Strain Name:
C57BL/6J-MtgxR6739Btlr/Mmmh
Stock Number:
044857-MU
Citation ID:
RRID:MMRRC_044857-MU
Other Names:
R6739 (G1)
Major Collection:

Strain Information

Ank2
Name: ankyrin 2, brain
Synonyms: Ank-2, Gm4392, Ankyrin-B, ankyrin B, Ankyrin-2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 109676
HGNC: HGNC:493
Adcy9
Name: adenylate cyclase 9
Synonyms: ACtp10, D16Wsu65e
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 11515
HGNC: HGNC:240
Homologene: 868
Il17rd
Name: interleukin 17 receptor D
Synonyms: Sef-S, 2810004A10Rik, Sef
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 171463
VEGA: 14
Homologene: 9717
Scn8a
Name: sodium channel, voltage-gated, type VIII, alpha
Synonyms: nmf58, nmf2, med, nmf335, motor end-plate disease, seal, nur14, NaCh6, ataxia 3, NMF335, mnd-2, mnd2, Nav1.6, C630029C19Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 20273
Homologene: 7927
Arhgap21
Name: Rho GTPase activating protein 21
Synonyms: 5530401C11Rik, ARHGAP10
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71435
Homologene: 10822
Triobp
Name: TRIO and F-actin binding protein
Synonyms: Mus EST 478828, EST478828, Tara
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 110253
Homologene: 5104
Arid1a
Name: AT-rich interaction domain 1A
Synonyms: Smarcf1, 1110030E03Rik, Osa1, BAF250a
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 93760
Homologene: 21216
Snrnp70
Name: small nuclear ribonucleoprotein 70 (U1)
Synonyms: 3200002N22Rik, Rnulp70, 2700022N21Rik, U1-70, Snrp70, Srnp70
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20637
Homologene: 20672
Etl4
Name: enhancer trap locus 4
Synonyms: Skt, Sickle tail, 6620402G01Rik, E330027G05Rik, 9430077C05Rik, Etl-4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 208618
Homologene: 10477
Picalm
Name: phosphatidylinositol binding clathrin assembly protein
Synonyms: fit1, fit-1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233489
Homologene: 111783
Dmxl1
Name: Dmx-like 1
Synonyms: C630007L23Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240283
HGNC: HGNC:2937
Homologene: 21136
Rsf1
Name: remodeling and spacing factor 1
Synonyms: p325, 4832420A03Rik, Hbxap, C030033M12Rik, XAP8
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233532
Homologene: 41142
Zfp451
Name: zinc finger protein 451
Synonyms: Kiaa0576-hp, 4930515K21Rik, 4933435G09Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98403
Homologene: 9188
Zfta
Name: zinc finger translocation associated
Synonyms: 2700081O15Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 108899
Homologene: 52179
Pitpnm1
Name: phosphatidylinositol transfer protein, membrane-associated 1
Synonyms: DRES9, RdgB
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18739
HGNC: HGNC:9003
Homologene: 3608
Ano4
Name: anoctamin 4
Synonyms: A330096O15Rik, Tmem16d
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 320091
Homologene: 66599
Rnf213
Name: ring finger protein 213
Synonyms: D11Ertd759e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 672511
Homologene: 45439
Mroh4
Name: maestro heat-like repeat family member 4
Synonyms: 1700016M24Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 69439
Homologene: 72545
Nlrp9c
Name: NLR family, pyrin domain containing 9C
Synonyms: Nalp-zeta, Nalp9c
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330490
Homologene: 116072
Rb1cc1
Name: RB1-inducible coiled-coil 1
Synonyms: Cc1, 2900055E04Rik, Fip200, 5930404L04Rik, LaXp180
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12421
Homologene: 7659
Lox
Name: lysyl oxidase
Synonyms: ras recision gene (rrg), TSC-160
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 16948
VEGA: 18
HGNC: HGNC:6664
Homologene: 1741
Vmn2r5
Name: vomeronasal 2, receptor 5
Synonyms: EG667060
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 667060
Dnm3
Name: dynamin 3
Synonyms: 9630020E24Rik, B230343F03Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 103967
Homologene: 22906
Ctbs
Name: chitobiase
Synonyms: 2210401K11Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 74245
HGNC: HGNC:2496
Homologene: 3231
Proz
Name: protein Z, vitamin K-dependent plasma glycoprotein
Synonyms: 1300015B06Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 66901
HGNC: HGNC:9460
Homologene: 2890
Or1x6
Name: olfactory receptor family 1 subfamily X member 6
Synonyms: Olfr1375, GA_x6K02T2QP88-4389999-4389056, Olfr1375-ps1, MOR126-2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258509
Igsf23
Name: immunoglobulin superfamily, member 23
Synonyms: 2210010C17Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 70080
Homologene: 52756
Krt75
Name: keratin 75
Synonyms: 4732468K03Rik, Krtcap1, Krt2-6hf, K6hf
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 109052
Homologene: 20983
Or10a5
Name: olfactory receptor family 10 subfamily A member 5
Synonyms: MOR263-1, GA_x6K02T2PBJ9-9415724-9416677, Olfr713, P3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259036
Homologene: 17470
Dpp4
Name: dipeptidylpeptidase 4
Synonyms: Dpp-4, THAM, Cd26
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 13482
HGNC: HGNC:3009
Homologene: 3279
Dmgdh
Name: dimethylglycine dehydrogenase precursor
Synonyms: 1200014D15Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 74129
Homologene: 8372
Gsg1
Name: germ cell associated 1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14840
Homologene: 7745
Cfap73
Name: cilia and flagella associated protein 73
Synonyms: Ccdc42b, Gm5988
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 546886
Homologene: 53205
Fbxw25
Name: F-box and WD-40 domain protein 25
Synonyms: E330001B16Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 546160
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 6,234,230 bp
  • A to G, chromosome 1 at 33,803,594 bp
  • T to C, chromosome 1 at 162,477,783 bp
  • A to G, chromosome 2 at 20,713,435 bp
  • G to A, chromosome 2 at 20,880,732 bp
  • C to T, chromosome 2 at 62,387,095 bp
  • A to G, chromosome 3 at 64,491,216 bp
  • A to T, chromosome 3 at 127,079,994 bp
  • A to T, chromosome 3 at 146,459,499 bp
  • T to A, chromosome 4 at 133,687,626 bp
  • T to C, chromosome 5 at 120,630,193 bp
  • T to A, chromosome 6 at 135,237,614 bp
  • A to G, chromosome 7 at 19,944,748 bp
  • T to C, chromosome 7 at 26,385,425 bp
  • A to T, chromosome 7 at 45,387,419 bp
  • C to A, chromosome 7 at 90,176,708 bp
  • G to GACGGCGGCT, chromosome 7 at 97,579,909 bp
  • T to C, chromosome 7 at 107,036,811 bp
  • A to T, chromosome 8 at 13,073,451 bp
  • A to G, chromosome 9 at 109,651,631 bp
  • T to C, chromosome 10 at 89,027,252 bp
  • T to A, chromosome 11 at 51,048,737 bp
  • T to A, chromosome 11 at 119,442,271 bp
  • T to A, chromosome 13 at 93,720,615 bp
  • A to G, chromosome 14 at 27,099,531 bp
  • T to C, chromosome 15 at 74,609,719 bp
  • T to A, chromosome 15 at 78,966,366 bp
  • T to C, chromosome 15 at 101,015,955 bp
  • C to T, chromosome 15 at 101,571,068 bp
  • A to G, chromosome 16 at 4,418,794 bp
  • T to C, chromosome 18 at 49,878,246 bp
  • T to C, chromosome 18 at 52,526,959 bp
  • T to A, chromosome 19 at 4,110,522 bp
  • C to T, chromosome 19 at 7,421,347 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6739 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044857-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.