Strain Name:
C57BL/6J-MtgxR6110Btlr/Mmmh
Stock Number:
044428-MU
Citation ID:
RRID:MMRRC_044428-MU
Other Names:
R6110 (G1)
Major Collection:

Strain Information

Pax2
Name: paired box 2
Synonyms: Pax-2, Opdc
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18504
HGNC: HGNC:8616
Homologene: 2968
Cacna1h
Name: calcium channel, voltage-dependent, T type, alpha 1H subunit
Synonyms: T-type Cav3.2, alpha13.2, Cav3.2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 58226
HGNC: HGNC:1395
Homologene: 56913
Vldlr
Name: very low density lipoprotein receptor
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 22359
Homologene: 443
Mfn1
Name: mitofusin 1
Synonyms: 6330416C07Rik, 2310002F04Rik, D3Ertd265e, HR2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 67414
Homologene: 11481
Ift70b
Name: intraflagellar transport 70B
Synonyms: Ttc30b, 2510042P03Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 72421
Homologene: 71716
Dip2c
Name: disco interacting protein 2 homolog C
Synonyms: 2900024P20Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 208440
Homologene: 40996
Wnk1
Name: WNK lysine deficient protein kinase 1
Synonyms: Hsn2, Prkwnk1, 6430573H23Rik, EG406236
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232341
Homologene: 14253
Setx
Name: senataxin
Synonyms: Als4, A930037J23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 269254
HGNC: HGNC:445
Homologene: 41003
Kat6b
Name: K(lysine) acetyltransferase 6B
Synonyms: Myst4, Morf, monocytic leukemia, qkf, querkopf, B130044K16Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 54169
Homologene: 136480
Kdm5a
Name: lysine demethylase 5A
Synonyms: Jarid1a, RBP2, Rbbp2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 214899
HGNC: HGNC:9886
Homologene: 3419
Clptm1
Name: cleft lip and palate associated transmembrane protein 1
Synonyms: N14, HS9
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 56457
HGNC: HGNC:2087
Homologene: 37464
Xpo1
Name: exportin 1
Synonyms: Crm1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 103573
Homologene: 2554
Ash1l
Name: ASH1 like histone lysine methyltransferase
Synonyms: 8030453L17Rik, KMT2H, chromatin remodeling factor, E430018P19Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 192195
Homologene: 10225
C2cd3
Name: C2 calcium-dependent domain containing 3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 277939
Homologene: 19524
Apob
Name: apolipoprotein B
Synonyms: apob-48, apob-100
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238055
HGNC: HGNC:603
Homologene: 328
Grhl1
Name: grainyhead like transcription factor 1
Synonyms: LBP-32, p61 MGR, p70 MGR, Tcfcp2l2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 195733
VEGA: 12
Homologene: 32219
Fam151a
Name: family with sequence simliarity 151, member A
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230579
Homologene: 17143
Nsun2
Name: NOL1/NOP2/Sun domain family member 2
Synonyms: Misu
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 28114
Homologene: 9817
Adam17
Name: a disintegrin and metallopeptidase domain 17
Synonyms: CD156b, Tace
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 11491
HGNC: HGNC:195
Homologene: 2395
Tnfrsf19
Name: tumor necrosis factor receptor superfamily, member 19
Synonyms: TAJ, TRADE, TAJ-ALPHA, Troy
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 29820
VEGA: 14
Homologene: 8481
Cd34
Name: CD34 antigen
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12490
HGNC: HGNC:1662
Homologene: 1343
Amy1
Name: amylase 1, salivary
Synonyms: Amy-1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 11722
Homologene: 20179
Pcdhb4
Name: protocadherin beta 4
Synonyms: PcdhbD, Pcdhb5A
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93875
HGNC: HGNC:8690
Homologene: 62176
Slc9c1
Name: solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1
Synonyms: LOC208169, spermNHE, Slc9a10
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 208169
Homologene: 19505
Efcab6
Name: EF-hand calcium binding domain 6
Synonyms: 4932408N08Rik, 4931407K02Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 77627
Homologene: 11259
Uba7
Name: ubiquitin-like modifier activating enzyme 7
Synonyms: Ube1l, 1300004C08Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74153
Homologene: 2502
Or2at4
Name: olfactory receptor family 2 subfamily AT member 4
Synonyms: GA_x6K02T2PBJ9-2411789-2412739, MOR101-1, Olfr520
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259066
Homologene: 17484
BC024139
Name: cDNA sequence BC024139
Synonyms: 6230424I18Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 271278
Homologene: 129974
Hcrtr2
Name: hypocretin (orexin) receptor 2
Synonyms: mOX2aR, OX2r, mOXR2, mOX2bR
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 387285
HGNC: HGNC:4849
Homologene: 1168
Cimap1a
Name: ciliary microtubule associated protein 1A
Synonyms: Odf3, 1700011O04Rik, SHIPPO1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 69287
Homologene: 12306
Sema4f
Name: sema domain, immunoglobulin domain (Ig), TM domain, and short cytoplasmic domain
Synonyms: Sema W
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 20355
Homologene: 3147
Sema3a
Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
Synonyms: semaphorin III, Semad, collapsin-1, SemD, sema III
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20346
Homologene: 31358
Zcchc4
Name: zinc finger, CCHC domain containing 4
Synonyms: 4930449I23Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 78796
Homologene: 14632
Dnm3
Name: dynamin 3
Synonyms: 9630020E24Rik, B230343F03Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 103967
Homologene: 22906
Vmn2r80
Name: vomeronasal 2, receptor 80
Synonyms: EG624765
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 624765
Homologene: 83483
Tyro3
Name: TYRO3 protein tyrosine kinase 3
Synonyms: Brt, Sky, Tif, Sky, Etk-2, Dtk, Rse
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22174
Homologene: 4585
Or1j17
Name: olfactory receptor family 1 subfamily J member 17
Synonyms: Olfr346, MOR136-11, GA_x6K02T2NLDC-33382467-33383396
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258940
Homologene: 133616
Or52d1
Name: olfactory receptor family 52 subfamily D member 1
Synonyms: MOR33-2, Olfr646, GA_x6K02T2PBJ9-6841330-6842268
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259058
Homologene: 17481
Parp9
Name: poly (ADP-ribose) polymerase family, member 9
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 80285
Homologene: 12720
Or5p70
Name: olfactory receptor family 5 subfamily P member 70
Synonyms: GA_x6K02T2PBJ9-10725148-10726140, Olfr495, MOR204-37
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258361
Homologene: 133600
Fap
Name: fibroblast activation protein
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14089
HGNC: HGNC:3590
Homologene: 48282
Or5b123
Name: olfactory receptor family 5 subfamily B member 123
Synonyms: GA_x6K02T2RE5P-3951719-3952666, MOR202-18, Olfr1487
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258629
Homologene: 110492
Actl7b
Name: actin-like 7b
Synonyms: t-actin 1, Tact1, ENSMUSG00000070980
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11471
HGNC: HGNC:162
Homologene: 21330
Plch1
Name: phospholipase C, eta 1
Synonyms: Plcl3, PLCeta1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 269437
Homologene: 88833
Or5j3
Name: olfactory receptor family 5 subfamily J member 3
Synonyms: MOR172-1, GA_x6K02T2Q125-47777498-47778436, Olfr1052
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 259012
Homologene: 79679
Tubgcp4
Name: tubulin, gamma complex component 4
Synonyms: D2Ertd435e, 4932441P04Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 51885
Homologene: 8690
Ptpn22
Name: protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
Synonyms: 70zpep, Ptpn8
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 19260
HGNC: HGNC:9652
Homologene: 7498
Vav3
Name: vav 3 oncogene
Synonyms: A530094I06Rik, Idd18.1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 57257
Homologene: 38143
Qars1
Name: glutaminyl-tRNA synthetase 1
Synonyms: 1200016L19Rik, Qars, 1110018N24Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 97541
HGNC: HGNC:9751
Homologene: 133975
Or6c215
Name: olfactory receptor family 6 subfamily C member 215
Synonyms: Olfr811, MOR110-6, GA_x6K02T2PULF-11481207-11480248
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258545
Homologene: 133725
Pate7
Name: prostate and testis expressed 7
Synonyms: Gm17727
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 100312986
Homologene: 129804
Mptx2
Name: mucosal pentraxin 2
Synonyms: Gm11062
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 100504232
Homologene: 134535
C4bp
Name: complement component 4 binding protein
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12269
HGNC: HGNC:1325
Mtfmt
Name: mitochondrial methionyl-tRNA formyltransferase
Synonyms: 2310020P08Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 69606
Homologene: 12320
Lipo5
Name: lipase, member O5
Synonyms: Gm8975
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 668095
Vmn2r44
Name: vomeronasal 2, receptor 44
Synonyms: EG434113
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 434113
Homologene: 113703
Btd
Name: biotinidase
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 26363
HGNC: HGNC:1122
Homologene: 37255
Alkal2
Name: ALK and LTK ligand 2
Synonyms: Fam150b, 6230419C23Rik, Augalpha, Augmentor alpha
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 100294583
VEGA: 12
Homologene: 87330
Pcdha11
Name: protocadherin alpha 11
Synonyms: Cnr7, A830022B16Rik, Crnr7
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 12942
HGNC: HGNC:8665
Homologene: 75095
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 130,639,072 bp
  • CAGCCTTCGTTGGGTG to C, chromosome 1 at 162,011,068 bp
  • G to A, chromosome 1 at 173,274,847 bp
  • G to A, chromosome 1 at 194,949,569 bp
  • T to G, chromosome 2 at 29,140,290 bp
  • T to C, chromosome 2 at 36,688,547 bp
  • T to G, chromosome 2 at 62,554,770 bp
  • T to C, chromosome 2 at 75,937,800 bp
  • T to A, chromosome 2 at 86,298,675 bp
  • T to C, chromosome 2 at 119,812,823 bp
  • T to C, chromosome 2 at 121,194,108 bp
  • G to A, chromosome 3 at 32,563,024 bp
  • G to T, chromosome 3 at 63,698,858 bp
  • T to A, chromosome 3 at 88,985,129 bp
  • A to G, chromosome 3 at 103,912,015 bp
  • C to T, chromosome 3 at 109,664,365 bp
  • C to T, chromosome 3 at 113,561,900 bp
  • T to C, chromosome 4 at 56,740,224 bp
  • G to A, chromosome 4 at 106,748,198 bp
  • T to C, chromosome 5 at 13,581,001 bp
  • A to G, chromosome 5 at 52,796,144 bp
  • A to G, chromosome 6 at 82,937,104 bp
  • A to T, chromosome 6 at 119,972,997 bp
  • T to C, chromosome 6 at 120,412,306 bp
  • A to T, chromosome 7 at 8,378,006 bp
  • G to A, chromosome 7 at 19,633,806 bp
  • C to T, chromosome 7 at 99,735,170 bp
  • T to A, chromosome 7 at 100,441,076 bp
  • A to G, chromosome 7 at 104,106,572 bp
  • G to T, chromosome 7 at 108,395,828 bp
  • G to T, chromosome 7 at 140,848,641 bp
  • A to T, chromosome 9 at 35,777,146 bp
  • T to C, chromosome 9 at 65,447,304 bp
  • T to C, chromosome 9 at 76,259,782 bp
  • T to A, chromosome 9 at 107,978,939 bp
  • T to C, chromosome 9 at 108,508,098 bp
  • T to A, chromosome 10 at 79,182,003 bp
  • G to A, chromosome 10 at 129,801,820 bp
  • C to A, chromosome 10 at 129,801,821 bp
  • T to C, chromosome 11 at 23,287,434 bp
  • T to C, chromosome 12 at 8,011,883 bp
  • A to T, chromosome 12 at 21,353,948 bp
  • A to G, chromosome 12 at 24,580,747 bp
  • G to A, chromosome 12 at 30,887,058 bp
  • T to C, chromosome 13 at 9,623,766 bp
  • C to G, chromosome 13 at 69,627,648 bp
  • C to T, chromosome 14 at 21,670,487 bp
  • G to A, chromosome 14 at 31,641,108 bp
  • A to T, chromosome 14 at 60,971,139 bp
  • A to G, chromosome 15 at 76,119,796 bp
  • T to G, chromosome 15 at 83,879,634 bp
  • A to G, chromosome 16 at 35,953,626 bp
  • T to C, chromosome 16 at 45,575,368 bp
  • G to T, chromosome 17 at 25,391,276 bp
  • T to C, chromosome 18 at 37,011,456 bp
  • T to C, chromosome 18 at 37,308,429 bp
  • C to T, chromosome 19 at 13,619,885 bp
  • A to G, chromosome 19 at 27,238,077 bp
  • T to C, chromosome 19 at 33,467,917 bp
  • T to A, chromosome 19 at 44,790,736 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6110 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044428-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.