Strain Name:
C57BL/6J-MtgxR6845Btlr/Mmmh
Stock Number:
044951-MU
Citation ID:
RRID:MMRRC_044951-MU
Other Names:
R6845 (G1)
Major Collection:

Strain Information

Kifc3
Name: kinesin family member C3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 16582
HGNC: HGNC:6326
Homologene: 124421
Vps33a
Name: VPS33A CORVET/HOPS core subunit
Synonyms: bf, 3830421M04Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 77573
Homologene: 11294
Cdon
Name: cell adhesion molecule-related/down-regulated by oncogenes
Synonyms: CAM-related/down-regulated by oncogenes, CDO
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 57810
Homologene: 22996
Mad1l1
Name: MAD1 mitotic arrest deficient 1-like 1
Synonyms: Mad1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 17120
HGNC: HGNC:6762
Homologene: 74500
Slc4a7
Name: solute carrier family 4, sodium bicarbonate cotransporter, member 7
Synonyms: E430014N10Rik, NBCn1, NBC3
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 218756
VEGA: 14
Homologene: 2680
Zfp207
Name: zinc finger protein 207
Synonyms: 8430401D15Rik, Zep
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 22680
Homologene: 134624
Tkfc
Name: triokinase, FMN cyclase
Synonyms: Dak
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 225913
VEGA: 19
Homologene: 56710
Kif11
Name: kinesin family member 11
Synonyms: Kifl1, Eg5, Knsl1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 16551
VEGA: 19
HGNC: HGNC:6388
Homologene: 3322
Rfc1
Name: replication factor C (activator 1) 1
Synonyms: Alp145, 140kDa, RFC140, Recc1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19687
HGNC: HGNC:9969
Homologene: 2187
Cabin1
Name: calcineurin binding protein 1
Synonyms: A330070M20Rik, Cain, Ppp3in
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 104248
VEGA: 10
Homologene: 49307
Ss18
Name: SS18, subunit of BAF chromatin remodeling complex
Synonyms: Ssxt
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 268996
VEGA: 18
Homologene: 38080
Ddx27
Name: DEAD box helicase 27
Synonyms: DEAD (Asp-Glu-Ala-Asp) box polypeptide 27
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228889
Homologene: 6431
Dlgap5
Name: DLG associated protein 5
Synonyms: Hurp, C86398, Dlg7
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 218977
Homologene: 8840
Tpp2
Name: tripeptidyl peptidase II
Synonyms: TppII
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22019
Homologene: 2471
Utp18
Name: UTP18 small subunit processome component
Synonyms: 6230425C22Rik, Wdr50
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217109
Homologene: 41087
Phldb1
Name: pleckstrin homology like domain, family B, member 1
Synonyms: D330037A14Rik, LL5A
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 102693
Homologene: 15903
Cit
Name: citron
Synonyms: citron kinase, Cit-k, CRIK-SK, C030025P15Rik, citron-N
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12704
HGNC: HGNC:1985
Homologene: 21404
Trpm4
Name: transient receptor potential cation channel, subfamily M, member 4
Synonyms: TRPM4B, 1110030C19Rik, LTRPC4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 68667
Homologene: 23033
Lrrtm1
Name: leucine rich repeat transmembrane neuronal 1
Synonyms: 4632401D06Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 74342
Homologene: 41763
Lrp10
Name: low-density lipoprotein receptor-related protein 10
Synonyms: Lrp9
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 65107
VEGA: 14
Homologene: 8535
Nbeal1
Name: neurobeachin like 1
Synonyms: A530050O19Rik, 2310076G13Rik, ALS2CR17, A530083I02Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 269198
Homologene: 16453
Ppp1r13l
Name: protein phosphatase 1, regulatory subunit 13 like
Synonyms: IASPP, wa3, NFkB interacting protein 1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 333654
Homologene: 84635
Plcxd2
Name: phosphatidylinositol-specific phospholipase C, X domain containing 2
Synonyms: EG433022
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 433022
Homologene: 44374
Fance
Name: Fanconi anemia, complementation group E
Synonyms: 2810451D06Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 72775
HGNC: HGNC:3586
Homologene: 11066
Myh6
Name: myosin, heavy polypeptide 6, cardiac muscle, alpha
Synonyms: Myhc-a, alpha cardiac MHC, Myhca, alphaMHC, alpha myosin, A830009F23Rik, cardiomyopathy, hypertrophic 1, alpha-MHC
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 17888
HGNC: HGNC:7576
Homologene: 124414
Il20ra
Name: interleukin 20 receptor, alpha
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237313
VEGA: 10
HGNC: HGNC:6003
Homologene: 8685
Dnah6
Name: dynein, axonemal, heavy chain 6
Synonyms: Dnahc6, A730004I20Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330355
HGNC: HGNC:2951
Homologene: 15221
Cplane1
Name: ciliogenesis and planar polarity effector 1
Synonyms: Hug, Jbts17, 2410089E03Rik, b2b012Clo
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 73692
Homologene: 11315
F3
Name: coagulation factor III
Synonyms: tissue factor, TF, CD142, Cf3, Cf-3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 14066
HGNC: HGNC:3541
Homologene: 1511
Slc22a21
Name: solute carrier family 22 (organic cation transporter), member 21
Synonyms: Slc22a9, Octn3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 56517
Homologene: 137336
Htra1
Name: HtrA serine peptidase 1
Synonyms: Prss11, HtrA1, RSPP11, insulin-like growth factor binding protein 5 protease, L56
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 56213
HGNC: HGNC:9476
Homologene: 31114
Lgi4
Name: leucine-rich repeat LGI family, member 4
Synonyms: clp
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243914
Homologene: 16408
Adam6a
Name: a disintegrin and metallopeptidase domain 6A
Synonyms: Adam6
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238406
HGNC: HGNC:213
Homologene: 128362
Slc34a2
Name: solute carrier family 34 (sodium phosphate), member 2
Synonyms: D5Ertd227e, NaPi-2b, type IIb Na/Picotransporter, Npt2b
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20531
Homologene: 2297
Aadacl2fm2
Name: AADACL2 family member 2
Synonyms: Gm5538
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 433597
Homologene: 79018
Foxs1
Name: forkhead box S1
Synonyms: Fkh3, FREAC10, Fkhl18
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14239
HGNC: HGNC:3735
Homologene: 20871
Il3ra
Name: interleukin 3 receptor, alpha chain
Synonyms: IL-3 receptor alpha chain, CD123, SUT-1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 16188
VEGA: 14
HGNC: HGNC:6012
Homologene: 48088
Mia2
Name: MIA SH3 domain ER export factor 2
Synonyms: Mgea, Ctage5, Mgea6, MEA6, D12Bwg0579e
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 338320
Homologene: 137655
Nol4l
Name: nucleolar protein 4-like
Synonyms: LOC381396, 8430427H17Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 329540
Homologene: 129589
Shank3
Name: SH3 and multiple ankyrin repeat domains 3
Synonyms: ProSAP2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 58234
Homologene: 75163
Mpp4
Name: membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)
Synonyms: DLG6
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227157
Homologene: 23296
Klre1
Name: killer cell lectin-like receptor family E member 1
Synonyms: Klre-1, NKG2I
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243655
Homologene: 17794
Gpr149
Name: G protein-coupled receptor 149
Synonyms: R35, 9630018L10Rik, Ieda, PGR10
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229357
Homologene: 16359
Gpd1l
Name: glycerol-3-phosphate dehydrogenase 1-like
Synonyms: D9Ertd660e, 2210409H23Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 333433
Homologene: 56097
Or5b109
Name: olfactory receptor family 5 subfamily B member 109
Synonyms: Olfr1463, GA_x6K02T2RE5P-3560863-3561795, MOR202-29P
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258120
HGNC: HGNC:8324
Homologene: 133886
Duoxa1
Name: dual oxidase maturation factor 1
Synonyms: Nip1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 213696
Homologene: 16043
Rnf133
Name: ring finger protein 133
Synonyms: Greul2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 386611
Homologene: 44549
Klk1b3
Name: kallikrein 1-related peptidase b3
Synonyms: Ngfg, mGk-3, Ngfg
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18050
Homologene: 68141
Hmgcs1
Name: 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1
Synonyms: B130032C06Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 208715
VEGA: 13
HGNC: HGNC:5007
Homologene: 1609
Trav13n-4
Name: T cell receptor alpha variable 13N-4
Synonyms: Gm10907, ENSMUSG00000072517
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 100126460
Krtap4-13
Name: keratin associated protein 4-13
Synonyms: 2300006N05Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69464
Homologene: 124486
Dnase1l1
Name: deoxyribonuclease 1-like 1
Synonyms: Dnl1ll, G4.8, Dnase1ll, 2310005K03Rik
Type: Gene
Species: Mouse
Chromosome: X
NCBI: 69537
HGNC: HGNC:2957
Homologene: 4896
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 43,978,508 bp
  • T to C, chromosome 1 at 59,144,804 bp
  • C to T, chromosome 1 at 60,281,310 bp
  • A to T, chromosome 2 at 122,305,191 bp
  • T to C, chromosome 2 at 152,932,699 bp
  • T to C, chromosome 2 at 153,416,662 bp
  • T to C, chromosome 2 at 167,022,096 bp
  • C to A, chromosome 3 at 59,752,118 bp
  • T to A, chromosome 3 at 62,604,521 bp
  • A to G, chromosome 3 at 121,732,475 bp
  • T to C, chromosome 4 at 143,949,824 bp
  • T to A, chromosome 5 at 53,069,169 bp
  • A to T, chromosome 5 at 65,311,116 bp
  • T to A, chromosome 5 at 115,984,888 bp
  • A to G, chromosome 5 at 123,535,272 bp
  • C to A, chromosome 5 at 140,009,169 bp
  • A to G, chromosome 6 at 23,649,342 bp
  • A to T, chromosome 6 at 73,133,542 bp
  • A to G, chromosome 6 at 77,243,881 bp
  • T to C, chromosome 6 at 129,584,239 bp
  • G to T, chromosome 7 at 19,371,398 bp
  • A to T, chromosome 7 at 31,061,085 bp
  • G to A, chromosome 7 at 44,201,703 bp
  • T to C, chromosome 7 at 45,322,329 bp
  • C to A, chromosome 7 at 130,936,291 bp
  • A to G, chromosome 8 at 95,108,679 bp
  • C to T, chromosome 9 at 35,486,956 bp
  • A to T, chromosome 9 at 44,716,062 bp
  • T to C, chromosome 9 at 114,933,717 bp
  • A to G, chromosome 10 at 19,759,311 bp
  • A to T, chromosome 10 at 74,630,633 bp
  • G to A, chromosome 10 at 75,721,508 bp
  • T to C, chromosome 11 at 53,979,640 bp
  • C to T, chromosome 11 at 80,395,491 bp
  • G to A, chromosome 11 at 93,885,756 bp
  • G to A, chromosome 11 at 99,809,366 bp
  • T to A, chromosome 12 at 59,184,278 bp
  • T to C, chromosome 12 at 113,544,097 bp
  • T to C, chromosome 13 at 119,701,138 bp
  • G to C, chromosome 14 at 14,346,517 bp
  • T to A, chromosome 14 at 14,775,000 bp
  • A to T, chromosome 14 at 47,416,563 bp
  • T to C, chromosome 14 at 53,362,399 bp
  • C to T, chromosome 14 at 54,469,688 bp
  • G to A, chromosome 14 at 54,944,749 bp
  • T to C, chromosome 15 at 8,221,904 bp
  • T to C, chromosome 15 at 89,548,325 bp
  • T to A, chromosome 16 at 46,009,860 bp
  • A to G, chromosome 17 at 28,317,591 bp
  • A to T, chromosome 18 at 14,655,164 bp
  • T to C, chromosome 19 at 10,599,332 bp
  • T to A, chromosome 19 at 13,234,633 bp
  • C to T, chromosome 19 at 37,404,117 bp
  • C to T, chromosome X at 74,277,038 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6845 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044951-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.