Strain Name:
C57BL/6J-MtgxR7331Btlr/Mmmh
Stock Number:
045424-MU
Citation ID:
RRID:MMRRC_045424-MU
Other Names:
R7331 (G1)
Major Collection:

Strain Information

Gabarap
Name: gamma-aminobutyric acid receptor associated protein
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 56486
HGNC: HGNC:4067
Homologene: 134119
Rpa1
Name: replication protein A1
Synonyms: RF-A, 5031405K23Rik, 70kDa, RP-A, Rpa
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 68275
Homologene: 2208
Enpp2
Name: ectonucleotide pyrophosphatase/phosphodiesterase 2
Synonyms: Npps2, Pdnp2, PD-Ialpha, Autotaxin, ATX
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 18606
HGNC: HGNC:3357
Homologene: 4526
Zfp101
Name: zinc finger protein 101
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22643
Homologene: 137226
Ttc3
Name: tetratricopeptide repeat domain 3
Synonyms: TPRD, D16Ium21e, D16Ium21, 2610202A04Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 22129
Homologene: 2487
Rfc1
Name: replication factor C (activator 1) 1
Synonyms: Alp145, 140kDa, RFC140, Recc1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19687
HGNC: HGNC:9969
Homologene: 2187
Hunk
Name: hormonally upregulated Neu-associated kinase
Synonyms: Bstk1, Mak-v
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 26559
VEGA: 16
Homologene: 8742
Uqcc1
Name: ubiquinol-cytochrome c reductase complex assembly factor 1
Synonyms: 2310079L17Rik, Uqcc, 3110038N19Rik, Cbp3, mbFZb, Bfzp, 2410003P15Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 56046
Homologene: 14709
Slc25a17
Name: solute carrier family 25 (mitochondrial carrier, peroxisomal membrane protein), member 17
Synonyms: 34kDa, PMP34
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 20524
VEGA: 15
Homologene: 4637
Slc45a4
Name: solute carrier family 45, member 4
Synonyms: 9330175B01Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 106068
Homologene: 69908
Nup107
Name: nucleoporin 107
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 103468
VEGA: 10
Homologene: 5555
Clcc1
Name: chloride channel CLIC-like 1
Synonyms: Mclc
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229725
Homologene: 9032
Ryr2
Name: ryanodine receptor 2, cardiac
Synonyms: 9330127I20Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20191
VEGA: 13
Homologene: 37423
Lix1
Name: limb and CNS expressed 1
Synonyms: 5730466L18Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 66643
Homologene: 12004
Tecr
Name: trans-2,3-enoyl-CoA reductase
Synonyms: D17Ertd178e, Gpsn2, 2410016D23Rik, A230102P12Rik, SC2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 106529
HGNC: HGNC:4551
Homologene: 36231
Fchsd1
Name: FCH and double SH3 domains 1
Synonyms: A030002D08Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 319262
Homologene: 14127
Cdc34
Name: cell division cycle 34
Synonyms: UBE2R1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216150
VEGA: 10
HGNC: HGNC:1734
Homologene: 55815
Sdccag8
Name: serologically defined colon cancer antigen 8
Synonyms: 5730470G24Rik, 2700048G21Rik, CCCAP
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 76816
Homologene: 4839
Btbd1
Name: BTB domain containing 1
Synonyms: 1190005H08Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 83962
HGNC: HGNC:1120
Homologene: 23529
Phf21b
Name: PHD finger protein 21B
Synonyms: A730032D07Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 271305
Homologene: 78154
Zyx
Name: zyxin
Synonyms: R75157
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 22793
Homologene: 31164
Gpr152
Name: G protein-coupled receptor 152
Synonyms: LOC269053, A930009H15Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 269053
VEGA: 19
Homologene: 35474
Adgrf5
Name: adhesion G protein-coupled receptor F5
Synonyms: 8430401C09Rik, Gpr116
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224792
VEGA: 17
Homologene: 9065
Piezo2
Name: piezo-type mechanosensitive ion channel component 2
Synonyms: Piezo2, Fam38b, 9030411M15Rik, Fam38b2, 9430028L06Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 667742
Homologene: 49695
Slc4a1
Name: solute carrier family 4 (anion exchanger), member 1
Synonyms: erythrocyte membrane protein band 3, Empb3, Ae1, CD233, l11Jus51, band 3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20533
Homologene: 133556
Il1r2
Name: interleukin 1 receptor, type II
Synonyms: IL-1 receptor beta chain, CD121b, Il1r-2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16178
HGNC: HGNC:5994
Homologene: 7783
V1rd19
Name: vomeronasal 1 receptor, D19
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 404287
Homologene: 104166
Lrp1b
Name: low density lipoprotein-related protein 1B
Synonyms: 9630004P12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 94217
HGNC: HGNC:6693
Homologene: 56810
Ryr3
Name: ryanodine receptor 3
Synonyms: calcium release channel isoform 3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20192
Homologene: 68151
Gm7247
Name: predicted gene 7247
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 638695
Slc7a14
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 14
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 241919
Homologene: 76320
Ctsj
Name: cathepsin J
Synonyms: CatRLP, Cat P, CATP, Ctsp, rat gene/Cathepsin L-related protein
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 26898
VEGA: 13
Homologene: 137246
Csmd2
Name: CUB and Sushi multiple domains 2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329942
Homologene: 89034
Foxn1
Name: forkhead box N1
Synonyms: Hfh11, whn, D11Bhm185e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 15218
Homologene: 2664
Psme3ip1
Name: proteasome activator subunit 3 interacting protein 1
Synonyms: 2310065K24Rik, 1700001O11Rik, Fam192a
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 102122
Homologene: 11797
2210408I21Rik
Name: RIKEN cDNA 2210408I21 gene
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 72371
Homologene: 89234
Iqub
Name: IQ motif and ubiquitin domain containing
Synonyms: Trs4, 4932408B21Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 214704
Homologene: 44790
Atg16l2
Name: autophagy related 16 like 2
Synonyms: 2410118P20Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 73683
Homologene: 18981
Stard6
Name: StAR related lipid transfer domain containing 6
Synonyms: 4833424I06Rik, 1700011K09Rik, 4933429L05Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 170461
Homologene: 12578
Fbh1
Name: F-box DNA helicase 1
Synonyms: Fbx18, Fbxo18
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 50755
Homologene: 9272
Dync2li1
Name: dynein cytoplasmic 2 light intermediate chain 1
Synonyms: mD2LIC, D2lic, 4933404O11Rik, LIC3, CGI-60
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 213575
VEGA: 17
Homologene: 9336
Dzank1
Name: double zinc ribbon and ankyrin repeat domains 1
Synonyms: 6330439K17Rik, Ankrd64, 2810039F03Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241688
Homologene: 10037
Bglap2
Name: bone gamma-carboxyglutamate protein 2
Synonyms: bone Gla protein, OG2, osteocalcin, mOC-B
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12097
HGNC: HGNC:1043
Homologene: 104130
Fastkd5
Name: FAST kinase domains 5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 380601
Homologene: 36400
Zar1
Name: zygote arrest 1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 317755
Homologene: 18370
Ero1b
Name: endoplasmic reticulum oxidoreductase 1 beta
Synonyms: 1700065B09Rik, Ero1lb, 1300013B24Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 67475
VEGA: 13
Homologene: 8740
Gm7694
Name: predicted gene 7694
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 665574
Homologene: 108141
Cycs
Name: cytochrome c, somatic
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 13063
Homologene: 133055
Scgb2b18
Name: secretoglobin, family 2B, member 18
Synonyms: Gm4692, Abpbg18
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100043856
Homologene: 83171
Eif4a3l2
Name: eukaryotic translation initiation factor 4A3 like 2
Synonyms: Gm5580
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 434080
Krtap10-28
Name: keratin associated protein 10-28
Synonyms: Gm9508
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 670895
VEGA: 10
Homologene: 115744
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 40,123,249 bp
  • A to T, chromosome 1 at 170,301,611 bp
  • C to G, chromosome 1 at 176,868,290 bp
  • A to T, chromosome 2 at 11,763,986 bp
  • A to T, chromosome 2 at 40,663,610 bp
  • C to A, chromosome 2 at 112,763,665 bp
  • A to T, chromosome 2 at 130,615,727 bp
  • A to T, chromosome 2 at 144,490,270 bp
  • A to G, chromosome 2 at 155,911,811 bp
  • T to C, chromosome 3 at 31,257,731 bp
  • A to T, chromosome 3 at 88,378,260 bp
  • A to G, chromosome 3 at 108,668,078 bp
  • A to T, chromosome 4 at 128,564,228 bp
  • T to C, chromosome 5 at 65,311,044 bp
  • T to A, chromosome 5 at 72,580,312 bp
  • A to G, chromosome 6 at 24,500,394 bp
  • A to G, chromosome 6 at 42,351,659 bp
  • A to G, chromosome 6 at 50,565,552 bp
  • G to A, chromosome 6 at 116,552,169 bp
  • T to A, chromosome 7 at 24,003,883 bp
  • C to T, chromosome 7 at 33,173,256 bp
  • T to A, chromosome 7 at 81,815,972 bp
  • C to A, chromosome 7 at 101,299,048 bp
  • A to G, chromosome 8 at 83,571,935 bp
  • T to A, chromosome 8 at 94,582,936 bp
  • A to G, chromosome 10 at 77,696,795 bp
  • T to C, chromosome 10 at 79,685,312 bp
  • G to A, chromosome 10 at 117,770,198 bp
  • A to G, chromosome 11 at 69,994,472 bp
  • A to G, chromosome 11 at 75,313,115 bp
  • A to G, chromosome 11 at 78,358,789 bp
  • G to A, chromosome 11 at 102,361,419 bp
  • A to G, chromosome 13 at 11,745,631 bp
  • A to G, chromosome 13 at 12,600,126 bp
  • G to A, chromosome 13 at 61,003,831 bp
  • A to T, chromosome 13 at 77,183,609 bp
  • A to G, chromosome 14 at 51,364,335 bp
  • T to C, chromosome 15 at 54,875,670 bp
  • G to T, chromosome 15 at 73,605,640 bp
  • G to A, chromosome 15 at 81,329,145 bp
  • G to C, chromosome 15 at 84,791,094 bp
  • T to A, chromosome 16 at 90,472,562 bp
  • T to A, chromosome 16 at 94,394,359 bp
  • A to T, chromosome 17 at 17,427,212 bp
  • T to C, chromosome 17 at 33,382,585 bp
  • T to C, chromosome 17 at 43,437,593 bp
  • T to A, chromosome 17 at 84,647,658 bp
  • T to C, chromosome 18 at 37,968,770 bp
  • A to G, chromosome 18 at 63,108,030 bp
  • A to G, chromosome 18 at 70,483,482 bp
  • A to G, chromosome 19 at 4,142,609 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7331 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045424-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.