Strain Name:
C57BL/6J-MtgxR7043Btlr/Mmmh
Stock Number:
045142-MU
Citation ID:
RRID:MMRRC_045142-MU
Other Names:
R7043 (G1)
Major Collection:

Strain Information

Tk1
Name: thymidine kinase 1
Synonyms: D530002A18Rik, Tk-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 21877
Homologene: 37749
Sptbn1
Name: spectrin beta, non-erythrocytic 1
Synonyms: 9930031C03Rik, brain spectrin, elf1, spectrin G, beta fodrin, Spnb2, non-erythrocytic, Spnb-2, elf3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20742
Homologene: 2354
Dst
Name: dystonin
Synonyms: Macf2, A830042E19Rik, Bpag1, Bpag, bullous pemphigoid antigen 1, nmf203, athetoid, nmf339, BPAG1, BPAG1-n, 2310001O04Rik, bullous pemphigoid antigen 1, ah
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Wwp2
Name: WW domain containing E3 ubiquitin protein ligase 2
Synonyms: 1300010O06Rik, AIP2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 66894
Homologene: 48490
Prpf6
Name: pre-mRNA splicing factor 6
Synonyms: ANT-1, 2610031L17Rik, 1190003A07Rik, U5-102K
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68879
Homologene: 5368
Sema3f
Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
Synonyms: Semak, Sema IV
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20350
Homologene: 20885
Ccna2
Name: cyclin A2
Synonyms: Ccn-1, CycA2, Cyca, Ccna, Ccn1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12428
HGNC: HGNC:1578
Homologene: 55562
Wwox
Name: WW domain-containing oxidoreductase
Synonyms: 9030416C10Rik, WOX1, 5330426P09Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 80707
Homologene: 56334
Zfp280d
Name: zinc finger protein 280D
Synonyms: Suhw4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235469
Homologene: 17151
Chd9
Name: chromodomain helicase DNA binding protein 9
Synonyms: 1810014J18Rik, 9030205D12Rik, A330063D19Rik, AD013
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 109151
Homologene: 11844
Zc3h3
Name: zinc finger CCCH type containing 3
Synonyms: Smicl
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223642
VEGA: 15
Homologene: 9029
Supt5
Name: suppressor of Ty 5, DSIF elongation factor subunit
Synonyms: Spt5, Supt5h
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20924
Homologene: 2384
Bdp1
Name: B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB
Synonyms: TFIIIB90, G630013P12Rik, TFC5, TAF3B1, B130055N23Rik, Tfnr, TFIIIB150
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 544971
Homologene: 34582
Syne1
Name: spectrin repeat containing, nuclear envelope 1
Synonyms: enaptin165, nesprin-1, A330049M09Rik, C130039F11Rik, SYNE-1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 64009
VEGA: 10
Homologene: 52329
Eri1
Name: exoribonuclease 1
Synonyms: Thex1, Eri1, 3110010F15Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 67276
Homologene: 32651
Eif5
Name: eukaryotic translation initiation factor 5
Synonyms: D12Ertd549e, 2810011H21Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217869
VEGA: 12
HGNC: HGNC:3299
Homologene: 49610
C2cd2l
Name: C2 calcium-dependent domain containing 2-like
Synonyms: 1300006O23Rik, Tmem24
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 71764
VEGA: 9
Homologene: 8876
Ndel1
Name: nudE neurodevelopment protein 1 like 1
Synonyms: mNudel, 2600006O07Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 83431
Homologene: 32567
Abca17
Name: ATP-binding cassette, sub-family A member 17
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 381072
Homologene: 86807
Gm14496
Name: predicted gene 14496
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 672125
Homologene: 129606
Avpr1a
Name: arginine vasopressin receptor 1A
Synonyms: V1aR
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 54140
HGNC: HGNC:895
Homologene: 568
Recql5
Name: RecQ protein-like 5
Synonyms: Recq5b, Recql5b
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 170472
HGNC: HGNC:9950
Homologene: 31232
Eif2s1
Name: eukaryotic translation initiation factor 2, subunit 1 alpha
Synonyms: 0910001O23Rik, eIF2alpha, 2410026C18Rik, Eif2a
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 13665
HGNC: HGNC:3265
Homologene: 3020
Mme
Name: membrane metallo endopeptidase
Synonyms: neutral endopeptidase, NEP, neprilysin, 6030454K05Rik, CD10
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 17380
HGNC: HGNC:7154
Homologene: 5275
H2-T23
Name: histocompatibility 2, T region locus 23
Synonyms: Qa-1, T18c, 37c, 37b, T18c(37), T23d, T23b, Qa1, H-2T23, Qed-1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 15040
HGNC: HGNC:4962
Homologene: 134018
Trp73
Name: transformation related protein 73
Synonyms: deltaNp73, TAp73, p73
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 22062
Homologene: 3960
F7
Name: coagulation factor VII
Synonyms: Cf7, FVII
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 14068
HGNC: HGNC:3544
Homologene: 7710
Ttn
Name: titin
Synonyms: shru, L56, mdm, connectin, D330041I19Rik, 2310057K23Rik, 2310074I15Rik, 2310036G12Rik, D830007G01Rik, 1100001C23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Kmt5b
Name: lysine methyltransferase 5B
Synonyms: C630029K18Rik, Suv4-20h1, Suv420h1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 225888
Homologene: 32351
Itga9
Name: integrin alpha 9
Synonyms: 6720458D17Rik, 2610002H11Rik, D9Ertd428e
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 104099
HGNC: HGNC:6145
Homologene: 1664
Stab2
Name: stabilin 2
Synonyms: FEEL-2, STAB-2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 192188
Homologene: 23022
Lrp1b
Name: low density lipoprotein-related protein 1B
Synonyms: 9630004P12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 94217
HGNC: HGNC:6693
Homologene: 56810
Skint5
Name: selection and upkeep of intraepithelial T cells 5
Synonyms: OTTMUSG00000008560
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242627
Homologene: 135888
Per2
Name: period circadian clock 2
Synonyms: mPer2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18627
HGNC: HGNC:8846
Homologene: 7885
Naip1
Name: NLR family, apoptosis inhibitory protein 1
Synonyms: Birc1a, D13Lsd1, Naip
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17940
VEGA: 13
HGNC: HGNC:7634
Homologene: 113589
Phf8l
Name: PHD finger protein 8 like
Synonyms: 4921501E09Rik, Phf8-ps
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 74042
VEGA: 17
Homologene: 66275
Crybg2
Name: crystallin beta-gamma domain containing 2
Synonyms: Aim1l
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230806
Homologene: 19232
Cd53
Name: CD53 antigen
Synonyms: Tspan25, Ox-44
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12508
HGNC: HGNC:1686
Homologene: 20152
Serpinb9f
Name: serine (or cysteine) peptidase inhibitor, clade B, member 9f
Synonyms: NK21, Spi13, ovalbumin
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20709
HGNC: HGNC:8955
Homologene: 69093
Vmn2r11
Name: vomeronasal 2, receptor 11
Synonyms: EG384219
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 384219
Homologene: 129606
Kcnb2
Name: potassium voltage gated channel, Shab-related subfamily, member 2
Synonyms: 9630047L19Rik, Kv2.2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98741
HGNC: HGNC:6232
Homologene: 31263
Rimbp3
Name: RIMS binding protein 3
Synonyms: LOC385766, LOC239731, RIM-BP3
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 239731
Homologene: 77940
Actr3b
Name: ARP3 actin-related protein 3B
Synonyms: ARP11, Arp3b
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 242894
Homologene: 4180
Zfp365
Name: zinc finger protein 365
Synonyms: DBZ, Su48
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216049
Homologene: 8975
Gpr85
Name: G protein-coupled receptor 85
Synonyms: 2900026B03Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 64450
HGNC: HGNC:4536
Homologene: 10355
Syt12
Name: synaptotagmin XII
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 171180
Homologene: 15895
Slc35g3
Name: solute carrier family 35, member G3
Synonyms: Amac1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 56293
Homologene: 89413
Or52ab2
Name: olfactory receptor family 52 subfamily AB member 2
Synonyms: MOR23-2, GA_x6K02T2PBJ9-6029614-6030561, Olfr597
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258135
Homologene: 132401
Cdpf1
Name: cysteine rich, DPF motif domain containing 1
Synonyms: 2210021J22Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 72355
Homologene: 45673
Nthl1
Name: nth (endonuclease III)-like 1 (E.coli)
Synonyms: Nth1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 18207
VEGA: 17
HGNC: HGNC:8028
Homologene: 1897
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 15,312,926 bp
  • A to G, chromosome 1 at 34,257,911 bp
  • G to T, chromosome 1 at 91,419,408 bp
  • T to C, chromosome 2 at 40,922,414 bp
  • A to G, chromosome 2 at 76,897,133 bp
  • A to T, chromosome 2 at 181,649,504 bp
  • T to G, chromosome 2 at 182,000,327 bp
  • T to C, chromosome 3 at 36,570,153 bp
  • T to A, chromosome 3 at 63,345,217 bp
  • T to C, chromosome 3 at 106,763,261 bp
  • A to T, chromosome 4 at 113,717,107 bp
  • A to G, chromosome 4 at 134,091,136 bp
  • T to G, chromosome 4 at 154,067,007 bp
  • A to G, chromosome 5 at 25,849,938 bp
  • T to C, chromosome 5 at 109,052,232 bp
  • T to A, chromosome 6 at 13,835,877 bp
  • C to A, chromosome 7 at 28,320,010 bp
  • C to A, chromosome 7 at 103,321,085 bp
  • A to T, chromosome 8 at 13,033,997 bp
  • A to C, chromosome 8 at 35,478,638 bp
  • G to T, chromosome 8 at 91,034,215 bp
  • A to G, chromosome 8 at 107,457,900 bp
  • G to T, chromosome 8 at 114,679,838 bp
  • A to T, chromosome 9 at 44,316,551 bp
  • A to G, chromosome 9 at 72,319,257 bp
  • C to T, chromosome 9 at 107,691,400 bp
  • C to T, chromosome 9 at 118,769,116 bp
  • T to C, chromosome 10 at 5,072,193 bp
  • A to G, chromosome 10 at 67,909,826 bp
  • T to C, chromosome 10 at 86,870,246 bp
  • C to T, chromosome 10 at 122,449,681 bp
  • A to G, chromosome 11 at 30,103,323 bp
  • A to G, chromosome 11 at 68,822,624 bp
  • T to C, chromosome 11 at 69,761,650 bp
  • C to T, chromosome 11 at 115,930,676 bp
  • A to G, chromosome 11 at 117,815,953 bp
  • G to T, chromosome 12 at 78,877,108 bp
  • A to G, chromosome 12 at 111,544,596 bp
  • T to C, chromosome 13 at 33,325,987 bp
  • A to T, chromosome 13 at 100,078,707 bp
  • A to G, chromosome 13 at 100,426,914 bp
  • A to G, chromosome 15 at 75,809,636 bp
  • G to A, chromosome 15 at 76,209,128 bp
  • A to T, chromosome 15 at 85,808,284 bp
  • G to A, chromosome 16 at 17,211,108 bp
  • A to G, chromosome 17 at 24,265,500 bp
  • T to G, chromosome 17 at 24,638,670 bp
  • T to C, chromosome 17 at 33,065,332 bp
  • A to T, chromosome 17 at 36,031,911 bp
  • T to A, chromosome 19 at 3,815,220 bp
  • T to A, chromosome 19 at 4,451,021 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7043 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045142-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.