Strain Name:
C57BL/6J-MtgxR6843Btlr/Mmmh
Stock Number:
044949-MU
Citation ID:
RRID:MMRRC_044949-MU
Other Names:
R6843 (G1)
Major Collection:

Strain Information

Ptprk
Name: protein tyrosine phosphatase receptor type K
Synonyms: RPTPkappa, PTPk
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19272
VEGA: 10
HGNC: HGNC:9674
Homologene: 55693
Hdac1
Name: histone deacetylase 1
Synonyms: HD1, RPD3, MommeD5
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 433759
HGNC: HGNC:4852
Homologene: 68426
Plekha7
Name: pleckstrin homology domain containing, family A member 7
Synonyms: A430081P20Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233765
Homologene: 52172
Crybg3
Name: beta-gamma crystallin domain containing 3
Synonyms: Gm9581
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224273
Homologene: 28544
Bcl2l13
Name: BCL2 like 13
Synonyms: Mil-1, E430016C20Rik, BCL-RAMBO, Mil1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 94044
Homologene: 9111
Ppfibp2
Name: PTPRF interacting protein, binding protein 2 (liprin beta 2)
Synonyms: Cclp1, liprin beta 2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 19024
HGNC: HGNC:9250
Homologene: 7486
Cep85
Name: centrosomal protein 85
Synonyms: Ccdc21, 2410030J07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 70012
Homologene: 11254
Xdh
Name: xanthine dehydrogenase
Synonyms: XO, Xox1, Xor, Xox-1, xanthine oxidase
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22436
VEGA: 17
Homologene: 324
Ash1l
Name: ASH1 like histone lysine methyltransferase
Synonyms: 8030453L17Rik, KMT2H, chromatin remodeling factor, E430018P19Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 192195
Homologene: 10225
Syt7
Name: synaptotagmin VII
Synonyms: B230112P13Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 54525
VEGA: 19
Homologene: 20889
Oprl1
Name: opioid receptor-like 1
Synonyms: LC132, NOP, ORL1, MOR-C, XOR1, N/OFQ receptor, nociceptin/ orphaninFQ receptor, morc
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18389
HGNC: HGNC:8155
Homologene: 22609
Ghsr
Name: growth hormone secretagogue receptor
Synonyms: Ghsr1a, C530020I22Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 208188
HGNC: HGNC:4267
Homologene: 57161
Apip
Name: APAF1 interacting protein
Synonyms: CGI-29, APIP2, Mmrp19
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 56369
Homologene: 6277
Cryaa
Name: crystallin, alpha A
Synonyms: alpha-A-crystallin, Crya1, Acry-1, DAcry-1, Crya-1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12954
VEGA: 17
HGNC: HGNC:2388
Homologene: 48053
Fhip1a
Name: FHF complex subunit HOOK interacting protein 1A
Synonyms: Fam160a1, 9930021J17Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229488
Homologene: 85149
Srrm3
Name: serine/arginine repetitive matrix 3
Synonyms: 2900083I11Rik, SRm300-like, Srrm2l
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 58212
Homologene: 136723
Clk4
Name: CDC like kinase 4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12750
Homologene: 56895
Snapc4
Name: small nuclear RNA activating complex, polypeptide 4
Synonyms: 5730436L13Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227644
Homologene: 2321
A2m
Name: alpha-2-macroglobulin
Synonyms: A2mp
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232345
HGNC: HGNC:7
Homologene: 37248
Exoc3l
Name: exocyst complex component 3-like
Synonyms: C730015A04Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 277978
Homologene: 18629
Mprip
Name: myosin phosphatase Rho interacting protein
Synonyms: Rhoip3, Gm34094, RIP3, p116Rip, p116 Rho interacting protein
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 26936
Homologene: 9034
Pcdhga11
Name: protocadherin gamma subfamily A, 11
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93723
HGNC: HGNC:8698
Homologene: 110934
Vmn2r80
Name: vomeronasal 2, receptor 80
Synonyms: EG624765
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 624765
Homologene: 83483
Or6c209
Name: olfactory receptor family 6 subfamily C member 209
Synonyms: GA_x6K02T2PULF-11325750-11326685, Olfr799, MOR114-2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258929
Homologene: 37000
Heg1
Name: heart development protein with EGF-like domains 1
Synonyms: 4632417D23Rik, 9530025L16Rik, 5530401I02Rik, LOC268884
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 77446
Homologene: 35276
Plekha6
Name: pleckstrin homology domain containing, family A member 6
Synonyms: Pepp3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240753
Homologene: 135779
Palmd
Name: palmdelphin
Synonyms: PALML, 4631423C22Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 114301
Homologene: 9804
Csmd2
Name: CUB and Sushi multiple domains 2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329942
Homologene: 89034
Nrap
Name: nebulin-related anchoring protein
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18175
HGNC: HGNC:7988
Homologene: 4499
Sqor
Name: sulfide quinone oxidoreductase
Synonyms: 0610039J17Rik, flavo-binding protein, 4930557M22Rik, Sqrdl
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 59010
Homologene: 10921
Zfp932
Name: zinc finger protein 932
Synonyms: 2310001H12Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 69504
Homologene: 137770
Akr1c21
Name: aldo-keto reductase family 1, member C21
Synonyms: 9430025F20Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 77337
Homologene: 134114
Hdac3
Name: histone deacetylase 3
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 15183
HGNC: HGNC:4854
Homologene: 48250
Or1i2
Name: olfactory receptor family 1 subfamily I member 1
Synonyms: MOR128-3, Olfr1357, GA_x6K02T2QGN0-3196801-3197742, MOR128-4
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 257883
HGNC: HGNC:8207
Homologene: 72920
Epb42
Name: erythrocyte membrane protein band 4.2
Synonyms: Epb4.2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 13828
HGNC: HGNC:3381
Homologene: 93
Dll4
Name: delta like canonical Notch ligand 4
Synonyms: Delta4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 54485
HGNC: HGNC:2910
Homologene: 10411
Or5b99
Name: olfactory receptor family 5 subfamily B member 99
Synonyms: Olfr1451, MOR202-1, GA_x6K02T2RE5P-3328502-3329434
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258700
HGNC: HGNC:8323
Homologene: 128082
Map2k1
Name: mitogen-activated protein kinase kinase 1
Synonyms: Prkmk1, Mek1, MAP kinase kinase 1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 26395
HGNC: HGNC:6840
Homologene: 2063
Vmn1r66
Name: vomeronasal 1 receptor 66
Synonyms: V1re11
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 171264
Cnr2
Name: cannabinoid receptor 2
Synonyms: CB2-R, CB2, cannabinoid receptor 2 (spleen)
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12802
HGNC: HGNC:2160
Homologene: 1389
Mapk13
Name: mitogen-activated protein kinase 13
Synonyms: p38 delta MAP kinase, Serk4, SAPK4
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 26415
HGNC: HGNC:6875
Homologene: 48133
Or4f14
Name: olfactory receptor family 4 subfamily F member 14
Synonyms: GA_x6K02T2Q125-72954873-72953935, MOR245-15, Olfr1306
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258023
Homologene: 128383
Dbx2
Name: developing brain homeobox 2
Synonyms: LOC383001, 9430056A22Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223843
Homologene: 54981
Stx1b
Name: syntaxin 1B
Synonyms: Stx1b2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 56216
Homologene: 69375
Map4k2
Name: mitogen-activated protein kinase kinase kinase kinase 2
Synonyms: BL44, Rab8ip
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 26412
HGNC: HGNC:6864
Homologene: 3370
Or52b3
Name: olfactory receptor family 52 subfamily B member 3
Synonyms: MOR31-3, GA_x6K02T2PBJ9-5274337-5275287, Olfr549
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259105
Homologene: 86245
Anks1b
Name: ankyrin repeat and sterile alpha motif domain containing 1B
Synonyms: AIDA-1b, LOC380650, E530015N03Rik, Gm10937, C030032C09Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 77531
Homologene: 51570
Tvp23a
Name: trans-golgi network vesicle protein 23A
Synonyms: Fam18a
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 383103
Homologene: 19919
Serpinb9g
Name: serine (or cysteine) peptidase inhibitor, clade B, member 9g
Synonyms: NK21B, 1600002F03Rik, ovalbumin
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 93806
HGNC: HGNC:8955
Homologene: 69093
Igkv4-90
Name: immunoglobulin kappa chain variable 4-90
Synonyms: Gm16906
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 434034
Gm9195
Name: predicted gene 9195
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 675947
Homologene: 139067
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 133,274,878 bp
  • C to A, chromosome 2 at 26,373,599 bp
  • T to G, chromosome 2 at 103,092,489 bp
  • T to C, chromosome 2 at 111,912,915 bp
  • A to T, chromosome 2 at 119,325,994 bp
  • T to A, chromosome 2 at 121,027,685 bp
  • T to C, chromosome 2 at 122,784,980 bp
  • G to T, chromosome 2 at 122,809,295 bp
  • A to G, chromosome 2 at 181,715,754 bp
  • A to C, chromosome 3 at 27,372,527 bp
  • G to A, chromosome 3 at 85,673,045 bp
  • T to A, chromosome 3 at 88,985,388 bp
  • T to A, chromosome 3 at 116,924,215 bp
  • A to G, chromosome 4 at 128,463,794 bp
  • A to G, chromosome 4 at 129,542,590 bp
  • C to G, chromosome 4 at 134,155,856 bp
  • C to T, chromosome 4 at 135,917,589 bp
  • T to C, chromosome 5 at 110,008,715 bp
  • T to C, chromosome 5 at 135,852,281 bp
  • A to G, chromosome 6 at 68,807,686 bp
  • G to A, chromosome 6 at 120,848,617 bp
  • A to T, chromosome 6 at 121,638,401 bp
  • T to A, chromosome 7 at 10,274,765 bp
  • A to G, chromosome 7 at 102,554,721 bp
  • C to T, chromosome 7 at 107,727,731 bp
  • G to T, chromosome 7 at 116,143,320 bp
  • G to A, chromosome 7 at 127,814,979 bp
  • T to A, chromosome 8 at 105,290,097 bp
  • A to T, chromosome 9 at 64,187,691 bp
  • T to C, chromosome 10 at 28,591,982 bp
  • T to C, chromosome 10 at 78,612,057 bp
  • C to A, chromosome 10 at 79,169,668 bp
  • T to A, chromosome 10 at 90,948,598 bp
  • A to G, chromosome 10 at 129,647,179 bp
  • T to G, chromosome 11 at 51,276,249 bp
  • A to G, chromosome 11 at 59,759,728 bp
  • A to G, chromosome 13 at 4,575,214 bp
  • G to T, chromosome 13 at 33,492,917 bp
  • A to G, chromosome 14 at 72,441,211 bp
  • T to G, chromosome 15 at 95,654,459 bp
  • G to A, chromosome 16 at 10,447,020 bp
  • T to A, chromosome 16 at 33,719,526 bp
  • G to A, chromosome 16 at 59,559,796 bp
  • T to A, chromosome 17 at 28,775,453 bp
  • A to G, chromosome 17 at 31,678,173 bp
  • C to T, chromosome 17 at 73,923,130 bp
  • A to G, chromosome 18 at 37,756,325 bp
  • A to T, chromosome 18 at 37,941,954 bp
  • A to T, chromosome 19 at 6,353,447 bp
  • A to G, chromosome 19 at 10,421,771 bp
  • G to T, chromosome 19 at 12,998,998 bp
  • T to C, chromosome 19 at 56,380,219 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6843 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044949-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.