Strain Name:
C57BL/6J-MtgxR7994Btlr/Mmmh
Stock Number:
046035-MU
Citation ID:
RRID:MMRRC_046035-MU
Other Names:
R7994 (G1)
Major Collection:

Strain Information

Tert
Name: telomerase reverse transcriptase
Synonyms: TR
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 21752
VEGA: 13
Homologene: 31141
Cort
Name: cortistatin
Synonyms: CST, PCST
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12854
HGNC: HGNC:2257
Homologene: 997
Ilrun
Name: inflammation and lipid regulator with UBA-like and NBR1-like domains
Synonyms: D17Wsu92e
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224647
Homologene: 32575
Fam3c
Name: FAM3 metabolism regulating signaling molecule C
Synonyms: D6Wsu176e, Ilei, Fam3c
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 27999
Homologene: 8926
Madcam1
Name: mucosal vascular addressin cell adhesion molecule 1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 17123
VEGA: 10
HGNC: HGNC:6765
Homologene: 8413
Ppp1r13b
Name: protein phosphatase 1, regulatory subunit 13B
Synonyms: ASPP1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 21981
VEGA: 12
Homologene: 9090
Scrib
Name: scribbled planar cell polarity
Synonyms: Crc, Scrb1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 105782
Homologene: 44228
Myh10
Name: myosin, heavy polypeptide 10, non-muscle
Synonyms: nonmuscle myosin heavy chain IIB, SMemb, NMHC-B, nonmuscle myosin heavy chain II-B, Myhn-2, 5730504C04Rik, myosin IIB, Fltn, Myhn2, Fltn, NMHC II-B, Myosin IIB, 9330167F11Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 77579
HGNC: HGNC:7568
Homologene: 55941
Nup93
Name: nucleoporin 93
Synonyms: 2410008G02Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 71805
Homologene: 40971
Commd10
Name: COMM domain containing 10
Synonyms: 2310003A05Rik, DRWMS2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 69456
VEGA: 18
Homologene: 9404
Brpf1
Name: bromodomain and PHD finger containing, 1
Synonyms: 4930540D11Rik, 4833438B11Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 78783
Homologene: 31251
Amotl1
Name: angiomotin-like 1
Synonyms: 2310067L22Rik, 4932416D09Rik, JEAP, 2310010G08Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 75723
Homologene: 43977
Hipk2
Name: homeodomain interacting protein kinase 2
Synonyms: 1110014O20Rik, Stank, B230339E18Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 15258
Homologene: 68766
Syt2
Name: synaptotagmin II
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20980
Homologene: 22516
Zfp157
Name: zinc finger protein 157
Synonyms: A630094N24Rik, 2610020C11Rik, Roma
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 72154
Homologene: 57009
Gtf3c2
Name: general transcription factor IIIC, polypeptide 2, beta
Synonyms: 2610510G03Rik, 1300004C11Rik, TFIIIC110, TFIIIC-BETA
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71752
HGNC: HGNC:4665
Homologene: 37490
Srcap
Name: Snf2-related CREBBP activator protein
Synonyms: D030022P06Rik, F630004O05Rik, B930091H02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100043597
Homologene: 38213
Col4a3
Name: collagen, type IV, alpha 3
Synonyms: tumstatin, alpha3(IV)
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12828
HGNC: HGNC:2204
Homologene: 68033
Ercc5
Name: excision repair cross-complementing rodent repair deficiency, complementation group 5
Synonyms: Xpg
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22592
HGNC: HGNC:3437
Homologene: 133551
Ttn
Name: titin
Synonyms: shru, L56, mdm, connectin, D330041I19Rik, 2310057K23Rik, 2310074I15Rik, 2310036G12Rik, D830007G01Rik, 1100001C23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Otop1
Name: otopetrin 1
Synonyms: tlt, A530025J20Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 21906
Homologene: 35244
Prkag3
Name: protein kinase, AMP-activated, gamma 3 non-catalytic subunit
Synonyms: AMPKg3S, AMPKg3L, AMPKg3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 241113
HGNC: HGNC:9387
Homologene: 23006
Dclre1b
Name: DNA cross-link repair 1B
Synonyms: SNMIB, Apollo, mSNM1B
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 140917
Homologene: 32553
Cfap44
Name: cilia and flagella associated protein 44
Synonyms: D16Ertd642e, Wdr52, 6330444M21Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 212517
Homologene: 75085
Adad1
Name: adenosine deaminase domain containing 1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 21744
Homologene: 7569
Abcb9
Name: ATP-binding cassette, sub-family B member 9
Synonyms: TAPL
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 56325
HGNC: HGNC:50
Homologene: 10491
Serpinb1a
Name: serine (or cysteine) peptidase inhibitor, clade B, member 1a
Synonyms: M/NEI, MNEI, ovalbumin, EIA, LEI, ELANH2, 1190005M04Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 66222
HGNC: HGNC:3311
Homologene: 133768
Sobp
Name: sine oculis binding protein
Synonyms: 5330439J01Rik, jc, Jxc1, 2900009C16Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 109205
Homologene: 41216
Or10al3
Name: olfactory receptor family 10 subfamily AL member 3
Synonyms: MOR263-7, Olfr119, GA_x6K02T2PSCP-2159633-2160598
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258095
Homologene: 17195
Twnk
Name: twinkle mtDNA helicase
Synonyms: twinkle, Twinl, D19Ertd626e, Peo1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226153
VEGA: 19
HGNC: HGNC:1160
Homologene: 11052
Zswim8
Name: zinc finger SWIM-type containing 8
Synonyms: 4832404P21Rik, 2310021P13Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 268721
VEGA: 14
Homologene: 34313
Notch4
Name: notch 4
Synonyms: Int-3, N4, Int3
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 18132
HGNC: HGNC:7884
Homologene: 3351
Cebpz
Name: CCAAT/enhancer binding protein zeta
Synonyms: Cebpa-rs1, CBF2, Cbf
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12607
VEGA: 17
Homologene: 4210
Or52a5
Name: olfactory receptor family 52 subfamily A member 5
Synonyms: GA_x6K02T2PBJ9-6504436-6503489, MOR22-3, Olfr68, 3'[b]2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18369
Homologene: 130658
Or6k4
Name: olfactory receptor family 6 subfamily K member 4
Synonyms: GA_x6K02T2P20D-21025190-21024243, MOR105-2, Olfr424
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 258716
Homologene: 103798
Gabbr2
Name: gamma-aminobutyric acid type B receptor subunit 2
Synonyms: LOC242425, Gababr2, GB2, Gpr51
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242425
HGNC: HGNC:4507
Homologene: 55902
Cnga1
Name: cyclic nucleotide gated channel alpha 1
Synonyms: Cncg
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12788
HGNC: HGNC:2148
Homologene: 55432
Or1x6
Name: olfactory receptor family 1 subfamily X member 6
Synonyms: Olfr1375, GA_x6K02T2QP88-4389999-4389056, MOR126-2, Olfr1375-ps1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258509
Gsto1
Name: glutathione S-transferase omega 1
Synonyms: p28, GSTX
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 14873
Homologene: 37971
Zfp503
Name: zinc finger protein 503
Synonyms: Zpo2, ZNF503, Nolz1, B830002A16Rik, Nolz-1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 218820
Homologene: 41888
Asz1
Name: ankyrin repeat, SAM and basic leucine zipper domain containing 1
Synonyms: ORF3, Gasz, 4933400N19Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 74068
HGNC: HGNC:1350
Homologene: 11374
Spata31e4
Name: spermatogenesis associated 31 subfamily E member 4
Synonyms: Gm8765
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 667693
Homologene: 134512
Plekha8
Name: pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8
Synonyms: FAPP2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 231999
Homologene: 32284
Coq9
Name: coenzyme Q9
Synonyms: 2310005O14Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 67914
Homologene: 6477
Rcor3
Name: REST corepressor 3
Synonyms: C730034D20Rik, 4921514E24Rik, E130101E15Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 214742
Homologene: 135671
Gadd45g
Name: growth arrest and DNA-damage-inducible 45 gamma
Synonyms: OIG37, CR6
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 23882
HGNC: HGNC:4097
Homologene: 21334
Snrnp25
Name: small nuclear ribonucleoprotein 25 (U11/U12)
Synonyms: 3300001G02Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 78372
Homologene: 11592
Fam221b
Name: family with sequence similarity 221, member B
Synonyms: 4930412F15Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242408
Homologene: 52184
Npas2
Name: neuronal PAS domain protein 2
Synonyms: bHLHe9, MOP4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18143
HGNC: HGNC:7895
Homologene: 1887
Tafa4
Name: TAFA chemokine like family member 4
Synonyms: Tafa4, C130034I18Rik, Fam19a4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 320701
Homologene: 18561
Srcin1
Name: SRC kinase signaling inhibitor 1
Synonyms: p140Cap, P140
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 56013
Homologene: 10324
Efcab8
Name: EF-hand calcium binding domain 8
Synonyms: EG329541
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 100504221
Mgat1
Name: mannoside acetylglucosaminyltransferase 1
Synonyms: Mgat-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17308
HGNC: HGNC:7044
Homologene: 1804
Pcdhgb6
Name: protocadherin gamma subfamily B, 6
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93703
HGNC: HGNC:8713
Homologene: 49573
Igkv4-80
Name: immunoglobulin kappa variable 4-80
Synonyms: Gm16729
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 545848
Or56b2j
Name: olfactory receptor family 56 subfamily B member 2J
Synonyms: GA_x6K02T2PBJ9-7331927-7332961, MOR40-12, Olfr663
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 257914
Homologene: 133594
Gm49368
Name: predicted gene, 49368
Type: Gene
Species: Mouse
Chromosome: 7
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 39,328,337 bp
  • T to C, chromosome 1 at 44,178,334 bp
  • T to A, chromosome 1 at 74,747,255 bp
  • G to A, chromosome 1 at 82,662,906 bp
  • A to T, chromosome 1 at 134,747,592 bp
  • G to T, chromosome 1 at 174,136,707 bp
  • C to A, chromosome 1 at 192,101,645 bp
  • T to C, chromosome 2 at 76,791,095 bp
  • G to A, chromosome 2 at 153,783,804 bp
  • T to C, chromosome 3 at 37,091,971 bp
  • T to C, chromosome 3 at 103,803,386 bp
  • C to T, chromosome 4 at 43,665,514 bp
  • C to T, chromosome 4 at 46,736,349 bp
  • A to T, chromosome 4 at 149,125,305 bp
  • T to C, chromosome 5 at 31,169,873 bp
  • C to T, chromosome 5 at 38,299,851 bp
  • T to A, chromosome 5 at 72,604,660 bp
  • G to C, chromosome 5 at 124,082,027 bp
  • T to A, chromosome 5 at 138,455,188 bp
  • T to C, chromosome 6 at 18,054,641 bp
  • T to C, chromosome 6 at 22,308,460 bp
  • T to C, chromosome 6 at 38,818,468 bp
  • T to C, chromosome 6 at 54,615,245 bp
  • G to T, chromosome 6 at 69,016,637 bp
  • C to T, chromosome 6 at 96,863,886 bp
  • C to G, chromosome 6 at 113,315,041 bp
  • T to A, chromosome 7 at 103,777,400 bp
  • T to A, chromosome 7 at 104,704,428 bp
  • T to C, chromosome 7 at 127,541,758 bp
  • A to G, chromosome 7 at 128,085,646 bp
  • A to G, chromosome 8 at 94,306,302 bp
  • A to C, chromosome 8 at 94,853,157 bp
  • T to A, chromosome 9 at 14,593,361 bp
  • A to T, chromosome 10 at 43,021,167 bp
  • A to T, chromosome 10 at 79,668,235 bp
  • T to A, chromosome 11 at 32,207,569 bp
  • T to C, chromosome 11 at 49,261,943 bp
  • T to G, chromosome 11 at 51,048,140 bp
  • T to C, chromosome 11 at 68,790,244 bp
  • C to T, chromosome 11 at 97,531,916 bp
  • T to C, chromosome 12 at 111,832,342 bp
  • T to A, chromosome 13 at 32,843,050 bp
  • T to A, chromosome 13 at 50,702,864 bp
  • T to C, chromosome 13 at 51,847,767 bp
  • T to A, chromosome 13 at 73,648,955 bp
  • T to A, chromosome 14 at 20,708,004 bp
  • C to A, chromosome 14 at 21,985,006 bp
  • G to A, chromosome 15 at 76,064,582 bp
  • T to C, chromosome 16 at 44,432,138 bp
  • C to A, chromosome 17 at 27,767,943 bp
  • C to A, chromosome 17 at 34,578,090 bp
  • C to T, chromosome 17 at 37,701,435 bp
  • T to C, chromosome 17 at 78,934,599 bp
  • A to G, chromosome 18 at 37,742,671 bp
  • A to G, chromosome 18 at 46,958,919 bp
  • A to G, chromosome 19 at 45,007,838 bp
  • G to A, chromosome 19 at 47,859,460 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7994 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
046035-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.