Strain Name:
C57BL/6J-MtgxR7445Btlr/Mmmh
Stock Number:
045521-MU
Citation ID:
RRID:MMRRC_045521-MU
Other Names:
R7445 (G1)
Major Collection:

Strain Information

Smarca4
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
Synonyms: SW1/SNF, Brg1, b2b508.1Clo, b2b692Clo, SNF2beta
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20586
Homologene: 135927
Ntrk2
Name: neurotrophic tyrosine kinase, receptor, type 2
Synonyms: trkB, Tkrb, C030027L06Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 18212
VEGA: 13
HGNC: HGNC:8032
Homologene: 4504
Slco1a5
Name: solute carrier organic anion transporter family, member 1a5
Synonyms: Oatp3, Slc21a7
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 108096
Homologene: 56603
Rnd1
Name: Rho family GTPase 1
Synonyms: A830014L09Rik, Arhs
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223881
Homologene: 8706
Brd7
Name: bromodomain containing 7
Synonyms: BP75, CELTIX1, bromodomain protein 75 kDa
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 26992
Homologene: 8085
Ncapg2
Name: non-SMC condensin II complex, subunit G2
Synonyms: Luzp5, Mtb, 5830426I05Rik, mCAP-G2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 76044
VEGA: 12
Homologene: 9820
Samd4b
Name: sterile alpha motif domain containing 4B
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233033
Homologene: 35268
Ncbp1
Name: nuclear cap binding protein subunit 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 433702
HGNC: HGNC:7658
Homologene: 1859
Cog5
Name: component of oligomeric golgi complex 5
Synonyms: 5430405C01Rik, GOLTC1, GTC90
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238123
VEGA: 12
Homologene: 42221
Heatr1
Name: HEAT repeat containing 1
Synonyms: B130016L12Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 217995
VEGA: 13
Homologene: 34562
Pcmtd1
Name: protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1
Synonyms: 8430411F12Rik, A030012M09Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 319263
Homologene: 14180
Chaf1a
Name: chromatin assembly factor 1, subunit A
Synonyms: CAF-1, p150
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 27221
VEGA: 17
HGNC: HGNC:1910
Homologene: 4003
Ank3
Name: ankyrin 3, epithelial
Synonyms: Ank-3, AnkG, 2900054D09Rik, Ankyrin-3, Ankyrin-G
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 11735
HGNC: HGNC:494
Homologene: 56908
Ipo8
Name: importin 8
Synonyms: OM-1, Ranbp8, Om1, C130009K11Rik, 6230418K12Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 320727
HGNC: HGNC:9853
Homologene: 48430
Pyroxd1
Name: pyridine nucleotide-disulphide oxidoreductase domain 1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232491
Homologene: 11758
Camta1
Name: calmodulin binding transcription activator 1
Synonyms: 1810059M14Rik, 2310058O09Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100072
Homologene: 18942
Cacna2d3
Name: calcium channel, voltage-dependent, alpha2/delta subunit 3
Synonyms: alpha 2 delta-3, alpha2delta3
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 12294
Homologene: 74929
Ms4a14
Name: membrane-spanning 4-domains, subfamily A, member 14
Synonyms: LOC383435
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 383435
Homologene: 138453
Ice1
Name: interactor of little elongation complex ELL subunit 1
Synonyms: BC018507
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218333
VEGA: 13
Homologene: 18902
Csmd1
Name: CUB and Sushi multiple domains 1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 94109
Homologene: 69536
Tnik
Name: TRAF2 and NCK interacting kinase
Synonyms: 4831440I19Rik, C530008O15Rik, 1500031A17Rik, C630040K21Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 665113
Homologene: 77943
Ptprq
Name: protein tyrosine phosphatase receptor type Q
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237523
HGNC: HGNC:9679
Homologene: 83557
Svep1
Name: sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
Synonyms: 4833413O10Rik, D430029O09Rik, 1110021D17Rik, Polydom
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 64817
Homologene: 23386
Eif3f
Name: eukaryotic translation initiation factor 3, subunit F
Synonyms: Eif3s5, 0610037M02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 66085
HGNC: HGNC:3275
Homologene: 2783
Naip2
Name: NLR family, apoptosis inhibitory protein 2
Synonyms: Naip-rs6, Naip2, Birc1b
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17948
HGNC: HGNC:7634
Homologene: 136092
Degs1l
Name: delta 4-desaturase, sphingolipid 1 like
Synonyms: 9130409I23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 619326
Homologene: 134522
Wdfy4
Name: WD repeat and FYVE domain containing 4
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 545030
Homologene: 83473
Mapkapk2
Name: MAP kinase-activated protein kinase 2
Synonyms: MAPKAP kinase 2, MK2, Rps6kc1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17164
HGNC: HGNC:6887
Homologene: 56412
Ermap
Name: erythroblast membrane-associated protein
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 27028
Homologene: 22782
Lmntd1
Name: lamin tail domain containing 1
Synonyms: 4933403M22Rik, Lmna-rs1, Ifltd1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 74071
Homologene: 69453
Rapgef5
Name: Rap guanine nucleotide exchange factor (GEF) 5
Synonyms: mr-gef, D030051B22Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217944
VEGA: 12
Homologene: 56563
Rbm46
Name: RNA binding motif protein 46
Synonyms: ENSMUSG00000033882, LOC329687
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 633285
Homologene: 17016
Mei4
Name: meiotic double-stranded break formation protein 4
Synonyms: 4930486G11Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 75033
Homologene: 87251
Tigd4
Name: tigger transposable element derived 4
Synonyms: C130063O11Rik, Tigd4
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 403175
Homologene: 131124
Rnf122
Name: ring finger protein 122
Synonyms: 1110063C11Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 68867
Homologene: 11717
Col11a1
Name: collagen, type XI, alpha 1
Synonyms: C530001D20Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12814
HGNC: HGNC:2186
Homologene: 56389
Acsbg3
Name: acyl-CoA synthetase bubblegum family member 3
Synonyms: 1700061G19Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 78625
Homologene: 28378
0610040J01Rik
Name: RIKEN cDNA 0610040J01 gene
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 76261
Homologene: 49537
P3h2
Name: prolyl 3-hydroxylase 2
Synonyms: Leprel1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 210530
Homologene: 10062
Klra10
Name: killer cell lectin-like receptor subfamily A, member 10
Synonyms: Ly49J, Ly49i2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16628
Homologene: 110821
Nmur2
Name: neuromedin U receptor 2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216749
Homologene: 49618
Cnnm1
Name: cyclin M1
Synonyms: Acdp1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 83674
VEGA: 19
HGNC: HGNC:102
Homologene: 10673
Maip1
Name: matrix AAA peptidase interacting protein 1
Synonyms: 9430016H08Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 68115
Homologene: 11565
Tmem117
Name: transmembrane protein 117
Synonyms: B930062P21Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 320709
VEGA: 15
Homologene: 12992
Ptgs1
Name: prostaglandin-endoperoxide synthase 1
Synonyms: COX1, Cox-1, cyclooxygenase 1, Cox-3, Pghs1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19224
HGNC: HGNC:9604
Homologene: 743
Or4c58
Name: olfactory receptor family 4 subfamily C member 58
Synonyms: GA_x6K02T2Q125-51285881-51284976, IC3, MOR232-5, Olfr48
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18347
Homologene: 85936
Or2ag1
Name: olfactory receptor family 2 subfamily AG member 1
Synonyms: MOR283-2, GA_x6K02T2PBJ9-9256348-9255398, Olfr705
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259034
Homologene: 128075
Mtcl3
Name: MTCL family member 3
Synonyms: 6330407J23Rik, Soga3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 67412
VEGA: 10
Homologene: 28227
Gpd1l
Name: glycerol-3-phosphate dehydrogenase 1-like
Synonyms: D9Ertd660e, 2210409H23Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 333433
Homologene: 56097
Pcyox1
Name: prenylcysteine oxidase 1
Synonyms: 1200015P13Rik, PCL1, Pcly
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 66881
Homologene: 9458
Ccdc28b
Name: coiled coil domain containing 28B
Synonyms: 1810010N17Rik, 1110002E08Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 66264
Homologene: 11509
Ppl
Name: periplakin
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 19041
VEGA: 16
HGNC: HGNC:9273
Homologene: 2026
Vgll4
Name: vestigial like family member 4
Synonyms: VGL-4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232334
Homologene: 18603
Trpv6
Name: transient receptor potential cation channel, subfamily V, member 6
Synonyms: CAT, Ecac2, Cac, CaT1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 64177
Homologene: 56812
Pdxk
Name: pyridoxal (pyridoxine, vitamin B6) kinase
Synonyms: 2310036D04Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216134
HGNC: HGNC:8819
Homologene: 2731
Prkra
Name: protein kinase, interferon inducible double stranded RNA dependent activator
Synonyms: PRK, RAX, lear, Pact
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 23992
HGNC: HGNC:9438
Homologene: 2738
1700034E13Rik
Name: RIKEN cDNA 1700034E13 gene
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 78414
Homologene: 19041
Dnajc30
Name: DnaJ heat shock protein family (Hsp40) member C30
Synonyms: Wbscr18, 1300007M11Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 66114
Homologene: 36428
Tmem72
Name: transmembrane protein 72
Synonyms: C230095G01Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 319776
Homologene: 18704
Stk16
Name: serine/threonine kinase 16
Synonyms: Embryo-Derived Protein Kinase, EDPK, Krct, PKL12
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20872
Homologene: 2739
Smok3c
Name: sperm motility kinase 3C
Synonyms: EG622486
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 622486
Homologene: 128738
Trav14-2
Name: T cell receptor alpha variable 14-2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 667567
Ascl4
Name: achaete-scute family bHLH transcription factor 4
Synonyms: bHLHa44, 1700054F16Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 67341
Homologene: 19806
Smok2a
Name: sperm motility kinase 2A
Synonyms: Smok2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 27263
Homologene: 128738
Ap4s1
Name: adaptor-related protein complex AP-4, sigma 1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 11782
VEGA: 12
HGNC: HGNC:575
Homologene: 32513
Or6c5b
Name: olfactory receptor family 6 subfamily C member 5B
Synonyms: GA_x6K02T2PULF-11089673-11090600, EG546488, Olfr785-ps1, MOR111-14_i, Gm44444, Olfr785, MOR111-8P
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 546488
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 7,120,420 bp
  • T to C, chromosome 1 at 57,407,031 bp
  • T to C, chromosome 1 at 75,213,652 bp
  • A to G, chromosome 1 at 131,097,519 bp
  • A to G, chromosome 1 at 181,055,012 bp
  • C to A, chromosome 2 at 36,245,210 bp
  • T to C, chromosome 2 at 76,633,598 bp
  • T to A, chromosome 2 at 89,844,272 bp
  • A to G, chromosome 3 at 28,663,909 bp
  • T to A, chromosome 3 at 82,864,210 bp
  • G to A, chromosome 3 at 84,595,164 bp
  • A to T, chromosome 3 at 114,193,929 bp
  • T to A, chromosome 4 at 46,149,914 bp
  • A to T, chromosome 4 at 58,094,122 bp
  • G to A, chromosome 4 at 119,188,710 bp
  • A to G, chromosome 4 at 129,622,607 bp
  • C to T, chromosome 4 at 151,144,291 bp
  • T to A, chromosome 5 at 63,898,619 bp
  • T to C, chromosome 5 at 135,064,378 bp
  • T to A, chromosome 5 at 138,064,495 bp
  • T to A, chromosome 6 at 41,621,342 bp
  • T to C, chromosome 6 at 86,391,679 bp
  • C to T, chromosome 6 at 114,862,196 bp
  • A to G, chromosome 6 at 116,698,330 bp
  • T to C, chromosome 6 at 130,275,856 bp
  • C to A, chromosome 6 at 142,259,008 bp
  • A to T, chromosome 6 at 142,358,501 bp
  • T to A, chromosome 6 at 145,429,967 bp
  • T to C, chromosome 6 at 148,789,817 bp
  • G to A, chromosome 7 at 28,406,456 bp
  • A to G, chromosome 7 at 106,873,342 bp
  • C to T, chromosome 7 at 108,934,658 bp
  • A to G, chromosome 8 at 16,158,254 bp
  • A to T, chromosome 8 at 31,118,500 bp
  • A to T, chromosome 8 at 88,361,708 bp
  • G to A, chromosome 9 at 21,686,247 bp
  • A to G, chromosome 9 at 81,890,239 bp
  • C to T, chromosome 9 at 114,920,674 bp
  • T to C, chromosome 10 at 29,197,003 bp
  • A to G, chromosome 10 at 69,992,124 bp
  • T to C, chromosome 10 at 78,447,967 bp
  • C to T, chromosome 10 at 85,928,500 bp
  • A to T, chromosome 10 at 107,590,959 bp
  • A to T, chromosome 10 at 129,409,885 bp
  • A to G, chromosome 11 at 56,032,940 bp
  • T to G, chromosome 12 at 31,919,672 bp
  • T to C, chromosome 12 at 51,738,641 bp
  • A to G, chromosome 12 at 116,419,268 bp
  • A to G, chromosome 12 at 117,755,969 bp
  • G to T, chromosome 13 at 12,431,038 bp
  • A to G, chromosome 13 at 58,846,762 bp
  • T to C, chromosome 13 at 70,596,167 bp
  • A to C, chromosome 13 at 100,161,782 bp
  • A to G, chromosome 14 at 29,058,618 bp
  • C to T, chromosome 14 at 33,070,618 bp
  • A to G, chromosome 14 at 53,641,058 bp
  • T to C, chromosome 15 at 94,714,918 bp
  • G to T, chromosome 15 at 98,670,669 bp
  • T to C, chromosome 16 at 5,089,068 bp
  • T to A, chromosome 16 at 25,985,065 bp
  • G to A, chromosome 17 at 13,226,639 bp
  • A to G, chromosome 17 at 56,062,170 bp
  • G to A, chromosome 17 at 56,882,973 bp
  • T to A, chromosome 18 at 52,660,481 bp
  • T to G, chromosome 19 at 11,302,972 bp
  • G to A, chromosome 19 at 43,440,821 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7445 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045521-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.