Strain Name:
C57BL/6J-MtgxR7342Btlr/Mmmh
Stock Number:
045432-MU
Citation ID:
RRID:MMRRC_045432-MU
Other Names:
R7342 (G1)
Major Collection:

Strain Information

Ptf1a
Name: pancreas specific transcription factor, 1a
Synonyms: bHLHa29, PTF1-p48
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19213
Homologene: 10304
Macf1
Name: microtubule-actin crosslinking factor 1
Synonyms: Aclp7, trabeculin alpha, Acf7
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11426
Homologene: 136191
Ctbp2
Name: C-terminal binding protein 2
Synonyms: D7Ertd45e, Gtrgeo6, Ribeye
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13017
HGNC: HGNC:2495
Homologene: 75187
Arid4b
Name: AT-rich interaction domain 4B
Synonyms: Rbp1l1, 6330417L24Rik, RBBP1L1, 6720480E17Rik, SAP180, BRCAA1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 94246
Homologene: 12847
Lrp2
Name: low density lipoprotein receptor-related protein 2
Synonyms: b2b1625.2Clo, D230004K18Rik, Megalin, Gp330
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14725
HGNC: HGNC:6694
Homologene: 20952
Prex2
Name: phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
Synonyms: C030045D06Rik, 6230420N16Rik, Depdc2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 109294
Homologene: 23523
Kif1b
Name: kinesin family member 1B
Synonyms: Kif1b beta, A530096N05Rik, N-3 kinesin, D4Mil1e, KIF1Bp204, KIF1Bp130, Kif1b alpha
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 16561
Homologene: 99835
Ptprg
Name: protein tyrosine phosphatase receptor type G
Synonyms: 5430405N12Rik, RPTPgamma
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 19270
HGNC: HGNC:9671
Homologene: 2129
Myo9b
Name: myosin IXb
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 17925
HGNC: HGNC:7609
Homologene: 3058
Lrp6
Name: low density lipoprotein receptor-related protein 6
Synonyms: skam26Jus, ska26, skax26, Cd
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16974
HGNC: HGNC:6698
Homologene: 1747
Scp2
Name: sterol carrier protein 2, liver
Synonyms: SCPx, SCP-2, ns-LTP, NSL-TP, nonspecific lipid transfer protein
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 20280
Homologene: 37717
Adam8
Name: a disintegrin and metallopeptidase domain 8
Synonyms: CD156a, MS2, CD156, E430039A18Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 11501
HGNC: HGNC:215
Homologene: 74384
Ash1l
Name: ASH1 like histone lysine methyltransferase
Synonyms: 8030453L17Rik, KMT2H, chromatin remodeling factor, E430018P19Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 192195
Homologene: 10225
Taf1b
Name: TATA-box binding protein associated factor, RNA polymerase I, B
Synonyms: p63, mTAFI68, 4930408G01Rik, A230108M10Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 21340
VEGA: 12
Homologene: 31331
Calcr
Name: calcitonin receptor
Synonyms: Clr
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12311
HGNC: HGNC:1440
Homologene: 1320
Cand1
Name: cullin associated and neddylation disassociated 1
Synonyms: D10Ertd516e, 2310038O07Rik, 6330512O03Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 71902
Homologene: 10202
Arhgap17
Name: Rho GTPase activating protein 17
Synonyms: WBP15, Nadrin, Nadrin2, 5730403H17Rik, Rich1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 70497
Homologene: 9984
Aarsd1
Name: alanyl-tRNA synthetase domain containing 1
Synonyms: 2310044P18Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69684
Homologene: 6821
Creld2
Name: cysteine-rich with EGF-like domains 2
Synonyms: 5730592L21Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 76737
VEGA: 15
Homologene: 11526
Ms4a6d
Name: membrane-spanning 4-domains, subfamily A, member 6D
Synonyms: Ms4a11
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 68774
Homologene: 130755
Zfp54
Name: zinc finger protein 54
Synonyms: Zfp76, clone 18, Zfp-54, KRAB10
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22712
Homologene: 129791
Rhpn2
Name: rhophilin, Rho GTPase binding protein 2
Synonyms: 1300002E07Rik, D7Ertd784e
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 52428
Homologene: 12407
Gosr1
Name: golgi SNAP receptor complex member 1
Synonyms: GS28, GOS-28, Cis-Golgi SNARE
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 53334
HGNC: HGNC:4430
Homologene: 37977
Gtf2f2
Name: general transcription factor IIF, polypeptide 2
Synonyms: 1110031C13Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 68705
VEGA: 14
HGNC: HGNC:4653
Homologene: 37884
Slc38a9
Name: solute carrier family 38, member 9
Synonyms: 9430067K09Rik, 9130023D20Rik, 4833412L08Rik, 6720411P22Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 268706
VEGA: 13
Homologene: 18139
Clstn1
Name: calsyntenin 1
Synonyms: alcadein alpha, calsyntenin-1, 1810034E21Rik, Cst-1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 65945
Homologene: 8814
Lbr
Name: lamin B receptor
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98386
HGNC: HGNC:6518
Homologene: 2455
Cfi
Name: complement component factor i
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12630
HGNC: HGNC:5394
Homologene: 171
Uggt2
Name: UDP-glucose glycoprotein glucosyltransferase 2
Synonyms: A230065J02Rik, 3110001A05Rik, 1810064L21Rik, 3110027P15Rik, Ugcgl2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 66435
Homologene: 56875
Unc13b
Name: unc-13 homolog B
Synonyms: Munc13-2, Unc13h2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 22249
Homologene: 31376
Itpr2
Name: inositol 1,4,5-triphosphate receptor 2
Synonyms: Ip3r2, Itpr5
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16439
HGNC: HGNC:6181
Homologene: 37593
Spats2l
Name: spermatogenesis associated, serine-rich 2-like
Synonyms: 2810022L02Rik, A230104H11Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 67198
Homologene: 56711
Foxn4
Name: forkhead box N4
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 116810
Homologene: 17526
Nuak1
Name: NUAK family, SNF1-like kinase, 1
Synonyms: B230104P22Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 77976
Homologene: 8896
Dnah3
Name: dynein, axonemal, heavy chain 3
Synonyms: Dnahc3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 381917
HGNC: HGNC:2949
Homologene: 19674
Naip2
Name: NLR family, apoptosis inhibitory protein 2
Synonyms: Naip-rs6, Naip2, Birc1b
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17948
HGNC: HGNC:7634
Homologene: 136092
Neb
Name: nebulin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17996
HGNC: HGNC:7720
Homologene: 136285
Sstr1
Name: somatostatin receptor 1
Synonyms: sst1, Smstr-1, Smstr1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20605
Homologene: 820
Tfip11
Name: tuftelin interacting protein 11
Synonyms: Tip39
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 54723
Homologene: 40813
Ttc23l
Name: tetratricopeptide repeat domain 23-like
Synonyms: 4930401A09Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 75777
Homologene: 44907
Cblif
Name: cobalamin binding intrinsic factor
Synonyms: Gif
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 14603
HGNC: HGNC:4268
Homologene: 3773
Dpp6
Name: dipeptidylpeptidase 6
Synonyms: In(5)6H-p, LOC384168, Rw, Dpp-6, B930011P16Rik, Peplb
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 13483
HGNC: HGNC:3010
Homologene: 22560
Dgkb
Name: diacylglycerol kinase, beta
Synonyms: DGK-beta, C630029D13Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217480
VEGA: 12
HGNC: HGNC:2850
Homologene: 37875
B4gat1
Name: beta-1,4-glucuronyltransferase 1
Synonyms: B3gnt6, BETA3GNT1, 1500032M01Rik, iGNT, B3gnt1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 108902
VEGA: 19
Homologene: 38239
Cmklr1
Name: chemerin chemokine-like receptor 1
Synonyms: ChemR23, Gpcr27
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14747
HGNC: HGNC:2121
Homologene: 129967
Or14a260
Name: olfactory receptor family 14 subfamily A member 260
Synonyms: Olfr307, GA_x6K02T2NHDJ-9772012-9772953, MOR219-1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258610
Atp6v0a2
Name: ATPase, H+ transporting, lysosomal V0 subunit A2
Synonyms: Tj6, TJ6s, ATP6a2, Atp6n2, 8430408C20Rik, V-ATPase a2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 21871
Homologene: 56523
Plin4
Name: perilipin 4
Synonyms: S3-12
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 57435
Homologene: 69311
Cntnap5a
Name: contactin associated protein-like 5A
Synonyms: Caspr5-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 636808
Homologene: 43974
Lrrcc1
Name: leucine rich repeat and coiled-coil domain containing 1
Synonyms: 4932441F23Rik, 1200008A14Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 71710
Homologene: 12559
Cel
Name: carboxyl ester lipase
Synonyms: 1810036E18Rik, BAL
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12613
HGNC: HGNC:1848
Homologene: 37529
Abcc1
Name: ATP-binding cassette, sub-family C member 1
Synonyms: Mrp1, Abcc1a, Mdrap, MRP, Abcc1b
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 17250
HGNC: HGNC:51
Homologene: 133779
Ctsh
Name: cathepsin H
Synonyms: Cat H
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 13036
HGNC: HGNC:2535
Homologene: 36159
Pgbd5
Name: piggyBac transposable element derived 5
Synonyms: 2900019M05Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 209966
Homologene: 11583
Slc17a9
Name: solute carrier family 17, member 9
Synonyms: 1700019H03Rik, Vnut
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228993
Homologene: 76562
Paip2b
Name: poly(A) binding protein interacting protein 2B
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232164
Homologene: 25798
Tgoln1
Name: trans-golgi network protein
Synonyms: TGN38A, TGN38, Ttgn1, D6Ertd384e
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 22134
Homologene: 137224
Rpl18a
Name: ribosomal protein L18A
Synonyms: 2510019J09Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 76808
Homologene: 68104
Cxcl10
Name: C-X-C motif chemokine ligand 10
Synonyms: IP-10, gIP-10, IP10, Scyb10, CRG-2, C7, mob-1, INP10, Ifi10
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 15945
Homologene: 1203
Slc4a1ap
Name: solute carrier family 4 (anion exchanger), member 1, adaptor protein
Synonyms: kanadaptin
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20534
Homologene: 7543
Sftpb
Name: surfactant associated protein B
Synonyms: SP-B, Sftp-3, Sftp3, SF-B
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 20388
Homologene: 456
Vmac
Name: vimentin-type intermediate filament associated coiled-coil protein
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106639
VEGA: 17
Homologene: 18727
Ighg2b
Name: immunoglobulin heavy constant gamma 2B
Synonyms: gamma2b, IgG2b
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 16016
Vmn2r125
Name: vomeronasal 2, receptor 125
Synonyms: Gm20782
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 670059
VEGA: 4
Or8c18
Name: olfactory receptor family 8 subfamily C member 18
Synonyms: MOR170-10P, GA_x6K02T2PVTD-31985209-31986136, Olfr896
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258030
VEGA: 9
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 11,162,325 bp
  • C to A, chromosome 1 at 57,885,947 bp
  • A to G, chromosome 1 at 116,060,122 bp
  • C to T, chromosome 1 at 181,825,621 bp
  • A to G, chromosome 2 at 19,447,166 bp
  • A to T, chromosome 2 at 28,560,637 bp
  • A to T, chromosome 2 at 52,281,667 bp
  • A to G, chromosome 2 at 69,479,290 bp
  • T to C, chromosome 2 at 180,736,762 bp
  • T to A, chromosome 3 at 14,554,371 bp
  • G to T, chromosome 3 at 88,965,997 bp
  • T to A, chromosome 3 at 129,875,132 bp
  • T to C, chromosome 4 at 43,258,703 bp
  • T to A, chromosome 4 at 108,091,321 bp
  • T to C, chromosome 4 at 123,382,124 bp
  • A to T, chromosome 4 at 143,896,950 bp
  • A to C, chromosome 4 at 149,214,090 bp
  • G to A, chromosome 4 at 149,629,430 bp
  • T to C, chromosome 4 at 156,350,843 bp
  • T to C, chromosome 5 at 27,714,554 bp
  • C to T, chromosome 5 at 31,536,290 bp
  • T to A, chromosome 5 at 92,348,170 bp
  • T to A, chromosome 5 at 112,327,972 bp
  • C to T, chromosome 5 at 113,614,293 bp
  • C to A, chromosome 5 at 114,258,699 bp
  • A to G, chromosome 5 at 124,646,736 bp
  • T to A, chromosome 6 at 3,691,536 bp
  • G to A, chromosome 6 at 72,309,875 bp
  • G to C, chromosome 6 at 72,616,278 bp
  • T to A, chromosome 6 at 83,814,826 bp
  • G to T, chromosome 6 at 134,450,818 bp
  • A to T, chromosome 6 at 146,327,187 bp
  • A to G, chromosome 7 at 35,334,346 bp
  • G to A, chromosome 7 at 86,336,087 bp
  • T to G, chromosome 7 at 120,029,985 bp
  • T to C, chromosome 7 at 123,327,244 bp
  • T to C, chromosome 7 at 133,014,312 bp
  • T to C, chromosome 7 at 139,986,391 bp
  • T to C, chromosome 8 at 70,895,398 bp
  • T to C, chromosome 8 at 71,355,774 bp
  • G to A, chromosome 8 at 124,433,970 bp
  • A to G, chromosome 9 at 38,292,278 bp
  • A to T, chromosome 9 at 90,074,987 bp
  • T to C, chromosome 10 at 84,374,967 bp
  • A to T, chromosome 10 at 119,211,787 bp
  • T to C, chromosome 11 at 76,730,207 bp
  • T to G, chromosome 11 at 101,417,192 bp
  • A to T, chromosome 12 at 24,558,344 bp
  • A to G, chromosome 12 at 38,100,433 bp
  • A to G, chromosome 12 at 58,213,670 bp
  • A to G, chromosome 12 at 113,306,430 bp
  • A to C, chromosome 13 at 14,136,219 bp
  • A to T, chromosome 13 at 100,189,356 bp
  • G to T, chromosome 13 at 112,669,591 bp
  • T to C, chromosome 14 at 12,237,151 bp
  • T to C, chromosome 14 at 75,906,877 bp
  • T to A, chromosome 14 at 118,994,972 bp
  • G to A, chromosome 15 at 10,551,497 bp
  • A to G, chromosome 15 at 88,826,407 bp
  • C to A, chromosome 16 at 14,465,169 bp
  • A to G, chromosome 17 at 21,427,752 bp
  • T to C, chromosome 17 at 56,104,608 bp
  • T to C, chromosome 17 at 56,715,644 bp
  • G to A, chromosome 19 at 5,039,658 bp
  • G to A, chromosome 19 at 11,590,073 bp
  • A to T, chromosome 19 at 11,763,223 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7342 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045432-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.