Strain Name:
C57BL/6J-MtgxR8121Btlr/Mmmh
Stock Number:
067550-MU
Citation ID:
RRID:MMRRC_067550-MU
Other Names:
R8121 (G1)
Major Collection:

Strain Information

Kcnj10
Name: potassium inwardly-rectifying channel, subfamily J, member 10
Synonyms: Kir4.1, Kir1.2, BIRK-1, BIR10, Kir4.1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16513
HGNC: HGNC:6256
Homologene: 1689
Ppp4c
Name: protein phosphatase 4, catalytic subunit
Synonyms: PPX, 1110002D08Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 56420
HGNC: HGNC:9319
Homologene: 2038
Rarg
Name: retinoic acid receptor, gamma
Synonyms: RARgamma2, RAR gamma 2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 19411
HGNC: HGNC:9866
Homologene: 20263
Nup210l
Name: nucleoporin 210-like
Synonyms: 4930548O11Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 77595
Homologene: 28122
Pip5k1b
Name: phosphatidylinositol-4-phosphate 5-kinase, type 1 beta
Synonyms: Pipk5b
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18719
HGNC: HGNC:8995
Homologene: 100644
Neurl4
Name: neuralized E3 ubiquitin protein ligase 4
Synonyms: 0610025P10Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216860
Homologene: 13029
Setx
Name: senataxin
Synonyms: Als4, A930037J23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 269254
HGNC: HGNC:445
Homologene: 41003
Arfgap2
Name: ADP-ribosylation factor GTPase activating protein 2
Synonyms: Zfp289, 2310032E02Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 77038
Homologene: 8735
Tbcd
Name: tubulin-specific chaperone d
Synonyms: 2310057L06Rik, A030005L14Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 108903
Homologene: 4368
Iqgap2
Name: IQ motif containing GTPase activating protein 2
Synonyms: 4933417J23Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 544963
VEGA: 13
HGNC: HGNC:6111
Homologene: 101543
Slc12a2
Name: solute carrier family 12, member 2
Synonyms: Nkcc1, mBSC2, sodium/potassium/chloride cotransporters, sy-ns
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 20496
VEGA: 18
Homologene: 20283
Ctdp1
Name: CTD phosphatase subunit 1
Synonyms: 4930563P03Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 67655
HGNC: HGNC:2498
Homologene: 31254
Dpp8
Name: dipeptidylpeptidase 8
Synonyms: 4932434F09Rik, 2310004I03Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74388
VEGA: 9
Homologene: 57098
Spg11
Name: SPG11, spatacsin vesicle trafficking associated
Synonyms: spastic paraplegia 11, 6030465E24Rik, C530005A01Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 214585
Homologene: 41614
Lmo7
Name: LIM domain only 7
Synonyms: LOC380928, FBXO20
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 380928
HGNC: HGNC:6646
Homologene: 83924
Atraid
Name: all-trans retinoic acid induced differentiation factor
Synonyms: p18, HSPC013, 0610007C21Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 381629
Homologene: 15412
Dapk1
Name: death associated protein kinase 1
Synonyms: 2810425C21Rik, DAP-Kinase, D13Ucla1, 2310039H24Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 69635
VEGA: 13
HGNC: HGNC:2674
Homologene: 3626
Fbxw11
Name: F-box and WD-40 domain protein 11
Synonyms: HOS, 2310065A07Rik, Fbxw1b, BTRCP2, BTRC2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 103583
Homologene: 76444
Mavs
Name: mitochondrial antiviral signaling protein
Synonyms: IPS-1, D430028G21Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228607
Homologene: 17004
Nptx1
Name: neuronal pentraxin 1
Synonyms: Np1, D11Bwg1004e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18164
HGNC: HGNC:7952
Homologene: 1891
Cdh6
Name: cadherin 6
Synonyms: cad6, K-cadherin
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12563
VEGA: 15
HGNC: HGNC:1765
Homologene: 21027
Entpd3
Name: ectonucleoside triphosphate diphosphohydrolase 3
Synonyms: NTPDase-3, Cd39l3, HB6
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 215446
HGNC: HGNC:3365
Homologene: 68171
Ces1h
Name: carboxylesterase 1H
Synonyms: 2310039D24Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 75704
HGNC: HGNC:1863
Homologene: 119757
Scn7a
Name: sodium channel, voltage-gated, type VII, alpha
Synonyms: Scn6a, Nax, NaG, Nav2, Nav2.3, 1110034K09Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20272
Homologene: 55706
Pkdrej
Name: polycystin (PKD) family receptor for egg jelly
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 18766
VEGA: 15
HGNC: HGNC:9015
Homologene: 4427
Myh8
Name: myosin, heavy polypeptide 8, skeletal muscle, perinatal
Synonyms: Myhsp, Myhs-p, 4832426G23Rik, MyHC-pn
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17885
HGNC: HGNC:7578
Homologene: 68256
Cfap58
Name: cilia and flagella associated protein 58
Synonyms: Ccdc147, LOC381229
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 381229
VEGA: 19
Homologene: 77312
Dnah9
Name: dynein, axonemal, heavy chain 9
Synonyms: Dnahc9, D11Ertd686e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237806
HGNC: HGNC:2953
Homologene: 20357
Macc1
Name: metastasis associated in colon cancer 1
Synonyms: 4732474O15Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238455
Homologene: 18813
Gm5114
Name: predicted gene 5114
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330513
Homologene: 45597
Wnk2
Name: WNK lysine deficient protein kinase 2
Synonyms: X83337, ESTM15, 1810073P09Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 75607
Homologene: 19155
Fscn1
Name: fascin actin-bundling protein 1
Synonyms: Fan1, fascin-1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14086
Homologene: 48164
Cryz
Name: crystallin, zeta
Synonyms: SEZ9, quinone reductase, Sez9
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12972
HGNC: HGNC:2419
Homologene: 133907
Sema3a
Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
Synonyms: semaphorin III, Semad, collapsin-1, SemD, sema III
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20346
Homologene: 31358
Cd101
Name: CD101 antigen
Synonyms: Igsf2, LOC381460
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 630146
HGNC: HGNC:5949
Homologene: 3142
Slco2b1
Name: solute carrier organic anion transporter family, member 2b1
Synonyms: OATP-B, Slc21a9
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101488
Homologene: 21419
Sgcz
Name: sarcoglycan zeta
Synonyms: C230085N17Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244431
Homologene: 26726
1700003E16Rik
Name: RIKEN cDNA 1700003E16 gene
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 71837
Homologene: 52846
Or4p18
Name: olfactory receptor family 4 subfamily P member 18
Synonyms: Olfr1179, MOR225-2, GA_x6K02T2Q125-49890854-49889931
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258919
Homologene: 74070
Or2b11
Name: olfactory receptor family 2 subfamily B member 11
Synonyms: Olfr222, MOR256-45P, GA_x6K02SYYHDF-1415-2371
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 257962
Homologene: 71979
Serpinb6c
Name: serine (or cysteine) peptidase inhibitor, clade B, member 6c
Synonyms: Spi3C, ovalbumin, SPIC
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 97848
HGNC: HGNC:8950
Lrrc17
Name: leucine rich repeat containing 17
Synonyms: 37kDa, 4833425M04Rik, 6130400C22Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 74511
Homologene: 55929
Vmn2r124
Name: vomeronasal 2, receptor 124
Synonyms: Vmn2r-ps113, Gm7196
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 637021
Homologene: 115024
Or4k41
Name: olfactory receptor family 4 subfamily K member 41
Synonyms: MOR248-15, GA_x6K02T2Q125-72500603-72501520, Olfr1287
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 257935
Abi3bp
Name: ABI family member 3 binding protein
Synonyms: TARSH, eratin, D930038M13Rik, 5033411B22Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 320712
VEGA: 16
Homologene: 134172
Zfp936
Name: zinc finger protein 936
Synonyms: EG435970, Gm9272, I1C0022H11Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 668620
Cdk14
Name: cyclin dependent kinase 14
Synonyms: Pftk1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18647
HGNC: HGNC:8883
Homologene: 7888
Cd177
Name: CD177 antigen
Synonyms: 1190003K14Rik, Pdp3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 68891
Homologene: 49628
Arhgap45
Name: Rho GTPase activating protein 45
Synonyms: Hmha1, 6330406L22Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70719
Homologene: 69120
Clec2d
Name: C-type lectin domain family 2, member d
Synonyms: Clrb, Ocil, Clr-b
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 93694
Homologene: 136309
Plekha3
Name: pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 3
Synonyms: FAPP1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 83435
Homologene: 10417
Vmn1r65
Name: vomeronasal 1 receptor 65
Synonyms: V3R6, V1rd6
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 81013
Homologene: 110799
Pla2g2f
Name: phospholipase A2, group IIF
Synonyms: mGIIFsPLA2s
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 26971
Homologene: 8084
Ltb4r1
Name: leukotriene B4 receptor 1
Synonyms: BLTR, BLT1, mBLTR
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 16995
HGNC: HGNC:6713
Homologene: 22477
Slc7a9
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 9
Synonyms: CSNU3, bo, + amino acid transporter, bo, +AT
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 30962
Homologene: 56668
Tbc1d22b
Name: TBC1 domain family, member 22B
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 381085
Homologene: 23043
Unc93a
Name: unc-93 homolog A
Synonyms: Unc93l
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 381058
Homologene: 10356
Nt5c1a
Name: 5'-nucleotidase, cytosolic IA
Synonyms: LOC230718, Cn1a
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230718
Homologene: 57173
Or7g22
Name: olfactory receptor family 7 subfamily G member 22
Synonyms: GA_x6K02T2PVTD-12873838-12874776, Olfr837, MOR152-2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258558
HGNC: HGNC:8466
Homologene: 115507
Zfp853
Name: zinc finger protein 853
Synonyms: LOC330230
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 330230
Krtap10-4
Name: keratin associated protein 10-4
Synonyms: A030009A09Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 100191037
Homologene: 115744
Nicn1
Name: nicolin 1
Synonyms: 1500032A17Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 66257
Homologene: 11936
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 172,369,242 bp
  • T to A, chromosome 2 at 29,145,034 bp
  • A to T, chromosome 2 at 66,700,859 bp
  • A to T, chromosome 2 at 76,686,648 bp
  • A to T, chromosome 2 at 88,402,696 bp
  • T to C, chromosome 2 at 91,265,683 bp
  • A to G, chromosome 2 at 111,449,160 bp
  • A to G, chromosome 2 at 122,069,867 bp
  • A to C, chromosome 2 at 131,245,475 bp
  • G to A, chromosome 3 at 90,115,121 bp
  • G to A, chromosome 3 at 101,020,582 bp
  • A to G, chromosome 3 at 154,621,745 bp
  • T to C, chromosome 4 at 123,208,442 bp
  • A to G, chromosome 4 at 138,752,310 bp
  • T to A, chromosome 4 at 143,965,041 bp
  • A to T, chromosome 5 at 5,227,195 bp
  • C to A, chromosome 5 at 13,599,247 bp
  • A to G, chromosome 5 at 21,570,331 bp
  • G to A, chromosome 5 at 31,054,298 bp
  • T to C, chromosome 5 at 142,960,861 bp
  • G to A, chromosome 5 at 143,288,263 bp
  • A to T, chromosome 6 at 83,161,911 bp
  • C to T, chromosome 6 at 129,184,884 bp
  • C to T, chromosome 7 at 6,008,465 bp
  • A to G, chromosome 7 at 24,759,642 bp
  • C to A, chromosome 7 at 35,454,117 bp
  • T to A, chromosome 7 at 39,408,128 bp
  • C to T, chromosome 7 at 43,190,123 bp
  • G to A, chromosome 7 at 99,685,553 bp
  • A to G, chromosome 7 at 126,787,324 bp
  • A to G, chromosome 8 at 37,523,303 bp
  • T to C, chromosome 8 at 93,353,476 bp
  • G to A, chromosome 9 at 19,137,692 bp
  • A to G, chromosome 9 at 65,078,080 bp
  • C to A, chromosome 9 at 108,295,105 bp
  • T to A, chromosome 9 at 120,555,654 bp
  • G to A, chromosome 10 at 77,827,006 bp
  • A to G, chromosome 10 at 80,018,075 bp
  • A to G, chromosome 11 at 32,720,646 bp
  • A to T, chromosome 11 at 59,571,044 bp
  • A to G, chromosome 11 at 66,017,375 bp
  • G to T, chromosome 11 at 67,289,821 bp
  • A to T, chromosome 11 at 69,908,230 bp
  • G to A, chromosome 11 at 119,542,666 bp
  • A to G, chromosome 11 at 121,597,143 bp
  • A to G, chromosome 12 at 119,446,589 bp
  • T to C, chromosome 13 at 33,880,218 bp
  • A to T, chromosome 13 at 49,060,939 bp
  • A to G, chromosome 13 at 60,761,398 bp
  • T to C, chromosome 13 at 95,724,568 bp
  • G to A, chromosome 14 at 55,768,122 bp
  • T to C, chromosome 14 at 101,926,300 bp
  • T to C, chromosome 15 at 13,044,671 bp
  • C to T, chromosome 15 at 85,815,454 bp
  • A to G, chromosome 15 at 102,239,958 bp
  • A to T, chromosome 16 at 56,631,878 bp
  • T to C, chromosome 17 at 13,109,673 bp
  • A to T, chromosome 17 at 18,062,171 bp
  • G to T, chromosome 17 at 29,572,971 bp
  • T to A, chromosome 18 at 57,899,331 bp
  • A to T, chromosome 18 at 80,456,008 bp
  • A to T, chromosome 19 at 24,359,991 bp
  • A to G, chromosome 19 at 48,029,104 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8121 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067550-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.