Strain Name:
C57BL/6J-MtgxR6827Btlr/Mmmh
Stock Number:
044938-MU
Citation ID:
RRID:MMRRC_044938-MU
Other Names:
R6827 (G1)
Major Collection:

Strain Information

Ntrk2
Name: neurotrophic tyrosine kinase, receptor, type 2
Synonyms: trkB, Tkrb, C030027L06Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 18212
VEGA: 13
HGNC: HGNC:8032
Homologene: 4504
Prrc2b
Name: proline-rich coiled-coil 2B
Synonyms: Bat2l, 5830434P21Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227723
Homologene: 106649
Ncaph2
Name: non-SMC condensin II complex, subunit H2
Synonyms: Kleisin beta, D15Ertd785e, 0610010J20Rik, 2610524G04Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 52683
Homologene: 12045
Ubxn4
Name: UBX domain protein 4
Synonyms: 1300013G12Rik, Ubxd2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 67812
Homologene: 40962
Dmxl1
Name: Dmx-like 1
Synonyms: C630007L23Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240283
HGNC: HGNC:2937
Homologene: 21136
Trps1
Name: transcriptional repressor GATA binding 1
Synonyms: D15Ertd586e, trichorhinophalangeal syndrome I (human)
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 83925
Homologene: 8556
Naf1
Name: nuclear assembly factor 1 ribonucleoprotein
Synonyms: LOC234344
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234344
Homologene: 128518
Unc5b
Name: unc-5 netrin receptor B
Synonyms: 6330415E02Rik, D10Bwg0792e, Unc5h2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 107449
VEGA: 10
Homologene: 32538
Lef1
Name: lymphoid enhancer binding factor 1
Synonyms: Lef-1, lymphoid enhancer factor 1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 16842
HGNC: HGNC:6551
Homologene: 7813
Wnt2b
Name: wingless-type MMTV integration site family, member 2B
Synonyms: Wnt13
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 22414
Homologene: 22526
Scyl2
Name: SCY1-like 2 (S. cerevisiae)
Synonyms: CVAK104, D10Ertd802e
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 213326
Homologene: 13349
Trpm4
Name: transient receptor potential cation channel, subfamily M, member 4
Synonyms: TRPM4B, 1110030C19Rik, LTRPC4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 68667
Homologene: 23033
Zranb1
Name: zinc finger, RAN-binding domain containing 1
Synonyms: D7Wsu87e, 9330160G10Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 360216
Homologene: 9728
Bcr
Name: BCR activator of RhoGEF and GTPase
Synonyms: 5133400C09Rik, breakpoint cluster region
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 110279
VEGA: 10
HGNC: HGNC:1014
Homologene: 3192
Moxd1
Name: monooxygenase, DBH-like 1
Synonyms: 3230402N08Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 59012
Homologene: 22904
Naip5
Name: NLR family, apoptosis inhibitory protein 5
Synonyms: Naip-rs3, Lgn1, Birc1e
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17951
HGNC: HGNC:7634
Homologene: 113589
Dscam
Name: DS cell adhesion molecule
Synonyms: Down syndrome cell adhesion molecule, 4932410A21Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 13508
HGNC: HGNC:3039
Homologene: 74393
Fbxl13
Name: F-box and leucine-rich repeat protein 13
Synonyms: 4921539K22Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 320118
Homologene: 27057
Slc22a5
Name: solute carrier family 22 (organic cation transporter), member 5
Synonyms: Octn2, Lstpl
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20520
Homologene: 68295
Gypa
Name: glycophorin A
Synonyms: GPA, CD235a
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 14934
Lrrc10
Name: leucine rich repeat containing 10
Synonyms: Hrlrrp, Serdin1, D330003I11Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237560
VEGA: 10
Homologene: 17154
Kcnh6
Name: potassium voltage-gated channel, subfamily H (eag-related), member 6
Synonyms: m-erg2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 192775
Homologene: 32740
Pbld1
Name: phenazine biosynthesis-like protein domain containing 1
Synonyms: 0610038K03Rik, Pbld
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 68371
VEGA: 10
Homologene: 41470
Kdr
Name: kinase insert domain protein receptor
Synonyms: VEGF receptor-2, VEGFR-2, VEGFR2, orv, vascular endothelial growth factor receptor- 2, Flk-1, Flk1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 16542
HGNC: HGNC:6307
Homologene: 55639
Zfp518b
Name: zinc finger protein 518B
Synonyms: 6820424L24Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100515
Homologene: 19115
Arhgef26
Name: Rho guanine nucleotide exchange factor 26
Synonyms: 8430436L14Rik, 4631416L12Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 622434
Homologene: 9204
Tmem168
Name: transmembrane protein 168
Synonyms: 8430437G11Rik, 5730526F17Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 101118
Homologene: 11202
Hk3
Name: hexokinase 3
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 212032
HGNC: HGNC:4925
Homologene: 55633
Cchcr1
Name: coiled-coil alpha-helical rod protein 1
Synonyms: Hcr
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240084
Homologene: 10396
Asb3
Name: ankyrin repeat and SOCS box-containing 3
Synonyms: 2400011J03Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 65257
Homologene: 9391
Gm572
Name: predicted gene 572
Synonyms: LOC230909, b2b1167Clo
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230909
Homologene: 52134
Ephx1
Name: epoxide hydrolase 1, microsomal
Synonyms: Eph1, Eph-1, mEH
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13849
HGNC: HGNC:3401
Homologene: 94
Wfdc3
Name: WAP four-disulfide core domain 3
Synonyms: 1700127F16Rik, 1700015L13Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71856
Homologene: 122221
Pcdhac2
Name: protocadherin alpha subfamily C, 2
Synonyms: CNRc2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 353237
HGNC: HGNC:8677
Homologene: 49562
Sdf2l1
Name: stromal cell-derived factor 2-like 1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 64136
Homologene: 11101
Tex51
Name: testis expressed 51
Synonyms: Gm35060
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 102638514
Homologene: 132337
Gm3573
Name: predicted gene 3573
Type: Gene
Species: Mouse
Chromosome: 14
Or51v15-ps1
Name: olfactory receptor family 51 subfamily V member 15, pseudogene 1
Synonyms: MOR4-3P, EG667639, MOR4-4_p, Olfr621-ps1, GA_x6K02T2PBJ9-6352653-6351709
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 667639
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 128,276,977 bp
  • A to G, chromosome 1 at 180,989,888 bp
  • G to T, chromosome 2 at 32,200,951 bp
  • C to T, chromosome 2 at 164,734,258 bp
  • C to A, chromosome 3 at 62,423,498 bp
  • A to G, chromosome 3 at 104,947,092 bp
  • T to C, chromosome 3 at 131,200,404 bp
  • T to C, chromosome 4 at 148,658,086 bp
  • T to A, chromosome 5 at 21,522,178 bp
  • T to C, chromosome 5 at 38,671,539 bp
  • G to T, chromosome 5 at 75,944,545 bp
  • A to T, chromosome 6 at 13,582,838 bp
  • T to C, chromosome 7 at 45,318,628 bp
  • C to A, chromosome 7 at 103,629,825 bp
  • T to C, chromosome 7 at 132,949,745 bp
  • A to T, chromosome 8 at 66,877,691 bp
  • A to T, chromosome 8 at 80,504,788 bp
  • C to T, chromosome 10 at 24,279,850 bp
  • C to A, chromosome 10 at 60,780,232 bp
  • C to A, chromosome 10 at 63,067,433 bp
  • T to C, chromosome 10 at 75,131,064 bp
  • T to C, chromosome 10 at 89,669,804 bp
  • A to G, chromosome 10 at 117,045,640 bp
  • A to G, chromosome 11 at 31,101,211 bp
  • A to T, chromosome 11 at 53,871,616 bp
  • A to G, chromosome 11 at 106,009,099 bp
  • C to A, chromosome 13 at 55,011,352 bp
  • T to C, chromosome 13 at 59,126,568 bp
  • C to A, chromosome 13 at 100,245,929 bp
  • T to A, chromosome 14 at 42,188,472 bp
  • T to A, chromosome 15 at 50,822,563 bp
  • T to C, chromosome 15 at 89,371,327 bp
  • C to G, chromosome 16 at 17,132,294 bp
  • T to A, chromosome 16 at 97,038,991 bp
  • A to G, chromosome 17 at 35,530,405 bp
  • C to T, chromosome 18 at 32,458,660 bp
  • G to A, chromosome 18 at 37,144,653 bp
  • C to T, chromosome 18 at 49,921,024 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6827 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044938-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.