Strain Name:
C57BL/6J-MtgxR6609Btlr/Mmmh
Stock Number:
044732-MU
Citation ID:
RRID:MMRRC_044732-MU
Other Names:
R6609 (G1)
Major Collection:

Strain Information

Slc26a5
Name: solute carrier family 26, member 5
Synonyms: prestin, Pres
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 80979
HGNC: HGNC:9359
Homologene: 69472
Bpifb3
Name: BPI fold containing family B, member 3
Synonyms: Rya3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 378700
Homologene: 18807
Kl
Name: klotho
Synonyms: alpha-kl
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 16591
HGNC: HGNC:6344
Homologene: 68415
Get4
Name: golgi to ER traffic protein 4
Synonyms: 1110007L15Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 67604
Homologene: 41080
Ylpm1
Name: YLP motif containing 1
Synonyms: Zap3, A930013E17Rik, ZAP
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 56531
Homologene: 87707
Mki67
Name: antigen identified by monoclonal antibody Ki 67
Synonyms: Ki67, Ki-67, D630048A14Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17345
HGNC: HGNC:7107
Homologene: 1814
Plcg2
Name: phospholipase C, gamma 2
Synonyms: PLCgamma2, Plcg-2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234779
HGNC: HGNC:9066
Homologene: 55671
Zfp985
Name: zinc finger protein 985
Synonyms: Gm13154
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 433804
Homologene: 133076
Cyth1
Name: cytohesin 1
Synonyms: CTH-1, Pscd1, CLM1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19157
HGNC: HGNC:9501
Homologene: 31262
Cdc7
Name: cell division cycle 7
Synonyms: Cdc7, Cdc7l1, muCdc7
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12545
HGNC: HGNC:1745
Homologene: 31166
C1rl
Name: complement component 1, r subcomponent-like
Synonyms: C1rl1, C1r-LP
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232371
Homologene: 9559
Cdc42bpa
Name: CDC42 binding protein kinase alpha
Synonyms: A930014J19Rik, DMPK-like
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226751
HGNC: HGNC:1737
Homologene: 55765
Dnah6
Name: dynein, axonemal, heavy chain 6
Synonyms: Dnahc6, A730004I20Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330355
HGNC: HGNC:2951
Homologene: 15221
Ptprq
Name: protein tyrosine phosphatase receptor type Q
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237523
HGNC: HGNC:9679
Homologene: 83557
Muc6
Name: mucin 6, gastric
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 353328
HGNC: HGNC:7517
Homologene: 18768
Lama3
Name: laminin, alpha 3
Synonyms: nicein, 150kDa, [a]3B
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 16774
HGNC: HGNC:6483
Homologene: 18279
Hsf5
Name: heat shock transcription factor family member 5
Synonyms: LOC327992
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 327992
Homologene: 52701
Cacna1s
Name: calcium channel, voltage-dependent, L type, alpha 1S subunit
Synonyms: Cchl1a3, Cav1.1, muscle dysgenesis, DHPR alpha1s, mdg, sj, fmd
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12292
HGNC: HGNC:1397
Homologene: 37257
Cacna1b
Name: calcium channel, voltage-dependent, N type, alpha 1B subunit
Synonyms: Cchn1a, alpha(1B), Cav2.2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12287
HGNC: HGNC:1389
Homologene: 20184
Pxdn
Name: peroxidasin
Synonyms: VPO1, 2310075M15Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 69675
Homologene: 33907
Grik5
Name: glutamate receptor, ionotropic, kainate 5 (gamma 2)
Synonyms: GluRgamma2, KA2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 14809
HGNC: HGNC:4583
Homologene: 1578
Abcb5
Name: ATP-binding cassette, sub-family B member 5
Synonyms: 9230106F14Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 77706
HGNC: HGNC:46
Homologene: 83488
Ndufb5
Name: NADH:ubiquinone oxidoreductase subunit B5
Synonyms: 0610007D05Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 66046
HGNC: HGNC:7700
Homologene: 31093
Pde1a
Name: phosphodiesterase 1A, calmodulin-dependent
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18573
HGNC: HGNC:8774
Homologene: 21043
Gm136
Name: predicted gene 136
Synonyms: LOC214568
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 214568
Homologene: 79759
Kcnc2
Name: potassium voltage gated channel, Shaw-related subfamily, member 2
Synonyms: KShIIIA, Kv3.2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 268345
VEGA: 10
HGNC: HGNC:6234
Homologene: 71199
Lrrc14
Name: leucine rich repeat containing 14
Synonyms: E130306I01Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223664
Homologene: 40970
Or6ae1
Name: olfactory receptor family 6 subfamily AE member 1
Synonyms: Olfr522, MOR103-5, GA_x6K02T2PBJ9-42315125-42314187
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258954
Homologene: 62435
Tmem102
Name: transmembrane protein 102
Synonyms: Cbap, Tmem102-ps
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380705
Homologene: 86820
Mettl15
Name: methyltransferase like 15
Synonyms: Mett5d1, 0610027B03Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 76894
Homologene: 12661
Cep20
Name: centrosomal protein 20
Synonyms: Fopnl, 0610037P05Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 66086
Homologene: 11919
Or4f60
Name: olfactory receptor family 4 subfamily F member 60
Synonyms: GA_x6K02T2Q125-73119859-73118924, MOR245-23, Olfr1313
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258257
Homologene: 106834
Smco4
Name: single-pass membrane protein with coiled-coil domains 4
Synonyms: BC017612
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 170748
VEGA: 9
Homologene: 136181
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 136,113,391 bp
  • T to G, chromosome 1 at 180,101,274 bp
  • C to T, chromosome 2 at 24,653,049 bp
  • T to A, chromosome 2 at 79,906,140 bp
  • T to C, chromosome 2 at 109,137,342 bp
  • T to C, chromosome 2 at 112,072,164 bp
  • T to A, chromosome 2 at 153,920,648 bp
  • C to G, chromosome 3 at 32,741,683 bp
  • T to A, chromosome 4 at 34,746,526 bp
  • A to T, chromosome 4 at 147,583,121 bp
  • T to C, chromosome 4 at 147,583,667 bp
  • T to C, chromosome 5 at 21,819,719 bp
  • G to A, chromosome 5 at 106,973,058 bp
  • A to G, chromosome 5 at 139,269,065 bp
  • A to T, chromosome 5 at 150,988,962 bp
  • G to A, chromosome 6 at 73,053,695 bp
  • T to C, chromosome 6 at 124,508,624 bp
  • G to T, chromosome 7 at 25,015,526 bp
  • T to C, chromosome 7 at 135,699,829 bp
  • C to A, chromosome 7 at 140,162,563 bp
  • G to C, chromosome 7 at 141,640,433 bp
  • G to A, chromosome 8 at 117,568,170 bp
  • C to T, chromosome 9 at 15,544,735 bp
  • T to C, chromosome 10 at 107,572,968 bp
  • G to C, chromosome 10 at 112,271,856 bp
  • T to A, chromosome 11 at 69,805,114 bp
  • C to T, chromosome 11 at 87,635,953 bp
  • A to T, chromosome 11 at 118,170,860 bp
  • T to C, chromosome 12 at 30,002,941 bp
  • C to G, chromosome 12 at 85,015,277 bp
  • C to T, chromosome 12 at 118,928,762 bp
  • T to C, chromosome 15 at 76,714,253 bp
  • TTGTG to TTG, chromosome 16 at 14,300,145 bp
  • G to A, chromosome 18 at 12,513,678 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6609 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044732-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.