15186
HGNC: HGNC:4855
Homologene: 20490
Zfp60
Name: zinc finger protein 60
Synonyms: 6330516O17Rik, Mfg-3, Mfg3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22718
Homologene: 137228
Dpy19l4
Name: dpy-19 like 4
Synonyms: LOC381510, Narg3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 381510
Homologene: 18773
B3gat2
Name: beta-1,3-glucuronyltransferase 2
Synonyms: GlcAT-S
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 280645
HGNC: HGNC:922
Homologene: 50574
Bmper
Name: BMP-binding endothelial regulator
Synonyms: 3110056H04Rik, Cv2, CV-2, crossveinless-2, Crim3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 73230
VEGA: 9
Homologene: 12494
Nlrp4a
Name: NLR family, pyrin domain containing 4A
Synonyms: Nalp-eta, E330028A19Rik, Nalp4a
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243880
Homologene: 79696
Fam20a
Name: FAM20A, golgi associated secretory pathway pseudokinase
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 208659
Homologene: 9719
Nlrp1b
Name: NLR family, pyrin domain containing 1B
Synonyms: Nalp1b
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 637515
Homologene: 19080
Kif17
Name: kinesin family member 17
Synonyms: Kif17b, 5930435E01Rik, N-4 kinesin
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 16559
Homologene: 5883
Or1j20
Name: olfactory receptor family 1 subfamily J member 20
Synonyms: MOR136-10, GA_x6K02T2NLDC-33564136-33565083, Olfr352
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258942
Homologene: 121523
Lrrc7
Name: leucine rich repeat containing 7
Synonyms: densin
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242274
Homologene: 10817
Zfp790
Name: zinc finger protein 790
Synonyms: 6330581L23Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233056
Homologene: 51695
Aadacl4fm1
Name: AADACL4 family member 1
Synonyms: LOC381572, 9430007A20Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 381572
Homologene: 28662
Mtpap
Name: mitochondrial poly(A) polymerase
Synonyms: 0610027A18Rik, Papd1, Tent6
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 67440
VEGA: 18
Homologene: 10008
Trim14
Name: tripartite motif-containing 14
Synonyms: 5830400N10Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 74735
Homologene: 13241
Dpp6
Name: dipeptidylpeptidase 6
Synonyms: In(5)6H-p, LOC384168, Rw, Dpp-6, B930011P16Rik, Peplb
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 13483
HGNC: HGNC:3010
Homologene: 22560
Tma16
Name: translation machinery associated 16
Synonyms: 1810029B16Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 66282
Homologene: 10146
Sspo
Name: SCO-spondin
Synonyms: Scospondin, C79529
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243369
Homologene: 45453
Slc6a7
Name: solute carrier family 6 (neurotransmitter transporter, L-proline), member 7
Synonyms: Prot
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240332
VEGA: 18
Homologene: 8592
Vmn2r53
Name: vomeronasal 2, receptor 53
Synonyms: EG637908
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 637908
Homologene: 104040
Or8k53
Name: olfactory receptor family 8 subfamily K member 53
Synonyms: GA_x6K02T2Q125-47819205-47818258, Olfr1055, MOR186-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 259023
Homologene: 131140
Abraxas2
Name: BRISC complex subunit
Synonyms: KIAA0157, C430003P19Rik, Fam175b
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 109359
Homologene: 12970
Tectb
Name: tectorin beta
Synonyms: Tctnb, [b]-tectorin
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 21684
Homologene: 7568
Ankdd1a
Name: ankyrin repeat and death domain containing 1A
Synonyms: EG330963, LOC384945
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 330963
VEGA: 9
Homologene: 65619
Cyp4f39
Name: cytochrome P450, family 4, subfamily f, polypeptide 39
Synonyms: 4732474A20Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 320997
VEGA: 17
Homologene: 69814
Osmr
Name: oncostatin M receptor
Synonyms: OSMRB
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 18414
HGNC: HGNC:8507
Homologene: 2972
Cers5
Name: ceramide synthase 5
Synonyms: 2310081H14Rik, Lass5, CerS5, Trh4
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 71949
Homologene: 23634
Zfp948
Name: zinc finger protein 948
Synonyms: BC049807
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 381066
VEGA: 17
Rusf1
Name: RUS family member 1
Synonyms: BC017158
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233913
Homologene: 11232
Lgr5
Name: leucine rich repeat containing G protein coupled receptor 5
Synonyms: Gpr49
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14160
HGNC: HGNC:4504
Homologene: 20807
Crocc2
Name: ciliary rootlet coiled-coil, rootletin family member 2
Synonyms: LOC381284, E030010N08Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 381284
Homologene: 141152
Cfhr2
Name: complement factor H-related 2
Synonyms: FHR-B
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 545366
Homologene: 134349
Vmn1r62
Name: vomeronasal 1 receptor 62
Synonyms: V1rd8, V1rd2, V3R2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 81016
Homologene: 41799
Zfp69
Name: zinc finger protein 69
Synonyms: LOC381549, Zfp63, KRAB2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 381549
Homologene: 45693
Vash2
Name: vasohibin 2
Synonyms: B130052G07Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226841
Homologene: 57005
4930447C04Rik
Name: RIKEN cDNA 4930447C04 gene
Synonyms: Six6as, Six6os1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 75801
Homologene: 49922
Trim63
Name: tripartite motif-containing 63
Synonyms: MuRF1, Rnf28
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 433766
Homologene: 41878
Or8b36
Name: olfactory receptor family 8 subfamily B member 36
Synonyms: MOR162-6, GA_x6K02T2PVTD-31705144-31706073, Olfr883
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258414
Homologene: 86689
Zfp382
Name: zinc finger protein 382
Synonyms: 5930415A09Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233060
Homologene: 32798
Or52n20
Name: olfactory receptor family 52 subfamily N member 20
Synonyms: Olfr659, MOR34-4, GA_x6K02T2PBJ9-7298889-7299857
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259052
Homologene: 74118
Arl4d
Name: ADP-ribosylation factor-like 4D
Synonyms: Arfl4, Arl5, Arf4l, 1110036H21Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 80981
HGNC: HGNC:656
Homologene: 1255
Lipi
Name: lipase, member I
Synonyms: lpd1, D930038D03Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 320355
Homologene: 77864
AC153874.1
Name:
Type: Gene
Species: Mouse
Chromosome: 10
C2cd4d
Name: C2 calcium-dependent domain containing 4D
Synonyms: LOC271944, Gm659
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 271944
Homologene: 86310
Rbp2
Name: retinol binding protein 2, cellular
Synonyms: Crbp-2, Rbp-2, CrbpII
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 19660
HGNC: HGNC:9920
Homologene: 3070
Hint1
Name: histidine triad nucleotide binding protein 1
Synonyms: Ipk1, PKC inhibitor/ interacting protein, protein kinase C inhibitor 1, PRKCNH1, PKCI-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 15254
HGNC: HGNC:4912
Homologene: 3904
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 23,815,467 bp
  • A to T, chromosome 1 at 93,215,710 bp
  • C to T, chromosome 1 at 139,831,079 bp
  • C to A, chromosome 1 at 190,958,683 bp
  • A to T, chromosome 2 at 36,870,465 bp
  • C to T, chromosome 2 at 69,436,681 bp
  • A to T, chromosome 2 at 86,347,581 bp
  • A to G, chromosome 2 at 126,607,406 bp
  • C to A, chromosome 3 at 94,364,435 bp
  • A to G, chromosome 3 at 158,160,609 bp
  • T to A, chromosome 4 at 11,289,671 bp
  • A to G, chromosome 4 at 41,480,386 bp
  • G to T, chromosome 4 at 46,507,257 bp
  • G to A, chromosome 4 at 120,949,517 bp
  • A to G, chromosome 4 at 134,325,697 bp
  • C to T, chromosome 4 at 138,288,193 bp
  • A to T, chromosome 4 at 144,528,502 bp
  • A to T, chromosome 5 at 27,725,671 bp
  • T to C, chromosome 6 at 48,457,366 bp
  • G to A, chromosome 7 at 5,676,084 bp
  • T to A, chromosome 7 at 12,598,639 bp
  • A to G, chromosome 7 at 26,449,396 bp
  • T to C, chromosome 7 at 27,748,776 bp
  • G to T, chromosome 7 at 29,828,222 bp
  • G to A, chromosome 7 at 30,134,538 bp
  • T to A, chromosome 7 at 81,023,436 bp
  • A to AGGGCGACGG, chromosome 7 at 97,579,904 bp
  • T to A, chromosome 7 at 104,671,589 bp
  • T to C, chromosome 7 at 128,273,543 bp
  • G to A, chromosome 7 at 132,874,965 bp
  • G to T, chromosome 8 at 9,971,739 bp
  • T to C, chromosome 8 at 66,481,466 bp
  • C to A, chromosome 9 at 23,406,791 bp
  • ATTGCTGTTT to ATTGCTGTTTGCTGTTT, chromosome 9 at 38,026,540 bp
  • TTGCTGT to TTGCTGTCTGCTGT, chromosome 9 at 38,026,541 bp
  • GTTT to GTTTGCTGTTTT, chromosome 9 at 38,026,546 bp
  • TTT to TTTGCTGATT, chromosome 9 at 38,026,547 bp
  • T to TGCTGTTC, chromosome 9 at 38,026,549 bp
  • C to T, chromosome 9 at 65,508,061 bp
  • G to T, chromosome 9 at 98,490,647 bp
  • A to T, chromosome 9 at 107,635,117 bp
  • T to A, chromosome 10 at 77,847,127 bp
  • A to G, chromosome 10 at 115,452,924 bp
  • A to T, chromosome 10 at 117,056,055 bp
  • G to A, chromosome 11 at 54,869,990 bp
  • T to A, chromosome 11 at 70,011,767 bp
  • T to A, chromosome 11 at 71,228,397 bp
  • T to C, chromosome 11 at 101,667,253 bp
  • A to C, chromosome 11 at 109,674,630 bp
  • A to G, chromosome 12 at 72,889,767 bp
  • A to G, chromosome 14 at 110,750,247 bp
  • A to G, chromosome 15 at 6,823,638 bp
  • A to G, chromosome 15 at 99,747,115 bp
  • T to A, chromosome 16 at 75,573,915 bp
  • T to C, chromosome 17 at 21,587,167 bp
  • T to C, chromosome 17 at 32,483,294 bp
  • T to C, chromosome 18 at 4,396,175 bp
  • A to G, chromosome 18 at 61,002,385 bp
  • T to A, chromosome 18 at 77,979,211 bp
  • A to G, chromosome 19 at 8,838,633 bp
  • CT to C, chromosome 19 at 55,192,662 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6312 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044415-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.