Strain Name:
C57BL/6J-MtgxR7198Btlr/Mmmh
Stock Number:
045337-MU
Citation ID:
RRID:MMRRC_045337-MU
Other Names:
R7198 (G1)
Major Collection:

Strain Information

Wrn
Name: Werner syndrome RecQ like helicase
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 22427
Homologene: 6659
Uba3
Name: ubiquitin-like modifier activating enzyme 3
Synonyms: ubiquitin activating enzyme 3, Ube1c, A830034N06Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 22200
Homologene: 2951
Usp32
Name: ubiquitin specific peptidase 32
Synonyms: 2900074J03Rik, 6430526O11Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237898
Homologene: 13066
Cct2
Name: chaperonin containing TCP1 subunit 2
Synonyms: Cctb
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 12461
VEGA: 10
HGNC: HGNC:1615
Homologene: 4696
Tnip1
Name: TNFAIP3 interacting protein 1
Synonyms: ABIN1, VAN, Nef, A20-binding inhibitor of NF-kappa B activation
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 57783
Homologene: 31355
Fer
Name: FER tyrosine kinase
Synonyms: Fert2, Fert, C330004K01Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 14158
VEGA: 17
HGNC: HGNC:3655
Homologene: 74300
Scaf8
Name: SR-related CTD-associated factor 8
Synonyms: A930036P18Rik, A630086M08Rik, Rbm16
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106583
VEGA: 17
Homologene: 8928
Smc5
Name: structural maintenance of chromosomes 5
Synonyms: Smc5l1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226026
VEGA: 19
Homologene: 41009
Scaf4
Name: SR-related CTD-associated factor 4
Synonyms: Sfrs15, Srsf15, Sra4
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224432
VEGA: 16
Homologene: 16227
Ipmk
Name: inositol polyphosphate multikinase
Synonyms: 2410017C19Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 69718
Homologene: 76214
Cpxm2
Name: carboxypeptidase X, M14 family member 2
Synonyms: 4632435C11Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 55987
Homologene: 69259
Bcl9
Name: B cell CLL/lymphoma 9
Synonyms: 2610202E01Rik, 8030475K17Rik, A330041G23Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 77578
HGNC: HGNC:1008
Homologene: 3191
Baz2b
Name: bromodomain adjacent to zinc finger domain, 2B
Synonyms: 5830435C13Rik, D2Ertd794e
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 407823
HGNC: HGNC:963
Homologene: 8394
Samd12
Name: sterile alpha motif domain containing 12
Synonyms: A830094I09Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 320679
Homologene: 35979
Gm14325
Name: predicted gene 14325
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 329575
Homologene: 134324
Baiap3
Name: BAI1-associated protein 3
Synonyms: LOC381076
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 545192
HGNC: HGNC:948
Homologene: 20844
Nphp3
Name: nephronophthisis 3 (adolescent)
Synonyms: nephrocystin 3, D330020E01Rik, pcy, 3632410F03Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74025
HGNC: HGNC:7907
Homologene: 32697
Cdh23
Name: cadherin related 23 (otocadherin)
Synonyms: nmf112, 4930542A03Rik, USH1D, sals, ahl, bob, mdfw, nmf252, nmf181
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 22295
Homologene: 11142
Mthfd2l
Name: methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like
Synonyms: 1110019K23Rik, C630010D07Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 665563
Homologene: 28295
Bbs1
Name: Bardet-Biedl syndrome 1
Synonyms: D19Ertd609e
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 52028
VEGA: 19
HGNC: HGNC:966
Homologene: 11641
Nek10
Name: NIMA (never in mitosis gene a)- related kinase 10
Synonyms: LOC238944
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 674895
Homologene: 130947
Col12a1
Name: collagen, type XII, alpha 1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12816
HGNC: HGNC:2188
Homologene: 3217
Liph
Name: lipase, member H
Synonyms: PLA1B, mPA-PLA1, D16Wsu119e, C130037N08Rik, LPDLR, Lpdlr
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 239759
VEGA: 16
Homologene: 71802
Hivep2
Name: human immunodeficiency virus type I enhancer binding protein 2
Synonyms: Schnurri-2, MIBP1, Gm20114, Shn-2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 15273
HGNC: HGNC:4921
Homologene: 4900
Ltbp1
Name: latent transforming growth factor beta binding protein 1
Synonyms: 9430031G15Rik, LTBP-1, b2b1000Clo, Ltbp1L
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 268977
HGNC: HGNC:6714
Homologene: 522
Plekhg4
Name: pleckstrin homology domain containing, family G (with RhoGef domain) member 4
Synonyms: 4931414L13Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 102075
Homologene: 18516
Gm11639
Name: predicted gene 11639
Synonyms: Gm11639, Efcab15
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 105242472
Xylt1
Name: xylosyltransferase 1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233781
Homologene: 32534
Dclk1
Name: doublecortin-like kinase 1
Synonyms: Click-I, 1700113D08Rik, Dcl, DCLK, CPG16, Dcamkl1, 2810480F11Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 13175
HGNC: HGNC:2700
Homologene: 130530
Chl1
Name: cell adhesion molecule L1-like
Synonyms: A530023M13Rik, close homolog of L1, LICAM2, CALL
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12661
HGNC: HGNC:1939
Homologene: 21314
Abca8a
Name: ATP-binding cassette, sub-family A member 8a
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217258
HGNC: HGNC:38
Homologene: 131160
Dnai4
Name: dynein axonemal intermediate chain 4
Synonyms: Wdr78
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242584
Homologene: 11702
Hsdl1
Name: hydroxysteroid dehydrogenase like 1
Synonyms: 2700067E09Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 72552
Homologene: 100660
Spag17
Name: sperm associated antigen 17
Synonyms: PF6, 4931427F14Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 74362
Homologene: 52601
Dpy19l3
Name: dpy-19 like C-mannosyltransferase 3
Synonyms: 9330164H19Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233115
Homologene: 18692
Tmprss11c
Name: transmembrane protease, serine 11c
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 435845
Homologene: 78847
Slc27a1
Name: solute carrier family 27 (fatty acid transporter), member 1
Synonyms: FATP1, Fatp
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 26457
Homologene: 8063
Or5h19
Name: olfactory receptor family 5 subfamily H member 19
Synonyms: Olfr187, GA_x54KRFPKG5P-55265713-55264787, MOR183-8
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 258319
Homologene: 133069
Kdm4d
Name: lysine (K)-specific demethylase 4D
Synonyms: Jmjd2d
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244694
Homologene: 69244
Wnt11
Name: wingless-type MMTV integration site family, member 11
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22411
Homologene: 20970
Cyp3a41b
Name: cytochrome P450, family 3, subfamily a, polypeptide 41B
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100041375
HGNC: HGNC:2638
Homologene: 133568
Pou6f2
Name: POU domain, class 6, transcription factor 2
Synonyms: D130006K24Rik, RPF-1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218030
Or6c33
Name: olfactory receptor family 6 subfamily C member 33
Synonyms: MOR116-1, GA_x6K02T2PULF-11688441-11689379, Olfr820
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258670
Homologene: 17337
Tdpoz4
Name: TD and POZ domain containing 4
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 399675
Homologene: 130121
Psg27
Name: pregnancy-specific beta-1-glycoprotein 27
Synonyms: cea15, EG545925
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 545925
Homologene: 110989
Kcnd3
Name: potassium voltage-gated channel, Shal-related family, member 3
Synonyms: potassium channel Kv4.3M, Kv4.3, potassium channel Kv4.3L
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 56543
HGNC: HGNC:6239
Homologene: 21036
Tssc4
Name: tumor-suppressing subchromosomal transferable fragment 4
Synonyms: ESTM671070
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 56844
Homologene: 4169
Oscp1
Name: organic solute carrier partner 1
Synonyms: 1810007P19Rik, 6030436A01Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230751
Homologene: 71010
Zfp677
Name: zinc finger protein 677
Synonyms: A830058L05Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 210503
Homologene: 138402
Lats2
Name: large tumor suppressor 2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 50523
HGNC: HGNC:6515
Homologene: 56678
Pigq
Name: phosphatidylinositol glycan anchor biosynthesis, class Q
Synonyms: Gpi1h, Gpi1, Gpi1p, Gpih
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 14755
Homologene: 31228
Meltf
Name: melanotransferrin
Synonyms: MTf, melanotransferrin, CD228, Mfi2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 30060
VEGA: 16
HGNC: HGNC:7037
Homologene: 4335
Snx31
Name: sorting nexin 31
Synonyms: 4631426E05Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 66696
Homologene: 23551
Chit1
Name: chitinase 1
Synonyms: 2300002L19Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 71884
HGNC: HGNC:1936
Homologene: 68318
Msgn1
Name: mesogenin 1
Synonyms: Msgn
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 56184
VEGA: 12
Homologene: 10466
Or4a47
Name: olfactory receptor family 4 subfamily A member 47
Synonyms: MOR231-1, Olfr1256, GA_x6K02T2Q125-51276848-51275928
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258985
Homologene: 128157
Ly6d
Name: lymphocyte antigen 6 family member D
Synonyms: Ly61, Ly-61, Thb
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 17068
Homologene: 2742
Mup18
Name: major urinary protein 18
Synonyms: Gm12561
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100048884
Homologene: 74304
Pcdha4
Name: protocadherin alpha 4
Synonyms: Crnr1, Cnr1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 12936
HGNC: HGNC:8670
Homologene: 130626
Zscan4-ps1
Name: zinc finger and SCAN domain containing 4, pseudogene 1
Synonyms: EG545912
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 545912
Gm47995
Name: predicted gene, 47995
Type: Gene
Species: Mouse
Chromosome: 1
Gm6176
Name: predicted gene 6176
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 620736
Homologene: 128656
Gm11042
Name: predicted gene 11042
Type: Gene
Species: Mouse
Chromosome: 12
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 134,150,491 bp
  • A to G, chromosome 1 at 151,198,653 bp
  • A to G, chromosome 2 at 59,962,206 bp
  • T to C, chromosome 2 at 89,835,732 bp
  • A to G, chromosome 2 at 177,832,005 bp
  • A to C, chromosome 3 at 55,477,875 bp
  • T to G, chromosome 3 at 93,797,355 bp
  • T to A, chromosome 3 at 97,205,195 bp
  • T to C, chromosome 3 at 97,208,867 bp
  • T to C, chromosome 3 at 100,095,572 bp
  • T to C, chromosome 3 at 105,459,540 bp
  • G to C, chromosome 4 at 61,673,336 bp
  • A to G, chromosome 4 at 103,062,413 bp
  • A to G, chromosome 4 at 126,086,666 bp
  • A to T, chromosome 5 at 86,231,832 bp
  • T to A, chromosome 5 at 90,946,846 bp
  • A to G, chromosome 5 at 145,582,520 bp
  • A to T, chromosome 6 at 97,205,551 bp
  • A to G, chromosome 6 at 103,706,556 bp
  • T to A, chromosome 7 at 11,065,699 bp
  • T to A, chromosome 7 at 18,561,801 bp
  • T to A, chromosome 7 at 22,051,171 bp
  • T to C, chromosome 7 at 35,749,765 bp
  • T to C, chromosome 7 at 98,847,381 bp
  • T to A, chromosome 7 at 117,656,584 bp
  • T to A, chromosome 7 at 132,080,084 bp
  • T to A, chromosome 7 at 143,070,987 bp
  • C to T, chromosome 8 at 33,324,318 bp
  • T to C, chromosome 8 at 71,579,427 bp
  • A to G, chromosome 8 at 105,378,697 bp
  • C to T, chromosome 8 at 119,567,868 bp
  • T to C, chromosome 9 at 14,464,020 bp
  • A to C, chromosome 9 at 79,650,032 bp
  • A to G, chromosome 9 at 104,004,775 bp
  • T to A, chromosome 10 at 14,129,966 bp
  • T to C, chromosome 10 at 60,312,599 bp
  • A to G, chromosome 10 at 71,348,052 bp
  • A to G, chromosome 10 at 117,053,124 bp
  • T to A, chromosome 10 at 130,017,891 bp
  • G to A, chromosome 11 at 54,917,804 bp
  • GAACAAGTCCACAACAA to GAACAA, chromosome 11 at 85,022,855 bp
  • T to A, chromosome 11 at 104,751,885 bp
  • C to T, chromosome 11 at 110,078,655 bp
  • G to T, chromosome 12 at 11,208,901 bp
  • T to A, chromosome 12 at 74,315,114 bp
  • G to A, chromosome 13 at 18,129,163 bp
  • T to A, chromosome 14 at 14,850,947 bp
  • A to T, chromosome 14 at 57,697,125 bp
  • A to G, chromosome 15 at 36,555,310 bp
  • T to A, chromosome 15 at 53,860,253 bp
  • A to T, chromosome 15 at 74,762,535 bp
  • T to C, chromosome 16 at 21,966,022 bp
  • A to G, chromosome 16 at 31,883,799 bp
  • C to T, chromosome 16 at 59,036,093 bp
  • A to T, chromosome 16 at 90,252,430 bp
  • T to A, chromosome 17 at 3,163,098 bp
  • T to G, chromosome 17 at 21,398,417 bp
  • G to A, chromosome 17 at 25,243,840 bp
  • C to T, chromosome 17 at 25,934,225 bp
  • T to A, chromosome 17 at 63,921,688 bp
  • T to C, chromosome 17 at 75,226,967 bp
  • T to A, chromosome 18 at 36,953,560 bp
  • A to T, chromosome 19 at 4,895,015 bp
  • G to A, chromosome 19 at 23,259,700 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7198 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045337-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.