Strain Name:
C57BL/6J-MtgxR6826Btlr/Mmmh
Stock Number:
045019-MU
Citation ID:
RRID:MMRRC_045019-MU
Other Names:
R6826 (G1)
Major Collection:

Strain Information

Dnm2
Name: dynamin 2
Synonyms: b2b2159Clo, Dyn2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 13430
HGNC: HGNC:2974
Homologene: 90883
Crhr2
Name: corticotropin releasing hormone receptor 2
Synonyms: CRF 2 receptor, CRH-R2, CRFR2beta, CRFR2alpha, Crfr2, CRF-R2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12922
HGNC: HGNC:2358
Homologene: 55612
Prrc2b
Name: proline-rich coiled-coil 2B
Synonyms: 5830434P21Rik, Bat2l
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227723
Homologene: 106649
Wee1
Name: WEE 1 homolog 1 (S. pombe)
Synonyms: Wee1A
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22390
Homologene: 31152
Dnajc17
Name: DnaJ heat shock protein family (Hsp40) member C17
Synonyms: 1700025B16Rik, D9Bwg1371e
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 69408
Homologene: 49527
Dock9
Name: dedicator of cytokinesis 9
Synonyms: D14Wsu89e, B230309H04Rik, Zizimin1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 105445
Homologene: 41026
Copb1
Name: coatomer protein complex, subunit beta 1
Synonyms: Copb1, 2610019B04Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 70349
HGNC: HGNC:2231
Homologene: 5664
Snx16
Name: sorting nexin 16
Synonyms: 4930522N22Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 74718
Homologene: 11169
Mlh3
Name: mutL homolog 3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217716
VEGA: 12
HGNC: HGNC:7128
Homologene: 91153
Acaca
Name: acetyl-Coenzyme A carboxylase alpha
Synonyms: acetyl-CoA carboxylase, LOC327983, Acc1, A530025K05Rik, Acac
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 107476
HGNC: HGNC:84
Homologene: 31015
Leng8
Name: leukocyte receptor cluster (LRC) member 8
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232798
Homologene: 13612
Rps9
Name: ribosomal protein S9
Synonyms: 3010033P07Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 76846
Homologene: 68145
Midn
Name: midnolin
Synonyms: 3000003C15Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 59090
Homologene: 32510
Smcr8
Name: Smith-Magenis syndrome chromosome region, candidate 8 homolog (human)
Synonyms: 2310076G09Rik, D030073L15Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237782
Homologene: 16989
Jag1
Name: jagged 1
Synonyms: Ozz, ABE2, Headturner, Htu, Serrate-1, Gsfabe2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16449
HGNC: HGNC:6188
Homologene: 180
Dnah1
Name: dynein, axonemal, heavy chain 1
Synonyms: MDHC7, Dnahc1, B230373P09Rik, E030034C22Rik, ferf1, G1-415-19
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 110084
VEGA: 14
HGNC: HGNC:2940
Homologene: 67131
Peg10
Name: paternally expressed 10
Synonyms: MyEF-3 like, Mar2, Mart2, MEF3L, HB-1, MyEF-3, Edr, Rtl2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 170676
Homologene: 116067
F10
Name: coagulation factor X
Synonyms: Cf10, AI194738, fX
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 14058
HGNC: HGNC:3528
Homologene: 30976
Rasgrp3
Name: RAS, guanyl releasing protein 3
Synonyms: LOC240168
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240168
VEGA: 17
Homologene: 15019
Ppp1r3a
Name: protein phosphatase 1, regulatory subunit 3A
Synonyms: GM, RGL
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 140491
HGNC: HGNC:9291
Homologene: 48124
Elmod1
Name: ELMO/CED-12 domain containing 1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 270162
VEGA: 9
Homologene: 10280
Pde9a
Name: phosphodiesterase 9A
Synonyms: PDE9A1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 18585
HGNC: HGNC:8795
Homologene: 113565
Vmn2r3
Name: vomeronasal 2, receptor 3
Synonyms: EG637004
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 637004
Bmpr1b
Name: bone morphogenetic protein receptor, type 1B
Synonyms: BMPR-IB, Alk6, CFK-43a, Acvrlk6
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12167
HGNC: HGNC:1077
Homologene: 20322
Clca3a2
Name: chloride channel accessory 3A2
Synonyms: Clca2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 80797
HGNC: HGNC:2017
Homologene: 77224
Vmn2r1
Name: vomeronasal 2, receptor 1
Synonyms: V2r83, EG56544
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 56544
Homologene: 84832
Ap4b1
Name: adaptor-related protein complex AP-4, beta 1
Synonyms: 1810038H16Rik, AP-4 beta-4
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 67489
HGNC: HGNC:572
Homologene: 38203
Vmn2r25
Name: vomeronasal 2, receptor 25
Synonyms: EG545874
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 545874
Homologene: 135915
Abca6
Name: ATP-binding cassette, sub-family A member 6
Synonyms: 6330565N06Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 76184
HGNC: HGNC:36
Homologene: 71264
Myh4
Name: myosin, heavy polypeptide 4, skeletal muscle
Synonyms: MM, Minmus, Myhsf, MYH-2B, Minimsc, MHC2B, MyHC-IIb
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17884
HGNC: HGNC:7574
Homologene: 123880
Zfp541
Name: zinc finger protein 541
Synonyms: EG666528
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 666528
Homologene: 12991
Zfp811
Name: zinc finger protein 811
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240063
Elmo3
Name: engulfment and cell motility 3
Synonyms: CED-12
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234683
Homologene: 23475
Tesc
Name: tescalcin
Synonyms: 2410011K10Rik, TE-1, 1010001A17Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 57816
Homologene: 75158
Mdga1
Name: MAM domain containing glycosylphosphatidylinositol anchor 1
Synonyms: Mamdc3, 1200011I03Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 74762
Homologene: 17780
Foxred2
Name: FAD-dependent oxidoreductase domain containing 2
Synonyms: A430097D04Rik, LOC239554, D15Bwg0759e
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239554
Homologene: 11800
Ptprb
Name: protein tyrosine phosphatase receptor type B
Synonyms: VE-PTP, 3230402H02Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19263
VEGA: 10
HGNC: HGNC:9665
Homologene: 2125
Slc24a5
Name: solute carrier family 24, member 5
Synonyms: F630045L20Rik, NCX5, NCKX5, Oca6
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 317750
Homologene: 18400
Cyp11a1
Name: cytochrome P450, family 11, subfamily a, polypeptide 1
Synonyms: Cyp11a, P450scc, cholesterol side chain cleavage, cscc, Scc, D9Ertd411e
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 13070
HGNC: HGNC:2590
Homologene: 37347
Pde6b
Name: phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide
Synonyms: rd1, rd10, r, rd, Pdeb
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18587
HGNC: HGNC:8786
Homologene: 237
Hyal6
Name: hyaluronoglucosaminidase 6
Synonyms: Hyal-ps1, 4932701A20Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 74409
HGNC: HGNC:5324
Homologene: 78028
Serpina1e
Name: serine (or cysteine) peptidase inhibitor, clade A, member 1E
Synonyms: PI5, Spi1-5
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20704
HGNC: HGNC:8941
Homologene: 20103
Fmo4
Name: flavin containing monooxygenase 4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226564
HGNC: HGNC:3772
Homologene: 68219
Or5b3
Name: olfactory receptor family 5 subfamily B member 3
Synonyms: MOR202-11, GA_x6K02T2RE5P-3743369-3744289, Olfr1469
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258690
HGNC: HGNC:8324
Homologene: 133675
Apol7e
Name: apolipoprotein L 7e
Synonyms: ENSMUSG00000071716
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 666348
VEGA: 15
HGNC: HGNC:619
Homologene: 40940
Akr1c12
Name: aldo-keto reductase family 1, member C12
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 622402
HGNC: HGNC:387
Homologene: 121208
Tnfaip8l3
Name: tumor necrosis factor, alpha-induced protein 8-like 3
Synonyms: 9930029P06Rik, LOC244882
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244882
VEGA: 9
Homologene: 19480
Wfdc3
Name: WAP four-disulfide core domain 3
Synonyms: 1700015L13Rik, 1700127F16Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71856
Homologene: 122221
Pdrg1
Name: p53 and DNA damage regulated 1
Synonyms: 1110004D19Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68559
Homologene: 12779
Zfp579
Name: zinc finger protein 579
Synonyms: 1110003A17Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 68490
Homologene: 17629
Slfn14
Name: schlafen 14
Synonyms: Slfn14-ps, LOC237890
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237890
Homologene: 19082
Igkv5-48
Name: immunoglobulin kappa variable 5-48
Synonyms: ENSMUSG00000029975, Gm10881
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 619846
Sdf2l1
Name: stromal cell-derived factor 2-like 1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 64136
Homologene: 11101
Or10ag55-ps1
Name: olfactory receptor family 10 subfamily AG member 55, pseudogene 1
Synonyms: MOR264-10P, GA_x6K02T2Q125-48769330-48770299, MOR264-27_p, Olfr1117-ps1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258110
Cdhr17
Name: cadherin related family member 17
Synonyms: Gm28710
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 102640594
Homologene: 141132
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 162,803,769 bp
  • A to G, chromosome 2 at 32,222,288 bp
  • G to A, chromosome 2 at 87,284,328 bp
  • T to C, chromosome 2 at 119,180,927 bp
  • G to A, chromosome 2 at 125,068,858 bp
  • A to G, chromosome 2 at 137,116,175 bp
  • A to C, chromosome 2 at 153,010,256 bp
  • C to T, chromosome 2 at 164,734,258 bp
  • A to T, chromosome 3 at 10,438,088 bp
  • T to A, chromosome 3 at 64,105,146 bp
  • A to T, chromosome 3 at 64,274,906 bp
  • G to A, chromosome 3 at 103,812,908 bp
  • A to T, chromosome 3 at 141,857,406 bp
  • T to C, chromosome 3 at 144,818,054 bp
  • A to G, chromosome 5 at 16,808,294 bp
  • C to T, chromosome 5 at 108,430,592 bp
  • A to G, chromosome 5 at 118,056,418 bp
  • C to CATCAGGATG, chromosome 6 at 4,756,353 bp
  • C to A, chromosome 6 at 14,718,981 bp
  • A to G, chromosome 6 at 24,734,372 bp
  • T to C, chromosome 6 at 55,117,740 bp
  • T to C, chromosome 6 at 69,726,600 bp
  • A to G, chromosome 6 at 123,823,112 bp
  • C to A, chromosome 7 at 3,705,776 bp
  • T to A, chromosome 7 at 4,145,320 bp
  • G to T, chromosome 7 at 4,994,426 bp
  • A to G, chromosome 7 at 16,078,982 bp
  • T to C, chromosome 7 at 110,124,663 bp
  • T to C, chromosome 7 at 114,226,719 bp
  • T to C, chromosome 8 at 13,046,165 bp
  • A to T, chromosome 8 at 105,306,746 bp
  • T to A, chromosome 9 at 21,504,471 bp
  • T to C, chromosome 9 at 53,919,599 bp
  • G to T, chromosome 9 at 54,027,499 bp
  • A to G, chromosome 9 at 58,025,087 bp
  • T to A, chromosome 10 at 80,154,127 bp
  • T to A, chromosome 10 at 116,317,372 bp
  • G to T, chromosome 11 at 60,778,862 bp
  • T to C, chromosome 11 at 67,246,531 bp
  • C to A, chromosome 11 at 83,281,818 bp
  • T to C, chromosome 11 at 84,195,536 bp
  • T to C, chromosome 11 at 110,216,605 bp
  • A to T, chromosome 12 at 85,245,824 bp
  • A to G, chromosome 12 at 103,949,138 bp
  • A to G, chromosome 13 at 4,275,734 bp
  • T to C, chromosome 14 at 31,286,290 bp
  • G to A, chromosome 14 at 121,622,918 bp
  • T to A, chromosome 15 at 77,718,291 bp
  • G to T, chromosome 15 at 77,947,085 bp
  • C to G, chromosome 16 at 17,132,294 bp
  • T to C, chromosome 17 at 29,970,026 bp
  • A to G, chromosome 17 at 31,466,440 bp
  • A to G, chromosome 17 at 32,797,788 bp
  • G to T, chromosome 17 at 75,503,246 bp
  • T to A, chromosome 19 at 13,411,088 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6826 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045019-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.