Strain Name:
C57BL/6J-MtgxR7183Btlr/Mmmh
Stock Number:
045235-MU
Citation ID:
RRID:MMRRC_045235-MU
Other Names:
R7183 (G1)
Major Collection:

Strain Information

Vps33a
Name: VPS33A CORVET/HOPS core subunit
Synonyms: bf, 3830421M04Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 77573
Homologene: 11294
Gsn
Name: gelsolin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227753
HGNC: HGNC:4620
Homologene: 147
Cd86
Name: CD86 antigen
Synonyms: MB7-2, Ly58, Cd28l2, B70, B7.2, B7-2, Ly-58
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 12524
HGNC: HGNC:1705
Homologene: 10443
Cacna1g
Name: calcium channel, voltage-dependent, T type, alpha 1G subunit
Synonyms: a1G, Cav3.1d
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12291
HGNC: HGNC:1394
Homologene: 22544
P4htm
Name: prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
Synonyms: P4h-tm, 4933406E20Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74443
Homologene: 41765
Col6a1
Name: collagen, type VI, alpha 1
Synonyms: Col6a-1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 12833
HGNC: HGNC:2211
Homologene: 1391
Tlk2
Name: tousled-like kinase 2 (Arabidopsis)
Synonyms: 4933403M19Rik, PKUalpha, protein kinase U-alpha
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 24086
Homologene: 4993
Tpr
Name: translocated promoter region, nuclear basket protein
Synonyms: 2610029M07Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 108989
Homologene: 37753
Smchd1
Name: SMC hinge domain containing 1
Synonyms: MommeD1, 4931400A14Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 74355
Homologene: 23665
Ywhaq
Name: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
Synonyms: 2700028P07Rik, 14-3-3 tau, 14-3-3 theta
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 22630
Homologene: 105677
Actn1
Name: actinin, alpha 1
Synonyms: 3110023F10Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 109711
VEGA: 12
HGNC: HGNC:163
Homologene: 55553
Arhgap32
Name: Rho GTPase activating protein 32
Synonyms: p200RhoGAP, PX-RICS, 3426406O18Rik, Grit, GC-GAP
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 330914
Homologene: 8812
Cdc42bpg
Name: CDC42 binding protein kinase gamma
Synonyms: MRCKgamma
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 240505
Homologene: 28384
Dennd1b
Name: DENN domain containing 1B
Synonyms: F730008N07Rik, 6820401H01Rik, 4930467M19Rik, 4632404N19Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329260
Homologene: 11739
Cir1
Name: corepressor interacting with RBPJ, 1
Synonyms: CIR, 1700023B02Rik, 2810021A19Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66935
Homologene: 3589
Tnc
Name: tenascin C
Synonyms: C130033P17Rik, TN, hexabrachion, Hxb, cytotactin, tenascin-C, TN-C
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 21923
HGNC: HGNC:5318
Homologene: 55636
Arhgap33
Name: Rho GTPase activating protein 33
Synonyms: Tcgap, Snx26, NOMA-GAP
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233071
Homologene: 76448
Pfkl
Name: phosphofructokinase, liver, B-type
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 18641
HGNC: HGNC:8876
Homologene: 55668
Zfp87
Name: zinc finger protein 87
Synonyms: 2210039O17Rik, 4631412O18Rik, Mzf22, KRAB4, Zfp72
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 170763
Crmp1
Name: collapsin response mediator protein 1
Synonyms: DRP-1, Ulip3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12933
HGNC: HGNC:2365
Homologene: 20347
Emc3
Name: ER membrane protein complex subunit 3
Synonyms: 0610039A15Rik, Tmem111
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 66087
Homologene: 100707
Smox
Name: spermine oxidase
Synonyms: B130066H01Rik, SMO
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228608
Homologene: 69268
Rbp3
Name: retinol binding protein 3, interstitial
Synonyms: Rbp-3, Irbp
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 19661
VEGA: 14
HGNC: HGNC:9921
Homologene: 9261
Chst4
Name: carbohydrate sulfotransferase 4
Synonyms: HEC-GlcNAc6ST, high endothelial cell GlcNAC-6-sulphotransferase, GST-3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 26887
HGNC: HGNC:1972
Homologene: 4216
Ercc5
Name: excision repair cross-complementing rodent repair deficiency, complementation group 5
Synonyms: Xpg
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22592
HGNC: HGNC:3437
Homologene: 133551
Kcnd2
Name: potassium voltage-gated channel, Shal-related family, member 2
Synonyms: Kv4.2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16508
HGNC: HGNC:6238
Homologene: 40828
Uggt2
Name: UDP-glucose glycoprotein glucosyltransferase 2
Synonyms: A230065J02Rik, 3110001A05Rik, 1810064L21Rik, 3110027P15Rik, Ugcgl2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 66435
Homologene: 56875
Fat3
Name: FAT atypical cadherin 3
Synonyms: D430038H04Rik, LOC234973, LOC382129, 9430076A06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 270120
VEGA: 9
Homologene: 82252
Ccdc125
Name: coiled-coil domain containing 125
Synonyms: 5830436D01Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 76041
VEGA: 13
Homologene: 27932
Dnah17
Name: dynein, axonemal, heavy chain 17
Synonyms: LOC382552, Dnahcl1, Dnahc17, 2810003K23Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69926
HGNC: HGNC:2946
Homologene: 72102
Or7g20
Name: olfactory receptor family 7 subfamily G member 20
Synonyms: MOR150-3, GA_x6K02T2PVTD-12771995-12772930, Olfr835
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 257872
HGNC: HGNC:8466
Homologene: 133702
Rubcnl
Name: RUN and cysteine rich domain containing beclin 1 interacting protein like
Synonyms: 5031414D18Rik, LOC380917
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 271221
VEGA: 14
Homologene: 57021
Spata31e2
Name: spermatogenesis associated 31 subfamily E member 2
Synonyms: 4931408C20Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 210940
Homologene: 86827
Ccdc39
Name: coiled-coil domain containing 39
Synonyms: b2b1304Clo, b2b2025.1Clo, b2b1735Clo, 4921507O14Rik, prh, D3Ertd789e
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 51938
Homologene: 12149
Cadm2
Name: cell adhesion molecule 2
Synonyms: Igsf4d, 2900078E11Rik, A830029E02Rik, Necl3, SynCAM2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 239857
Homologene: 17705
Ahnak
Name: AHNAK nucleoprotein
Synonyms: DY6, 1110004P15Rik, 2310047C17Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 66395
VEGA: 19
HGNC: HGNC:347
Homologene: 67425
Tas2r123
Name: taste receptor, type 2, member 123
Synonyms: Tas2r23, T2R23, mt2r55, mGR23, STC 9-2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 353167
Homologene: 45450
Thbs2
Name: thrombospondin 2
Synonyms: Thrombospondin-2, Thbs-2, TSP2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 21826
VEGA: 17
Homologene: 2438
Heg1
Name: heart development protein with EGF-like domains 1
Synonyms: 4632417D23Rik, 9530025L16Rik, 5530401I02Rik, LOC268884
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 77446
Homologene: 35276
Phlpp2
Name: PH domain and leucine rich repeat protein phosphatase 2
Synonyms: Phlppl, C130044A18Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244650
Homologene: 71015
Pde6c
Name: phosphodiesterase 6C, cGMP specific, cone, alpha prime
Synonyms: cpfl1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 110855
VEGA: 19
HGNC: HGNC:8787
Homologene: 4521
Pdzd7
Name: PDZ domain containing 7
Synonyms: EG435601, Pdzk7
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 100503041
Homologene: 129509
Cdkl1
Name: cyclin dependent kinase like 1
Synonyms: 4933411O17Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 71091
VEGA: 12
HGNC: HGNC:1781
Homologene: 55805
Or5m12
Name: olfactory receptor family 5 subfamily M member 12
Synonyms: MOR197-1, Olfr1024, GA_x6K02T2Q125-47384320-47383337
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 257900
Homologene: 128271
Fn3krp
Name: fructosamine 3 kinase related protein
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 238024
Homologene: 11093
Rgl2
Name: ral guanine nucleotide dissociation stimulator-like 2
Synonyms: Rlf, KE1.5, Rgt2, Rab2l
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 19732
HGNC: HGNC:9769
Homologene: 3494
Vmn2r101
Name: vomeronasal 2, receptor 101
Synonyms: EG627576
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627576
Homologene: 115024
Apba2
Name: amyloid beta precursor protein binding family A member 2
Synonyms: X11-like, Mint 2, X11L
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 11784
HGNC: HGNC:579
Homologene: 4021
Masp2
Name: MBL associated serine protease 2
Synonyms: MASP-2, MAp19
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 17175
HGNC: HGNC:6902
Homologene: 4819
Haus6
Name: HAUS augmin-like complex, subunit 6
Synonyms: D4Ertd27e, 6230416J20Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230376
Homologene: 9760
Pik3c2b
Name: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta
Synonyms: PI3K-C2beta, C330011J12Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240752
HGNC: HGNC:8972
Homologene: 20582
Gmnc
Name: geminin coiled-coil domain containing
Synonyms: LOC385639, LOC239789, Gm606
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 239789
VEGA: 16
Homologene: 79940
Timm44
Name: translocase of inner mitochondrial membrane 44
Synonyms: 0710005E20Rik, Tim44, Mimt44, D8Ertd118e
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 21856
Homologene: 4631
Siae
Name: sialic acid acetylesterase
Synonyms: clone 165, Ysg2, LSE
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 22619
Homologene: 8001
Or5b102
Name: olfactory receptor family 5 subfamily B member 102
Synonyms: MOR202-14, Olfr1454, GA_x6K02T2RE5P-3390804-3391727
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258687
HGNC: HGNC:8324
Homologene: 120159
Cyp2j8
Name: cytochrome P450, family 2, subfamily j, polypeptide 8
Synonyms: OTTMUSG00000007938, Cyp2j8-ps
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 665095
HGNC: HGNC:2634
Homologene: 133819
Hoxd9
Name: homeobox D9
Synonyms: Hox-4.4, Hox-5.2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 15438
HGNC: HGNC:5140
Homologene: 8409
Mab21l3
Name: mab-21-like 3
Synonyms: BC037703
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242125
Homologene: 17564
Ehd1
Name: EH-domain containing 1
Synonyms: RME-1, Past1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 13660
HGNC: HGNC:3242
Homologene: 81678
Prg3
Name: proteoglycan 3
Synonyms: major basic protein 2, MBP2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 53856
HGNC: HGNC:9363
Homologene: 4441
Eif1ad14
Name: eukaryotic translation initiation factor 1A domain containing 14
Synonyms: Gm2035
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 100039076
VEGA: 12
Igkv10-96
Name: immunoglobulin kappa variable 10-96
Synonyms: Gm16637
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 692165
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 26,682,833 bp
  • A to T, chromosome 1 at 44,161,808 bp
  • G to T, chromosome 1 at 44,161,809 bp
  • T to C, chromosome 1 at 133,066,465 bp
  • A to T, chromosome 1 at 139,170,252 bp
  • A to T, chromosome 1 at 150,406,551 bp
  • C to T, chromosome 2 at 35,294,948 bp
  • A to G, chromosome 2 at 73,286,386 bp
  • G to T, chromosome 2 at 74,698,365 bp
  • G to A, chromosome 2 at 84,991,504 bp
  • G to T, chromosome 2 at 84,993,023 bp
  • T to A, chromosome 2 at 85,904,142 bp
  • T to C, chromosome 2 at 131,520,566 bp
  • T to G, chromosome 3 at 33,814,471 bp
  • C to T, chromosome 3 at 101,815,153 bp
  • A to G, chromosome 4 at 64,013,128 bp
  • A to T, chromosome 4 at 86,583,752 bp
  • A to T, chromosome 4 at 96,479,181 bp
  • A to G, chromosome 4 at 148,612,157 bp
  • C to A, chromosome 5 at 37,288,817 bp
  • T to C, chromosome 5 at 123,535,215 bp
  • G to A, chromosome 6 at 21,216,437 bp
  • A to C, chromosome 6 at 68,632,216 bp
  • G to T, chromosome 6 at 113,531,384 bp
  • A to G, chromosome 6 at 132,847,698 bp
  • T to A, chromosome 7 at 30,525,871 bp
  • G to A, chromosome 7 at 64,733,545 bp
  • T to C, chromosome 8 at 4,267,311 bp
  • C to A, chromosome 8 at 109,939,953 bp
  • T to C, chromosome 8 at 110,029,998 bp
  • A to C, chromosome 9 at 15,922,837 bp
  • G to T, chromosome 9 at 19,035,332 bp
  • A to G, chromosome 9 at 32,186,383 bp
  • G to A, chromosome 9 at 37,616,946 bp
  • A to T, chromosome 9 at 108,581,860 bp
  • A to G, chromosome 10 at 76,716,259 bp
  • G to A, chromosome 10 at 78,002,082 bp
  • C to T, chromosome 11 at 94,439,737 bp
  • T to C, chromosome 11 at 105,221,359 bp
  • G to A, chromosome 11 at 118,129,188 bp
  • T to C, chromosome 11 at 121,421,605 bp
  • T to C, chromosome 12 at 21,416,869 bp
  • T to C, chromosome 12 at 69,748,932 bp
  • T to A, chromosome 12 at 80,168,932 bp
  • G to A, chromosome 12 at 87,919,722 bp
  • A to G, chromosome 13 at 67,517,474 bp
  • A to G, chromosome 13 at 100,690,358 bp
  • A to G, chromosome 14 at 33,955,204 bp
  • T to A, chromosome 14 at 75,049,626 bp
  • A to T, chromosome 14 at 119,019,637 bp
  • A to G, chromosome 15 at 76,205,705 bp
  • C to T, chromosome 16 at 26,960,529 bp
  • A to G, chromosome 16 at 33,738,550 bp
  • CA to CAA, chromosome 16 at 36,606,555 bp
  • C to A, chromosome 16 at 66,882,832 bp
  • T to A, chromosome 17 at 14,690,116 bp
  • T to A, chromosome 17 at 19,612,178 bp
  • T to C, chromosome 17 at 33,934,990 bp
  • A to T, chromosome 17 at 71,353,516 bp
  • A to G, chromosome 19 at 6,297,654 bp
  • A to G, chromosome 19 at 6,310,797 bp
  • T to C, chromosome 19 at 9,017,668 bp
  • A to G, chromosome 19 at 13,064,316 bp
  • T to C, chromosome 19 at 38,133,090 bp
  • A to G, chromosome 19 at 45,037,114 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7183 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045235-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.