Strain Name:
C57BL/6J-MtgxR8135Btlr/Mmmh
Stock Number:
067563-MU
Citation ID:
RRID:MMRRC_067563-MU
Other Names:
R8135 (G1)
Major Collection:

Strain Information

Fasl
Name: Fas ligand
Synonyms: CD178, Tnfsf6, Fas-L, APT1LG1, Fasl, CD95L
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14103
Homologene: 533
Gaa
Name: glucosidase, alpha, acid
Synonyms: E430018M07Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14387
HGNC: HGNC:4065
Homologene: 37268
Zmynd8
Name: zinc finger, MYND-type containing 8
Synonyms: 2010005I16Rik, ZMYND8, RACK7, 3632413B07Rik, Prkcbp1, 1110013E22Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228880
HGNC: HGNC:9397
Homologene: 32679
Sipa1l1
Name: signal-induced proliferation-associated 1 like 1
Synonyms: 4931426N11Rik, Spar
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217692
VEGA: 12
Homologene: 9189
Camk1g
Name: calcium/calmodulin-dependent protein kinase I gamma
Synonyms: CaMKIgamma, CLICK-III
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 215303
Homologene: 48706
Set
Name: SET nuclear oncogene
Synonyms: 2610030F17Rik, StF-IT-1, 5730420M11Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 56086
Homologene: 55707
Phip
Name: pleckstrin homology domain interacting protein
Synonyms: Wdr11, 2810004D21Rik, 4632404O06Rik, Ndrp
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 83946
Homologene: 41209
Dhx8
Name: DEAH-box helicase 8
Synonyms: RNA helicase, Ddx8, mDEAH6
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217207
HGNC: HGNC:2749
Homologene: 3628
Galnt5
Name: polypeptide N-acetylgalactosaminyltransferase 5
Synonyms: ppGaNTase-T5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241391
HGNC: HGNC:4127
Homologene: 8733
Robo2
Name: roundabout guidance receptor 2
Synonyms: D230004I22Rik, 2600013A04Rik, 9430089E08Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 268902
Homologene: 43188
Map2
Name: microtubule-associated protein 2
Synonyms: MAP-2, G1-397-34, repro4, Mtap2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17756
HGNC: HGNC:6839
Homologene: 1779
Acsl3
Name: acyl-CoA synthetase long-chain family member 3
Synonyms: C85929, Facl3, 2610510B12Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74205
HGNC: HGNC:3570
Homologene: 3278
Tbc1d2
Name: TBC1 domain family, member 2
Synonyms: PARIS-1, LOC381605, A630005A06Rik, PARIS1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 381605
Homologene: 10190
Cfi
Name: complement component factor i
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12630
HGNC: HGNC:5394
Homologene: 171
Spdye4b
Name: speedy/RINGO cell cycle regulator family, member E4B
Synonyms: 4933411G11Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 330228
Homologene: 138445
Enpp4
Name: ectonucleotide pyrophosphatase/phosphodiesterase 4
Synonyms: 4933413N07Rik, LOC224794
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224794
HGNC: HGNC:3359
Homologene: 28264
Unc80
Name: unc-80, NALCN activator
Synonyms: C230061B10Rik, C030018G13Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329178
Homologene: 122243
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: OTTMUSG00000005786, LOC380698
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380698
Homologene: 70869
Iqcg
Name: IQ motif containing G
Synonyms: stubby12d, G1-374-12, repro1, 2400003L07Rik, esgd12d
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 69707
Homologene: 32776
Nhsl1
Name: NHS like 1
Synonyms: D10Bwg0940e, A630035H13Rik, 5730409E15Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 215819
Homologene: 27834
Edem1
Name: ER degradation enhancer, mannosidase alpha-like 1
Synonyms: A130059K23Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 192193
Homologene: 33836
B3galnt2
Name: UDP-GalNAc:betaGlcNAc beta 1,3-galactosaminyltransferase, polypeptide 2
Synonyms: D230016N13Rik, A930105D20Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 97884
VEGA: 13
Homologene: 17595
Gsdma2
Name: gasdermin A2
Synonyms: 2210411P14Rik, Gsdml2, 2210009F20Rik, 2210006M16Rik, 2200001G21Rik, Gsdm2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 76758
Tecpr1
Name: tectonin beta-propeller repeat containing 1
Synonyms: 2210010N04Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 70381
Homologene: 9120
Csf2rb
Name: colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
Synonyms: beta c, CDw131, common beta chain, Il3rb1, Csf2rb1, Il3r, Il5rb, AIC2B, Bc
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12983
VEGA: 15
HGNC: HGNC:2436
Homologene: 339
Adam7
Name: a disintegrin and metallopeptidase domain 7
Synonyms: EAP1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 11500
HGNC: HGNC:214
Homologene: 2830
H2-M10.4
Name: histocompatibility 2, M region locus 10.4
Synonyms: 15H
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224753
Homologene: 117973
Pde6a
Name: phosphodiesterase 6A, cGMP-specific, rod, alpha
Synonyms: Pdea
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225600
HGNC: HGNC:8785
Homologene: 380
Adra1d
Name: adrenergic receptor, alpha 1d
Synonyms: Adra-1, alpha1D-AR, Gpcr8, Adra1, Adra1a
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11550
HGNC: HGNC:280
Homologene: 551
Pigc
Name: phosphatidylinositol glycan anchor biosynthesis, class C
Synonyms: 3110030E07Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 67292
HGNC: HGNC:8960
Homologene: 7109
Vmn1r74
Name: vomeronasal 1 receptor 74
Synonyms: V1rg5
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 171240
Homologene: 110796
Fut2
Name: fucosyltransferase 2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 14344
HGNC: HGNC:4013
Homologene: 10325
Nipal2
Name: NIPA-like domain containing 2
Synonyms: Npal2, 9330161F08Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223473
VEGA: 15
Homologene: 41586
Dph7
Name: diphthamine biosynethesis 7
Synonyms: Wdr85, 2810443J12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 67228
Homologene: 5432
Vwa1
Name: von Willebrand factor A domain containing 1
Synonyms: WARP, 4932416A11Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 246228
Homologene: 11270
Ctsz
Name: cathepsin Z
Synonyms: cathepsin X, D2Wsu143e, CTSX
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 64138
HGNC: HGNC:2547
Homologene: 1022
Rps2
Name: ribosomal protein S2
Synonyms: Llrep3, Rps2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 16898
Homologene: 37714
Zfp397
Name: zinc finger protein 397
Synonyms: 6720480F11Rik, 2810411K16Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 69256
VEGA: 18
Homologene: 117445
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 66,413,669 bp
  • A to T, chromosome 1 at 66,509,287 bp
  • A to G, chromosome 1 at 78,696,995 bp
  • A to G, chromosome 1 at 161,787,128 bp
  • A to G, chromosome 1 at 161,970,565 bp
  • A to G, chromosome 1 at 193,354,027 bp
  • T to C, chromosome 2 at 24,969,544 bp
  • T to A, chromosome 2 at 30,069,427 bp
  • T to A, chromosome 2 at 58,014,868 bp
  • C to T, chromosome 2 at 131,561,772 bp
  • T to C, chromosome 2 at 165,812,426 bp
  • T to C, chromosome 2 at 174,429,153 bp
  • A to G, chromosome 3 at 129,855,000 bp
  • T to C, chromosome 4 at 46,609,071 bp
  • T to A, chromosome 4 at 155,772,894 bp
  • T to C, chromosome 5 at 143,195,022 bp
  • T to A, chromosome 5 at 144,198,602 bp
  • G to T, chromosome 6 at 108,829,061 bp
  • T to A, chromosome 7 at 11,847,603 bp
  • T to C, chromosome 7 at 45,651,142 bp
  • A to T, chromosome 9 at 82,930,374 bp
  • A to G, chromosome 10 at 18,531,432 bp
  • A to T, chromosome 11 at 59,031,877 bp
  • A to G, chromosome 11 at 98,652,046 bp
  • A to G, chromosome 11 at 101,738,264 bp
  • T to C, chromosome 11 at 119,278,384 bp
  • A to G, chromosome 12 at 82,341,301 bp
  • T to A, chromosome 13 at 13,970,869 bp
  • A to T, chromosome 14 at 68,516,573 bp
  • A to T, chromosome 15 at 34,678,573 bp
  • T to A, chromosome 15 at 78,348,119 bp
  • T to A, chromosome 16 at 33,029,024 bp
  • T to G, chromosome 16 at 73,933,160 bp
  • A to G, chromosome 17 at 24,720,435 bp
  • T to C, chromosome 17 at 36,461,770 bp
  • T to C, chromosome 17 at 44,101,335 bp
  • T to A, chromosome 18 at 23,956,507 bp
  • T to C, chromosome 18 at 61,285,925 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8135 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067563-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.