Strain Name:
C57BL/6J-MtgxR6867Btlr/Mmmh
Stock Number:
045028-MU
Citation ID:
RRID:MMRRC_045028-MU
Other Names:
R6867 (G1)
Major Collection:

Strain Information

Neurod4
Name: neurogenic differentiation 4
Synonyms: MATH-3, bHLHa4, Atoh3, Math3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 11923
VEGA: 10
Homologene: 7234
Rasgrp2
Name: RAS, guanyl releasing protein 2
Synonyms: CalDAG-GEFI, Caldaggef1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 19395
HGNC: HGNC:9879
Homologene: 4250
Zfand6
Name: zinc finger, AN1-type domain 6
Synonyms: 3110005P07Rik, Za20d3, Awp1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 65098
Homologene: 10372
Tesk2
Name: testis-specific kinase 2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230661
Homologene: 5188
Enox1
Name: ecto-NOX disulfide-thiol exchanger 1
Synonyms: D230005D02Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 239188
VEGA: 14
Homologene: 56793
Wdr20
Name: WD repeat domain 20
Synonyms: Wdr20a, 2310040A13Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 69641
Homologene: 32684
Slc39a1
Name: solute carrier family 39 (zinc transporter), member 1
Synonyms: Zirtl, zip1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 30791
Homologene: 40906
Orc3
Name: origin recognition complex, subunit 3
Synonyms: Orc3l
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 50793
HGNC: HGNC:8489
Homologene: 8225
Nek1
Name: NIMA (never in mitosis gene a)-related expressed kinase 1
Synonyms: kat, kidney, anemia and testis, D8Ertd790e
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 18004
HGNC: HGNC:7744
Homologene: 14376
Rag1
Name: recombination activating 1
Synonyms: Rag-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19373
HGNC: HGNC:9831
Homologene: 387
Dlx1
Name: distal-less homeobox 1
Synonyms: DII B, Dlx-1, Dlx
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 13390
HGNC: HGNC:2914
Homologene: 22558
Vps50
Name: VPS50 EARP/GARPII complex subunit
Synonyms: Ccdc132, 1700034M03Rik, 8430415E05Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 73288
Homologene: 11498
Flrt2
Name: fibronectin leucine rich transmembrane protein 2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 399558
HGNC: HGNC:3761
Homologene: 8291
Gna13
Name: guanine nucleotide binding protein, alpha 13
Synonyms: Galpha13
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14674
HGNC: HGNC:4381
Homologene: 55976
Trim25
Name: tripartite motif-containing 25
Synonyms: Zfp147, estrogen-responsive finger protein
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217069
Homologene: 48325
Tmco3
Name: transmembrane and coiled-coil domains 3
Synonyms: B230339H12Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234076
Homologene: 32376
Gcgr
Name: glucagon receptor
Synonyms: GR
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14527
HGNC: HGNC:4192
Homologene: 131
Cyp7b1
Name: cytochrome P450, family 7, subfamily b, polypeptide 1
Synonyms: D3Ertd552e, hct-1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 13123
HGNC: HGNC:2652
Homologene: 3544
Slc35e2
Name: solute carrier family 35, member E2
Synonyms: A530082C11Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 320541
Homologene: 84987
Hydin
Name: HYDIN, axonemal central pair apparatus protein
Synonyms: 4930545D19Rik, hyrh, hy-3, hy3, 1700034M11Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244653
Homologene: 52118
Wdr95
Name: WD40 repeat domain 95
Synonyms: 4930434E21Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 381693
Homologene: 124480
Ush2a
Name: usherin
Synonyms: MUSH2A, LOC269160, Ush2a, A930037M10Rik, A930011D15Rik, LOC381317, Ushrn
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22283
Homologene: 66151
Kdm5d
Name: lysine demethylase 5D
Synonyms: Jarid1d, Smcy, HY
Type: Gene
Species: Mouse
Chromosome: Y
NCBI: 20592
Homologene: 55838
Dock10
Name: dedicator of cytokinesis 10
Synonyms: A630054M16Rik, Zizimin3, Jr5, Jr4, ZIZ3, 9330153B10Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 210293
Homologene: 45952
F3
Name: coagulation factor III
Synonyms: tissue factor, TF, CD142, Cf3, Cf-3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 14066
HGNC: HGNC:3541
Homologene: 1511
Mprip
Name: myosin phosphatase Rho interacting protein
Synonyms: Rhoip3, Gm34094, RIP3, p116Rip, p116 Rho interacting protein
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 26936
Homologene: 9034
Or8u10
Name: olfactory receptor family 8 subfamily U member 10
Synonyms: MOR256-34P, MOR171-52, Olfr1037, GA_x6K02T2Q125-47560740-47559775
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 259151
Homologene: 66572
Cep162
Name: centrosomal protein 162
Synonyms: 4922501C03Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 382090
Homologene: 8930
Megf8
Name: multiple EGF-like-domains 8
Synonyms: b2b288Clo, b2b1702Clo, m687Ddg, Egfl4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 269878
HGNC: HGNC:3233
Homologene: 15988
Myrfl
Name: myelin regulatory factor-like
Synonyms: Gm239, LOC237558
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237558
VEGA: 10
Homologene: 88588
Fam186a
Name: family with sequence similarity 186, member A
Synonyms: LOC380973, 1700030F18Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 72277
Hsd11b2
Name: hydroxysteroid 11-beta dehydrogenase 2
Synonyms: 11HSD2, 11(beta)-HSD2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 15484
HGNC: HGNC:5209
Homologene: 20088
Veph1
Name: ventricular zone expressed PH domain-containing 1
Synonyms: 2810471M23Rik, Veph
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 72789
Homologene: 11624
Rgl2
Name: ral guanine nucleotide dissociation stimulator-like 2
Synonyms: Rlf, KE1.5, Rgt2, Rab2l
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 19732
HGNC: HGNC:9769
Homologene: 3494
Apold1
Name: apolipoprotein L domain containing 1
Synonyms: LOC381823
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 381823
Homologene: 12781
Ipp
Name: IAP promoted placental gene
Synonyms: Mipp, D4Jhu8
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 16351
HGNC: HGNC:6108
Homologene: 4309
Vps28
Name: vacuolar protein sorting 28
Synonyms: D730005C08Rik, 1110014J03Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 66914
VEGA: 15
Homologene: 69205
Zfp703
Name: zinc finger protein 703
Synonyms: End2, 1110032O19Rik, Zeppo1, Csmn1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 353310
Homologene: 81391
Mtres1
Name: mitochondrial transcription rescue factor 1
Synonyms: 1700021F05Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 67851
Homologene: 41137
Gm6741
Name: predicted gene 6741
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627235
VEGA: 17
Or1ab2
Name: olfactory receptor family 1 subfamily AB member 2
Synonyms: GA_x6K02T2NUPS-241490-242431, Olfr374, MOR130-1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 258335
Homologene: 131127
Vmn2r43
Name: vomeronasal 2, receptor 43
Synonyms: EC2-V2R
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 381838
Homologene: 113703
Igdcc3
Name: immunoglobulin superfamily, DCC subclass, member 3
Synonyms: 2810401C09Rik, WI-14920, Punc
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 19289
VEGA: 9
HGNC: HGNC:9700
Homologene: 3590
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 80,531,259 bp
  • A to G, chromosome 1 at 188,910,973 bp
  • C to A, chromosome 2 at 71,531,009 bp
  • A to G, chromosome 2 at 86,085,738 bp
  • T to C, chromosome 2 at 101,641,947 bp
  • T to C, chromosome 3 at 18,097,230 bp
  • T to A, chromosome 3 at 66,255,037 bp
  • T to A, chromosome 3 at 90,249,452 bp
  • T to C, chromosome 3 at 121,729,371 bp
  • A to G, chromosome 4 at 34,605,539 bp
  • T to A, chromosome 4 at 116,510,409 bp
  • T to A, chromosome 4 at 116,801,798 bp
  • A to G, chromosome 4 at 155,618,700 bp
  • A to G, chromosome 5 at 149,580,923 bp
  • A to G, chromosome 6 at 3,517,835 bp
  • T to C, chromosome 6 at 134,984,056 bp
  • A to G, chromosome 7 at 8,255,126 bp
  • A to G, chromosome 7 at 25,331,035 bp
  • A to G, chromosome 7 at 84,615,914 bp
  • T to A, chromosome 8 at 13,313,927 bp
  • C to A, chromosome 8 at 26,978,640 bp
  • C to A, chromosome 8 at 61,072,330 bp
  • C to T, chromosome 8 at 72,109,863 bp
  • G to A, chromosome 8 at 105,522,317 bp
  • A to G, chromosome 8 at 110,539,802 bp
  • A to G, chromosome 9 at 65,183,038 bp
  • A to T, chromosome 9 at 87,217,081 bp
  • ACTGCACCACCT to ACT, chromosome 10 at 43,532,725 bp
  • T to A, chromosome 10 at 116,848,282 bp
  • C to G, chromosome 10 at 130,270,714 bp
  • T to C, chromosome 11 at 59,749,630 bp
  • T to C, chromosome 11 at 89,010,887 bp
  • T to C, chromosome 11 at 109,396,122 bp
  • T to A, chromosome 11 at 120,536,469 bp
  • T to C, chromosome 12 at 95,779,382 bp
  • T to C, chromosome 12 at 110,793,699 bp
  • T to C, chromosome 14 at 77,699,299 bp
  • A to T, chromosome 15 at 76,622,671 bp
  • T to A, chromosome 15 at 99,945,850 bp
  • A to G, chromosome 17 at 33,932,687 bp
  • T to C, chromosome 17 at 91,236,911 bp
  • G to A, chromosome 19 at 6,413,183 bp
  • A to G, chromosome Y at 927,425 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6867 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045028-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.