Strain Name:
C57BL/6J-MtgxR6605Btlr/Mmmh
Stock Number:
044728-MU
Citation ID:
RRID:MMRRC_044728-MU
Other Names:
R6605 (G1)
Major Collection:

Strain Information

Npr3
Name: natriuretic peptide receptor 3
Synonyms: NPR-C, Nppc receptor, B430320C24Rik, lgj, longjohn
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 18162
VEGA: 15
HGNC: HGNC:7945
Homologene: 699
Gpr19
Name: G protein-coupled receptor 19
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14760
HGNC: HGNC:4473
Homologene: 4476
Gpr26
Name: G protein-coupled receptor 26
Synonyms: 9630036A11Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233919
HGNC: HGNC:4481
Homologene: 17764
Pcnt
Name: pericentrin (kendrin)
Synonyms: m275Asp, Pcnt2, m239Asp
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 18541
VEGA: 10
Akap13
Name: A kinase anchor protein 13
Synonyms: 5730522G15Rik, 1700026G02Rik, PROTO-LB, Ht31, PROTO-LBC, 5830460E08Rik, AKAP-Lbc
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 75547
HGNC: HGNC:371
Homologene: 4903
Zbtb17
Name: zinc finger and BTB domain containing 17
Synonyms: Miz1, Zfp100, mZ13
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 22642
Homologene: 2575
Syn3
Name: synapsin III
Synonyms: Synapsin IIIa
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 27204
Homologene: 68320
Fosb
Name: FBJ osteosarcoma oncogene B
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 14282
HGNC: HGNC:3797
Homologene: 31403
Rnd2
Name: Rho family GTPase 2
Synonyms: Rohn, Arhn
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11858
Homologene: 21123
Eva1c
Name: eva-1 homolog C
Synonyms: 4931408A02Rik, Fam176c, 1700092M14Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 70967
Homologene: 14383
Ptprs
Name: protein tyrosine phosphatase receptor type S
Synonyms: PTP-NU3, Ptpt9, RPTPsigma, PTPsigma
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 19280
HGNC: HGNC:9681
Homologene: 20626
Tpst2
Name: protein-tyrosine sulfotransferase 2
Synonyms: grt, grm, Tango13b, D5Ucla3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22022
Homologene: 2666
Copg2
Name: coatomer protein complex, subunit gamma 2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 54160
HGNC: HGNC:2237
Homologene: 56292
Prdm4
Name: PR domain containing 4
Synonyms: 2810470D21Rik, 1700031E19Rik, SC1, SC-1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 72843
VEGA: 10
HGNC: HGNC:9348
Homologene: 8235
Asxl3
Name: ASXL transcriptional regulator 3
Synonyms: D430002O22Rik, LOC381127, D930044O18Rik, C230079D11Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 211961
Homologene: 19371
Acat2
Name: acetyl-Coenzyme A acetyltransferase 2
Synonyms: Tcp1-rs1, Tcp-1x
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 110460
HGNC: HGNC:94
Homologene: 55855
Lrp1
Name: low density lipoprotein receptor-related protein 1
Synonyms: b2b1554Clo, A2mr, CD91
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16971
HGNC: HGNC:6692
Homologene: 1744
Wdr17
Name: WD repeat domain 17
Synonyms: 3010002I12Rik, B230207L18Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244484
Homologene: 12460
Adgrv1
Name: adhesion G protein-coupled receptor V1
Synonyms: Mgr1, Mass1, Gpr98, VLGR1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 110789
Homologene: 19815
Ifit2
Name: interferon-induced protein with tetratricopeptide repeats 2
Synonyms: Ifi54
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 15958
HGNC: HGNC:5409
Homologene: 1187
Gm11639
Name: predicted gene 11639
Synonyms: Gm11639, Efcab15
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 105242472
Gucy2g
Name: guanylate cyclase 2g
Synonyms: 2410077I05Rik, GC-G
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 73707
Homologene: 44544
Taok2
Name: TAO kinase 2
Synonyms: TAO1, PSK1, 1110033K02Rik, MAP3K17, TAO2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 381921
Homologene: 74531
Abcc6
Name: ATP-binding cassette, sub-family C member 6
Synonyms: Dyscalc1, Mrp6, DCC
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 27421
HGNC: HGNC:57
Homologene: 55559
Cd79b
Name: CD79B antigen
Synonyms: Igb, Igbeta, Ig-beta, B29
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 15985
HGNC: HGNC:1699
Homologene: 521
Spata31h1
Name: SPATA31 subfamily H member 1
Synonyms: 4932415D10Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 102635990
VEGA: 10
Homologene: 82476
Asb2
Name: ankyrin repeat and SOCS box-containing 2
Synonyms: 1110008E15Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 65256
Homologene: 69202
Pnpt1
Name: polyribonucleotide nucleotidyltransferase 1
Synonyms: PNPase, polynucleotide phosphorylase, 1200003F12Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71701
Homologene: 12404
Pou2f2
Name: POU domain, class 2, transcription factor 2
Synonyms: Oct-2, Otf2, Oct2d, Oct2a, Oct2c, Otf-2, Oct2b
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18987
HGNC: HGNC:9213
Homologene: 55674
Lgr5
Name: leucine rich repeat containing G protein coupled receptor 5
Synonyms: Gpr49
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14160
HGNC: HGNC:4504
Homologene: 20807
Zw10
Name: zw10 kinetochore protein
Synonyms: MmZw10, 6330566F14Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 26951
VEGA: 9
Homologene: 37959
Or2y1b
Name: olfactory receptor family 2 subfamily Y member 1B
Synonyms: Olfr10, MOR256-55, GA_x6K02T2QP88-6117098-6116163, L45
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18307
Homologene: 81347
Rflna
Name: refilin A
Synonyms: Fam101a, 3110032G18Rik, cfm2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 73121
Homologene: 18764
Taar8a
Name: trace amine-associated receptor 8A
Synonyms: LOC215859
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 215859
Homologene: 77586
Pnlip
Name: pancreatic lipase
Synonyms: 1810007A24Rik, PTL, pancreatic triglyceride lipase
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 69060
VEGA: 19
HGNC: HGNC:9155
Homologene: 30999
Mief1
Name: mitochondrial elongation factor 1
Synonyms: Smcr7l
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239555
VEGA: 15
Homologene: 10374
Zfp772
Name: zinc finger protein 772
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232855
Homologene: 128539
Defa5
Name: defensin, alpha, 5
Synonyms: Defcr5
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 13239
Homologene: 113382
Trdv2-1
Name: T cell receptor delta variable 2-1
Synonyms: ENSMUSG00000068352
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 100101942
Gm5141
Name: predicted gene 5141
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 380850
Homologene: 136271
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 4 at 141,464,950 bp
  • A to T, chromosome 5 at 112,276,734 bp
  • A to G, chromosome 5 at 125,011,288 bp
  • A to G, chromosome 6 at 30,858,822 bp
  • T to C, chromosome 6 at 134,870,435 bp
  • T to C, chromosome 7 at 7,205,548 bp
  • T to C, chromosome 7 at 19,309,358 bp
  • A to C, chromosome 7 at 25,093,581 bp
  • T to A, chromosome 7 at 45,981,057 bp
  • A to G, chromosome 7 at 75,579,768 bp
  • T to A, chromosome 7 at 126,878,758 bp
  • G to A, chromosome 7 at 131,984,164 bp
  • A to C, chromosome 8 at 21,297,588 bp
  • A to C, chromosome 8 at 54,681,524 bp
  • A to G, chromosome 9 at 49,069,626 bp
  • A to T, chromosome 10 at 24,076,776 bp
  • A to G, chromosome 10 at 76,429,198 bp
  • A to T, chromosome 10 at 82,296,037 bp
  • A to G, chromosome 10 at 85,904,138 bp
  • A to G, chromosome 10 at 86,057,564 bp
  • A to C, chromosome 10 at 115,457,867 bp
  • G to A, chromosome 10 at 127,560,136 bp
  • T to A, chromosome 11 at 29,138,567 bp
  • A to T, chromosome 11 at 49,317,714 bp
  • C to T, chromosome 11 at 101,468,999 bp
  • T to A, chromosome 11 at 104,999,281 bp
  • C to T, chromosome 11 at 106,312,713 bp
  • G to T, chromosome 12 at 103,345,684 bp
  • G to A, chromosome 13 at 62,774,387 bp
  • G to A, chromosome 13 at 81,487,962 bp
  • A to G, chromosome 14 at 53,946,542 bp
  • C to G, chromosome 15 at 11,905,432 bp
  • T to A, chromosome 15 at 80,248,491 bp
  • T to A, chromosome 16 at 90,866,348 bp
  • A to G, chromosome 17 at 12,943,887 bp
  • A to T, chromosome 17 at 56,422,195 bp
  • A to T, chromosome 18 at 22,517,077 bp
  • C to T, chromosome 19 at 34,573,497 bp
  • T to A, chromosome 19 at 55,241,028 bp
  • A to T, chromosome 19 at 58,671,742 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6605 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044728-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.