Strain Name:
C57BL/6J-MtgxR7373Btlr/Mmmh
Stock Number:
045456-MU
Citation ID:
RRID:MMRRC_045456-MU
Other Names:
R7373 (G1)
Major Collection:

Strain Information

Itgb8
Name: integrin beta 8
Synonyms: 4832412O06Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 320910
HGNC: HGNC:6163
Homologene: 18567
Aldh7a1
Name: aldehyde dehydrogenase family 7, member A1
Synonyms: Atq1, D18Wsu181e
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 110695
HGNC: HGNC:877
Homologene: 913
Dst
Name: dystonin
Synonyms: Macf2, A830042E19Rik, Bpag1, Bpag, bullous pemphigoid antigen 1, nmf203, athetoid, nmf339, BPAG1, BPAG1-n, 2310001O04Rik, bullous pemphigoid antigen 1, ah
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Anks3
Name: ankyrin repeat and sterile alpha motif domain containing 3
Synonyms: 2700067D09Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 72615
VEGA: 16
Homologene: 12475
Ehmt1
Name: euchromatic histone methyltransferase 1
Synonyms: 9230102N17Rik, KMT1D
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 77683
Homologene: 11698
Lrp2
Name: low density lipoprotein receptor-related protein 2
Synonyms: b2b1625.2Clo, D230004K18Rik, Megalin, Gp330
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14725
HGNC: HGNC:6694
Homologene: 20952
Lims1
Name: LIM and senescent cell antigen-like domains 1
Synonyms: PINCH1, Lims1l, 4921524A02Rik, C430041B13Rik, 2310016J22Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 110829
HGNC: HGNC:6616
Homologene: 68428
Igf1r
Name: insulin-like growth factor I receptor
Synonyms: IGF-1R, A330103N21Rik, hyft, CD221, line 186
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16001
HGNC: HGNC:5465
Homologene: 30997
Kif20b
Name: kinesin family member 20B
Synonyms: 33cex, N-6 kinesin, C330014J10Rik, Kif20b, Mphosph1, magoo
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 240641
VEGA: 19
HGNC: HGNC:7212
Homologene: 9418
Zfr
Name: zinc finger RNA binding protein
Synonyms: C920030H05Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 22763
Homologene: 8009
Ndufa9
Name: NADH:ubiquinone oxidoreductase subunit A9
Synonyms: 1010001N11Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 66108
HGNC: HGNC:7693
Homologene: 3666
Fasn
Name: fatty acid synthase
Synonyms: A630082H08Rik, FAS
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14104
HGNC: HGNC:3594
Homologene: 55800
Ttk
Name: Ttk protein kinase
Synonyms: Esk1, Mps1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 22137
Homologene: 2489
Secisbp2l
Name: SECIS binding protein 2-like
Synonyms: 3110001I20Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 70354
Homologene: 18923
Mff
Name: mitochondrial fission factor
Synonyms: 5230400G24Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 75734
Homologene: 87000
Sqle
Name: squalene epoxidase
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 20775
Homologene: 2355
Lrrk2
Name: leucine-rich repeat kinase 2
Synonyms: cI-46, 9330188B09Rik, D630001M17Rik, 4921513O20Rik, LOC381026
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 66725
Homologene: 18982
Mfsd5
Name: major facilitator superfamily domain containing 5
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 106073
VEGA: 15
Homologene: 69517
Rpl28
Name: ribosomal protein L28
Synonyms: D7Wsu21e
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 19943
Homologene: 768
Fgfr3
Name: fibroblast growth factor receptor 3
Synonyms: HBGFR, sam3, Fgfr-3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14184
HGNC: HGNC:3690
Homologene: 55437
Cdcp1
Name: CUB domain containing protein 1
Synonyms: 9030022E12Rik, E030027H19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 109332
Homologene: 11276
Cldn1
Name: claudin 1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 12737
HGNC: HGNC:2032
Homologene: 9620
Recql5
Name: RecQ protein-like 5
Synonyms: Recq5b, Recql5b
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 170472
HGNC: HGNC:9950
Homologene: 31232
Dnah8
Name: dynein, axonemal, heavy chain 8
Synonyms: Hst6.7b, Dnahc8, P1-Loop
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 13417
VEGA: 17
HGNC: HGNC:2952
Homologene: 1049
Fat1
Name: FAT atypical cadherin 1
Synonyms: mFat1, 2310038E12Rik, Fath
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 14107
HGNC: HGNC:3595
Homologene: 66302
Trpv1
Name: transient receptor potential cation channel, subfamily V, member 1
Synonyms: OTRPC1, VR-1, capsaicin receptor, Vr1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 193034
Homologene: 12920
Csmd1
Name: CUB and Sushi multiple domains 1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 94109
Homologene: 69536
Kat2a
Name: K(lysine) acetyltransferase 2A
Synonyms: 1110051E14Rik, Gcn5l2, Gcn5, PCAF-B/GCN5
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14534
HGNC: HGNC:4201
Homologene: 41343
Tmco5
Name: transmembrane and coiled-coil domains 5
Synonyms: 1700095F04Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 67356
Homologene: 41661
Hormad1
Name: HORMA domain containing 1
Synonyms: 4921522K05Rik, Nohma
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 67981
Homologene: 69415
Pde10a
Name: phosphodiesterase 10A
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 23984
HGNC: HGNC:8772
Homologene: 4852
Dennd4a
Name: DENN domain containing 4A
Synonyms: F730015K02Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 102442
VEGA: 9
Homologene: 55933
Dll3
Name: delta like canonical Notch ligand 3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13389
HGNC: HGNC:2909
Homologene: 7291
Atp2c2
Name: ATPase, Ca++ transporting, type 2C, member 2
Synonyms: 1810010G06Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 69047
Homologene: 73463
Tm7sf2
Name: transmembrane 7 superfamily member 2
Synonyms: 3110041O18Rik, ANG1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 73166
Homologene: 68305
Adamts2
Name: ADAM metallopeptidase with thrombospondin type 1 motif 2
Synonyms: a disintegrin and metalloproteinase with thrombospondin repeats, procollagen N-proteinase, ADAM-TS2, hPCPNI
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216725
HGNC: HGNC:218
Homologene: 8597
Lrrc46
Name: leucine rich repeat containing 46
Synonyms: 1700006D24Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69297
Homologene: 12307
Crybg1
Name: crystallin beta-gamma domain containing 1
Synonyms: Aim1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 11630
HGNC: HGNC:356
Homologene: 18168
Bsn
Name: bassoon
Synonyms: presynaptic cytomatrix protein
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12217
HGNC: HGNC:1117
Homologene: 31161
Otogl
Name: otogelin-like
Synonyms: Gm6924
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 628870
Homologene: 46008
Pcnx2
Name: pecanex homolog 2
Synonyms: Pcnxl2, E330039K12Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 270109
HGNC: HGNC:8736
Homologene: 8987
Vmn2r58
Name: vomeronasal 2, receptor 58
Synonyms: EG628422
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 628422
Cfap57
Name: cilia and flagella associated protein 57
Synonyms: C130004B06Rik, LOC384050, 1110020C03Rik, Wdr65
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 68625
Homologene: 51350
Or51a39
Name: olfactory receptor family 51 subfamily A member 39
Synonyms: Olfr33, MTPCR33, MOR11-2, GA_x6K02T2PBJ9-5431102-5430146
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18332
Homologene: 81534
Sh3bgr
Name: SH3-binding domain glutamic acid-rich protein
Synonyms: 5430437A18Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 50795
Homologene: 56376
Vmn2r120
Name: vomeronasal 2, receptor 120
Synonyms: EG224916
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224916
Catsper3
Name: cation channel, sperm associated 3
Synonyms: 4921522D01Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 76856
Homologene: 12658
Cntnap5a
Name: contactin associated protein-like 5A
Synonyms: Caspr5-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 636808
Homologene: 43974
Slc22a15
Name: solute carrier family 22 (organic anion/cation transporter), member 15
Synonyms: A530052I06Rik, 2610034P21Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242126
Homologene: 41263
Shcbp1l
Name: Shc SH2-domain binding protein 1-like
Synonyms: 1700012A16Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 71836
Homologene: 12800
Tas2r106
Name: taste receptor, type 2, member 106
Synonyms: mGR06, mt2r44, Tas2r6, T2R06
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 387341
Homologene: 130071
Or4f58
Name: olfactory receptor family 4 subfamily F member 58
Synonyms: Olfr1311, MOR245-21, GA_x6K02T2Q125-73069292-73068354
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258271
Homologene: 133656
Tll1
Name: tolloid-like
Synonyms: Tll-1, b2b2476Clo
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 21892
Homologene: 49202
Hlx
Name: H2.0-like homeobox
Synonyms: Hlx1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 15284
HGNC: HGNC:4978
Homologene: 7363
Miga2
Name: mitoguardin 2
Synonyms: R74766, Fam73b, 5730472N09Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 108958
Homologene: 13125
Cpsf4l
Name: cleavage and polyadenylation specific factor 4-like
Synonyms: 1500000C01Rik, D11Ertd636e, 0610010C04Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 52670
Homologene: 32669
Mmel1
Name: membrane metallo-endopeptidase-like 1
Synonyms: Nep2, Nl1, SEP, NEPLP gamma, NEPLP beta, NEPLP alpha, Mell1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 27390
Homologene: 22778
Meox2
Name: mesenchyme homeobox 2
Synonyms: Mox2, Mox-2, Gax
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 17286
HGNC: HGNC:7014
Homologene: 4330
Obox2
Name: oocyte specific homeobox 2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 246792
Homologene: 44937
Vmn2r-ps117
Name: vomeronasal 2, receptor, pseudogene 117
Synonyms: EG665303
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 665303
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 34,188,391 bp
  • A to G, chromosome 1 at 82,737,117 bp
  • A to T, chromosome 1 at 116,580,637 bp
  • C to A, chromosome 1 at 153,425,240 bp
  • T to C, chromosome 1 at 184,730,865 bp
  • A to G, chromosome 2 at 24,919,573 bp
  • A to G, chromosome 2 at 30,382,071 bp
  • G to T, chromosome 2 at 69,500,692 bp
  • T to A, chromosome 2 at 112,021,442 bp
  • G to T, chromosome 2 at 116,886,745 bp
  • A to T, chromosome 2 at 125,757,271 bp
  • A to T, chromosome 3 at 95,576,317 bp
  • A to C, chromosome 3 at 101,877,897 bp
  • C to T, chromosome 4 at 118,614,931 bp
  • T to A, chromosome 4 at 154,889,208 bp
  • C to A, chromosome 5 at 33,727,690 bp
  • C to A, chromosome 6 at 126,834,458 bp
  • A to T, chromosome 6 at 131,678,354 bp
  • T to C, chromosome 7 at 4,793,603 bp
  • A to T, chromosome 7 at 15,397,220 bp
  • A to G, chromosome 7 at 28,294,632 bp
  • C to T, chromosome 7 at 41,837,788 bp
  • T to A, chromosome 7 at 68,195,078 bp
  • T to A, chromosome 7 at 102,714,099 bp
  • T to C, chromosome 8 at 15,992,713 bp
  • A to G, chromosome 8 at 45,026,665 bp
  • A to T, chromosome 8 at 64,051,357 bp
  • A to T, chromosome 8 at 119,730,252 bp
  • C to T, chromosome 8 at 125,808,027 bp
  • C to A, chromosome 9 at 64,897,269 bp
  • G to A, chromosome 9 at 83,854,877 bp
  • T to C, chromosome 9 at 108,113,484 bp
  • C to T, chromosome 9 at 123,177,900 bp
  • T to C, chromosome 10 at 44,004,140 bp
  • T to C, chromosome 10 at 58,409,620 bp
  • G to T, chromosome 10 at 107,901,251 bp
  • G to A, chromosome 11 at 50,795,435 bp
  • A to G, chromosome 11 at 73,240,673 bp
  • C to A, chromosome 11 at 97,038,880 bp
  • C to T, chromosome 11 at 100,708,566 bp
  • C to T, chromosome 11 at 113,699,831 bp
  • T to C, chromosome 11 at 115,928,372 bp
  • A to T, chromosome 11 at 120,813,976 bp
  • A to T, chromosome 12 at 37,108,798 bp
  • A to G, chromosome 12 at 119,202,475 bp
  • T to C, chromosome 13 at 55,808,132 bp
  • T to A, chromosome 15 at 12,140,559 bp
  • T to C, chromosome 15 at 59,317,809 bp
  • T to C, chromosome 15 at 91,700,004 bp
  • T to A, chromosome 15 at 102,280,992 bp
  • T to C, chromosome 16 at 4,955,871 bp
  • G to T, chromosome 16 at 26,360,856 bp
  • G to A, chromosome 16 at 96,205,835 bp
  • T to A, chromosome 17 at 8,942,992 bp
  • A to T, chromosome 17 at 18,824,686 bp
  • T to C, chromosome 17 at 30,767,965 bp
  • G to T, chromosome 17 at 57,509,406 bp
  • G to A, chromosome 18 at 56,542,317 bp
  • A to G, chromosome 19 at 6,066,646 bp
  • T to C, chromosome 19 at 34,935,671 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7373 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045456-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.