Strain Name:
C57BL/6J-MtgxR7600Btlr/Mmmh
Stock Number:
045642-MU
Citation ID:
RRID:MMRRC_045642-MU
Other Names:
R7600 (G1)
Major Collection:

Strain Information

Cnnm2
Name: cyclin M2
Synonyms: Acdp2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 94219
VEGA: 19
HGNC: HGNC:103
Homologene: 9761
Ptch2
Name: patched 2
Synonyms: ptc2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 19207
HGNC: HGNC:9586
Homologene: 37842
Dst
Name: dystonin
Synonyms: Macf2, A830042E19Rik, Bpag1, Bpag, bullous pemphigoid antigen 1, nmf203, athetoid, nmf339, BPAG1, BPAG1-n, 2310001O04Rik, bullous pemphigoid antigen 1, ah
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Pdzd2
Name: PDZ domain containing 2
Synonyms: LOC223364, 4930537L06Rik, Pdzk3, A930022H17Rik, Gm21706
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 68070
Homologene: 23393
Tubgcp5
Name: tubulin, gamma complex component 5
Synonyms: GCP5, B130010C12Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233276
Homologene: 14172
Nol10
Name: nucleolar protein 10
Synonyms: LOC217431
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217431
VEGA: 12
Homologene: 5998
Aldh4a1
Name: aldehyde dehydrogenase 4 family, member A1
Synonyms: Ahd1, P5CDH, A930035F14Rik, Ahd-1, ALDH4, Ssdh1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 212647
HGNC: HGNC:406
Homologene: 6081
Zfp318
Name: zinc finger protein 318
Synonyms: TZF, 2610034E08Rik, D530032D06Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 57908
Homologene: 22808
Mllt3
Name: myeloid/lymphoid or mixed-lineage leukemia; translocated to, 3
Synonyms: 2610012I03Rik, 2210011H10Rik, 3830408D16Rik, D4Ertd321e, Af9
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 70122
HGNC: HGNC:7136
Homologene: 37933
Dsp
Name: desmoplakin
Synonyms: 5730453H04Rik, DP, rul, 2300002E22Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 109620
HGNC: HGNC:3052
Homologene: 37922
Cldn1
Name: claudin 1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 12737
HGNC: HGNC:2032
Homologene: 9620
Clec12b
Name: C-type lectin domain family 12, member B
Synonyms: 4933425B16Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 71183
Homologene: 19247
Lrp10
Name: low-density lipoprotein receptor-related protein 10
Synonyms: Lrp9
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 65107
VEGA: 14
Homologene: 8535
Olfm3
Name: olfactomedin 3
Synonyms: optimedin, B230206G02Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229759
Homologene: 17103
Zfp142
Name: zinc finger protein 142
Synonyms: 9330177B18Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 77264
Homologene: 3723
Trpm2
Name: transient receptor potential cation channel, subfamily M, member 2
Synonyms: TRPC7, Trrp7, 9830168K16Rik, LTRPC2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 28240
Homologene: 20709
Lrp1
Name: low density lipoprotein receptor-related protein 1
Synonyms: b2b1554Clo, A2mr, CD91
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16971
HGNC: HGNC:6692
Homologene: 1744
Trpm3
Name: transient receptor potential cation channel, subfamily M, member 3
Synonyms: MLSN2, melastatin 2, 6330504P12Rik, LTRPC3, B930001P07Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226025
VEGA: 19
Homologene: 62287
Zfp608
Name: zinc finger protein 608
Synonyms: 4932417D18Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 269023
VEGA: 18
Homologene: 18485
Nlrp1a
Name: NLR family, pyrin domain containing 1A
Synonyms: Nalp1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 195046
Homologene: 133820
Snrpn
Name: small nuclear ribonucleoprotein N
Synonyms: Peg4, 2410045I01Rik, Pwcr1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20646
Homologene: 68297
Fras1
Name: Fraser extracellular matrix complex subunit 1
Synonyms: E130113P14Rik, bl
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231470
Homologene: 23516
Catsperg2
Name: cation channel sperm associated auxiliary subunit gamma 2
Synonyms: 1700067C01Rik, CATSPERG
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 76718
Homologene: 10915
Ahnak
Name: AHNAK nucleoprotein
Synonyms: DY6, 1110004P15Rik, 2310047C17Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 66395
VEGA: 19
HGNC: HGNC:347
Homologene: 67425
Adam25
Name: ADAM metallopeptidase domain 25
Synonyms: testase 2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 23793
HGNC: HGNC:199
Homologene: 128364
Col6a4
Name: collagen, type VI, alpha 4
Synonyms: Dvwa, EG235580, Vwa6, 1110001D15Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 68553
Homologene: 130754
Zcwpw1
Name: zinc finger, CW type with PWWP domain 1
Synonyms: LOC381678
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 381678
Homologene: 9944
Sntb1
Name: syntrophin, basic 1
Synonyms: 59-1 DAP, beta1-Syntrophin
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 20649
Homologene: 9618
Sytl2
Name: synaptotagmin-like 2
Synonyms: Slp2-d, Slp2, Slp2-a, Slp2-b, Slp2-c
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 83671
Homologene: 131343
Atxn1
Name: ataxin 1
Synonyms: 2900016G23Rik, Sca1, Atx1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20238
VEGA: 13
Homologene: 281
Ttc24
Name: tetratricopeptide repeat domain 24
Synonyms: A430025D11Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 214191
Homologene: 82282
Myo18b
Name: myosin XVIIIb
Synonyms: 4932408L24Rik, 4933411E19Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 74376
Homologene: 53435
Epb42
Name: erythrocyte membrane protein band 4.2
Synonyms: Epb4.2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 13828
HGNC: HGNC:3381
Homologene: 93
Tas2r129
Name: taste receptor, type 2, member 129
Synonyms: T2R29, mGR29, mt2r60, Tas2r29
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 387354
Homologene: 130074
Tle2
Name: transducin-like enhancer of split 2
Synonyms: Grg2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 21886
Homologene: 20693
Sp110
Name: Sp110 nuclear body protein
Synonyms: 5830484A20Rik, Ifi75, 5031415C07Rik, 52kDa, Ipr1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 109032
HGNC: HGNC:5401
Homologene: 82192
Vmn1r17
Name: vomeronasal 1 receptor 17
Synonyms: V1rc16
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 171189
Homologene: 115643
Prl7a2
Name: prolactin family 7, subfamily a, member 2
Synonyms: PLP-F, Prlpf
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 19114
Homologene: 49263
Kbtbd8
Name: kelch repeat and BTB (POZ) domain containing 8
Synonyms: SSEC-51, SSEC51, SSEC 51, Takrp
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243574
Homologene: 13043
Vmn1r232
Name: vomeronasal 1 receptor 232
Synonyms: V1re4
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 171227
Homologene: 121611
Dnajc9
Name: DnaJ heat shock protein family (Hsp40) member C9
Synonyms: 5330419I01Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 108671
VEGA: 14
Homologene: 9055
Or2a57
Name: olfactory receptor family 2 subfamily A member 57
Synonyms: Olfr47, IB12, GA_x6K02T2P3E9-4322325-4321360, MOR261-9
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 18346
Homologene: 133700
Tcstv7a
Name: Tcstv family member 7A
Synonyms: clone L5, AF067063, clone L2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 380878
Or2t43
Name: olfactory receptor family 2 subfamily T member 43
Synonyms: Olfr327-ps1, GA_x6K02T00261-652-347, GA_x6K02T2NKPP-858022-858862, MOR275-10_p, Olfr224, MOR275-3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258198
Homologene: 133015
Igkv1-117
Name: immunoglobulin kappa variable 1-117
Synonyms: Gm16797
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16098
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 34,266,930 bp
  • A to G, chromosome 1 at 74,573,668 bp
  • G to A, chromosome 1 at 85,579,092 bp
  • A to G, chromosome 2 at 121,021,826 bp
  • A to T, chromosome 3 at 88,072,013 bp
  • T to C, chromosome 3 at 115,096,940 bp
  • G to T, chromosome 4 at 87,841,219 bp
  • A to T, chromosome 4 at 117,096,225 bp
  • A to G, chromosome 4 at 139,645,004 bp
  • T to C, chromosome 5 at 96,684,436 bp
  • G to A, chromosome 5 at 112,878,103 bp
  • A to T, chromosome 5 at 137,800,134 bp
  • C to A, chromosome 6 at 43,235,836 bp
  • T to C, chromosome 6 at 57,360,921 bp
  • T to A, chromosome 6 at 68,121,116 bp
  • T to A, chromosome 6 at 95,122,592 bp
  • A to G, chromosome 6 at 129,376,263 bp
  • G to T, chromosome 6 at 132,951,174 bp
  • A to T, chromosome 7 at 29,704,858 bp
  • A to G, chromosome 7 at 55,808,513 bp
  • A to G, chromosome 7 at 59,988,603 bp
  • T to C, chromosome 7 at 90,376,144 bp
  • G to A, chromosome 8 at 40,755,817 bp
  • T to G, chromosome 9 at 106,066,999 bp
  • T to C, chromosome 10 at 77,938,051 bp
  • T to G, chromosome 10 at 81,586,313 bp
  • C to T, chromosome 10 at 127,555,706 bp
  • T to C, chromosome 11 at 58,567,336 bp
  • C to A, chromosome 11 at 71,098,914 bp
  • T to G, chromosome 12 at 17,369,480 bp
  • T to G, chromosome 13 at 27,659,281 bp
  • C to A, chromosome 13 at 38,191,715 bp
  • T to G, chromosome 13 at 45,557,060 bp
  • A to T, chromosome 13 at 119,828,696 bp
  • A to G, chromosome 14 at 20,388,725 bp
  • G to T, chromosome 14 at 54,469,395 bp
  • G to T, chromosome 15 at 12,372,734 bp
  • A to T, chromosome 15 at 55,792,188 bp
  • T to C, chromosome 16 at 26,360,919 bp
  • A to T, chromosome 17 at 20,913,737 bp
  • C to T, chromosome 17 at 46,384,284 bp
  • T to C, chromosome 18 at 54,988,020 bp
  • A to T, chromosome 19 at 9,004,574 bp
  • A to G, chromosome 19 at 22,926,094 bp
  • A to T, chromosome 19 at 46,762,067 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7600 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045642-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.