Strain Name:
C57BL/6J-MtgxR6475Btlr/Mmmh
Stock Number:
044608-MU
Citation ID:
RRID:MMRRC_044608-MU
Other Names:
R6475 (G1)
Major Collection:

Strain Information

Gba1
Name: glucosylceramidase beta 1
Synonyms: betaGC, GC, GCase, GBA1, Gba, glucocerebrosidase
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 14466
HGNC: HGNC:4177
Homologene: 68040
Sez6
Name: seizure related gene 6
Synonyms: sez-6, D11Bhm177e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20370
Homologene: 10948
Rpp38
Name: ribonuclease P/MRP 38 subunit
Synonyms: C330006A15Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227522
Homologene: 4680
Senp2
Name: SUMO/sentrin specific peptidase 2
Synonyms: 4930538C18Rik, 2310007L05Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 75826
VEGA: 16
Homologene: 11005
Hsd17b4
Name: hydroxysteroid (17-beta) dehydrogenase 4
Synonyms: MFP2, Mfp-2, 17[b]-HSD, perMFE-2, multifunctional protein 2, MFE-2, D-bifunctional protein
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 15488
HGNC: HGNC:5213
Homologene: 358
Cog4
Name: component of oligomeric golgi complex 4
Synonyms: D8Ertd515e
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 102339
Homologene: 7155
Bmpr2
Name: bone morphogenetic protein receptor type 2
Synonyms: BMPR-II, BMPRII, BMP-2, 2610024H22Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12168
HGNC: HGNC:1078
Homologene: 929
Robo3
Name: roundabout guidance receptor 3
Synonyms: Robo3a, Rbig1, Rig1, Rig-1, Robo3b
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 19649
Homologene: 32119
Eif2ak1
Name: eukaryotic translation initiation factor 2 alpha kinase 1
Synonyms: Hri
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 15467
Homologene: 8290
Fgfr2
Name: fibroblast growth factor receptor 2
Synonyms: Fgfr-2, Fgfr2b, Fgfr-7, KGFRTr, Bek, svs, Fgfr7
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 14183
HGNC: HGNC:3689
Homologene: 22566
Zfp799
Name: zinc finger protein 799
Synonyms: 6030490I01Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240064
Homologene: 107106
Egfr
Name: epidermal growth factor receptor
Synonyms: 9030024J15Rik, Erbb, Errb1, avian erythroblastic leukemia viral (v-erb-b) oncogene homolog, Wa5
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 13649
HGNC: HGNC:3236
Homologene: 74545
Cpne6
Name: copine VI
Synonyms: neuronal copine
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 12891
HGNC: HGNC:2319
Homologene: 81815
Grik4
Name: glutamate receptor, ionotropic, kainate 4
Synonyms: KA1, 6330551K01Rik, KA-1, GluRgamma1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 110637
HGNC: HGNC:4582
Homologene: 81829
Klf5
Name: Kruppel-like transcription factor 5
Synonyms: IKLF, 4930520J07Rik, Bteb2, CKLF
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 12224
VEGA: 14
HGNC: HGNC:6349
Homologene: 37520
Sec31a
Name: SEC31 homolog A, COPII coat complex component
Synonyms: Sec31l1, 1810024J13Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 69162
Homologene: 42056
Septin10
Name: septin 10
Synonyms: 4921515A04Rik, 9430099J10Rik, Sept10
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 103080
VEGA: 10
Homologene: 27035
Fam185a
Name: family with sequence similarity 185, member A
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 330050
Homologene: 51828
Mctp2
Name: multiple C2 domains, transmembrane 2
Synonyms: LOC244049
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244049
Homologene: 69254
Cd209a
Name: CD209a antigen
Synonyms: CIRE, DC-SIGN1, SIGNR5, CD209, Dcsign, DC-SIGN
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 170786
Homologene: 129771
Pthlh
Name: parathyroid hormone-like peptide
Synonyms: parathyroid hormone-related peptide, parathyroid hormone-related protein, PTH-like, parathyroid hormone-like hormone, PTH-related peptide, Pthrp
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 19227
HGNC: HGNC:9607
Homologene: 2113
Map4k1
Name: mitogen-activated protein kinase kinase kinase kinase 1
Synonyms: Hpk1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 26411
HGNC: HGNC:6863
Homologene: 5199
Med12l
Name: mediator complex subunit 12-like
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 329650
Homologene: 43143
Egfem1
Name: EGF-like and EMI domain containing 1
Synonyms: 6130401L20Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 75740
Homologene: 135950
Pkd1l3
Name: polycystic kidney disease 1 like 3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244646
Homologene: 14627
Rapgef5
Name: Rap guanine nucleotide exchange factor (GEF) 5
Synonyms: mr-gef, D030051B22Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217944
VEGA: 12
Homologene: 56563
Fbxl4
Name: F-box and leucine-rich repeat protein 4
Synonyms: FBL5, FBL4
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 269514
Homologene: 8128
Col14a1
Name: collagen, type XIV, alpha 1
Synonyms: 5730412L22Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12818
HGNC: HGNC:2191
Homologene: 18741
Naip1
Name: NLR family, apoptosis inhibitory protein 1
Synonyms: Birc1a, D13Lsd1, Naip
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17940
VEGA: 13
HGNC: HGNC:7634
Homologene: 113589
Itgb7
Name: integrin beta 7
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 16421
HGNC: HGNC:6162
Homologene: 20247
Ush1c
Name: USH1 protein network component harmonin
Synonyms: Usher syndrome 1C, 2010016F01Rik, harmonin
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 72088
Homologene: 77476
Dhx30
Name: DExH-box helicase 30
Synonyms: 2810477H02Rik, C130058C04Rik, DEAH (Asp-Glu-Ala-His) box polypeptide 30, Ddx30, helG
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 72831
Homologene: 15779
Kif14
Name: kinesin family member 14
Synonyms: N-3 kinesin, D1Ertd367e
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 381293
Homologene: 8916
Daglb
Name: diacylglycerol lipase, beta
Synonyms: E330036I19Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231871
Homologene: 34715
Or2v1
Name: olfactory receptor family 2 subfamily V member 1
Synonyms: GA_x6K02T2QP88-6300500-6299553, Olfr56, IF7, MOR276-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18356
HGNC: HGNC:8280
Homologene: 22608
Tnni3k
Name: TNNI3 interacting kinase
Synonyms: D830019J24Rik, Cark
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 435766
Homologene: 41084
Tubb2a
Name: tubulin, beta 2A class IIA
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 22151
VEGA: 13
Homologene: 134314
Tmbim7
Name: transmembrane BAX inhibitor motif containing 7
Synonyms: Tmbim1b, Lfg5, 4930511M11Rik, 4930500J03Rik, 4930403J02Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 75010
Homologene: 81927
Epb42
Name: erythrocyte membrane protein band 4.2
Synonyms: Epb4.2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 13828
HGNC: HGNC:3381
Homologene: 93
Iqub
Name: IQ motif and ubiquitin domain containing
Synonyms: Trs4, 4932408B21Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 214704
Homologene: 44790
Cdh18
Name: cadherin 18
Synonyms: B230220E17Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 320865
HGNC: HGNC:1757
Homologene: 55858
Or2ag2
Name: olfactory receptor family 2 subfamily AG member 2
Synonyms: Olfr706, GA_x6K02T2PBJ9-9271198-9270248, MOR283-11
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258350
Homologene: 133646
Klhl29
Name: kelch-like 29
Synonyms: A230106N14Rik, Kbtbd9
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 208439
VEGA: 12
Homologene: 66272
Rita1
Name: RBPJ interacting and tubulin associated 1
Synonyms: 1110008J03Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100764
Homologene: 12585
Trdn
Name: triadin
Synonyms: triadin-1, EG432451, triadin 3, triadin 1, 2310045H21Rik, triadin-2, triadin-3, triadin 2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 76757
VEGA: 10
Homologene: 38137
Or4f14
Name: olfactory receptor family 4 subfamily F member 14
Synonyms: GA_x6K02T2Q125-72954873-72953935, MOR245-15, Olfr1306
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258023
Homologene: 128383
Gabra1
Name: gamma-aminobutyric acid type A receptor subunit alpha 1
Synonyms: GABAA alpha 1, GABAAR alpha1, Gabra-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14394
HGNC: HGNC:4075
Homologene: 629
Igdcc4
Name: immunoglobulin superfamily, DCC subclass, member 4
Synonyms: Nope, 9330155G14Rik, WI-16786, WI-18508
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 56741
VEGA: 9
Homologene: 10570
Haao
Name: 3-hydroxyanthranilate 3,4-dioxygenase
Synonyms: 0610012J07Rik, 3-HAOxase, 0610007K21Rik, 3-HAO, 3HAO
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 107766
VEGA: 17
HGNC: HGNC:4796
Homologene: 8148
Defb43
Name: defensin beta 43
Synonyms: EG654458
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 654458
Homologene: 86860
Erlec1
Name: endoplasmic reticulum lectin 1
Synonyms: 4933407N01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 66753
Homologene: 9247
Spesp1
Name: sperm equatorial segment protein 1
Synonyms: 4921508E09Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 66712
VEGA: 9
Homologene: 49838
Ccr4
Name: C-C motif chemokine receptor 4
Synonyms: CC CKR-4, Cmkbr4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12773
VEGA: 9
HGNC: HGNC:1605
Homologene: 21135
Zfp768
Name: zinc finger protein 768
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233890
Homologene: 11650
Krtap5-20
Name: keratin associated protein 5-20
Synonyms: Gm4559
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100043627
VEGA: 7
Mup9
Name: major urinary protein 9
Synonyms: Gm14076
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100038948
Homologene: 74304
Or8g28
Name: olfactory receptor family 8 subfamily G member 28
Synonyms: GA_x6K02T2PVTD-32955932-32954982, MOR171-20, Olfr945
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258499
VEGA: 9
HGNC: HGNC:8484
Homologene: 133643
Gm3409
Name: predicted gene 3409
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100041566
Homologene: 86127
Asb5
Name: ankyrin repeat and SOCs box-containing 5
Synonyms: 1110018D09Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 76294
Homologene: 12637
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 59,868,344 bp
  • T to C, chromosome 1 at 136,527,411 bp
  • T to C, chromosome 2 at 3,329,607 bp
  • G to A, chromosome 2 at 111,912,859 bp
  • T to C, chromosome 2 at 121,027,133 bp
  • A to T, chromosome 3 at 29,657,163 bp
  • A to G, chromosome 3 at 59,257,079 bp
  • A to G, chromosome 3 at 89,205,928 bp
  • A to T, chromosome 3 at 154,941,058 bp
  • T to A, chromosome 4 at 22,433,661 bp
  • A to T, chromosome 4 at 60,419,806 bp
  • G to A, chromosome 5 at 3,664,319 bp
  • A to G, chromosome 5 at 21,425,283 bp
  • T to C, chromosome 5 at 100,385,270 bp
  • G to A, chromosome 5 at 120,611,570 bp
  • G to T, chromosome 5 at 143,481,651 bp
  • T to G, chromosome 5 at 143,818,010 bp
  • T to A, chromosome 5 at 146,537,786 bp
  • T to A, chromosome 6 at 24,449,745 bp
  • G to T, chromosome 6 at 147,257,190 bp
  • T to C, chromosome 7 at 28,987,022 bp
  • T to C, chromosome 7 at 46,229,219 bp
  • A to T, chromosome 7 at 72,200,344 bp
  • A to G, chromosome 7 at 106,886,397 bp
  • A to T, chromosome 7 at 127,344,655 bp
  • T to A, chromosome 7 at 130,201,120 bp
  • A to G, chromosome 7 at 142,274,150 bp
  • A to T, chromosome 8 at 3,747,031 bp
  • T to A, chromosome 8 at 54,550,575 bp
  • A to C, chromosome 8 at 109,623,212 bp
  • T to A, chromosome 8 at 110,880,894 bp
  • T to C, chromosome 9 at 37,423,290 bp
  • T to A, chromosome 9 at 39,258,082 bp
  • T to C, chromosome 9 at 42,629,008 bp
  • C to T, chromosome 9 at 62,272,433 bp
  • A to T, chromosome 9 at 65,120,321 bp
  • A to G, chromosome 9 at 110,085,052 bp
  • A to G, chromosome 9 at 114,492,979 bp
  • T to A, chromosome 10 at 33,464,555 bp
  • T to C, chromosome 10 at 59,192,311 bp
  • A to G, chromosome 11 at 16,891,259 bp
  • G to A, chromosome 11 at 30,948,442 bp
  • A to T, chromosome 11 at 42,162,555 bp
  • C to T, chromosome 11 at 49,134,933 bp
  • A to G, chromosome 11 at 77,973,844 bp
  • C to T, chromosome 12 at 5,091,030 bp
  • T to A, chromosome 12 at 117,718,207 bp
  • A to G, chromosome 13 at 34,075,459 bp
  • T to C, chromosome 13 at 100,409,088 bp
  • A to G, chromosome 14 at 55,513,653 bp
  • G to T, chromosome 14 at 63,011,872 bp
  • A to G, chromosome 14 at 99,301,381 bp
  • A to G, chromosome 15 at 23,226,936 bp
  • T to G, chromosome 15 at 55,445,822 bp
  • T to A, chromosome 15 at 102,216,266 bp
  • G to T, chromosome 16 at 22,023,800 bp
  • A to G, chromosome 17 at 32,820,846 bp
  • A to G, chromosome 17 at 83,831,684 bp
  • T to A, chromosome 18 at 50,172,262 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6475 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044608-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.