Strain Name:
C57BL/6J-MtgxR7003Btlr/Mmmh
Stock Number:
045108-MU
Citation ID:
RRID:MMRRC_045108-MU
Other Names:
R7003 (G1)
Major Collection:

Strain Information

Kif16b
Name: kinesin family member 16B
Synonyms: N-3 kinesin, 8430434E15Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16558
Homologene: 135708
Cep104
Name: centrosomal protein 104
Synonyms: BC046331
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230967
Homologene: 44919
Etl4
Name: enhancer trap locus 4
Synonyms: Sickle tail, 6620402G01Rik, Skt, 9430077C05Rik, Etl-4, E330027G05Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 208618
Homologene: 10477
Ap2a2
Name: adaptor-related protein complex 2, alpha 2 subunit
Synonyms: 2410074K14Rik, L25, Adtab, alpha-adaptin C, alpha-C adaptin
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 11772
HGNC: HGNC:562
Homologene: 5335
Ube3a
Name: ubiquitin protein ligase E3A
Synonyms: Hpve6a, A130086L21Rik, 5830462N02Rik, E6-AP ubiquitin protein ligase
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22215
Homologene: 7988
Gpatch2l
Name: G patch domain containing 2 like
Synonyms: 1700020O03Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 70373
VEGA: 12
Homologene: 9942
Atg2b
Name: autophagy related 2B
Synonyms: C030004M05Rik, 2410024A21Rik, C630028L02Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 76559
VEGA: 12
Homologene: 9974
Amhr2
Name: anti-Mullerian hormone type 2 receptor
Synonyms: MISIIR, MIS TypeII receptor
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 110542
HGNC: HGNC:465
Homologene: 10746
Rif1
Name: replication timing regulatory factor 1
Synonyms: 5730435J01Rik, D2Ertd145e, 6530403D07Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 51869
Homologene: 41231
Rnf123
Name: ring finger protein 123
Synonyms: KPC1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 84585
Homologene: 11112
Polr3c
Name: polymerase (RNA) III (DNA directed) polypeptide C
Synonyms: RPC62, 4933407E01Rik, RPC3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 74414
Homologene: 38185
Psap
Name: prosaposin
Synonyms: SGP-1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19156
HGNC: HGNC:9498
Homologene: 37680
Zfp846
Name: zinc finger protein 846
Synonyms: 2210010B09Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244721
Homologene: 87243
Bcr
Name: BCR activator of RhoGEF and GTPase
Synonyms: 5133400C09Rik, breakpoint cluster region
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 110279
VEGA: 10
HGNC: HGNC:1014
Homologene: 3192
Tenm3
Name: teneurin transmembrane protein 3
Synonyms: 2610100B16Rik, Odz3, Ten-m3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 23965
Homologene: 22673
Cmip
Name: c-Maf inducing protein
Synonyms: 4933407C03Rik, 5830471E12Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 74440
Homologene: 18869
Vac14
Name: Vac14 homolog (S. cerevisiae)
Synonyms: ingls, Trx, D8Wsu151e, Tax1bp2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234729
Homologene: 6528
Mplkipl1
Name: M-phase specific PLK1 intereacting protein like 1
Synonyms: Gm7102
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 633057
Gpr155
Name: G protein-coupled receptor 155
Synonyms: 1110017O10Rik, F730029F15Rik, DEPDC3, PGR22
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68526
Homologene: 16584
Atp12a
Name: ATPase, H+/K+ transporting, nongastric, alpha polypeptide
Synonyms: HKalpha2, ATPase H+K+-transporting, alpha 2, Atp1al1, cHKA
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 192113
VEGA: 14
Homologene: 68197
Dok7
Name: docking protein 7
Synonyms: A930013K19Rik, Dok-7, Oit5, EF-12
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231134
Homologene: 18210
Or2d3b
Name: olfactory receptor family 2 subfamily D member 3B
Synonyms: Olfr1532-ps1, MOR260-9P, Olfr708, GA_x6K02T2PBJ9-9297671-9298594, MOR260-6P, Olfr1532, MOR260-9P
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258173
Homologene: 133899
Clspn
Name: claspin
Synonyms: E130314M08Rik, C85083
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 269582
Homologene: 11138
P2rx5
Name: purinergic receptor P2X, ligand-gated ion channel, 5
Synonyms: P2X5
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 94045
HGNC: HGNC:8536
Homologene: 1924
Armc3
Name: armadillo repeat containing 3
Synonyms: 4921513G22Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 70882
Homologene: 31589
Cplane1
Name: ciliogenesis and planar polarity effector 1
Synonyms: Hug, Jbts17, 2410089E03Rik, b2b012Clo
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 73692
Homologene: 11315
Adgrv1
Name: adhesion G protein-coupled receptor V1
Synonyms: Mgr1, Mass1, Gpr98, VLGR1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 110789
Homologene: 19815
Lgsn
Name: lengsin, lens protein with glutamine synthetase domain
Synonyms: Gluld1, lengsin, Lgs
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 266744
Homologene: 9569
Skint6
Name: selection and upkeep of intraepithelial T cells 6
Synonyms: OTTMUSG00000008519
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230622
Homologene: 135888
Krba1
Name: KRAB-A domain containing 1
Synonyms: A930040G15Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 77827
Homologene: 15880
Nt5e
Name: 5' nucleotidase, ecto
Synonyms: ecto-5'-nucleotidase, Nt5, 2210401F01Rik, CD73
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 23959
HGNC: HGNC:8021
Homologene: 1895
Tarm1
Name: T cell-interacting, activating receptor on myeloid cells 1
Synonyms: Gm9904, 9930022N03Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 245126
Homologene: 120241
Zfp175
Name: zinc finger protein 175
Synonyms: Zfp658
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 210104
Homologene: 134007
Sdk1
Name: sidekick cell adhesion molecule 1
Synonyms: 6720466O15Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 330222
Homologene: 27395
Lrrc4b
Name: leucine rich repeat containing 4B
Synonyms: Lrig4, NGL-3, Ngl3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 272381
Homologene: 45681
Dsel
Name: dermatan sulfate epimerase-like
Synonyms: 9330132E09Rik, DS-epi2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 319901
Homologene: 12964
Inpp5e
Name: inositol polyphosphate-5-phosphatase E
Synonyms: 1200002L24Rik, 72kDa
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 64436
Homologene: 56863
Adam6b
Name: a disintegrin and metallopeptidase domain 6B
Synonyms: 4930523C11Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238405
Homologene: 128362
Hpn
Name: hepsin
Synonyms: Hlb320
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 15451
HGNC: HGNC:5155
Homologene: 20498
Rnf19a
Name: ring finger protein 19A
Synonyms: XY body protein, Dorfin, Rnf19, XYbp
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 30945
VEGA: 15
Homologene: 8501
Or8g26
Name: olfactory receptor family 8 subfamily G member 26
Synonyms: Olfr943, GA_x6K02T2PVTD-32881408-32882343, MOR171-44
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258323
VEGA: 9
HGNC: HGNC:8484
Homologene: 110526
Plekhd1
Name: pleckstrin homology domain containing, family D (with coiled-coil domains) member 1
Synonyms: 3830431G21Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217682
Homologene: 15090
Irs3
Name: insulin receptor substrate 3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 16369
HGNC: HGNC:6127
Homologene: 84788
Neil3
Name: nei like 3 (E. coli)
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234258
Homologene: 10094
Or2f2
Name: olfactory receptor family 2 subfamily F member 2
Synonyms: Olfr452, GA_x6K02T2P3E9-4769843-4768890, MOR257-5P
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 258207
HGNC: HGNC:8247
Homologene: 128141
Actr3b
Name: ARP3 actin-related protein 3B
Synonyms: ARP11, Arp3b
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 242894
Homologene: 4180
Shc3
Name: src homology 2 domain-containing transforming protein C3
Synonyms: ShcC, N-Shc, Rai
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20418
VEGA: 13
Homologene: 7536
Or1j1
Name: olfactory receptor family 1 subfamily J member 1
Synonyms: MOR136-14, Olfr3, GA_x6K02T2NLDC-33507606-33506665, Y71
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18328
HGNC: HGNC:8208
Homologene: 66579
Plod3
Name: procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
Synonyms: lysyl hydroxylase 3, LH3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 26433
HGNC: HGNC:9083
Homologene: 843
Vmn1r225
Name: vomeronasal 1 receptor 225
Synonyms: V1re5
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 171228
Alox8
Name: arachidonate 8-lipoxygenase
Synonyms: 8S-lipoxygenase, Alox15b, 8-LOX, 8S-LOX
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11688
HGNC: HGNC:434
Homologene: 886
Phtf2
Name: putative homeodomain transcription factor 2
Synonyms: 1110054G21Rik, 9530062N20Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 68770
Homologene: 10713
Spesp1
Name: sperm equatorial segment protein 1
Synonyms: 4921508E09Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 66712
VEGA: 9
Homologene: 49838
Akr1c6
Name: aldo-keto reductase family 1, member C6
Synonyms: 3alpha-HSD, Hsd17b5, Akr1c1, estradiol 17-beta-dehydrogenase (A-specific)
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 83702
Homologene: 84695
Slc7a12
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 12
Synonyms: Asc-2, XAT1, asc-type amino acid transporter 2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 140918
Homologene: 76812
Actbl2
Name: actin, beta-like 2
Synonyms: 4732495G21Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238880
Homologene: 134276
D630039A03Rik
Name: RIKEN cDNA D630039A03 gene
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242484
Homologene: 52276
Ttc9c
Name: tetratricopeptide repeat domain 9C
Synonyms: 6330408J23Rik, 2210019E14Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 70387
Homologene: 18361
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 31,203,943 bp
  • C to T, chromosome 1 at 111,860,295 bp
  • T to C, chromosome 2 at 19,270,028 bp
  • C to T, chromosome 2 at 20,805,884 bp
  • A to G, chromosome 2 at 26,397,865 bp
  • A to G, chromosome 2 at 36,813,035 bp
  • A to G, chromosome 2 at 52,076,989 bp
  • A to G, chromosome 2 at 73,343,617 bp
  • A to C, chromosome 2 at 142,758,829 bp
  • T to C, chromosome 3 at 14,505,520 bp
  • G to T, chromosome 3 at 96,723,638 bp
  • T to C, chromosome 4 at 57,910,521 bp
  • A to G, chromosome 4 at 113,105,912 bp
  • T to A, chromosome 4 at 126,592,720 bp
  • T to C, chromosome 4 at 153,993,561 bp
  • A to G, chromosome 5 at 20,794,401 bp
  • A to C, chromosome 5 at 25,798,463 bp
  • A to T, chromosome 5 at 35,079,555 bp
  • T to A, chromosome 5 at 136,989,644 bp
  • C to T, chromosome 5 at 137,645,277 bp
  • G to A, chromosome 5 at 142,096,734 bp
  • C to T, chromosome 6 at 42,790,465 bp
  • A to G, chromosome 6 at 48,413,080 bp
  • A to T, chromosome 7 at 3,497,423 bp
  • C to T, chromosome 7 at 31,110,942 bp
  • A to G, chromosome 7 at 43,574,748 bp
  • C to T, chromosome 7 at 44,445,156 bp
  • C to T, chromosome 7 at 59,276,440 bp
  • A to T, chromosome 7 at 106,915,112 bp
  • A to G, chromosome 7 at 141,629,196 bp
  • T to C, chromosome 8 at 48,240,444 bp
  • T to C, chromosome 8 at 53,600,966 bp
  • T to A, chromosome 8 at 110,712,798 bp
  • T to C, chromosome 8 at 117,384,988 bp
  • T to C, chromosome 9 at 20,587,892 bp
  • A to T, chromosome 9 at 39,184,943 bp
  • A to T, chromosome 9 at 62,282,020 bp
  • A to G, chromosome 9 at 88,364,752 bp
  • T to A, chromosome 9 at 108,063,683 bp
  • T to A, chromosome 10 at 60,299,497 bp
  • T to C, chromosome 10 at 75,061,561 bp
  • T to C, chromosome 11 at 69,191,590 bp
  • T to C, chromosome 11 at 73,167,974 bp
  • T to C, chromosome 12 at 80,721,960 bp
  • G to A, chromosome 12 at 86,244,184 bp
  • A to G, chromosome 12 at 105,654,249 bp
  • C to T, chromosome 12 at 113,490,042 bp
  • A to G, chromosome 13 at 4,454,515 bp
  • T to A, chromosome 13 at 51,466,552 bp
  • C to T, chromosome 13 at 81,522,104 bp
  • T to A, chromosome 13 at 111,255,956 bp
  • A to G, chromosome 14 at 56,373,380 bp
  • T to G, chromosome 15 at 8,228,762 bp
  • G to A, chromosome 15 at 36,254,504 bp
  • A to G, chromosome 15 at 102,446,333 bp
  • A to G, chromosome 17 at 20,503,154 bp
  • A to T, chromosome 19 at 8,818,540 bp
  • A to G, chromosome 19 at 61,175,881 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7003 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045108-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.