Strain Name:
C57BL/6J-MtgxR7765Btlr/Mmmh
Stock Number:
045821-MU
Citation ID:
RRID:MMRRC_045821-MU
Other Names:
R7765 (G1)
Major Collection:

Strain Information

Ntsr1
Name: neurotensin receptor 1
Synonyms: Ntsr1, NTR-1, NT-1R, NTR1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18216
HGNC: HGNC:8039
Homologene: 68261
Lyst
Name: lysosomal trafficking regulator
Synonyms: D13Sfk13
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17101
VEGA: 13
HGNC: HGNC:1968
Homologene: 61
Ip6k1
Name: inositol hexaphosphate kinase 1
Synonyms: Ihpk1, 1200016D08Rik, InsP6, InsP6k1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 27399
Homologene: 56602
Dst
Name: dystonin
Synonyms: Macf2, A830042E19Rik, Bpag1, Bpag, bullous pemphigoid antigen 1, nmf203, athetoid, nmf339, BPAG1, BPAG1-n, 2310001O04Rik, bullous pemphigoid antigen 1, ah
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Lefty1
Name: left right determination factor 1
Synonyms: Stra3, Lefty, Ebaf, lefty-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13590
HGNC: HGNC:6552
Homologene: 49231
Usp32
Name: ubiquitin specific peptidase 32
Synonyms: 2900074J03Rik, 6430526O11Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237898
Homologene: 13066
Ddx27
Name: DEAD box helicase 27
Synonyms: DEAD (Asp-Glu-Ala-Asp) box polypeptide 27
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228889
Homologene: 6431
Ccdc93
Name: coiled-coil domain containing 93
Synonyms: 9230102M16Rik, 4633402D15Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 70829
Homologene: 10393
Unk
Name: unkempt family zinc finger
Synonyms: Zc3h5, B230379M23Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217331
Homologene: 18194
Rad51b
Name: RAD51 paralog B
Synonyms: Rad51b, Rad51l1, R51H2, mREC2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 19363
VEGA: 12
HGNC: HGNC:9822
Homologene: 50190
Kif18a
Name: kinesin family member 18A
Synonyms: B130001M12Rik, N-8 kinesin, gcd2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228421
Homologene: 41820
Hmgxb4
Name: HMG box domain containing 4
Synonyms: Hmgb2l1, 4733401K04Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 70823
HGNC: HGNC:5003
Homologene: 4007
Apaf1
Name: apoptotic peptidase activating factor 1
Synonyms: 6230400I06Rik, Apaf1l
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 11783
HGNC: HGNC:576
Homologene: 7626
Brap
Name: BRCA1 associated protein
Synonyms: 3010002G07Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 72399
HGNC: HGNC:1099
Homologene: 4926
Dnttip2
Name: deoxynucleotidyltransferase, terminal, interacting protein 2
Synonyms: 4930588M11Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99480
Homologene: 124162
Scn10a
Name: sodium channel, voltage-gated, type X, alpha
Synonyms: Nav1.8
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20264
VEGA: 9
Homologene: 21300
Chn2
Name: chimerin 2
Synonyms: 1700026N20Rik, 4930557O16Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 69993
HGNC: HGNC:1944
Homologene: 31213
Npc1
Name: NPC intracellular cholesterol transporter 1
Synonyms: D18Ertd139e, lcsd, D18Ertd723e, C85354, A430089E03Rik, nmf164
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 18145
HGNC: HGNC:7897
Homologene: 228
Csnk2a1-ps3
Name: casein kinase 2, alpha 1 polypeptide, pseudogene 3
Synonyms: Csnk2a3, Csnk2a1-rs3, Gm10031
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 100039026
Kank1
Name: KN motif and ankyrin repeat domains 1
Synonyms: A930031B09Rik, D330024H06Rik, Ankrd15
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 107351
Homologene: 17706
Sidt2
Name: SID1 transmembrane family, member 2
Synonyms: CGI-40
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 214597
Homologene: 22943
Ap2a1
Name: adaptor-related protein complex 2, alpha 1 subunit
Synonyms: Adtaa
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 11771
HGNC: HGNC:561
Homologene: 68997
Mctp2
Name: multiple C2 domains, transmembrane 2
Synonyms: LOC244049
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244049
Homologene: 69254
Prss22
Name: serine protease 22
Synonyms: BSSP-4, 4733401N09Rik, SP001LA
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 70835
VEGA: 17
Homologene: 23344
Nr2e1
Name: nuclear receptor subfamily 2, group E, member 1
Synonyms: Nr2e1, tailless, Mtll, Tlx
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 21907
HGNC: HGNC:7973
Homologene: 37750
Fhdc1
Name: FH2 domain containing 1
Synonyms: 6330505N24Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229474
Homologene: 18920
Usf3
Name: upstream transcription factor family member 3
Synonyms: LOC207806, Gm608, LOC385650, 5530400K22Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 207806
Homologene: 19504
Cfap46
Name: cilia and flagella associated protein 46
Synonyms: Ttc40, 9330101J02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 212124
Pigg
Name: phosphatidylinositol glycan anchor biosynthesis, class G
Synonyms: Gpi7
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 433931
Homologene: 39421
Myh8
Name: myosin, heavy polypeptide 8, skeletal muscle, perinatal
Synonyms: Myhsp, Myhs-p, 4832426G23Rik, MyHC-pn
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17885
HGNC: HGNC:7578
Homologene: 68256
Or8g35
Name: olfactory receptor family 8 subfamily G member 35
Synonyms: MOR171-34, MOR171-50, GA_x6K02T2PVTD-33167297-33166353, Olfr955
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258242
VEGA: 9
Homologene: 133698
Klf17
Name: Kruppel-like transcription factor 17
Synonyms: 7420700M05Rik, D4Ertd561e, Zfp393
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 75753
Homologene: 12621
Mprip
Name: myosin phosphatase Rho interacting protein
Synonyms: Rhoip3, Gm34094, RIP3, p116Rip, p116 Rho interacting protein
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 26936
Homologene: 9034
Hltf
Name: helicase-like transcription factor
Synonyms: Smarca3, P113, Snf2l3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20585
Homologene: 30136
Pcdhb22
Name: protocadherin beta 22
Synonyms: PcdhbV, Pcdhb15
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93893
HGNC: HGNC:8686
Homologene: 113752
Kmt2d
Name: lysine (K)-specific methyltransferase 2D
Synonyms: Mll4, C430014K11Rik, Mll2, bapa
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 381022
HGNC: HGNC:7133
Homologene: 86893
Adam2
Name: a disintegrin and metallopeptidase domain 2
Synonyms: Ftnb, Ph30-beta, fertilin beta
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 11495
VEGA: 14
HGNC: HGNC:198
Homologene: 1127
Nrxn3
Name: neurexin III
Synonyms: neurexin III beta, neurexin III alpha, D12Bwg0831e, neurexin III alpha, 9330112C09Rik, neurexin III beta, 4933401A11Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 18191
HGNC: HGNC:8010
Homologene: 83225
Or8h10
Name: olfactory receptor family 8 subfamily H member 10
Synonyms: MOR206-4, GA_x6K02T2Q125-48465387-48464422, Olfr1100
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258587
Homologene: 34954
Efhd2
Name: EF hand domain containing 2
Synonyms: 2600015J22Rik, swiprosin 1, D4Wsu27e
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 27984
Homologene: 32580
Gcnt1
Name: glucosaminyl (N-acetyl) transferase 1, core 2
Synonyms: C2 GlcNAcT, IGnT, 5630400D21Rik, beta-1, 6-N-acetylglucosaminyltransferase
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 14537
HGNC: HGNC:4203
Homologene: 37486
Adam28
Name: a disintegrin and metallopeptidase domain 28
Synonyms: D430033C21Rik, MDC-L, Dtgn1, C130072N01Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 13522
VEGA: 14
HGNC: HGNC:206
Homologene: 40705
Vwa5b2
Name: von Willebrand factor A domain containing 5B2
Synonyms: EG328644
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 328643
Homologene: 28056
Pdss2
Name: prenyl (solanesyl) diphosphate synthase, subunit 2
Synonyms: PLMP, mDLP1, kd, 5430420P03Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 71365
Homologene: 56885
Ctif
Name: CBP80/20-dependent translation initiation factor
Synonyms: LOC269037, Gm672
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 269037
VEGA: 18
Homologene: 56682
4933416C03Rik
Name: RIKEN cDNA 4933416C03 gene
Type: Gene
Species: Mouse
Chromosome: 10
Tuba4a
Name: tubulin, alpha 4A
Synonyms: Tuba4, M[a]4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22145
Homologene: 68496
Tst
Name: thiosulfate sulfurtransferase, mitochondrial
Synonyms: Rhodanese
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 22117
VEGA: 15
Homologene: 37759
Or2y1e
Name: olfactory receptor family 2 subfamily Y member 1E
Synonyms: MOR256-27, Olfr1391, GA_x6K02T2QP88-6107233-6106298
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258460
Homologene: 17264
Tll1
Name: tolloid-like
Synonyms: Tll-1, b2b2476Clo
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 21892
Homologene: 49202
Serpinb3d
Name: serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3D
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 394252
Homologene: 130559
Stox1
Name: storkhead box 1
Synonyms: 4732470K04Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216021
Homologene: 17649
Ifi214
Name: interferon activated gene 214
Synonyms: BC094916, Pyhin-B
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 545384
HGNC: HGNC:5395
Homologene: 115929
Zfp995
Name: zinc finger protein 995
Synonyms: 2210404O09Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 70081
Homologene: 133253
Asb14
Name: ankyrin repeat and SOCS box-containing 14
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 142687
Homologene: 15445
Pate2
Name: prostate and testis expressed 2
Synonyms: LOC330921, mANLP1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 330921
Homologene: 86016
Fcmr
Name: Fc fragment of IgM receptor
Synonyms: Faim3, 1810037B05Rik, FcmuR
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 69169
Homologene: 48347
Pfn3
Name: profilin 3
Synonyms: 1700012P12Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 75477
VEGA: 13
Homologene: 12603
Prm3
Name: protamine 3
Synonyms: Pxg, PX, Pxg
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 19120
Homologene: 74292
Efcab8
Name: EF-hand calcium binding domain 8
Synonyms: EG329541
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 100504221
Sh3yl1
Name: Sh3 domain YSC-like 1
Synonyms: YSC84, Ray
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 24057
Homologene: 31662
Cib3
Name: calcium and integrin binding family member 3
Synonyms: C730014M21Rik, KIP3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234421
Homologene: 14287
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 34,275,694 bp
  • C to T, chromosome 1 at 75,216,359 bp
  • T to G, chromosome 1 at 107,079,782 bp
  • T to G, chromosome 1 at 121,499,313 bp
  • T to A, chromosome 1 at 130,874,288 bp
  • G to A, chromosome 1 at 156,524,784 bp
  • A to T, chromosome 1 at 173,524,836 bp
  • A to G, chromosome 1 at 180,936,547 bp
  • T to A, chromosome 2 at 86,978,194 bp
  • G to A, chromosome 2 at 109,306,940 bp
  • A to G, chromosome 2 at 153,843,190 bp
  • T to A, chromosome 2 at 167,027,959 bp
  • T to A, chromosome 2 at 180,538,817 bp
  • T to C, chromosome 3 at 20,091,483 bp
  • T to A, chromosome 3 at 84,444,599 bp
  • A to G, chromosome 3 at 122,275,945 bp
  • T to A, chromosome 4 at 117,760,615 bp
  • T to C, chromosome 4 at 141,874,575 bp
  • T to G, chromosome 5 at 108,314,054 bp
  • A to T, chromosome 5 at 121,662,129 bp
  • T to C, chromosome 6 at 54,298,152 bp
  • G to A, chromosome 7 at 44,909,736 bp
  • T to C, chromosome 7 at 72,090,331 bp
  • T to G, chromosome 7 at 139,651,564 bp
  • A to G, chromosome 8 at 64,051,449 bp
  • A to G, chromosome 8 at 72,204,425 bp
  • C to A, chromosome 8 at 75,000,808 bp
  • A to C, chromosome 9 at 35,669,901 bp
  • A to G, chromosome 9 at 39,470,316 bp
  • A to T, chromosome 9 at 45,941,575 bp
  • A to G, chromosome 9 at 108,032,089 bp
  • A to G, chromosome 9 at 119,609,904 bp
  • A to G, chromosome 10 at 42,574,437 bp
  • C to T, chromosome 10 at 43,464,632 bp
  • C to T, chromosome 10 at 62,665,999 bp
  • A to G, chromosome 10 at 91,023,782 bp
  • T to A, chromosome 10 at 116,113,253 bp
  • A to G, chromosome 11 at 49,327,744 bp
  • C to T, chromosome 11 at 59,758,221 bp
  • T to A, chromosome 11 at 67,303,655 bp
  • A to T, chromosome 11 at 84,994,408 bp
  • T to A, chromosome 11 at 116,053,082 bp
  • T to C, chromosome 12 at 30,958,869 bp
  • T to C, chromosome 12 at 79,803,270 bp
  • A to G, chromosome 12 at 89,813,484 bp
  • T to G, chromosome 13 at 13,709,532 bp
  • T to A, chromosome 13 at 55,415,087 bp
  • G to T, chromosome 14 at 26,897,761 bp
  • T to C, chromosome 14 at 66,059,896 bp
  • C to T, chromosome 14 at 68,609,106 bp
  • A to T, chromosome 15 at 78,405,616 bp
  • A to G, chromosome 15 at 98,852,334 bp
  • CTCTTCTTCTTCTTC to CTCTTCTTCTTC, chromosome 16 at 10,790,701 bp
  • C to T, chromosome 16 at 20,594,611 bp
  • T to C, chromosome 16 at 44,219,063 bp
  • A to G, chromosome 17 at 21,882,003 bp
  • C to T, chromosome 17 at 23,994,618 bp
  • A to T, chromosome 18 at 12,195,048 bp
  • A to G, chromosome 18 at 37,519,105 bp
  • A to T, chromosome 18 at 75,605,644 bp
  • C to T, chromosome 19 at 17,329,359 bp
  • GCGAACG to GCG, chromosome 19 at 25,411,205 bp
  • G to A, chromosome X at 155,054,178 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7765 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045821-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.