Strain Name:
C57BL/6J-MtgxR6816Btlr/Mmmh
Stock Number:
044928-MU
Citation ID:
RRID:MMRRC_044928-MU
Other Names:
R6816 (G1)
Major Collection:

Strain Information

Sulf2
Name: sulfatase 2
Synonyms: 2010004N24Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 72043
Homologene: 10313
Hgs
Name: HGF-regulated tyrosine kinase substrate
Synonyms: tn, Hrs
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 15239
HGNC: HGNC:4897
Homologene: 37954
Kmt2c
Name: lysine (K)-specific methyltransferase 2C
Synonyms: HALR, E330008K23Rik, Mll3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231051
Homologene: 46480
Sema3b
Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
Synonyms: LUCA-1, SemA, sema5, Semaa, semaV, SemA
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20347
Homologene: 20972
Sema3c
Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
Synonyms: 1110036B02Rik, Semae
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20348
Homologene: 36201
Ppp1r16b
Name: protein phosphatase 1, regulatory subunit 16B
Synonyms: ANKRD4, Wdt4, C130078N17Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228852
Homologene: 9194
Madcam1
Name: mucosal vascular addressin cell adhesion molecule 1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 17123
VEGA: 10
HGNC: HGNC:6765
Homologene: 8413
Stat3
Name: signal transducer and activator of transcription 3
Synonyms: 1110034C02Rik, Aprf
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20848
Homologene: 7960
Trip12
Name: thyroid hormone receptor interactor 12
Synonyms: Gtl6, 1110036I07Rik, 6720416K24Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14897
Homologene: 44226
E2f8
Name: E2F transcription factor 8
Synonyms: 4432406C08Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 108961
Homologene: 11654
Syt2
Name: synaptotagmin II
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20980
Homologene: 22516
Adgrg5
Name: adhesion G protein-coupled receptor G5
Synonyms: LOC382045, PGR27, Gpr114
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 382045
Homologene: 17828
Igf2r
Name: insulin-like growth factor 2 receptor
Synonyms: M6P/IGF2R, mannose-6-phosphate receptor, cation independent, CD222, CI-MPR, Mpr300, IGF-II/CI-MPR
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 16004
HGNC: HGNC:5467
Homologene: 676
Rab6a
Name: RAB6A, member RAS oncogene family
Synonyms: Rab6, 2610028L11Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 19346
HGNC: HGNC:9786
Homologene: 55697
Gdap2
Name: ganglioside-induced differentiation-associated-protein 2
Synonyms: D3Ertd801e
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 14547
Homologene: 7728
Tbl2
Name: transducin (beta)-like 2
Synonyms: C76179, WS-bTRP
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 27368
Homologene: 8260
Mon1a
Name: MON1 homolog A, secretory traffciking associated
Synonyms: 2810468K17Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 72825
Homologene: 7191
Magi3
Name: membrane associated guanylate kinase, WW and PDZ domain containing 3
Synonyms: 4732496O19Rik, 6530407C02Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99470
Homologene: 26431
Cep152
Name: centrosomal protein 152
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 99100
Homologene: 37159
Pigt
Name: phosphatidylinositol glycan anchor biosynthesis, class T
Synonyms: CGI-06, Ndap7, NDAP, 2510012P17Rik, 4930534E15Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 78928
Homologene: 6134
Tmprss2
Name: transmembrane protease, serine 2
Synonyms: D16Ertd61e, epitheliasin
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 50528
VEGA: 16
Homologene: 4136
Kcnu1
Name: potassium channel, subfamily U, member 1
Synonyms: Kcnma3, Slo3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 16532
Homologene: 7392
Iqch
Name: IQ motif containing H
Synonyms: 4921504K03Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 78250
Homologene: 11258
Fhod1
Name: formin homology 2 domain containing 1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234686
Homologene: 136406
Slc22a1
Name: solute carrier family 22 (organic cation transporter), member 1
Synonyms: Oct1, Lx1, Oct1, Orct, Orct1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 20517
VEGA: 17
Homologene: 20665
Ankrd36
Name: ankyrin repeat domain 36
Synonyms: 1700012M14Rik, GC3, 1700008J08Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 76389
Homologene: 137366
Mkrn2
Name: makorin, ring finger protein, 2
Synonyms: 2610002L04Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 67027
HGNC: HGNC:7113
Homologene: 8392
Lhpp
Name: phospholysine phosphohistidine inorganic pyrophosphate phosphatase
Synonyms: 2310007H09Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 76429
Homologene: 41469
Tex48
Name: testis expressed 48
Synonyms: 1700018C11Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 75524
Homologene: 87066
Vmn2r74
Name: vomeronasal 2, receptor 74
Synonyms: EG546980
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 546980
Homologene: 115466
Spire2
Name: spire type actin nucleation factor 2
Synonyms: Spir-2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234857
Homologene: 72212
Igfn1
Name: immunoglobulin-like and fibronectin type III domain containing 1
Synonyms: 9830123M21Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226438
Homologene: 130054
Zfp202
Name: zinc finger protein 202
Synonyms: C130037E22Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 80902
Homologene: 68317
Itih2
Name: inter-alpha trypsin inhibitor, heavy chain 2
Synonyms: Itih-2, Intin2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16425
HGNC: HGNC:6167
Homologene: 1668
P2ry1
Name: purinergic receptor P2Y, G-protein coupled 1
Synonyms: P2y1r, P2Y1 receptor, P2Y1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18441
HGNC: HGNC:8539
Homologene: 1926
Wdr35
Name: WD repeat domain 35
Synonyms: 4930459M12Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 74682
Homologene: 10814
Tspoap1
Name: TSPO associated protein 1
Synonyms: peripheral, Bzrap1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 207777
Homologene: 37961
Klk1b26
Name: kallikrein 1-related petidase b26
Synonyms: Klk26, Egfbp2, PRECE-2, mGK-26, EGF-BP type B
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16618
Homologene: 68141
Sult2b1
Name: sulfotransferase family, cytosolic, 2B, member 1
Synonyms: SULT2B, Gm5897
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 54200
Homologene: 49487
Ralb
Name: v-ral simian leukemia viral oncogene B
Synonyms: 5730472O18Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 64143
HGNC: HGNC:9840
Homologene: 20632
Ajm1
Name: apical junction component 1
Synonyms: Gm996, LOC381353
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 381353
Homologene: 19943
Map3k9
Name: mitogen-activated protein kinase kinase kinase 9
Synonyms: Mlk1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 338372
VEGA: 12
HGNC: HGNC:6861
Homologene: 76377
Taar8b
Name: trace amine-associated receptor 8B
Synonyms: LOC382348
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 382348
Homologene: 77586
Pdzk1
Name: PDZ domain containing 1
Synonyms: mPDZK1, 2610507N21Rik, Nherf3, 1700023D20Rik, 4921513F16Rik, D3Ertd537e
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 59020
Homologene: 1964
Grin2d
Name: glutamate receptor, ionotropic, NMDA2D (epsilon 4)
Synonyms: NMDAR2D, GluRepsilon4, GluN2D, NR2D
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 14814
HGNC: HGNC:4588
Homologene: 648
Dpf1
Name: double PHD fingers 1
Synonyms: Neud4, neuro-d4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 29861
Homologene: 3415
Nrarp
Name: Notch-regulated ankyrin repeat protein
Synonyms: 2700054M22Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 67122
Homologene: 32649
H2bc22
Name: H2B clustered histone 22
Synonyms: Hist1h2bp
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 319188
HGNC: HGNC:4758
Homologene: 134442
Fer1l5
Name: fer-1 like family member 5
Synonyms: 4930533C12Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 100534273
Homologene: 85232
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 36,406,510 bp
  • A to T, chromosome 1 at 84,793,714 bp
  • C to A, chromosome 1 at 119,477,982 bp
  • T to A, chromosome 1 at 134,745,800 bp
  • T to A, chromosome 1 at 135,959,728 bp
  • A to G, chromosome 2 at 10,105,706 bp
  • T to C, chromosome 2 at 25,181,307 bp
  • C to CTCTA, chromosome 2 at 25,579,721 bp
  • T to C, chromosome 2 at 125,595,027 bp
  • G to T, chromosome 2 at 158,761,675 bp
  • G to T, chromosome 2 at 164,501,132 bp
  • T to C, chromosome 2 at 166,082,754 bp
  • T to A, chromosome 3 at 61,003,832 bp
  • A to G, chromosome 3 at 96,854,570 bp
  • T to C, chromosome 3 at 100,191,705 bp
  • A to T, chromosome 3 at 104,089,911 bp
  • G to A, chromosome 4 at 63,611,955 bp
  • A to C, chromosome 5 at 17,670,465 bp
  • T to C, chromosome 5 at 25,405,532 bp
  • A to T, chromosome 5 at 94,683,914 bp
  • T to A, chromosome 5 at 135,159,215 bp
  • C to T, chromosome 6 at 115,611,728 bp
  • A to C, chromosome 7 at 29,311,662 bp
  • A to G, chromosome 7 at 44,016,868 bp
  • A to G, chromosome 7 at 45,733,678 bp
  • A to G, chromosome 7 at 45,833,682 bp
  • A to T, chromosome 7 at 48,875,583 bp
  • T to A, chromosome 7 at 85,961,413 bp
  • G to T, chromosome 7 at 100,629,873 bp
  • T to C, chromosome 7 at 132,634,033 bp
  • C to T, chromosome 8 at 25,937,734 bp
  • A to G, chromosome 8 at 94,941,683 bp
  • G to T, chromosome 8 at 105,330,544 bp
  • T to A, chromosome 8 at 123,359,413 bp
  • A to G, chromosome 9 at 40,211,813 bp
  • C to T, chromosome 9 at 63,480,759 bp
  • T to A, chromosome 9 at 107,600,350 bp
  • T to C, chromosome 9 at 107,900,410 bp
  • A to T, chromosome 10 at 24,092,181 bp
  • A to G, chromosome 10 at 79,665,440 bp
  • T to G, chromosome 11 at 5,643,765 bp
  • T to C, chromosome 11 at 87,765,665 bp
  • T to G, chromosome 11 at 100,911,267 bp
  • T to A, chromosome 11 at 120,471,571 bp
  • G to A, chromosome 12 at 9,027,724 bp
  • A to G, chromosome 12 at 81,722,254 bp
  • C to T, chromosome 13 at 21,787,777 bp
  • A to T, chromosome 16 at 97,568,467 bp
  • T to C, chromosome 17 at 12,652,483 bp
  • A to T, chromosome 17 at 12,714,082 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6816 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044928-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.