Strain Name:
C57BL/6J-MtgxR6389Btlr/Mmmh
Stock Number:
044538-MU
Citation ID:
RRID:MMRRC_044538-MU
Other Names:
R6389 (G1)
Major Collection:

Strain Information

Dst
Name: dystonin
Synonyms: Macf2, A830042E19Rik, Bpag1, Bpag, bullous pemphigoid antigen 1, nmf203, athetoid, nmf339, BPAG1, BPAG1-n, 2310001O04Rik, bullous pemphigoid antigen 1, ah
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Ctnnal1
Name: catenin alpha like 1
Synonyms: catenin (cadherin associated protein), alpha-like 1, Catnal1, ACRP
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 54366
HGNC: HGNC:2512
Homologene: 2815
Plekhm1
Name: pleckstrin homology domain containing, family M (with RUN domain) member 1
Synonyms: AP162, B2, D330036J23Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 353047
Homologene: 8871
Ube2o
Name: ubiquitin-conjugating enzyme E2O
Synonyms: B230113M03Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217342
Homologene: 11113
Tyw5
Name: tRNA-yW synthesizing protein 5
Synonyms: 1110034B05Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 68736
Homologene: 72085
Ubr1
Name: ubiquitin protein ligase E3 component n-recognin 1
Synonyms: E3 alpha
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22222
Homologene: 7582
Fnbp4
Name: formin binding protein 4
Synonyms: FBP30
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 55935
Homologene: 9087
Bms1
Name: BMS1, ribosome biogenesis factor
Synonyms: Bms1l
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 213895
Homologene: 7065
Actn1
Name: actinin, alpha 1
Synonyms: 3110023F10Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 109711
VEGA: 12
HGNC: HGNC:163
Homologene: 55553
Prr11
Name: proline rich 11
Synonyms: B930067F20Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 270906
Homologene: 10123
Nop56
Name: NOP56 ribonucleoprotein
Synonyms: NOP56, 56kDa with KKE/D repeat, Nol5a, 2310044F10Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 67134
Homologene: 4660
Naf1
Name: nuclear assembly factor 1 ribonucleoprotein
Synonyms: LOC234344
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234344
Homologene: 128518
Rrp1b
Name: ribosomal RNA processing 1B
Synonyms: 2600005C20Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 72462
Homologene: 57086
Bicc1
Name: BicC family RNA binding protein 1
Synonyms: Bic-C, jcpk
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 83675
Homologene: 12856
Tbr1
Name: T-box brain transcription factor 1
Synonyms: T-box brain gene 1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 21375
Homologene: 4807
Map3k1
Name: mitogen-activated protein kinase kinase kinase 1
Synonyms: MEKK1, Mekk
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 26401
HGNC: HGNC:6848
Homologene: 8056
Spag9
Name: sperm associated antigen 9
Synonyms: 3110018C07Rik, Mapk8ip4, 4831406C20Rik, syd1, JLP, 4733401I23Rik, JIP4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 70834
Homologene: 2954
Zfp799
Name: zinc finger protein 799
Synonyms: 6030490I01Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240064
Homologene: 107106
Dmp1
Name: dentin matrix protein 1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 13406
HGNC: HGNC:2932
Homologene: 68396
Pisd
Name: phosphatidylserine decarboxylase
Synonyms: 9030221M09Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 320951
HGNC: HGNC:8999
Homologene: 81653
D16Ertd472e
Name: DNA segment, Chr 16, ERATO Doi 472, expressed
Synonyms: 2310009O17Rik, 1700010I10Rik, E330003K22Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 67102
Homologene: 9696
Cul4a
Name: cullin 4A
Synonyms: 2810470J21Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 99375
HGNC: HGNC:2554
Homologene: 81724
Inpp5f
Name: inositol polyphosphate-5-phosphatase F
Synonyms: SAC2, 5830435P03Rik, cI-27
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101490
Homologene: 8962
Cnnm3
Name: cyclin M3
Synonyms: Acdp3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 94218
HGNC: HGNC:104
Homologene: 23029
Tnrc6c
Name: trinucleotide repeat containing 6C
Synonyms: 9930033H14Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217351
Homologene: 23137
Ptpn4
Name: protein tyrosine phosphatase, non-receptor type 4
Synonyms: PTPMEG, TEP/mPTPMEG, protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte), hPTP-MEG, testis-enriched phosphatase, TEP
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 19258
HGNC: HGNC:9656
Homologene: 2120
Clu
Name: clusterin
Synonyms: SP-40, ApoJ, Apolipoprotein J, Cli, testosterone repressed prostate message-2, complement lysis inhibitor, D14Ucla3, Sgp2, Sugp-2, Sgp-2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 12759
HGNC: HGNC:2095
Homologene: 1382
Slc9a4
Name: solute carrier family 9 (sodium/hydrogen exchanger), member 4
Synonyms: NHE4, D730009J23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 110895
Homologene: 72232
Ism2
Name: isthmin 2
Synonyms: Thsd3, LOC217738
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217738
Homologene: 83509
Klrg1
Name: killer cell lectin-like receptor subfamily G, member 1
Synonyms: 2F1-Ag
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 50928
HGNC: HGNC:6380
Homologene: 4244
Ksr2
Name: kinase suppressor of ras 2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 333050
Homologene: 45469
Cfap74
Name: cilia and flagella associated protein 74
Synonyms: 2010015L04Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 544678
Homologene: 129584
Siglecl2
Name: Siglec family like 2
Synonyms: 4931406B18Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 74054
Homologene: 105741
Dnah14
Name: dynein, axonemal, heavy chain 14
Synonyms: LOC381311, Gm980, A230079K17Rik, Dnahc14
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240960
HGNC: HGNC:2945
Homologene: 90078
Ncoa6
Name: nuclear receptor coactivator 6
Synonyms: NRC, ASC-2, PRIP, ASC2, RAP250, AIB3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 56406
Homologene: 137337
Lrrc7
Name: leucine rich repeat containing 7
Synonyms: densin
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242274
Homologene: 10817
Cadm4
Name: cell adhesion molecule 4
Synonyms: Igsf4c, Necl-4, SynCAM 4, Tsll2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 260299
Homologene: 17063
Hcn3
Name: hyperpolarization-activated, cyclic nucleotide-gated K+ 3
Synonyms: Hac3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 15168
Homologene: 22453
Abcb11
Name: ATP-binding cassette, sub-family B member 11
Synonyms: ABC16, Lith1, PFIC2, sister of P-glycoprotein, Bsep, PGY4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 27413
HGNC: HGNC:42
Homologene: 74509
Gm13941
Name: predicted gene 13941
Type: Gene
Species: Mouse
Chromosome: 2
Nt5e
Name: 5' nucleotidase, ecto
Synonyms: ecto-5'-nucleotidase, Nt5, 2210401F01Rik, CD73
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 23959
HGNC: HGNC:8021
Homologene: 1895
Or5w8
Name: olfactory receptor family 5 subfamily W member 8
Synonyms: MOR177-9, Olfr1151, GA_x6K02T2Q125-49358694-49359620
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258631
Homologene: 36999
Ago4
Name: argonaute RISC catalytic subunit 4
Synonyms: Eif2c4, argonaute 4, 5730550L01Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 76850
Homologene: 41184
Col20a1
Name: collagen, type XX, alpha 1
Synonyms: 1700051I12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 73368
Homologene: 75138
Vmn2r16
Name: vomeronasal 2, receptor 16
Synonyms: EG384220
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 384220
Homologene: 104825
Fpr-rs3
Name: formyl peptide receptor, related sequence 3
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 14290
HGNC: HGNC:3827
Homologene: 130087
Cntd1
Name: cyclin N-terminal domain containing 1
Synonyms: 5430417M23Rik, 1700051C09Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 68107
Homologene: 12237
Or4a27
Name: olfactory receptor family 4 subfamily A member 27
Synonyms: Olfr1197, MOR225-14, MOR225-10P, GA_x6K02T2Q125-50202854-50201910
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 433449
Homologene: 123770
Sel1l2
Name: sel-1 suppressor of lin-12-like 2 (C. elegans)
Synonyms: LOC228684
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228684
Homologene: 16802
Oxct2b
Name: 3-oxoacid CoA transferase 2B
Synonyms: Scot-t2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 353371
Homologene: 137359
Or52p2
Name: olfactory receptor family 52 subfamily P member 2
Synonyms: MOR29-1, GA_x6K02T2PBJ9-5307445-5306498, Olfr551
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258750
Homologene: 17381
Mcub
Name: modifier of curly bare
Synonyms: 9030408N13Rik, Ccdc109b
Type: Gene
Species: Mouse
Chromosome: 3
Ly9
Name: lymphocyte antigen 9
Synonyms: SLAMF3, CD229, Lgp100, T100
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17085
HGNC: HGNC:6730
Homologene: 1759
Tspan17
Name: tetraspanin 17
Synonyms: 2210021G21Rik, Fbxo23, Tm4sf17
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 74257
Homologene: 41762
Odad1
Name: outer dynein arm docking complex subunit 1
Synonyms: Ccdc114
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 211535
Homologene: 128610
Oxct2a
Name: 3-oxoacid CoA transferase 2A
Synonyms: Oxct2, Scot-t1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 64059
Homologene: 137359
Mup16
Name: major urinary protein 16
Synonyms: Gm2083
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100039177
Homologene: 74304
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 34,193,184 bp
  • T to C, chromosome 1 at 36,520,522 bp
  • A to G, chromosome 1 at 40,580,684 bp
  • T to C, chromosome 1 at 57,391,499 bp
  • T to A, chromosome 1 at 119,721,954 bp
  • G to C, chromosome 1 at 171,596,537 bp
  • G to A, chromosome 1 at 181,651,202 bp
  • A to G, chromosome 2 at 61,806,287 bp
  • A to T, chromosome 2 at 69,323,894 bp
  • C to T, chromosome 2 at 87,858,023 bp
  • A to G, chromosome 2 at 88,728,672 bp
  • C to T, chromosome 2 at 90,745,535 bp
  • T to C, chromosome 2 at 111,098,389 bp
  • G to T, chromosome 2 at 120,881,039 bp
  • C to A, chromosome 2 at 130,277,887 bp
  • C to A, chromosome 2 at 140,245,354 bp
  • A to G, chromosome 2 at 155,395,816 bp
  • T to C, chromosome 2 at 180,992,583 bp
  • C to T, chromosome 3 at 89,150,933 bp
  • T to C, chromosome 3 at 129,918,708 bp
  • T to G, chromosome 3 at 158,185,426 bp
  • A to G, chromosome 4 at 56,813,849 bp
  • T to C, chromosome 4 at 61,518,940 bp
  • G to T, chromosome 4 at 123,116,574 bp
  • T to A, chromosome 4 at 123,323,427 bp
  • T to A, chromosome 4 at 126,507,244 bp
  • T to C, chromosome 4 at 155,423,336 bp
  • A to G, chromosome 5 at 32,764,847 bp
  • A to T, chromosome 5 at 104,212,922 bp
  • A to T, chromosome 5 at 109,330,478 bp
  • G to A, chromosome 5 at 109,676,019 bp
  • A to G, chromosome 5 at 117,414,842 bp
  • T to C, chromosome 6 at 118,403,235 bp
  • T to C, chromosome 6 at 122,271,472 bp
  • A to C, chromosome 7 at 24,499,534 bp
  • A to C, chromosome 7 at 43,497,830 bp
  • G to T, chromosome 7 at 45,948,516 bp
  • A to T, chromosome 7 at 102,588,472 bp
  • A to G, chromosome 7 at 128,678,056 bp
  • A to G, chromosome 8 at 13,140,278 bp
  • C to T, chromosome 8 at 66,861,028 bp
  • T to C, chromosome 9 at 88,363,471 bp
  • A to T, chromosome 10 at 70,958,922 bp
  • G to A, chromosome 11 at 87,098,738 bp
  • A to G, chromosome 11 at 94,086,311 bp
  • A to T, chromosome 11 at 101,285,751 bp
  • G to T, chromosome 11 at 103,366,894 bp
  • A to C, chromosome 11 at 116,548,858 bp
  • A to G, chromosome 11 at 117,722,741 bp
  • T to A, chromosome 12 at 80,174,522 bp
  • T to C, chromosome 12 at 87,282,371 bp
  • A to T, chromosome 13 at 54,795,616 bp
  • T to C, chromosome 13 at 111,769,441 bp
  • G to C, chromosome 14 at 65,971,322 bp
  • A to G, chromosome 16 at 78,545,183 bp
  • A to T, chromosome 17 at 20,623,968 bp
  • A to G, chromosome 17 at 32,056,627 bp
  • A to G, chromosome 17 at 32,820,578 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6389 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044538-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.