Strain Name:
C57BL/6J-MtgxR6661Btlr/Mmmh
Stock Number:
044781-MU
Citation ID:
RRID:MMRRC_044781-MU
Other Names:
R6661 (G1)
Major Collection:

Strain Information

Nedd4
Name: neural precursor cell expressed, developmentally down-regulated 4
Synonyms: E430025J12Rik, Nedd4-1, Nedd4, Nedd4a
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 17999
HGNC: HGNC:7727
Homologene: 134533
Nes
Name: nestin
Synonyms: Ifaprc2, Marc2, RC2, ESTM46
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18008
HGNC: HGNC:7756
Homologene: 136487
Magi1
Name: membrane associated guanylate kinase, WW and PDZ domain containing 1
Synonyms: Gukmi1, Baiap1, BAP1, WWP3, AIP3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14924
HGNC: HGNC:946
Homologene: 31257
Mbd4
Name: methyl-CpG binding domain protein 4
Synonyms: Med1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 17193
HGNC: HGNC:6919
Homologene: 2916
Pik3c2a
Name: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha
Synonyms: PI3KC2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18704
HGNC: HGNC:8971
Homologene: 20581
Fbrsl1
Name: fibrosin-like 1
Synonyms: 2410025L10Rik, Gm29766, LOC381668
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 381668
Homologene: 45966
Trappc9
Name: trafficking protein particle complex 9
Synonyms: 2900005P22Rik, TRS130, 4632408O18Rik, Nibp, 1810044A24Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 76510
VEGA: 15
Homologene: 81931
Dennd4c
Name: DENN domain containing 4C
Synonyms: 1700065A05Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329877
Homologene: 23057
Gapvd1
Name: GTPase activating protein and VPS9 domains 1
Synonyms: 4432404J10Rik, 2010005B09Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66691
Homologene: 32637
Ctnnd1
Name: catenin delta 1
Synonyms: Catns, Ctnnd, catenin (cadherin associated protein), delta 1, p120-catenin, P120
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12388
HGNC: HGNC:2515
Homologene: 1017
Txnrd3
Name: thioredoxin reductase 3
Synonyms: Tgr, TR2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232223
Homologene: 60033
Slf1
Name: SMC5-SMC6 complex localization factor 1
Synonyms: 2700017A04Rik, C730024G01Rik, Brctd1, Brctx, Ankrd32
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 105377
Homologene: 13000
Dnah7a
Name: dynein, axonemal, heavy chain 7A
Synonyms: Dnahc7, LOC381341, Dnahc7a
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 627872
Homologene: 41287
Jcad
Name: junctional cadherin 5 associated
Synonyms: 9430020K01Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240185
VEGA: 18
Homologene: 19370
Chd2
Name: chromodomain helicase DNA binding protein 2
Synonyms: 5630401D06Rik, 2810013C04Rik, 2810040A01Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244059
HGNC: HGNC:1917
Homologene: 37462
Tcea1
Name: transcription elongation factor A (SII) 1
Synonyms: S-II
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 21399
Homologene: 55984
Cux2
Name: cut-like homeobox 2
Synonyms: Cutl2, Cux-2, 1700051K22Rik, Cux2, ENSMUSG00000072641
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 13048
Homologene: 22426
Fmnl2
Name: formin-like 2
Synonyms: 5430425K04Rik, man
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71409
Homologene: 70871
Arhgap44
Name: Rho GTPase activating protein 44
Synonyms: AU040829
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216831
Homologene: 65284
Arhgap28
Name: Rho GTPase activating protein 28
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 268970
Homologene: 18264
Prg2
Name: proteoglycan 2, bone marrow
Synonyms: EMBP, mMBP-1, mMBP
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19074
HGNC: HGNC:9362
Homologene: 2044
Celsr1
Name: cadherin, EGF LAG seven-pass G-type receptor 1
Synonyms: crash, Adgrc1, Crsh, Scy
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12614
VEGA: 15
HGNC: HGNC:1850
Homologene: 7665
Decr2
Name: 2-4-dienoyl-Coenzyme A reductase 2, peroxisomal
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 26378
HGNC: HGNC:2754
Homologene: 22223
Ushbp1
Name: USH1 protein network component harmonin binding protein 1
Synonyms: 2210404N08Rik, MCC2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234395
Homologene: 12914
Cacna1d
Name: calcium channel, voltage-dependent, L type, alpha 1D subunit
Synonyms: Cchl1a2, Cav1.3alpha1, 8430418G19Rik, Cchl1a, D-LTCC, Cacnl1a2, C79217
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 12289
VEGA: 14
HGNC: HGNC:1391
Homologene: 578
Sptbn5
Name: spectrin beta, non-erythrocytic 5
Synonyms: EG640524, Spnb5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 640524
Homologene: 41150
Brd10
Name: bromodomain containing 10
Synonyms: Gm9832, 9930021J03Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 240613
Homologene: 19046
Mroh8
Name: maestro heat-like repeat family member 8
Synonyms: 4922505G16Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 629499
Homologene: 51864
Selenbp2
Name: selenium binding protein 2
Synonyms: AP56, Lpsb2, acetaminophen-binding protein
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20342
Homologene: 2930
Or8h8
Name: olfactory receptor family 8 subfamily H member 8
Synonyms: Olfr1098, MOR206-1, GA_x6K02T2Q125-48410458-48409511
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258842
Homologene: 37005
Plxnb1
Name: plexin B1
Synonyms: 2900002G15Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235611
HGNC: HGNC:9103
Homologene: 130508
Tex14
Name: testis expressed gene 14 intercellular bridge forming factor
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 83560
Homologene: 12838
Krt2
Name: keratin 2
Synonyms: Krt2-17, Krt2e, Krt2-2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 16681
HGNC: HGNC:6439
Meis2
Name: Meis homeobox 2
Synonyms: Mrg1, Stra10, A430109D20Rik, Meis2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17536
HGNC: HGNC:7001
Homologene: 7846
Lrrc63
Name: leucine rich repeat containing 63
Synonyms: 4921509B22Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 70859
Homologene: 52823
Amy2a1
Name: amylase 2a1
Synonyms: mAmy2-6, Amy2-1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 100043207
Ccr4
Name: C-C motif chemokine receptor 4
Synonyms: CC CKR-4, Cmkbr4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12773
VEGA: 9
HGNC: HGNC:1605
Homologene: 21135
Tmbim4
Name: transmembrane BAX inhibitor motif containing 4
Synonyms: 0610007H07Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 68212
Homologene: 56740
Lrrc52
Name: leucine rich repeat containing 52
Synonyms: 4930413P14Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240899
Homologene: 35430
Smim10l1
Name: small integral membrane protein 10 like 1
Synonyms: 2700089E24Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 381820
Homologene: 130035
Ankrd9
Name: ankyrin repeat domain 9
Synonyms: 2500003O20Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 74251
Homologene: 17549
Gatb
Name: glutamyl-tRNA amidotransferase subunit B
Synonyms: Pet112l, Pet112, 9430026F02Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229487
HGNC: HGNC:8849
Homologene: 3357
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 4,858,429 bp
  • T to C, chromosome 1 at 53,623,450 bp
  • A to G, chromosome 1 at 167,466,353 bp
  • C to T, chromosome 2 at 34,728,438 bp
  • C to A, chromosome 2 at 53,108,285 bp
  • C to A, chromosome 2 at 84,609,642 bp
  • T to C, chromosome 2 at 84,983,276 bp
  • T to C, chromosome 2 at 86,923,148 bp
  • T to A, chromosome 2 at 115,864,270 bp
  • T to C, chromosome 2 at 120,072,375 bp
  • A to G, chromosome 2 at 157,225,627 bp
  • A to G, chromosome 3 at 85,652,419 bp
  • A to G, chromosome 3 at 87,976,936 bp
  • A to G, chromosome 3 at 94,702,514 bp
  • T to C, chromosome 3 at 113,531,714 bp
  • T to A, chromosome 4 at 86,799,389 bp
  • A to T, chromosome 5 at 110,378,097 bp
  • C to A, chromosome 5 at 121,869,297 bp
  • T to A, chromosome 6 at 89,654,152 bp
  • T to C, chromosome 6 at 93,943,308 bp
  • C to A, chromosome 6 at 115,849,155 bp
  • T to A, chromosome 6 at 133,105,550 bp
  • T to C, chromosome 7 at 73,490,482 bp
  • T to C, chromosome 7 at 116,368,758 bp
  • C to T, chromosome 8 at 71,390,661 bp
  • T to A, chromosome 9 at 72,686,095 bp
  • T to C, chromosome 9 at 109,104,299 bp
  • T to C, chromosome 9 at 114,495,963 bp
  • T to C, chromosome 10 at 120,224,651 bp
  • A to G, chromosome 11 at 65,010,008 bp
  • A to G, chromosome 11 at 87,495,016 bp
  • C to A, chromosome 12 at 110,977,768 bp
  • T to C, chromosome 13 at 77,043,845 bp
  • C to A, chromosome 14 at 30,089,875 bp
  • G to A, chromosome 14 at 75,125,193 bp
  • A to G, chromosome 15 at 72,590,144 bp
  • A to G, chromosome 15 at 85,918,934 bp
  • A to G, chromosome 15 at 101,815,963 bp
  • A to G, chromosome 17 at 26,083,587 bp
  • C to A, chromosome 17 at 67,845,751 bp
  • G to A, chromosome 18 at 4,675,256 bp
  • A to T, chromosome 19 at 29,723,464 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6661 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044781-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.