Strain Name:
C57BL/6J-MtgxR6515Btlr/Mmmh
Stock Number:
044642-MU
Citation ID:
RRID:MMRRC_044642-MU
Other Names:
R6515 (G1)
Major Collection:

Strain Information

Cdk4
Name: cyclin dependent kinase 4
Synonyms: Crk3, p34PSK-J3/cdk4
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 12567
HGNC: HGNC:1773
Homologene: 55429
Enpp2
Name: ectonucleotide pyrophosphatase/phosphodiesterase 2
Synonyms: Npps2, Pdnp2, PD-Ialpha, Autotaxin, ATX
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 18606
HGNC: HGNC:3357
Homologene: 4526
Spop
Name: speckle-type BTB/POZ protein
Synonyms: TEF2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20747
Homologene: 68354
Sec24d
Name: SEC24 homolog D, COPII coat complex component
Synonyms: LOC383951, 2310020L09Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 69608
Homologene: 40986
Hspa5
Name: heat shock protein 5
Synonyms: XAP-1 antigen, mBiP, D2Wsu141e, Grp78, Sez7, Hsce70, baffled, 78kDa, D2Wsu17e, Bip
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14828
HGNC: HGNC:5238
Homologene: 3908
Rbm34
Name: RNA binding motif protein 34
Synonyms: 4930547K05Rik, D8Ertd233e
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 52202
Homologene: 56691
Tenm3
Name: teneurin transmembrane protein 3
Synonyms: 2610100B16Rik, Odz3, Ten-m3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 23965
Homologene: 22673
Casp8ap2
Name: caspase 8 associated protein 2
Synonyms: D4Ertd659e, FLASH
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 26885
HGNC: HGNC:1510
Homologene: 8066
Itpr3
Name: inositol 1,4,5-triphosphate receptor 3
Synonyms: Ip3r3, Itpr-3, tf
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 16440
HGNC: HGNC:6182
Homologene: 1675
Atp4a
Name: ATPase, H+/K+ exchanging, gastric, alpha polypeptide
Synonyms: H+K+-transporting alpha 1, H+/K+-ATPase alpha
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 11944
HGNC: HGNC:819
Homologene: 68081
Pik3ap1
Name: phosphoinositide-3-kinase adaptor protein 1
Synonyms: BCAP, 1810044J04Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 83490
VEGA: 19
Homologene: 12848
Uggt2
Name: UDP-glucose glycoprotein glucosyltransferase 2
Synonyms: A230065J02Rik, 3110001A05Rik, 1810064L21Rik, 3110027P15Rik, Ugcgl2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 66435
Homologene: 56875
Svep1
Name: sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
Synonyms: 4833413O10Rik, D430029O09Rik, 1110021D17Rik, Polydom
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 64817
Homologene: 23386
Or4f62
Name: olfactory receptor family 4 subfamily F member 62
Synonyms: GA_x6K02T2Q125-73202172-73203134, Olfr1318, MOR245-16
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258022
Homologene: 134079
Mfsd6
Name: major facilitator superfamily domain containing 6
Synonyms: MMR2, 2210010L05Rik, 9630025I22Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98682
Homologene: 9784
Unc13a
Name: unc-13 homolog A
Synonyms: Munc13-1, 2410078G03Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 382018
Homologene: 11279
Thap12
Name: THAP domain containing 12
Synonyms: Dap4, Prkrir, 2900052B10Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 72981
HGNC: HGNC:9440
Homologene: 37952
Thsd7a
Name: thrombospondin, type I, domain containing 7A
Synonyms: LOC330267
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330267
Homologene: 46582
Bcl9l
Name: B cell CLL/lymphoma 9-like
Synonyms: DLNB11
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 80288
VEGA: 9
Homologene: 65615
Megf6
Name: multiple EGF-like-domains 6
Synonyms: Egfl3, 2600001P17Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230971
HGNC: HGNC:3232
Homologene: 45412
Klra17
Name: killer cell lectin-like receptor, subfamily A, member 17
Synonyms: Ly-49Q, Ly49Q, Ly49q1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 170733
Ppfia3
Name: protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
Synonyms: 2410127E16Rik, Liprin-alpha3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 76787
HGNC: HGNC:9247
Homologene: 37833
Apcdd1
Name: adenomatosis polyposis coli down-regulated 1
Synonyms: EIG180, Drapc1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 494504
VEGA: 18
Homologene: 77420
Hoxb5
Name: homeobox B5
Synonyms: Hox-2.1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 15413
HGNC: HGNC:5116
Homologene: 37585
Hspa4l
Name: heat shock protein 4 like
Synonyms: APG-1, Osp94, 94kDa
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18415
Homologene: 22610
Xirp1
Name: xin actin-binding repeat containing 1
Synonyms: Xin, Cmya1, mXin alpha
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 22437
VEGA: 9
Homologene: 7998
Rbm44
Name: RNA binding motif protein 44
Synonyms: LOC329207
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329207
Homologene: 66636
Oas1f
Name: 2'-5' oligoadenylate synthetase 1F
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 243262
HGNC: HGNC:8086
Homologene: 86720
Cnot6l
Name: CCR4-NOT transcription complex, subunit 6-like
Synonyms: 4932442K20Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231464
Homologene: 100830
Tle6
Name: transducin-like enhancer of split 6
Synonyms: 1810057E06Rik, Grg6
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 114606
Homologene: 11701
Ifit1bl1
Name: interferon induced protein with tetratricpeptide repeats 1B like 1
Synonyms: Gm14446
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 667373
Homologene: 78213
Cyp27b1
Name: cytochrome P450, family 27, subfamily b, polypeptide 1
Synonyms: Pddr, VddrI, P450c1, Cyp27b, Vddr, Vdd1, Cyp1, Cp2b, Cyp40, 25-hydroxyvitamin D3 1alpha-hydroxylase, P450VD1alpha, 25(OH)D 1alpha-hydroxylase, 1alpha(OH)ase
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 13115
HGNC: HGNC:2606
Homologene: 37139
Ggcx
Name: gamma-glutamyl carboxylase
Synonyms: vitamin K-dependent carboxylase
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 56316
HGNC: HGNC:4247
Homologene: 639
Cabyr
Name: calcium binding tyrosine phosphorylation regulated
Synonyms: 1700016C01Rik, CBP86, FSP-2, 4933421A18Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 71132
Homologene: 49299
Rnf151
Name: ring finger protein 151
Synonyms: 1700010O16Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 67504
VEGA: 17
Homologene: 12146
Pphln1-ps1
Name: periphilin 1, pseudogene 1
Synonyms: 3110001I22Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 66598
Nutm1
Name: NUT midline carcinoma, family member 1
Synonyms: Nut, BC125332
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 213765
Homologene: 18185
Pnlip
Name: pancreatic lipase
Synonyms: 1810007A24Rik, PTL, pancreatic triglyceride lipase
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 69060
VEGA: 19
HGNC: HGNC:9155
Homologene: 30999
Or10ak13
Name: olfactory receptor family 10 subfamily AK member 13
Synonyms: GA_x6K02SYWGW3-414-3, MOR259-10, GA_x6K02T2QD9B-18767132-18768073, Olfr219-ps1, Olfr1337
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 258306
Homologene: 121524
Tmem184a
Name: transmembrane protein 184a
Synonyms: Sdmg1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231832
Homologene: 64815
Ap1s3
Name: adaptor-related protein complex AP-1, sigma 3
Synonyms: [s]3A, Jr2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 252903
Homologene: 65622
Hbb-bh1
Name: hemoglobin Z, beta-like embryonic chain
Synonyms: betaH1, beta Hl globin
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 15132
Homologene: 110794
Kif19b
Name: kinesin family member 19B
Synonyms: Gm4869
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 101055939
Homologene: 82478
Cox17
Name: cytochrome c oxidase assembly protein 17, copper chaperone
Synonyms: COX17
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 12856
HGNC: HGNC:2264
Homologene: 38089
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 52,660,961 bp
  • T to C, chromosome 1 at 79,614,327 bp
  • T to C, chromosome 1 at 91,165,138 bp
  • T to A, chromosome 2 at 34,772,404 bp
  • T to C, chromosome 2 at 112,156,365 bp
  • A to C, chromosome 2 at 112,256,320 bp
  • A to G, chromosome 3 at 40,781,582 bp
  • G to A, chromosome 3 at 123,343,070 bp
  • A to G, chromosome 4 at 32,646,423 bp
  • C to T, chromosome 4 at 58,088,280 bp
  • T to C, chromosome 4 at 118,782,270 bp
  • C to T, chromosome 4 at 154,258,919 bp
  • C to A, chromosome 5 at 96,161,678 bp
  • T to C, chromosome 5 at 120,848,434 bp
  • A to G, chromosome 5 at 139,808,438 bp
  • T to C, chromosome 5 at 140,495,024 bp
  • T to A, chromosome 6 at 12,501,086 bp
  • T to C, chromosome 6 at 72,425,832 bp
  • A to T, chromosome 6 at 129,831,499 bp
  • A to G, chromosome 7 at 30,712,478 bp
  • T to C, chromosome 7 at 45,340,233 bp
  • A to G, chromosome 7 at 98,707,095 bp
  • T to C, chromosome 7 at 103,842,767 bp
  • G to C, chromosome 8 at 48,417,222 bp
  • A to G, chromosome 8 at 71,647,940 bp
  • A to T, chromosome 8 at 126,961,932 bp
  • A to G, chromosome 9 at 44,507,874 bp
  • T to C, chromosome 9 at 120,016,917 bp
  • G to A, chromosome 10 at 81,591,976 bp
  • G to T, chromosome 10 at 127,048,250 bp
  • C to T, chromosome 10 at 127,066,183 bp
  • C to A, chromosome 11 at 95,485,935 bp
  • A to T, chromosome 11 at 96,305,082 bp
  • A to T, chromosome 14 at 119,077,719 bp
  • T to A, chromosome 15 at 54,860,093 bp
  • G to A, chromosome 16 at 13,676,956 bp
  • C to A, chromosome 16 at 38,347,195 bp
  • A to T, chromosome 17 at 24,716,417 bp
  • C to T, chromosome 17 at 27,091,370 bp
  • A to G, chromosome 18 at 12,754,283 bp
  • T to A, chromosome 18 at 62,951,839 bp
  • T to C, chromosome 19 at 34,594,499 bp
  • A to G, chromosome 19 at 41,376,146 bp
  • T to C, chromosome 19 at 58,673,115 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6515 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044642-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.