Strain Name:
C57BL/6J-MtgxR7262Btlr/Mmmh
Stock Number:
045353-MU
Citation ID:
RRID:MMRRC_045353-MU
Other Names:
R7262 (G1)
Major Collection:

Strain Information

Itpk1
Name: inositol 1,3,4-triphosphate 5/6 kinase
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217837
HGNC: HGNC:6177
Homologene: 8588
Vcan
Name: versican
Synonyms: hdf, DPEAAE, heart defect, 5430420N07Rik, PG-M, Cspg2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 13003
HGNC: HGNC:2464
Homologene: 3228
Pcdh9
Name: protocadherin 9
Synonyms: 1500001L12Rik, C630029H24Rik, A730003J17Rik, LOC382930, C530050I23Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 211712
HGNC: HGNC:8661
Homologene: 10698
Serpinc1
Name: serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1
Synonyms: At3, At-3, ATIII, antithrombin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 11905
HGNC: HGNC:775
Homologene: 20139
Acap2
Name: ArfGAP with coiled-coil, ankyrin repeat and PH domains 2
Synonyms: 9530039J15Rik, Centb2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 78618
VEGA: 16
Homologene: 8182
Dab2ip
Name: disabled 2 interacting protein
Synonyms: AIP1, 2310011D08Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 69601
Homologene: 13058
Kntc1
Name: kinetochore associated 1
Synonyms: jgl
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 208628
Homologene: 32227
Ddx55
Name: DEAD box helicase 55
Synonyms: DEAD (Asp-Glu-Ala-Asp) box polypeptide 55, 2810021H22Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 67848
Homologene: 12196
Cttnbp2nl
Name: CTTNBP2 N-terminal like
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 80281
Homologene: 36371
Carnmt1
Name: carnosine N-methyltransferase 1
Synonyms: 2410127L17Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 67383
VEGA: 19
Homologene: 6806
Senp1
Name: SUMO1/sentrin specific peptidase 1
Synonyms: E330036L07Rik, D15Ertd528e, 2310046A20Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223870
Homologene: 8731
Epm2aip1
Name: EPM2A interacting protein 1
Synonyms: A930003G21Rik, EPM2A (laforin) interacting protein 1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 77781
Homologene: 8875
Cdcp1
Name: CUB domain containing protein 1
Synonyms: 9030022E12Rik, E030027H19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 109332
Homologene: 11276
Adh5
Name: alcohol dehydrogenase 5 (class III), chi polypeptide
Synonyms: Adh3, S-nitrosoglutathione reductase, Adh-5, GSNOR
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 11532
HGNC: HGNC:253
Homologene: 68076
Ubr2
Name: ubiquitin protein ligase E3 component n-recognin 2
Synonyms: ENSMUSG00000043296, 9930021A08Rik, E130209G04Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224826
VEGA: 17
Homologene: 26151
Pak4
Name: p21 (RAC1) activated kinase 4
Synonyms: 5730488L07Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 70584
Homologene: 4300
Gmfb
Name: glia maturation factor, beta
Synonyms: 3110001O16Rik, D14Ertd630e, 3110001H22Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 63985
HGNC: HGNC:4373
Homologene: 37882
Klhl6
Name: kelch-like 6
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 239743
Homologene: 15603
Ppp1r3a
Name: protein phosphatase 1, regulatory subunit 3A
Synonyms: GM, RGL
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 140491
HGNC: HGNC:9291
Homologene: 48124
Lama4
Name: laminin, alpha 4
Synonyms: laminin [a]4
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16775
HGNC: HGNC:6484
Homologene: 37604
Ltbp1
Name: latent transforming growth factor beta binding protein 1
Synonyms: 9430031G15Rik, LTBP-1, b2b1000Clo, Ltbp1L
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 268977
HGNC: HGNC:6714
Homologene: 522
Gm11639
Name: predicted gene 11639
Synonyms: Gm11639, Efcab15
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 105242472
Or4f6
Name: olfactory receptor family 4 subfamily F member 6
Synonyms: Olfr1310, GA_x6K02T2Q125-73056609-73055671, MOR245-3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258441
Homologene: 74053
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: OTTMUSG00000005786, LOC380698
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380698
Homologene: 70869
Phf8l
Name: PHD finger protein 8 like
Synonyms: 4921501E09Rik, Phf8-ps
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 74042
VEGA: 17
Homologene: 66275
Vmn2r80
Name: vomeronasal 2, receptor 80
Synonyms: EG624765
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 624765
Homologene: 83483
Pam
Name: peptidylglycine alpha-amidating monooxygenase
Synonyms: PHM
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18484
HGNC: HGNC:8596
Homologene: 37369
Lamp1
Name: lysosomal-associated membrane protein 1
Synonyms: Perk, CD107a, Lamp-1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 16783
HGNC: HGNC:6499
Homologene: 4061
Tcaf3
Name: TRPM8 channel-associated factor 3
Synonyms: Eapa2, Fam115e
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 403088
Homologene: 74374
Tbc1d16
Name: TBC1 domain family, member 16
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 207592
Homologene: 10380
Or10q1
Name: olfactory receptor family 10 subfamily Q member 1
Synonyms: Olfr1494, GA_x6K02T2RE5P-4082427-4083374, MOR266-1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258992
Homologene: 64855
Kif26b
Name: kinesin family member 26B
Synonyms: N-11 kinesin, D230039L06Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 269152
Homologene: 18623
Ccdc42
Name: coiled-coil domain containing 42
Synonyms: A530001H01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 276920
Homologene: 44902
Wdhd1
Name: WD repeat and HMG-box DNA binding protein 1
Synonyms: AND-1, D630024B06Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 218973
Homologene: 56019
Ap1m2
Name: adaptor protein complex AP-1, mu 2 subunit
Synonyms: [m]1B, D9Ertd818e, mu1B
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 11768
VEGA: 9
HGNC: HGNC:558
Homologene: 55906
Hdac3
Name: histone deacetylase 3
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 15183
HGNC: HGNC:4854
Homologene: 48250
Or52ad1
Name: olfactory receptor family 52 subfamily AD member 1
Synonyms: GA_x6K02T2PBJ9-6056235-6055291, Olfr600, MOR39-1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259048
Homologene: 17476
Cpvl
Name: carboxypeptidase, vitellogenic-like
Synonyms: 4933436L16Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 71287
Homologene: 80235
Dhx34
Name: DExH-box helicase 34
Synonyms: 1810012L18Rik, Ddx34, 1200013B07Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71723
Homologene: 69171
Ehbp1l1
Name: EH domain binding protein 1-like 1
Synonyms: G430002G23Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 114601
VEGA: 19
Homologene: 136059
Flot2
Name: flotillin 2
Synonyms: reggie-2, Esa
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14252
HGNC: HGNC:3758
Homologene: 3293
Tmem232
Name: transmembrane protein 232
Synonyms: LOC381107, E130009J12Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 381107
VEGA: 17
Homologene: 54378
Cyp2u1
Name: cytochrome P450, family 2, subfamily u, polypeptide 1
Synonyms: 8430436A10Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 71519
Homologene: 77704
Lrp8
Name: low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
Synonyms: Lr8b, 4932703M08Rik, apoER2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 16975
HGNC: HGNC:6700
Homologene: 31250
Cyp2c69
Name: cytochrome P450, family 2, subfamily c, polypeptide 69
Synonyms: AI098658
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 100043108
VEGA: 19
Homologene: 74936
Srl
Name: sarcalumenin
Synonyms: 9830004M20Rik, sar, sarcalumenin
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 106393
Homologene: 45500
Cep112
Name: centrosomal protein 112
Synonyms: 1700001M19Rik, 1700029K01Rik, Ccdc46, 8430407H02Rik, Macoco
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 76380
Homologene: 44915
H2-M3
Name: histocompatibility 2, M region locus 3
Synonyms: Hmt, H-2M3, R4B2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 14991
HGNC: HGNC:4964
Homologene: 133255
Tbc1d24
Name: TBC1 domain family, member 24
Synonyms: C530046L02Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224617
Homologene: 27469
Havcr2
Name: hepatitis A virus cellular receptor 2
Synonyms: Timd3, TIM-3, Tim3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 171285
Homologene: 129541
Fn3k
Name: fructosamine 3 kinase
Synonyms: 2310074G21Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 63828
Homologene: 23336
B230104I21Rik
Name: RIKEN cDNA B230104I21 gene
Type: Gene
Species: Mouse
Chromosome: 4
Jmjd7
Name: jumonji domain containing 7
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 433466
Homologene: 98398
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 97,854,723 bp
  • A to G, chromosome 1 at 160,989,659 bp
  • T to C, chromosome 1 at 178,917,654 bp
  • A to G, chromosome 2 at 35,622,286 bp
  • A to G, chromosome 2 at 112,008,557 bp
  • A to G, chromosome 2 at 120,031,986 bp
  • A to T, chromosome 3 at 105,032,746 bp
  • T to C, chromosome 3 at 131,297,956 bp
  • C to A, chromosome 3 at 138,445,372 bp
  • A to G, chromosome 4 at 107,847,464 bp
  • T to C, chromosome 4 at 154,349,634 bp
  • C to A, chromosome 5 at 123,786,973 bp
  • T to C, chromosome 5 at 124,566,856 bp
  • T to C, chromosome 6 at 14,719,070 bp
  • A to G, chromosome 6 at 42,593,801 bp
  • A to T, chromosome 6 at 53,932,515 bp
  • G to A, chromosome 7 at 16,203,698 bp
  • C to A, chromosome 7 at 28,565,200 bp
  • T to C, chromosome 7 at 103,346,557 bp
  • A to T, chromosome 8 at 13,167,296 bp
  • A to G, chromosome 9 at 21,302,466 bp
  • A to G, chromosome 9 at 111,272,660 bp
  • T to C, chromosome 9 at 123,173,615 bp
  • T to A, chromosome 10 at 39,094,934 bp
  • T to A, chromosome 10 at 79,169,745 bp
  • C to T, chromosome 11 at 46,469,561 bp
  • A to G, chromosome 11 at 59,115,889 bp
  • A to G, chromosome 11 at 68,594,573 bp
  • T to C, chromosome 11 at 78,057,349 bp
  • G to A, chromosome 11 at 104,854,606 bp
  • T to A, chromosome 11 at 108,664,641 bp
  • C to A, chromosome 11 at 119,155,095 bp
  • T to C, chromosome 11 at 121,448,915 bp
  • T to C, chromosome 12 at 102,675,453 bp
  • T to G, chromosome 13 at 89,705,161 bp
  • A to T, chromosome 14 at 46,814,929 bp
  • A to T, chromosome 14 at 47,251,973 bp
  • A to T, chromosome 14 at 93,015,705 bp
  • A to T, chromosome 15 at 98,066,498 bp
  • C to A, chromosome 16 at 4,497,551 bp
  • T to C, chromosome 16 at 19,982,796 bp
  • A to G, chromosome 16 at 31,127,319 bp
  • A to G, chromosome 17 at 24,207,846 bp
  • G to A, chromosome 17 at 33,066,997 bp
  • T to C, chromosome 17 at 37,271,193 bp
  • T to C, chromosome 17 at 47,000,739 bp
  • A to T, chromosome 17 at 65,500,117 bp
  • G to T, chromosome 17 at 75,364,368 bp
  • C to T, chromosome 18 at 37,945,563 bp
  • A to T, chromosome 19 at 5,718,446 bp
  • A to T, chromosome 19 at 13,749,171 bp
  • A to T, chromosome 19 at 18,677,864 bp
  • T to C, chromosome 19 at 39,886,732 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7262 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045353-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.