Strain Name:
C57BL/6J-MtgxR7510Btlr/Mmmh
Stock Number:
045583-MU
Citation ID:
RRID:MMRRC_045583-MU
Other Names:
R7510 (G1)
Major Collection:

Strain Information

Sptbn4
Name: spectrin beta, non-erythrocytic 4
Synonyms: Spnb4, dyn, 5830426A08Rik, 1700022P15Rik, nmf261, SpbIV, ROSA62, neuroaxonal dystrophy
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 80297
Homologene: 11879
Prkca
Name: protein kinase C, alpha
Synonyms: Pkca
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18750
HGNC: HGNC:9393
Homologene: 55679
Prdm5
Name: PR domain containing 5
Synonyms: E130112L17Rik, PFM2, 4432417F03Rik, 6530401I24Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 70779
HGNC: HGNC:9349
Homologene: 10274
Uaca
Name: uveal autoantigen with coiled-coil domains and ankyrin repeats
Synonyms: 2700059D02Rik, nucling
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 72565
VEGA: 9
Homologene: 74297
Larp4
Name: La ribonucleoprotein 4
Synonyms: D330037H05Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 207214
VEGA: 15
Homologene: 19173
Sap130
Name: Sin3A associated protein
Synonyms: 2610304F09Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 269003
VEGA: 18
Homologene: 11577
Rps6ka5
Name: ribosomal protein S6 kinase, polypeptide 5
Synonyms: MSK1, 6330404E13Rik, 3110005L17Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 73086
VEGA: 12
Homologene: 48302
Nrf1
Name: nuclear respiratory factor 1
Synonyms: D6Ertd415e
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 18181
HGNC: HGNC:7996
Homologene: 3674
Slc12a3
Name: solute carrier family 12, member 3
Synonyms: TSC, NCC
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 20497
Homologene: 287
Zfp160
Name: zinc finger protein 160
Synonyms: 6720480D16Rik, 6720480D16Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224585
VEGA: 17
Homologene: 137372
Gm14403
Name: predicted gene 14403
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 433520
Brms1l
Name: breast cancer metastasis-suppressor 1-like
Synonyms: 0710008O11Rik, BRMS1, D12Ertd407e
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 52592
VEGA: 12
Homologene: 9123
Furin
Name: furin, paired basic amino acid cleaving enzyme
Synonyms: PACE, Fur, 9130404I01Rik, Pcsk3, SPC1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18550
HGNC: HGNC:8568
Homologene: 1930
Atp2b1
Name: ATPase, Ca++ transporting, plasma membrane 1
Synonyms: PMCA1, 2810442I22Rik, E130111D10Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 67972
VEGA: 10
HGNC: HGNC:814
Homologene: 55597
Ghsr
Name: growth hormone secretagogue receptor
Synonyms: Ghsr1a, C530020I22Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 208188
HGNC: HGNC:4267
Homologene: 57161
Rfwd3
Name: ring finger and WD repeat domain 3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234736
Homologene: 41230
Numbl
Name: numb-like
Synonyms: nbl
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18223
HGNC: HGNC:8061
Homologene: 68413
Brca2
Name: breast cancer 2, early onset
Synonyms: RAB163, Fancd1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12190
HGNC: HGNC:1101
Homologene: 41
Sec61a1
Name: SEC61 translocon subunit alpha 1
Synonyms: Sec61a
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 53421
Homologene: 55537
Hexim1
Name: hexamethylene bis-acetamide inducible 1
Synonyms: CLP-1, Clp1, 7330426E13Rik, HIS1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 192231
Homologene: 31382
Scfd2
Name: Sec1 family domain containing 2
Synonyms: STXBP1L1, E430013M20Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 212986
Homologene: 77411
Ppp1r13l
Name: protein phosphatase 1, regulatory subunit 13 like
Synonyms: IASPP, wa3, NFkB interacting protein 1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 333654
Homologene: 84635
Papln
Name: papilin, proteoglycan-like sulfated glycoprotein
Synonyms: E030033C16Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 170721
Homologene: 71541
Itpr3
Name: inositol 1,4,5-triphosphate receptor 3
Synonyms: Ip3r3, Itpr-3, tf
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 16440
HGNC: HGNC:6182
Homologene: 1675
Fastkd2
Name: FAST kinase domains 2
Synonyms: 2810421I24Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 75619
Homologene: 8957
Kidins220
Name: kinase D-interacting substrate 220
Synonyms: 3110039L19Rik, C330002I19Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 77480
VEGA: 12
Homologene: 14254
Catsper1
Name: cation channel, sperm associated 1
Synonyms: KSper
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 225865
VEGA: 19
Homologene: 14207
Mlxipl
Name: MLX interacting protein-like
Synonyms: WS-bHLH, bHLHd14, Wbscr14, ChREBP
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 58805
Homologene: 32507
Ltbp1
Name: latent transforming growth factor beta binding protein 1
Synonyms: 9430031G15Rik, LTBP-1, b2b1000Clo, Ltbp1L
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 268977
HGNC: HGNC:6714
Homologene: 522
Madd
Name: MAP-kinase activating death domain
Synonyms: Rab3 GEP, 9630059K23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228355
HGNC: HGNC:6766
Homologene: 14249
Vmn2r1
Name: vomeronasal 2, receptor 1
Synonyms: EG56544, V2r83
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 56544
Homologene: 84832
Samd3
Name: sterile alpha motif domain containing 3
Synonyms: LOC268288
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 268288
VEGA: 10
Homologene: 67991
Mmab
Name: methylmalonic aciduria (cobalamin deficiency) cblB type homolog (human)
Synonyms: 9130222L19Rik, ATP:Cob(I)alamin Adenosyltransferase
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 77697
Homologene: 12680
Mmp1a
Name: matrix metallopeptidase 1a (interstitial collagenase)
Synonyms: Mcol-A
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 83995
VEGA: 9
HGNC: HGNC:7155
Homologene: 20544
Prickle2
Name: prickle planar cell polarity protein 2
Synonyms: 6720451F06Rik, 6230400G14Rik, Pk2, mpk2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243548
Homologene: 17889
Pcdhb14
Name: protocadherin beta 14
Synonyms: Pcdhb17, 2210006M07Rik, PcdhbN
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93885
Homologene: 70876
Serpinb9
Name: serine (or cysteine) peptidase inhibitor, clade B, member 9
Synonyms: PI-9, Spi6, ovalbumin
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20723
HGNC: HGNC:8955
Homologene: 37888
Synj1
Name: synaptojanin 1
Synonyms: A930006D20Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 104015
Homologene: 48252
Or13c7
Name: olfactory receptor family 13 subfamily C member 7
Synonyms: mOR37a, GA_x6K02T2N78B-16092200-16091241, Olfr155, Olfr37a, OR37A, MOR262-14
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 29845
Homologene: 84331
Pde7b
Name: phosphodiesterase 7B
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 29863
HGNC: HGNC:8792
Homologene: 32194
Dsc2
Name: desmocollin 2
Synonyms: Dsc2a, Dsc2b
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13506
HGNC: HGNC:3036
Homologene: 8397
Plin5
Name: perilipin 5
Synonyms: MLDP, 2310076L09Rik, Lsdp5
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 66968
Homologene: 41654
Prss3
Name: serine protease 3
Synonyms: MTG, Try3, Tb, TRY4, mesotrypsin
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 22073
Homologene: 88408
Txk
Name: TXK tyrosine kinase
Synonyms: A130089B16Rik, PTK4, Btkl, Rlk
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22165
Homologene: 2497
Or5v1b
Name: olfactory receptor family 5 subfamily V member 1B
Synonyms: GA_x6K02T2PSCP-1989071-1990024, MOR249-1P, Olfr111
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 545205
Homologene: 73968
Bend4
Name: BEN domain containing 4
Synonyms: EG666938, D330027G24Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 666938
Homologene: 52626
Saa2
Name: serum amyloid A 2
Synonyms: Saa-2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20209
Homologene: 128033
Prss51
Name: serine protease 51
Synonyms: 1700007N14Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 100504162
Homologene: 131540
Or5bw2
Name: olfactory receptor family 5 subfamily BW member 2
Synonyms: Olfr1350, MOR222-3, GA_x6K02T2QGBW-3300391-3301317
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258384
Fancf
Name: Fanconi anemia, complementation group F
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100040608
HGNC: HGNC:3587
Homologene: 75185
Hspa14
Name: heat shock protein 14
Synonyms: NST-1, HSP70L1, 70kDa, Hsp70-4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 50497
Homologene: 74307
Il18r1
Name: interleukin 18 receptor 1
Synonyms: Il18ralpha, Il1rrp
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16182
HGNC: HGNC:5988
Homologene: 2861
Tssc4
Name: tumor-suppressing subchromosomal transferable fragment 4
Synonyms: ESTM671070
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 56844
Homologene: 4169
Ccdc177
Name: coiled-coil domain containing 177
Synonyms: LOC380768, Gm1568
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 380768
VEGA: 12
Homologene: 128326
Disp1
Name: dispatched RND transporter family member 1
Synonyms: DispA, 1190008H24Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 68897
Homologene: 14133
Or12e13
Name: olfactory receptor family 12 subfamily E member 13
Synonyms: GA_x6K02T2Q125-49334566-49335510, MOR264-7, Olfr1148
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258220
Homologene: 79465
Or9g8
Name: olfactory receptor family 9 subfamily G member 8
Synonyms: MOR213-5, Olfr1014, GA_x6K02T2Q125-47255337-47256254
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258562
Homologene: 83447
Mlana
Name: melan-A
Synonyms: Mart1, A930034P04Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 77836
VEGA: 19
HGNC: HGNC:7124
Homologene: 4026
Tfec
Name: transcription factor EC
Synonyms: TFEC, Tcfec, bHLHe34
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 21426
Homologene: 32148
Or6c3b
Name: olfactory receptor family 6 subfamily C member 3B
Synonyms: Olfr803, GA_x6K02T2PULF-11370664-11369738, MOR111-3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258547
Homologene: 105153
Tigd5
Name: tigger transposable element derived 5
Synonyms: FLJ14926
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 105734
Homologene: 129878
Gpr31b
Name: G protein-coupled receptor 31, D17Leh66b region
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 436440
VEGA: 17
HGNC: HGNC:4486
Homologene: 48337
D030056L22Rik
Name: RIKEN cDNA D030056L22 gene
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 225995
VEGA: 19
Homologene: 49520
Rpl36a-ps1
Name: ribosomal protein L36A, pseudogene 1
Synonyms: Gm10077
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 100043787
VEGA: 14
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 40,474,875 bp
  • T to A, chromosome 1 at 63,737,789 bp
  • T to C, chromosome 1 at 183,088,411 bp
  • T to C, chromosome 2 at 3,498,122 bp
  • T to A, chromosome 2 at 85,776,809 bp
  • T to A, chromosome 2 at 87,833,528 bp
  • T to C, chromosome 2 at 91,177,976 bp
  • T to A, chromosome 2 at 177,508,610 bp
  • A to T, chromosome 3 at 27,372,374 bp
  • A to C, chromosome 3 at 64,086,501 bp
  • A to G, chromosome 4 at 43,854,482 bp
  • A to G, chromosome 5 at 67,427,384 bp
  • C to G, chromosome 5 at 72,736,383 bp
  • A to G, chromosome 5 at 74,212,327 bp
  • A to T, chromosome 5 at 114,435,222 bp
  • A to G, chromosome 5 at 135,133,118 bp
  • T to C, chromosome 5 at 150,536,691 bp
  • T to A, chromosome 6 at 16,835,233 bp
  • C to T, chromosome 6 at 30,151,634 bp
  • A to T, chromosome 6 at 41,375,110 bp
  • C to T, chromosome 6 at 65,927,992 bp
  • A to T, chromosome 6 at 88,512,603 bp
  • T to C, chromosome 6 at 92,376,470 bp
  • C to T, chromosome 7 at 6,569,961 bp
  • A to C, chromosome 7 at 19,368,801 bp
  • A to G, chromosome 7 at 27,271,987 bp
  • A to G, chromosome 7 at 27,428,268 bp
  • T to A, chromosome 7 at 46,753,509 bp
  • A to G, chromosome 7 at 51,862,205 bp
  • A to G, chromosome 7 at 80,393,585 bp
  • G to A, chromosome 7 at 143,069,981 bp
  • G to T, chromosome 8 at 94,365,849 bp
  • A to G, chromosome 8 at 111,280,027 bp
  • TG to TGG, chromosome 9 at 7,465,083 bp
  • G to A, chromosome 9 at 60,850,205 bp
  • T to C, chromosome 10 at 20,413,015 bp
  • A to T, chromosome 10 at 26,230,108 bp
  • C to T, chromosome 10 at 98,993,896 bp
  • G to T, chromosome 10 at 129,691,920 bp
  • A to G, chromosome 11 at 103,117,241 bp
  • A to T, chromosome 11 at 107,983,994 bp
  • T to A, chromosome 12 at 24,992,269 bp
  • A to T, chromosome 12 at 55,845,322 bp
  • C to A, chromosome 12 at 80,757,683 bp
  • G to A, chromosome 12 at 83,772,173 bp
  • T to C, chromosome 12 at 100,616,068 bp
  • T to A, chromosome 13 at 33,010,785 bp
  • G to A, chromosome 14 at 64,096,040 bp
  • G to A, chromosome 14 at 98,994,230 bp
  • T to C, chromosome 15 at 75,910,419 bp
  • T to C, chromosome 15 at 99,993,377 bp
  • A to G, chromosome 16 at 90,938,677 bp
  • A to G, chromosome 17 at 13,051,670 bp
  • G to A, chromosome 17 at 21,026,393 bp
  • A to G, chromosome 17 at 27,089,039 bp
  • T to A, chromosome 17 at 37,530,589 bp
  • T to A, chromosome 17 at 56,113,975 bp
  • T to A, chromosome 17 at 75,352,717 bp
  • C to T, chromosome 18 at 20,032,274 bp
  • C to T, chromosome 18 at 31,667,004 bp
  • A to G, chromosome 18 at 31,711,215 bp
  • T to C, chromosome 18 at 37,449,592 bp
  • A to T, chromosome 19 at 5,339,550 bp
  • G to T, chromosome 19 at 18,713,489 bp
  • G to A, chromosome 19 at 29,704,672 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7510 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045583-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.