Strain Name:
C57BL/6J-MtgxR7678Btlr/Mmmh
Stock Number:
045745-MU
Citation ID:
RRID:MMRRC_045745-MU
Other Names:
R7678 (G1)
Major Collection:

Strain Information

Hbegf
Name: heparin-binding EGF-like growth factor
Synonyms: Hegfl, Dtr, HB-EGF
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 15200
VEGA: 18
HGNC: HGNC:3059
Homologene: 1466
Lefty1
Name: left right determination factor 1
Synonyms: Stra3, Lefty, Ebaf, lefty-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13590
HGNC: HGNC:6552
Homologene: 49231
Ctbp2
Name: C-terminal binding protein 2
Synonyms: D7Ertd45e, Gtrgeo6, Ribeye
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13017
HGNC: HGNC:2495
Homologene: 75187
Cemip2
Name: cell migration inducing hyaluronidase 2
Synonyms: 3110012M15Rik, Tmem2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 83921
VEGA: 19
Homologene: 75008
E2f2
Name: E2F transcription factor 2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242705
HGNC: HGNC:3114
Homologene: 48264
Kpnb1
Name: karyopherin subunit beta 1
Synonyms: Impnb
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16211
HGNC: HGNC:6400
Homologene: 1707
Plxna1
Name: plexin A1
Synonyms: NOV, Plxn1, PlexA1, 2600013D04Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 18844
HGNC: HGNC:9099
Homologene: 56426
Faf1
Name: Fas-associated factor 1
Synonyms: Fam, Dffrx
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 14084
HGNC: HGNC:3578
Homologene: 5120
Ppfibp2
Name: PTPRF interacting protein, binding protein 2 (liprin beta 2)
Synonyms: Cclp1, liprin beta 2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 19024
HGNC: HGNC:9250
Homologene: 7486
Idh3a
Name: isocitrate dehydrogenase 3 (NAD+) alpha
Synonyms: 1500012E04Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 67834
VEGA: 9
HGNC: HGNC:5384
Homologene: 4037
Tfap4
Name: transcription factor AP4
Synonyms: D930048N17Rik, AP-4, Tcfap4, bHLHc41
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 83383
VEGA: 16
Homologene: 2424
Asxl1
Name: ASXL transcriptional regulator 1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228790
Homologene: 9098
Myo1d
Name: myosin ID
Synonyms: 9930104H07Rik, D11Ertd9e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 338367
HGNC: HGNC:7598
Homologene: 45576
Tcf20
Name: transcription factor 20
Synonyms: 2810438H08Rik, SPBP, stromelysin 1 PDGF responsive element binding protein
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 21411
VEGA: 15
Homologene: 4131
Glg1
Name: golgi apparatus protein 1
Synonyms: CFR, Selel, CFR-1, MG-160, MG160, ESL-1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 20340
HGNC: HGNC:4316
Homologene: 7533
Gcnt2
Name: glucosaminyl (N-acetyl) transferase 2 (I blood group)
Synonyms: IGnTC, 5330430K10Rik, IGnTA, IGnTB, IGnT
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 14538
VEGA: 13
HGNC: HGNC:4204
Homologene: 41535
Scfd2
Name: Sec1 family domain containing 2
Synonyms: STXBP1L1, E430013M20Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 212986
Homologene: 77411
Nbeal1
Name: neurobeachin like 1
Synonyms: A530050O19Rik, 2310076G13Rik, ALS2CR17, A530083I02Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 269198
Homologene: 16453
Smg5
Name: SMG5 nonsense mediated mRNA decay factor
Synonyms: Smg-5 homolog, nonsense mediated mRNA decay factor (C. elegans)
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229512
Homologene: 9095
Bpifb1
Name: BPI fold containing family B, member 1
Synonyms: U46068, von Ebner minor salivary protein, LPlunc1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228801
Homologene: 50047
Nbas
Name: neuroblastoma amplified sequence
Synonyms: 4933425L03Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 71169
VEGA: 12
Homologene: 41073
Ank1
Name: ankyrin 1, erythroid
Synonyms: pale, Ank-1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11733
HGNC: HGNC:492
Homologene: 55427
Tbkbp1
Name: TBK1 binding protein 1
Synonyms: 3110043L15Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 73174
Homologene: 8820
Med12l
Name: mediator complex subunit 12-like
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 329650
Homologene: 43143
Lrp1
Name: low density lipoprotein receptor-related protein 1
Synonyms: b2b1554Clo, A2mr, CD91
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16971
HGNC: HGNC:6692
Homologene: 1744
Itpr2
Name: inositol 1,4,5-triphosphate receptor 2
Synonyms: Ip3r2, Itpr5
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16439
HGNC: HGNC:6181
Homologene: 37593
Fat2
Name: FAT atypical cadherin 2
Synonyms: EMI2, mKIAA0811, LOC245827, Fath2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 245827
HGNC: HGNC:3596
Homologene: 1110
Col12a1
Name: collagen, type XII, alpha 1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12816
HGNC: HGNC:2188
Homologene: 3217
Unc80
Name: unc-80, NALCN activator
Synonyms: C230061B10Rik, C030018G13Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329178
Homologene: 122243
Hipk1
Name: homeodomain interacting protein kinase 1
Synonyms: 1110062K04Rik, Myak
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 15257
Homologene: 56483
Neb
Name: nebulin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17996
HGNC: HGNC:7720
Homologene: 136285
Myh7b
Name: myosin, heavy chain 7B, cardiac muscle, beta
Synonyms: Myh14
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 668940
Homologene: 66117
Zan
Name: zonadhesin
Synonyms: Zan
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22635
Homologene: 124417
Oog4
Name: oogenesin 4
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242737
Elmo2
Name: engulfment and cell motility 2
Synonyms: 1190002F24Rik, CED-12
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 140579
Homologene: 44338
Vmn2r5
Name: vomeronasal 2, receptor 5
Synonyms: EG667060
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 667060
Igsf10
Name: immunoglobulin superfamily, member 10
Synonyms: Adlican2, CMF608, 6530405F15Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242050
Homologene: 18712
Clec2g
Name: C-type lectin domain family 2, member g
Synonyms: Ocilrp1, 4632413B12Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 70809
Homologene: 136309
Lrrc10
Name: leucine rich repeat containing 10
Synonyms: Hrlrrp, Serdin1, D330003I11Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237560
VEGA: 10
Homologene: 17154
Spata46
Name: spermatogenesis associated 46
Synonyms: 1700015E13Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 76925
Homologene: 18799
Vmn2r53
Name: vomeronasal 2, receptor 53
Synonyms: EG637908
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 637908
Homologene: 104040
Capn13
Name: calpain 13
Synonyms: LOC381122
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 381122
VEGA: 17
Homologene: 27026
Ppip5k1
Name: diphosphoinositol pentakisphosphate kinase 1
Synonyms: B430315C20Rik, Hisppd2a
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 327655
Homologene: 49395
Nsd3
Name: nuclear receptor binding SET domain protein 3
Synonyms: WHISTLE, Whsc1l1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234135
Homologene: 56960
Npbwr1
Name: neuropeptides B/W receptor 1
Synonyms: Gpr7
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226304
HGNC: HGNC:4522
Homologene: 21096
Adam22
Name: a disintegrin and metallopeptidase domain 22
Synonyms: MDC2, 2900022I03Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 11496
HGNC: HGNC:201
Homologene: 37898
Cttnbp2
Name: cortactin binding protein 2
Synonyms: ORF4, 4732477G22Rik, 3010022N24Rik, Cortbp2, 9130022E09Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 30785
Homologene: 14125
Foxc2
Name: forkhead box C2
Synonyms: MFH-1, Fkh14, Hfhbf3, Mfh1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 14234
HGNC: HGNC:3801
Homologene: 21091
Eno3
Name: enolase 3, beta muscle
Synonyms: Eno-3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 13808
HGNC: HGNC:3354
Homologene: 68215
Slc22a19
Name: solute carrier family 22 (organic anion transporter), member 19
Synonyms: Oat5, D630043A20Rik, Slc22a9
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 207151
Homologene: 133125
Vmn2r107
Name: vomeronasal 2, receptor 107
Synonyms: V2r6
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22312
Homologene: 129750
Zfp618
Name: zinc finger protein 618
Synonyms: 2810031P15Rik, D430033D05Rik, Nedd10, 2810040O04Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 72701
Homologene: 18975
Sry
Name: sex determining region of Chr Y
Synonyms: Tdf, Tdy
Type: Gene
Species: Mouse
Chromosome: Y
NCBI: 21674
Trmt10c
Name: tRNA methyltransferase 10C, mitochondrial RNase P subunit
Synonyms: Rg9mtd1, D16Ertd454e, 1300018J16Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 52575
Homologene: 9858
Ecm1
Name: extracellular matrix protein 1
Synonyms: p85
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 13601
HGNC: HGNC:3153
Homologene: 3260
Fam178b
Name: family with sequence similarity 178, member B
Synonyms: 1700024G10Rik, LOC381337
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 381337
Homologene: 87288
Inf2
Name: inverted formin, FH2 and WH2 domain containing
Synonyms: EG629699, 2610204M08Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 70435
VEGA: 12
Homologene: 82406
Mtmr6
Name: myotubularin related protein 6
Synonyms: Gm38641, 4022440C11Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219135
VEGA: 14
HGNC: HGNC:7453
Homologene: 55842
Or11g1
Name: olfactory receptor family 11 subfamily G member 1
Synonyms: Olfr738, GA_x6K02T2PMLR-6110726-6111661, MOR106-3
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 258662
Homologene: 74220
Zfp493
Name: zinc finger protein 493
Synonyms: 2900054J07Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 72958
Ptpn18
Name: protein tyrosine phosphatase, non-receptor type 18
Synonyms: PTP-HSCF, Ptpk1, HSCF, FLP1, PTP-K1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 19253
HGNC: HGNC:9649
Homologene: 74971
Or7d11
Name: olfactory receptor family 7 subfamily D member 11
Synonyms: GA_x6K02T2PVTD-13795933-13794938, Olfr867, MOR143-2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 257898
HGNC: HGNC:8380
Homologene: 128152
Echdc3
Name: enoyl Coenzyme A hydratase domain containing 3
Synonyms: 2310005D12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 67856
Homologene: 11484
Or6c206
Name: olfactory receptor family 6 subfamily C member 206
Synonyms: MOR111-12, GA_x6K02T2PULF-10947193-10948131, Olfr776
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 404321
Homologene: 115559
Sbspon
Name: somatomedin B and thrombospondin, type 1 domain containing
Synonyms: LOC226866, Gm106
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226866
Homologene: 45950
Ms4a7
Name: membrane-spanning 4-domains, subfamily A, member 7
Synonyms: CD20l4, CFFMA, A430103C15Rik, 9130422I10Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 109225
Homologene: 10922
Gm9913
Name: predicted gene 9913
Type: Gene
Species: Mouse
Chromosome: 2
Fam162a
Name: family with sequence similarity 162, member A
Synonyms: 2310056P07Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 70186
VEGA: 16
Homologene: 8656
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 5,916,708 bp
  • T to C, chromosome 1 at 15,859,058 bp
  • G to A, chromosome 1 at 34,473,364 bp
  • T to A, chromosome 1 at 36,564,451 bp
  • G to C, chromosome 1 at 60,237,151 bp
  • T to C, chromosome 1 at 66,649,722 bp
  • A to G, chromosome 1 at 170,311,764 bp
  • A to G, chromosome 1 at 180,936,760 bp
  • C to T, chromosome 2 at 6,212,876 bp
  • A to G, chromosome 2 at 52,206,702 bp
  • A to G, chromosome 2 at 121,337,661 bp
  • A to T, chromosome 2 at 125,506,560 bp
  • T to C, chromosome 2 at 153,400,652 bp
  • C to T, chromosome 2 at 154,202,729 bp
  • C to A, chromosome 2 at 155,617,778 bp
  • G to A, chromosome 2 at 165,291,744 bp
  • A to G, chromosome 3 at 59,076,720 bp
  • A to T, chromosome 3 at 59,319,340 bp
  • A to T, chromosome 3 at 64,509,522 bp
  • A to G, chromosome 3 at 88,353,895 bp
  • A to G, chromosome 3 at 95,736,182 bp
  • G to A, chromosome 3 at 103,760,550 bp
  • C to A, chromosome 4 at 63,086,621 bp
  • G to A, chromosome 4 at 109,829,864 bp
  • T to A, chromosome 4 at 136,192,826 bp
  • CAA to CA, chromosome 4 at 143,437,452 bp
  • C to A, chromosome 5 at 8,087,750 bp
  • A to C, chromosome 5 at 74,458,636 bp
  • C to T, chromosome 5 at 137,463,540 bp
  • G to T, chromosome 6 at 18,382,810 bp
  • C to T, chromosome 6 at 89,331,900 bp
  • A to G, chromosome 6 at 128,979,437 bp
  • A to T, chromosome 6 at 146,187,550 bp
  • T to A, chromosome 7 at 12,598,498 bp
  • T to A, chromosome 7 at 107,716,666 bp
  • A to G, chromosome 7 at 133,014,624 bp
  • A to G, chromosome 8 at 23,117,058 bp
  • A to T, chromosome 8 at 25,659,817 bp
  • G to T, chromosome 8 at 111,178,865 bp
  • A to G, chromosome 8 at 121,118,095 bp
  • T to C, chromosome 9 at 20,054,605 bp
  • C to T, chromosome 9 at 54,595,169 bp
  • T to A, chromosome 9 at 79,651,486 bp
  • A to G, chromosome 10 at 117,045,757 bp
  • A to G, chromosome 10 at 127,574,053 bp
  • A to G, chromosome 10 at 129,261,068 bp
  • G to A, chromosome 11 at 55,282,330 bp
  • T to A, chromosome 11 at 70,659,167 bp
  • T to C, chromosome 11 at 80,676,893 bp
  • T to C, chromosome 11 at 97,149,483 bp
  • C to T, chromosome 11 at 97,169,173 bp
  • T to C, chromosome 12 at 13,415,661 bp
  • A to G, chromosome 12 at 112,606,994 bp
  • C to A, chromosome 13 at 40,953,719 bp
  • A to T, chromosome 13 at 67,779,695 bp
  • T to C, chromosome 14 at 50,414,014 bp
  • T to A, chromosome 14 at 60,289,652 bp
  • A to T, chromosome 15 at 82,851,565 bp
  • G to T, chromosome 16 at 4,551,766 bp
  • G to A, chromosome 16 at 36,049,937 bp
  • T to A, chromosome 16 at 56,034,939 bp
  • A to T, chromosome 17 at 20,356,639 bp
  • C to A, chromosome 17 at 73,315,305 bp
  • T to A, chromosome 18 at 36,507,548 bp
  • T to A, chromosome 19 at 7,710,937 bp
  • A to T, chromosome 19 at 11,324,504 bp
  • C to A, chromosome 19 at 21,798,116 bp
  • A to T, chromosome Y at 2,663,248 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7678 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045745-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.