Strain Name:
C57BL/6J-MtgxR7533Btlr/Mmmh
Stock Number:
045605-MU
Citation ID:
RRID:MMRRC_045605-MU
Other Names:
R7533 (G1)
Major Collection:

Strain Information

Kif3c
Name: kinesin family member 3C
Synonyms: N-4 kinesin
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 16570
VEGA: 12
HGNC: HGNC:6321
Homologene: 55640
Tnrc6b
Name: trinucleotide repeat containing 6b
Synonyms: A730065C02Rik, D230019K20Rik, 2700090M07Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 213988
VEGA: 15
Homologene: 66194
Cck
Name: cholecystokinin
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12424
VEGA: 9
HGNC: HGNC:1569
Homologene: 583
P4htm
Name: prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
Synonyms: P4h-tm, 4933406E20Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74443
Homologene: 41765
Wdfy3
Name: WD repeat and FYVE domain containing 3
Synonyms: D5Ertd66e, Bwf1, 2610509D04Rik, Bchs, Ggtb3, Alfy
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 72145
Homologene: 22855
Fcho2
Name: FCH domain only 2
Synonyms: 5832424M12Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218503
VEGA: 13
Homologene: 9030
Pi4ka
Name: phosphatidylinositol 4-kinase alpha
Synonyms: Pik4ca
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224020
HGNC: HGNC:8983
Homologene: 11171
Rad50
Name: RAD50 double strand break repair protein
Synonyms: Mrell, Rad50l
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19360
HGNC: HGNC:9816
Homologene: 38092
Ecpas
Name: Ecm29 proteasome adaptor and scaffold
Synonyms: AI314180
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230249
Homologene: 6056
Il7r
Name: interleukin 7 receptor
Synonyms: CD127, IL-7Ralpha, IL-7 receptor alpha chain
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 16197
VEGA: 15
HGNC: HGNC:6024
Homologene: 1646
Epha6
Name: Eph receptor A6
Synonyms: m-ehk2, Hek12, Ehk2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 13840
Homologene: 56396
Dctn2
Name: dynactin 2
Synonyms: C130077D06Rik, DCTN-50, p50, 2310042E05Rik, RBP50
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 69654
VEGA: 10
HGNC: HGNC:2712
Homologene: 4667
Ube3d
Name: ubiquitin protein ligase E3D
Synonyms: 2610018I03Rik, Ube2cbp
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 70348
Homologene: 18898
Ptgr1
Name: prostaglandin reductase 1
Synonyms: Zadh3, 2510002C21Rik, Ltb4dh
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67103
Homologene: 40820
Cfap74
Name: cilia and flagella associated protein 74
Synonyms: 2010015L04Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 544678
Homologene: 129584
Neb
Name: nebulin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17996
HGNC: HGNC:7720
Homologene: 136285
Fat4
Name: FAT atypical cadherin 4
Synonyms: 6030410K14Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 329628
Homologene: 14377
Neu4
Name: sialidase 4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 241159
Homologene: 15433
Ccser1
Name: coiled-coil serine rich 1
Synonyms: Fam190a, C130092O11Rik, 6230405M12Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232035
Homologene: 28086
Serpina1c
Name: serine (or cysteine) peptidase inhibitor, clade A, member 1C
Synonyms: PI6, PI3, Spi1-6, Spi1-3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20702
HGNC: HGNC:8941
Homologene: 20103
Padi6
Name: peptidyl arginine deiminase, type VI
Synonyms: Padi5, ePAD, Pad6
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242726
Homologene: 17695
Alpk2
Name: alpha-kinase 2
Synonyms: Hak
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225638
Homologene: 50475
Usp13
Name: ubiquitin specific peptidase 13 (isopeptidase T-3)
Synonyms: 2700071E21Rik, IsoT-3, ISOT3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 72607
Homologene: 68372
Igsf11
Name: immunoglobulin superfamily, member 11
Synonyms: BT-IgSF, 1700025L02Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 207683
Homologene: 17613
Vmn1r173
Name: vomeronasal 1 receptor 173
Synonyms: Gm5892
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 545934
Homologene: 79577
Itga3
Name: integrin alpha 3
Synonyms: VLA-3 alpha 3, alpha3-integrin
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16400
HGNC: HGNC:6139
Homologene: 21129
Atp8b2
Name: ATPase, class I, type 8B, member 2
Synonyms: Id
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 54667
Homologene: 23226
Zfp112
Name: zinc finger protein 112
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 57745
Homologene: 49338
Hace1
Name: HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1
Synonyms: A730034A22Rik, 1700042J16Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 209462
Homologene: 10807
Commd5
Name: COMM domain containing 5
Synonyms: 2310065H03Rik, D15Ertd81e, Hcarg
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 66398
Homologene: 8548
Sgsh
Name: N-sulfoglucosamine sulfohydrolase (sulfamidase)
Synonyms: 4632406A19Rik, sulphamidase
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 27029
Homologene: 167
Zfp61
Name: zinc finger protein 61
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22719
Homologene: 74923
Or52b3
Name: olfactory receptor family 52 subfamily B member 3
Synonyms: MOR31-3, GA_x6K02T2PBJ9-5274337-5275287, Olfr549
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259105
Homologene: 86245
Vmn2r29
Name: vomeronasal 2, receptor 29
Synonyms: 6430701C03Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 76229
Homologene: 113703
Agr2
Name: anterior gradient 2
Synonyms: Gob-4, HAG-2, XAG-2, mAG-2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 23795
HGNC: HGNC:328
Homologene: 4674
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 94,022,400 bp
  • G to A, chromosome 2 at 52,224,566 bp
  • A to G, chromosome 3 at 32,918,942 bp
  • A to C, chromosome 3 at 39,007,257 bp
  • G to A, chromosome 3 at 89,945,524 bp
  • T to C, chromosome 4 at 58,809,411 bp
  • C to T, chromosome 4 at 58,971,011 bp
  • T to C, chromosome 4 at 140,731,195 bp
  • C to A, chromosome 4 at 155,415,743 bp
  • G to A, chromosome 5 at 101,882,488 bp
  • A to T, chromosome 6 at 61,638,490 bp
  • G to T, chromosome 7 at 7,241,657 bp
  • C to T, chromosome 7 at 23,702,646 bp
  • A to T, chromosome 7 at 24,125,327 bp
  • T to C, chromosome 7 at 24,291,079 bp
  • T to C, chromosome 7 at 102,554,511 bp
  • A to G, chromosome 9 at 86,422,937 bp
  • T to C, chromosome 9 at 108,596,937 bp
  • T to C, chromosome 9 at 121,490,135 bp
  • A to T, chromosome 10 at 45,711,474 bp
  • A to G, chromosome 10 at 127,267,478 bp
  • T to C, chromosome 11 at 53,698,919 bp
  • G to T, chromosome 11 at 95,046,518 bp
  • T to C, chromosome 11 at 119,347,870 bp
  • T to A, chromosome 12 at 3,366,510 bp
  • T to C, chromosome 12 at 35,996,129 bp
  • T to A, chromosome 12 at 103,897,307 bp
  • G to T, chromosome 13 at 98,784,799 bp
  • G to A, chromosome 15 at 9,507,961 bp
  • G to A, chromosome 15 at 76,900,576 bp
  • T to C, chromosome 15 at 80,927,741 bp
  • T to C, chromosome 16 at 17,297,661 bp
  • T to G, chromosome 16 at 39,008,874 bp
  • T to C, chromosome 16 at 60,205,562 bp
  • A to T, chromosome 18 at 65,304,603 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7533 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045605-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.