Strain Name:
C57BL/6J-MtgxR7344Btlr/Mmmh
Stock Number:
045434-MU
Citation ID:
RRID:MMRRC_045434-MU
Other Names:
R7344 (G1)
Major Collection:

Strain Information

Lyst
Name: lysosomal trafficking regulator
Synonyms: D13Sfk13
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17101
VEGA: 13
HGNC: HGNC:1968
Homologene: 61
Fancd2
Name: Fanconi anemia, complementation group D2
Synonyms: 2410150O07Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 211651
HGNC: HGNC:3585
Homologene: 13212
Scrib
Name: scribbled planar cell polarity
Synonyms: Crc, Scrb1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 105782
Homologene: 44228
Vps54
Name: VPS54 GARP complex subunit
Synonyms: 5330404P15Rik, Vps54l, wr, mSLP8
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 245944
Homologene: 5605
Cep41
Name: centrosomal protein 41
Synonyms: 1700017E11Rik, 2810431D15Rik, Cep41, Tsga14
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 83922
Homologene: 10284
Mical3
Name: microtubule associated monooxygenase, calponin and LIM domain containing 3
Synonyms: C130040D16Rik, MICAL-3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 194401
Homologene: 85288
Epha8
Name: Eph receptor A8
Synonyms: EphA8, Hek3, Eek
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 13842
HGNC: HGNC:3391
Homologene: 22436
Supt16
Name: SPT16, facilitates chromatin remodeling subunit
Synonyms: Cdc68, Spt16, Fact140, Supt16h
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 114741
VEGA: 14
Homologene: 5207
Ecpas
Name: Ecm29 proteasome adaptor and scaffold
Synonyms: AI314180
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230249
Homologene: 6056
Npnt
Name: nephronectin
Synonyms: 1110009H02Rik, POEM
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 114249
Homologene: 14138
Zzz3
Name: zinc finger, ZZ domain containing 3
Synonyms: 6430567E01Rik, 3110065C23Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 108946
Homologene: 9182
Fam193a
Name: family with sequence homology 193, member A
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231128
Homologene: 2746
Prss58
Name: serine protease 58
Synonyms: BC048599
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232717
Homologene: 65285
Fbl
Name: fibrillarin
Synonyms: RNU3IP1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 14113
HGNC: HGNC:3599
Homologene: 1099
Zswim4
Name: zinc finger SWIM-type containing 4
Synonyms: E130119J17Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 212168
Homologene: 18183
Caprin2
Name: caprin family member 2
Synonyms: RNG140, C1qdc1, Eeg1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232560
Homologene: 11393
Tapt1
Name: transmembrane anterior posterior transformation 1
Synonyms: 4932414K18Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231225
Homologene: 80206
Smpd3
Name: sphingomyelin phosphodiesterase 3, neutral
Synonyms: fro, neutral sphingomyelinase II, nSMase2, Nsm2, 4631433G07Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 58994
Homologene: 10260
Anpep
Name: alanyl aminopeptidase, membrane
Synonyms: Apn, aminopeptidase N, Cd13
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16790
HGNC: HGNC:500
Homologene: 68163
Slc35d1
Name: solute carrier family 35 (UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter), member D1
Synonyms: UGTREL7
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242585
Homologene: 22870
Plcd4
Name: phospholipase C, delta 4
Synonyms: 4921507K24Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18802
HGNC: HGNC:9062
Homologene: 88782
Magi2
Name: membrane associated guanylate kinase, WW and PDZ domain containing 2
Synonyms: S-SCAM, Acvrinp1, Magi-2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 50791
Homologene: 8189
Or8b37
Name: olfactory receptor family 8 subfamily B member 37
Synonyms: MOR162-13, MOR162-11P, Olfr1550-ps1, Olfr884, GA_x6K02T2PVTD-31726544-31727473, MOR162-9P, MOR162-11P
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 257996
Homologene: 79400
Fcgbpl1
Name: Fc fragment of IgG binding protein like 1
Synonyms: 9530053A07Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 319482
Homologene: 130055
Atp7b
Name: ATPase, Cu++ transporting, beta polypeptide
Synonyms: WND, Wilson protein, Atp7a
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11979
HGNC: HGNC:870
Homologene: 20063
Stard9
Name: StAR related lipid transfer domain containing 9
Synonyms: Kif16a, E230025N21Rik, 4831403C07Rik, N-3 kinesin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 668880
Homologene: 130712
Fbxw16
Name: F-box and WD-40 domain protein 16
Synonyms: 7420402K12Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320083
Homologene: 110776
Rpgrip1
Name: retinitis pigmentosa GTPase regulator interacting protein 1
Synonyms: 4930505G06Rik, nmf247, A930002K18Rik, 4930401L23Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 77945
Homologene: 10679
Ildr2
Name: immunoglobulin-like domain containing receptor 2
Synonyms: 2810478N18Rik, D1Ertd471e, ENSMUSG00000040612, Dbsm1, OTTMUSG00000021748, 3110063L10Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 100039795
Homologene: 52388
Rp1l1
Name: retinitis pigmentosa 1 homolog like 1
Synonyms: Dcdc4, Rp1hl1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 271209
VEGA: 14
Homologene: 105870
Sacs
Name: sacsin
Synonyms: E130115J16Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 50720
Fbln2
Name: fibulin 2
Synonyms: 5730577E14Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14115
HGNC: HGNC:3601
Homologene: 1514
Serpinb10
Name: serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 10
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 241197
HGNC: HGNC:8942
Homologene: 68430
Mertk
Name: MER proto-oncogene tyrosine kinase
Synonyms: Eyk, nmf12, Nyk, Tyro 12, Mer
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17289
HGNC: HGNC:7027
Homologene: 4626
Vmn2r92
Name: vomeronasal 2, receptor 92
Synonyms: EG627111
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627111
Homologene: 115024
Cyp2c23
Name: cytochrome P450, family 2, subfamily c, polypeptide 23
Synonyms: Cyp2c44
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226143
Homologene: 115563
Lrrc8e
Name: leucine rich repeat containing 8 family, member E
Synonyms: 1810049O03Rik, C87354
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 72267
Homologene: 11817
Or1x6
Name: olfactory receptor family 1 subfamily X member 6
Synonyms: Olfr1375, GA_x6K02T2QP88-4389999-4389056, MOR126-2, Olfr1375-ps1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258509
Ipo4
Name: importin 4
Synonyms: 8430408O15Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 75751
Homologene: 5835
Or9g4
Name: olfactory receptor family 9 subfamily G member 4
Synonyms: MOR213-4, Olfr1006, GA_x6K02T2Q125-47154544-47153606
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258563
Homologene: 17295
Nod2
Name: nucleotide-binding oligomerization domain containing 2
Synonyms: Card15, Nlrc2, F830032C23Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 257632
HGNC: HGNC:5331
Homologene: 11156
Vmn2r101
Name: vomeronasal 2, receptor 101
Synonyms: EG627576
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627576
Homologene: 115024
Or5af1
Name: olfactory receptor family 5 subfamily AF member 1
Synonyms: Olfr312, GA_x6K02T2NKPP-575829-574903, MOR222-4P
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258065
Homologene: 77375
Rftn2
Name: raftlin family member 2
Synonyms: 2700010E02Rik, 3222401M22Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74013
Homologene: 16954
Slfn3
Name: schlafen 3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20557
Homologene: 133236
Rcc1l
Name: reculator of chromosome condensation 1 like
Synonyms: 5730496C04Rik, Wbscr16
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 94254
Homologene: 36477
Pus7l
Name: pseudouridylate synthase 7-like
Synonyms: 3000003F02Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 78895
Homologene: 12842
Itga7
Name: integrin alpha 7
Synonyms: [a]7, alpha7
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16404
VEGA: 10
HGNC: HGNC:6143
Homologene: 37592
4930438A08Rik
Name: RIKEN cDNA 4930438A08 gene
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 73988
Homologene: 104884
Irx5
Name: Iroquois homeobox 5
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 54352
Homologene: 38105
Gtf2a1l
Name: general transcription factor IIA, 1-like
Synonyms: Alf, 1700011N16Rik, Gtf2a1lf
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 71828
Homologene: 86732
Lpcat2
Name: lysophosphatidylcholine acyltransferase 2
Synonyms: Aytl1, lysoPAFAT/LPCAT2, Aytl1a, LPCAT2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 270084
Homologene: 41201
Dazap2
Name: DAZ associated protein 2
Synonyms: gt6-12, Gcap28, Brbp, Prtb
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 23994
VEGA: 15
HGNC: HGNC:2684
Homologene: 8038
Gm6793
Name: predicted gene 6793
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 627828
VEGA: 8
Gm17728
Name: predicted gene, 17728
Type: Gene
Species: Mouse
Chromosome: 17
Krtap2-20
Name: keratin associated protein 2-20
Synonyms: Gm11562
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 100502803
Homologene: 136079
Gm30083
Name: predicted gene, 30083
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 102631856
VEGA: 14
Gm7324
Name: predicted gene 7324
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 652988
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to C, chromosome 1 at 55,226,152 bp
  • A to T, chromosome 1 at 74,554,652 bp
  • T to C, chromosome 1 at 107,540,942 bp
  • T to A, chromosome 1 at 166,294,597 bp
  • A to T, chromosome 2 at 85,674,931 bp
  • A to T, chromosome 2 at 120,704,686 bp
  • C to A, chromosome 2 at 128,771,497 bp
  • T to C, chromosome 3 at 132,908,339 bp
  • T to C, chromosome 3 at 152,452,099 bp
  • A to T, chromosome 4 at 58,824,770 bp
  • A to T, chromosome 4 at 103,213,046 bp
  • T to A, chromosome 4 at 136,934,538 bp
  • G to A, chromosome 5 at 20,550,240 bp
  • A to G, chromosome 5 at 34,485,730 bp
  • A to T, chromosome 5 at 44,188,657 bp
  • A to T, chromosome 5 at 134,176,437 bp
  • C to T, chromosome 6 at 30,693,656 bp
  • A to G, chromosome 6 at 40,895,465 bp
  • A to G, chromosome 6 at 91,269,973 bp
  • T to C, chromosome 6 at 113,568,709 bp
  • T to A, chromosome 6 at 121,036,544 bp
  • A to G, chromosome 6 at 148,873,067 bp
  • T to C, chromosome 7 at 28,140,279 bp
  • C to T, chromosome 7 at 28,152,760 bp
  • T to A, chromosome 7 at 28,178,935 bp
  • G to T, chromosome 7 at 79,838,650 bp
  • C to T, chromosome 8 at 4,234,815 bp
  • T to C, chromosome 8 at 21,997,499 bp
  • G to A, chromosome 8 at 84,223,698 bp
  • T to C, chromosome 8 at 88,660,582 bp
  • A to G, chromosome 8 at 92,359,555 bp
  • T to C, chromosome 8 at 92,875,567 bp
  • C to T, chromosome 8 at 106,265,193 bp
  • T to A, chromosome 8 at 112,014,929 bp
  • T to C, chromosome 9 at 38,047,957 bp
  • A to G, chromosome 9 at 109,449,035 bp
  • A to G, chromosome 10 at 128,940,929 bp
  • T to C, chromosome 11 at 21,274,999 bp
  • T to G, chromosome 11 at 51,048,295 bp
  • A to C, chromosome 11 at 58,291,447 bp
  • A to T, chromosome 11 at 58,831,482 bp
  • T to C, chromosome 11 at 83,212,822 bp
  • T to G, chromosome 11 at 99,620,369 bp
  • T to A, chromosome 13 at 13,706,555 bp
  • A to G, chromosome 14 at 33,999,580 bp
  • A to G, chromosome 14 at 43,714,677 bp
  • A to T, chromosome 14 at 52,140,659 bp
  • A to T, chromosome 14 at 52,173,571 bp
  • C to T, chromosome 14 at 55,635,531 bp
  • A to G, chromosome 14 at 61,207,444 bp
  • G to A, chromosome 14 at 64,029,620 bp
  • T to C, chromosome 15 at 76,049,258 bp
  • A to G, chromosome 15 at 94,540,617 bp
  • T to A, chromosome 15 at 100,616,943 bp
  • G to T, chromosome 17 at 9,422,123 bp
  • A to G, chromosome 17 at 18,167,251 bp
  • T to C, chromosome 17 at 19,611,797 bp
  • G to A, chromosome 17 at 88,694,103 bp
  • A to T, chromosome 19 at 44,021,737 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7344 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045434-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.