Strain Name:
C57BL/6J-MtgxR6971Btlr/Mmmh
Stock Number:
045081-MU
Citation ID:
RRID:MMRRC_045081-MU
Other Names:
R6971 (G1)
Major Collection:

Strain Information

Pou2f1
Name: POU domain, class 2, transcription factor 1
Synonyms: oct-1, Oct-1A, Otf-1, Oct-1C, 2810482H01Rik, Oct-1z, Oct1, Oct-1B, Otf1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18986
HGNC: HGNC:9212
Homologene: 37658
Shprh
Name: SNF2 histone linker PHD RING helicase
Synonyms: D230017O13Rik, 2610103K11Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 268281
Homologene: 6489
Itgb8
Name: integrin beta 8
Synonyms: 4832412O06Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 320910
HGNC: HGNC:6163
Homologene: 18567
Vcan
Name: versican
Synonyms: hdf, DPEAAE, heart defect, 5430420N07Rik, PG-M, Cspg2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 13003
HGNC: HGNC:2464
Homologene: 3228
Amigo1
Name: adhesion molecule with Ig like domain 1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229715
Homologene: 46421
Ubp1
Name: upstream binding protein 1
Synonyms: LBP-1b, LBP-1a, NF2d9
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 22221
VEGA: 9
Homologene: 8435
Ccdc88c
Name: coiled-coil domain containing 88C
Synonyms: 0610010D24Rik, Daple
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 68339
VEGA: 12
Homologene: 18903
Sbno2
Name: strawberry notch 2
Synonyms: Stno
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216161
VEGA: 10
Homologene: 8981
Srbd1
Name: S1 RNA binding domain 1
Synonyms: D530025C17Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 78586
VEGA: 17
Homologene: 9994
Hectd1
Name: HECT domain E3 ubiquitin protein ligase 1
Synonyms: b2b327Clo, opm, A630086P08Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 207304
VEGA: 12
Homologene: 9115
Prrc2a
Name: proline-rich coiled-coil 2A
Synonyms: 3110039B05Rik, Bat-2, Bat2, G2, D17H6S51E, Wbp12
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 53761
Homologene: 10567
Brca1
Name: breast cancer 1, early onset
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12189
HGNC: HGNC:1100
Homologene: 5276
Stim2
Name: stromal interaction molecule 2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 116873
Homologene: 32490
Mier2
Name: MIER family member 2
Synonyms: 2700087H15Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70427
Homologene: 18941
Slc3a2
Name: solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
Synonyms: Ly-m10, Mdu1, Cd98, 4F2HC, Mgp-2hc, Ly-10
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 17254
Homologene: 1795
Sec63
Name: SEC63 homolog, protein translocation regulator
Synonyms: 5730478J10Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 140740
Homologene: 5220
Rnft2
Name: ring finger protein, transmembrane 2
Synonyms: B830028P19Rik, Tmem118
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 269695
Homologene: 41892
Cdk10
Name: cyclin dependent kinase 10
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234854
HGNC: HGNC:1770
Homologene: 55769
Hmcn2
Name: hemicentin 2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 665700
Homologene: 90772
Hps3
Name: HPS3, biogenesis of lysosomal organelles complex 2 subunit 1
Synonyms: Hermansky-Pudlak syndrome 3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12807
Homologene: 13019
Ttn
Name: titin
Synonyms: shru, L56, mdm, connectin, D330041I19Rik, 2310057K23Rik, 2310074I15Rik, 2310036G12Rik, D830007G01Rik, 1100001C23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Hmcn1
Name: hemicentin 1
Synonyms: LOC240793, EG545370
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 545370
Homologene: 23741
Vmn2r3
Name: vomeronasal 2, receptor 3
Synonyms: EG637004
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 637004
Aadacl4
Name: arylacetamide deacetylase like 4
Synonyms: Gm13177
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 435815
Homologene: 82530
Ccdc97
Name: coiled-coil domain containing 97
Synonyms: 1200014H14Rik, 2810446P04Rik, D7Ertd462e
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 52132
Homologene: 32701
Pfkfb2
Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
Synonyms: 4930568D07Rik, PFK-2/FBPase-2 gene B
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18640
HGNC: HGNC:8873
Homologene: 88554
Tecrl
Name: trans-2,3-enoyl-CoA reductase-like
Synonyms: Srd5a2l2, D330017N19Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 243078
Homologene: 27549
Nuggc
Name: nuclear GTPase, germinal center associated
Synonyms: LOC239151, Gm600, SLIP-GC
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 100503545
Homologene: 72641
Mdga2
Name: MAM domain containing glycosylphosphatidylinositol anchor 2
Synonyms: 9330209L04Rik, Mamdc1, Adp, Mdga2, 6720489L24Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 320772
Homologene: 45659
Prss36
Name: serine protease 36
Synonyms: polyserase-2, C330007D15Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 77613
Homologene: 18303
Dsc3
Name: desmocollin 3
Synonyms: 5430426I24Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13507
VEGA: 18
HGNC: HGNC:3037
Homologene: 1462
2210408I21Rik
Name: RIKEN cDNA 2210408I21 gene
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 72371
Homologene: 89234
Kcnt2
Name: potassium channel, subfamily T, member 2
Synonyms: E330038N15Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240776
Homologene: 16121
Zfp777
Name: zinc finger protein 777
Synonyms: 2500002G23Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 72306
Homologene: 56721
Adprhl1
Name: ADP-ribosylhydrolase like 1
Synonyms: D330008N11Rik, Arh2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234072
Homologene: 16311
1700113H08Rik
Name: RIKEN cDNA 1700113H08 gene
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 76640
Homologene: 45695
Urgcp
Name: upregulator of cell proliferation
Synonyms: 2010005J08Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 72046
Homologene: 69243
Ip6k2
Name: inositol hexaphosphate kinase 2
Synonyms: Ihpk2, 1500005N04Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 76500
Homologene: 56929
Fnip2
Name: folliculin interacting protein 2
Synonyms: D630023B12Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 329679
Homologene: 46417
Setdb2
Name: SET domain, bifurcated 2
Synonyms: KMT1F, LOC239122
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 239122
Homologene: 12903
Msl2
Name: MSL complex subunit 2
Synonyms: Msl2l1, E130103E02Rik, Rnf184
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 77853
Homologene: 10021
Or9k2b
Name: olfactory receptor family 9 subfamily K member 2B
Synonyms: GA_x6K02T2PULF-11851623-11850682, MOR210-2, Olfr826
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258671
Homologene: 121503
Vmn1r8
Name: vomeronasal 1 receptor 8
Synonyms: V1rc32
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 171205
Homologene: 83427
Gltpd2
Name: glycolipid transfer protein domain containing 2
Synonyms: C730027E14Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216871
Homologene: 51691
Ephx3
Name: epoxide hydrolase 3
Synonyms: Abhd9, 2310063B19Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 71932
Homologene: 69386
Pde2a
Name: phosphodiesterase 2A, cGMP-stimulated
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 207728
HGNC: HGNC:8777
Homologene: 1952
Glra1
Name: glycine receptor, alpha 1 subunit
Synonyms: B230397M16Rik, oscillator, nmf11, ot
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14654
HGNC: HGNC:4326
Homologene: 20083
C1qtnf7
Name: C1q and tumor necrosis factor related protein 7
Synonyms: 8430425G24Rik, 5530401N20Rik, CTRP7
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 109323
Homologene: 12900
Ttc33
Name: tetratricopeptide repeat domain 33
Synonyms: 2900001O04Rik, 2410099M07Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 67515
Homologene: 8226
Igfbpl1
Name: insulin-like growth factor binding protein-like 1
Synonyms: IGFBP-like protein, 2810011G06Rik, 2810453O06Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 75426
Homologene: 10292
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 130,700,796 bp
  • T to C, chromosome 1 at 140,512,908 bp
  • T to A, chromosome 1 at 150,993,051 bp
  • A to G, chromosome 1 at 165,931,689 bp
  • G to A, chromosome 2 at 31,432,321 bp
  • G to A, chromosome 2 at 76,942,049 bp
  • A to T, chromosome 3 at 20,011,535 bp
  • A to G, chromosome 3 at 64,259,247 bp
  • G to A, chromosome 3 at 79,481,121 bp
  • C to T, chromosome 3 at 108,188,136 bp
  • A to G, chromosome 4 at 45,816,333 bp
  • G to A, chromosome 4 at 144,622,733 bp
  • T to A, chromosome 5 at 43,609,050 bp
  • T to A, chromosome 5 at 54,118,299 bp
  • T to C, chromosome 5 at 83,354,802 bp
  • A to G, chromosome 5 at 118,194,570 bp
  • C to A, chromosome 6 at 48,024,691 bp
  • T to A, chromosome 6 at 57,036,415 bp
  • G to T, chromosome 7 at 25,714,959 bp
  • T to A, chromosome 7 at 101,510,313 bp
  • T to C, chromosome 7 at 127,945,238 bp
  • T to A, chromosome 8 at 13,223,476 bp
  • T to A, chromosome 8 at 123,227,674 bp
  • T to C, chromosome 9 at 101,100,843 bp
  • T to C, chromosome 9 at 108,797,311 bp
  • T to C, chromosome 9 at 113,972,763 bp
  • A to T, chromosome 10 at 11,166,693 bp
  • A to G, chromosome 10 at 42,783,442 bp
  • G to A, chromosome 10 at 79,542,429 bp
  • A to G, chromosome 10 at 80,060,034 bp
  • A to T, chromosome 10 at 87,165,041 bp
  • A to T, chromosome 10 at 130,180,769 bp
  • A to T, chromosome 11 at 5,718,115 bp
  • A to T, chromosome 11 at 55,536,499 bp
  • A to G, chromosome 11 at 70,520,464 bp
  • A to G, chromosome 11 at 101,534,005 bp
  • A to T, chromosome 12 at 51,748,743 bp
  • A to G, chromosome 12 at 66,550,561 bp
  • A to T, chromosome 12 at 100,954,227 bp
  • A to T, chromosome 12 at 119,190,631 bp
  • A to G, chromosome 13 at 77,193,187 bp
  • A to G, chromosome 13 at 89,678,133 bp
  • A to T, chromosome 14 at 59,415,740 bp
  • T to C, chromosome 14 at 65,608,856 bp
  • C to A, chromosome 15 at 5,212,042 bp
  • T to A, chromosome 17 at 32,188,203 bp
  • T to C, chromosome 17 at 35,159,501 bp
  • T to C, chromosome 17 at 86,099,290 bp
  • A to G, chromosome 18 at 19,966,218 bp
  • T to C, chromosome 19 at 8,709,610 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6971 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045081-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.