Strain Name:
C57BL/6J-MtgxR7275Btlr/Mmmh
Stock Number:
045358-MU
Citation ID:
RRID:MMRRC_045358-MU
Other Names:
R7275 (G1)
Major Collection:

Strain Information

Tyrp1
Name: tyrosinase-related protein 1
Synonyms: TRP1, TRP-1, Oca3, isa, Tyrp
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 22178
Homologene: 464
Mbtps1
Name: membrane-bound transcription factor peptidase, site 1
Synonyms: subtilisin/kexin isozyme-1, S1P, site-1 protease, SKI-1, 0610038M03Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 56453
Homologene: 2808
Lrp2
Name: low density lipoprotein receptor-related protein 2
Synonyms: b2b1625.2Clo, D230004K18Rik, Megalin, Gp330
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14725
HGNC: HGNC:6694
Homologene: 20952
Abtb3
Name: ankyrin repeat and BTB domain containing 3
Synonyms: Btbd11, 6330404E16Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 74007
Homologene: 72536
Cyp11b2
Name: cytochrome P450, family 11, subfamily b, polypeptide 2
Synonyms: Cyp11b-2, Cyp11b, aldosterone synthase, steroid-11-beta-hydroxylase
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 13072
Homologene: 128035
Kdm4b
Name: lysine (K)-specific demethylase 4B
Synonyms: 4732474L06Rik, Jmjd2b
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 193796
Homologene: 27773
Drosha
Name: drosha, ribonuclease type III
Synonyms: Etohi2, Rnasen, 1110013A17Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 14000
Homologene: 8293
Sulf1
Name: sulfatase 1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240725
Homologene: 49408
Cast
Name: calpastatin
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 12380
VEGA: 13
HGNC: HGNC:1515
Homologene: 7658
Dis3
Name: DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease
Synonyms: 2810028N01Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 72662
VEGA: 14
Homologene: 6910
Pirb
Name: paired Ig-like receptor B
Synonyms: Gp91, Lilrb3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18733
Homologene: 134028
Opn3
Name: opsin 3
Synonyms: Ecpn, ERO, encephalopsin, panopsin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13603
Homologene: 40707
Map3k14
Name: mitogen-activated protein kinase kinase kinase 14
Synonyms: Nik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 53859
HGNC: HGNC:6853
Homologene: 2940
Cdcp1
Name: CUB domain containing protein 1
Synonyms: 9030022E12Rik, E030027H19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 109332
Homologene: 11276
Tbc1d19
Name: TBC1 domain family, member 19
Synonyms: 2810453K03Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 67249
Homologene: 10130
Bpnt2
Name: 3'(2'), 5'-bisphosphate nucleotidase 2
Synonyms: Jaws, gPAPP, 1110001C20Rik, Impad1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242291
Homologene: 9852
Ube3d
Name: ubiquitin protein ligase E3D
Synonyms: 2610018I03Rik, Ube2cbp
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 70348
Homologene: 18898
Zp2
Name: zona pellucida glycoprotein 2
Synonyms: Zp-2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22787
Homologene: 48194
Ctnnd2
Name: catenin delta 2
Synonyms: Nprap, catenin (cadherin associated protein), delta 2, Catnd2, neurojugin
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 18163
VEGA: 15
HGNC: HGNC:2516
Homologene: 55574
Rapgef4
Name: Rap guanine nucleotide exchange factor (GEF) 4
Synonyms: 5730402K07Rik, 1300003D15Rik, cAMP-GEFII, 6330581N18Rik, Epac2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 56508
Homologene: 4451
Mttp
Name: microsomal triglyceride transfer protein
Synonyms: MTP, 1810043K16Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 17777
HGNC: HGNC:7467
Homologene: 212
Trpm3
Name: transient receptor potential cation channel, subfamily M, member 3
Synonyms: MLSN2, melastatin 2, 6330504P12Rik, LTRPC3, B930001P07Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226025
VEGA: 19
Homologene: 62287
Ceacam18
Name: CEA cell adhesion molecule 18
Synonyms: 2010110O04Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 72431
Homologene: 48111
Trappc14
Name: trafficking protein particle complex 14
Synonyms: BC037034, Map11
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231807
Homologene: 10106
Tubgcp6
Name: tubulin, gamma complex component 6
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 328580
Homologene: 32477
Il11ra1
Name: interleukin 11 receptor subunit alpha 1
Synonyms: Il-11ra, NR1, Il11ra, Il-11ra-alpha
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 16157
HGNC: HGNC:5967
Homologene: 88705
Neb
Name: nebulin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17996
HGNC: HGNC:7720
Homologene: 136285
Exoc7
Name: exocyst complex component 7
Synonyms: 70kDa, sec70, Exo70
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 53413
Homologene: 41019
Bche
Name: butyrylcholinesterase
Synonyms: C730038G20Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12038
HGNC: HGNC:983
Homologene: 20065
Ripk4
Name: receptor-interacting serine-threonine kinase 4
Synonyms: Ankrd3, PKK, RIP4, DIk, ANKK2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 72388
HGNC: HGNC:496
Homologene: 10772
Or1j12
Name: olfactory receptor family 1 subfamily J member 12
Synonyms: Olfr340, MOR136-1, GA_x6K02T2NLDC-33147742-33148680
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258953
Homologene: 74159
Obox6
Name: oocyte specific homeobox 6
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 252830
Dnai2
Name: dynein axonemal intermediate chain 2
Synonyms: C030015H18Rik, b2b3405Clo, Dnaic2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 432611
Homologene: 11311
Grik1
Name: glutamate receptor, ionotropic, kainate 1
Synonyms: GluK5, D16Ium24, Glurbeta1, Glur-5, D16Ium24e, A830007B11Rik, Glur5
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 14805
HGNC: HGNC:4579
Homologene: 68992
Ciao3
Name: cytosolic iron-sulfur assembly component 3
Synonyms: 9030612I22Rik, Narfl
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 67563
Homologene: 6750
Greb1l
Name: growth regulation by estrogen in breast cancer-like
Synonyms: mKIAA4095, AK220484
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 381157
Homologene: 73393
Slc6a19
Name: solute carrier family 6 (neurotransmitter transporter), member 19
Synonyms: 4632401C08Rik, B0AT1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 74338
Homologene: 52819
Syt16
Name: synaptotagmin XVI
Synonyms: Strep14, Syt14l, syt14r
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238266
VEGA: 12
Homologene: 12902
Zfp212
Name: Zinc finger protein 212
Synonyms: Znf212
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232784
Homologene: 8170
Rgsl1
Name: regulator of G-protein signaling like 1
Synonyms: Rgsl2, 4930415K13Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240816
Homologene: 129962
Agxt2
Name: alanine-glyoxylate aminotransferase 2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 268782
Homologene: 12887
Lrrc74a
Name: leucine rich repeat containing 74A
Synonyms: Gm6772, Lrrc74
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 627607
VEGA: 12
Homologene: 19331
Inpp5e
Name: inositol polyphosphate-5-phosphatase E
Synonyms: 1200002L24Rik, 72kDa
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 64436
Homologene: 56863
Osbpl3
Name: oxysterol binding protein-like 3
Synonyms: OSBP3, 6720421I08Rik, ORP3, 1200014M06Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 71720
Homologene: 49422
Nfasc
Name: neurofascin
Synonyms: D430023G06Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 269116
Homologene: 24945
Dsc2
Name: desmocollin 2
Synonyms: Dsc2a, Dsc2b
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13506
HGNC: HGNC:3036
Homologene: 8397
Pde8b
Name: phosphodiesterase 8B
Synonyms: B230331L10Rik, C030047E14Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218461
HGNC: HGNC:8794
Homologene: 2758
Slco4c1
Name: solute carrier organic anion transporter family, member 4C1
Synonyms: OATP4C1, OATP-M1, PRO2176, SLC21A20, OATP-H, C330017E21Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227394
Homologene: 62654
Ergic2
Name: ERGIC and golgi 2
Synonyms: 4930572C01Rik, 1200009B18Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 67456
Homologene: 6574
Stxbp6
Name: syntaxin binding protein 6 (amisyn)
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217517
Homologene: 8579
4933412E24Rik
Name: RIKEN cDNA 4933412E24 gene
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 71088
VEGA: 15
Homologene: 129990
Gm4846
Name: predicted gene 4846
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226601
Homologene: 136281
Acsm5
Name: acyl-CoA synthetase medium-chain family member 5
Synonyms: C730027J19Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 272428
Homologene: 69242
Or8k22
Name: olfactory receptor family 8 subfamily K member 22
Synonyms: MOR188-2, GA_x6K02T2Q125-47811880-47810942, Olfr1054
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 259021
Homologene: 133882
4930447C04Rik
Name: RIKEN cDNA 4930447C04 gene
Synonyms: Six6as, Six6os1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 75801
Homologene: 49922
Zhx1
Name: zinc fingers and homeoboxes 1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 22770
Homologene: 5225
Psmc3
Name: proteasome (prosome, macropain) 26S subunit, ATPase 3
Synonyms: Tat binding protein 1, TBP-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19182
HGNC: HGNC:9549
Homologene: 2097
Retreg1
Name: reticulophagy regulator 1
Synonyms: Fam134b, 1810015C04Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 66270
VEGA: 15
Homologene: 10368
Slc30a2
Name: solute carrier family 30 (zinc transporter), member 2
Synonyms: Znt2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230810
Homologene: 40855
Osr2
Name: odd-skipped related 2
Synonyms: Osr2A, Osr2B, 5430409I15Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 107587
VEGA: 15
Homologene: 14200
Asb16
Name: ankyrin repeat and SOCS box-containing 16
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217217
Homologene: 76813
Speer1c
Name: spermatogenesis associated glutamate (E)-rich protein 1C
Synonyms: Gm5152
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 381612
Fbxw25
Name: F-box and WD-40 domain protein 25
Synonyms: E330001B16Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 546160
Or8g22
Name: olfactory receptor family 8 subfamily G member 22, pseudogene 1
Synonyms: EG628171, MOR171-37, Olfr936, GA_x6K02T2PVTD-32743332-32742397
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 100503486
VEGA: 9
Mup13
Name: major urinary protein 13
Synonyms: Gm13513
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100039089
Homologene: 74304
Trgv3
Name: T cell receptor gamma, variable 3
Synonyms: Tcrg-V3, vgamma3
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 21637
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 12,850,965 bp
  • G to A, chromosome 1 at 96,871,772 bp
  • A to C, chromosome 1 at 132,634,263 bp
  • T to G, chromosome 1 at 153,804,130 bp
  • T to A, chromosome 1 at 166,487,079 bp
  • T to C, chromosome 1 at 175,665,473 bp
  • A to G, chromosome 2 at 26,408,092 bp
  • A to T, chromosome 2 at 36,452,839 bp
  • T to A, chromosome 2 at 52,206,944 bp
  • T to A, chromosome 2 at 69,459,531 bp
  • A to G, chromosome 2 at 72,208,101 bp
  • C to A, chromosome 2 at 86,332,792 bp
  • T to A, chromosome 2 at 91,055,930 bp
  • T to A, chromosome 3 at 73,700,636 bp
  • T to C, chromosome 3 at 138,123,785 bp
  • C to A, chromosome 4 at 4,792,962 bp
  • T to C, chromosome 4 at 41,765,109 bp
  • G to A, chromosome 4 at 61,226,753 bp
  • A to G, chromosome 4 at 80,837,584 bp
  • T to A, chromosome 4 at 134,349,270 bp
  • T to C, chromosome 5 at 10,245,225 bp
  • T to A, chromosome 5 at 53,872,276 bp
  • T to C, chromosome 5 at 138,263,577 bp
  • A to G, chromosome 6 at 47,920,744 bp
  • G to T, chromosome 6 at 50,346,430 bp
  • A to T, chromosome 6 at 148,195,259 bp
  • A to G, chromosome 7 at 3,716,178 bp
  • T to C, chromosome 7 at 15,833,880 bp
  • G to A, chromosome 7 at 43,641,884 bp
  • A to G, chromosome 7 at 119,537,288 bp
  • A to T, chromosome 7 at 120,135,353 bp
  • A to T, chromosome 8 at 119,542,750 bp
  • T to A, chromosome 9 at 39,047,519 bp
  • T to C, chromosome 9 at 86,440,626 bp
  • G to T, chromosome 9 at 109,654,592 bp
  • T to A, chromosome 9 at 123,185,054 bp
  • T to A, chromosome 10 at 85,654,482 bp
  • G to T, chromosome 11 at 102,269,109 bp
  • T to C, chromosome 11 at 103,227,022 bp
  • T to A, chromosome 11 at 114,757,228 bp
  • A to T, chromosome 11 at 116,304,862 bp
  • A to G, chromosome 12 at 44,902,003 bp
  • T to A, chromosome 12 at 72,910,021 bp
  • C to T, chromosome 12 at 74,266,709 bp
  • A to G, chromosome 12 at 86,740,979 bp
  • A to G, chromosome 13 at 19,243,018 bp
  • T to C, chromosome 13 at 73,686,078 bp
  • T to C, chromosome 13 at 74,727,334 bp
  • T to A, chromosome 13 at 95,042,934 bp
  • A to G, chromosome 14 at 99,087,489 bp
  • G to A, chromosome 15 at 10,358,667 bp
  • G to A, chromosome 15 at 12,846,083 bp
  • A to G, chromosome 15 at 25,971,598 bp
  • T to C, chromosome 15 at 30,905,709 bp
  • A to G, chromosome 15 at 35,300,886 bp
  • T to C, chromosome 15 at 58,054,362 bp
  • A to G, chromosome 15 at 60,015,889 bp
  • C to A, chromosome 15 at 74,853,991 bp
  • G to A, chromosome 15 at 89,102,943 bp
  • T to C, chromosome 16 at 87,912,820 bp
  • T to C, chromosome 16 at 97,743,957 bp
  • T to A, chromosome 17 at 25,775,134 bp
  • T to A, chromosome 17 at 56,396,333 bp
  • T to A, chromosome 18 at 10,544,561 bp
  • T to A, chromosome 18 at 20,051,179 bp
  • T to A, chromosome 19 at 22,978,684 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7275 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045358-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.