Strain Name:
C57BL/6J-MtgxR8175Btlr/Mmmh
Stock Number:
067600-MU
Citation ID:
RRID:MMRRC_067600-MU
Other Names:
R8175 (G1)
Major Collection:

Strain Information

Setd5
Name: SET domain containing 5
Synonyms: 2900045N06Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 72895
Homologene: 12485
Arhgap10
Name: Rho GTPase activating protein 10
Synonyms: A930033B01Rik, PSGAP-s, PSGAP-m
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 78514
Homologene: 12695
Fn1
Name: fibronectin 1
Synonyms: Fn, Fn-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14268
HGNC: HGNC:3778
Homologene: 1533
Atp1a1
Name: ATPase, Na+/K+ transporting, alpha 1 polypeptide
Synonyms: Atpa-1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 11928
HGNC: HGNC:799
Homologene: 564
Jade1
Name: jade family PHD finger 1
Synonyms: Phf17, D530048A03Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 269424
Homologene: 18162
Eif3g
Name: eukaryotic translation initiation factor 3, subunit G
Synonyms: Eif3s4, p44, D0Jmb4, TU-189B2, 44kDa
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 53356
VEGA: 9
HGNC: HGNC:3274
Homologene: 2784
Rabep1
Name: rabaptin, RAB GTPase binding effector protein 1
Synonyms: RAB5 effector protein, neurocrescin, rabaptin-5
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 54189
Homologene: 3451
Usp19
Name: ubiquitin specific peptidase 19
Synonyms: 8430421I07Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 71472
Homologene: 41730
Cse1l
Name: chromosome segregation 1 like
Synonyms: Capts, Cas, 2610100P18Rik, Xpo2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 110750
HGNC: HGNC:2431
Homologene: 1006
Pptc7
Name: PTC7 protein phosphatase homolog
Synonyms: 9130017A15Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 320717
Homologene: 6100
Epb41l3
Name: erythrocyte membrane protein band 4.1 like 3
Synonyms: NBL3, DAL1P, 4.1B, Epb4.1l3
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 13823
HGNC: HGNC:3380
Homologene: 49308
Ube4b
Name: ubiquitination factor E4B
Synonyms: D4Bwg0973e, 4930551I19Rik, UFD2, Ufd2p, UFD2a, 4933406G05Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 63958
Homologene: 107623
Coro1c
Name: coronin, actin binding protein 1C
Synonyms: CRN2, coronin 3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 23790
HGNC: HGNC:2254
Homologene: 56537
Itprid2
Name: ITPR interacting domain containing 2
Synonyms: Ssfa2, SPAG13, KRAP, CS1, CS-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 70599
Homologene: 4912
Ank3
Name: ankyrin 3, epithelial
Synonyms: Ank-3, AnkG, 2900054D09Rik, Ankyrin-3, Ankyrin-G
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 11735
HGNC: HGNC:494
Homologene: 56908
Capza2
Name: capping actin protein of muscle Z-line subunit alpha 2
Synonyms: 1110053K06Rik, Cappa2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12343
HGNC: HGNC:1490
Homologene: 55956
Slf1
Name: SMC5-SMC6 complex localization factor 1
Synonyms: 2700017A04Rik, C730024G01Rik, Brctd1, Brctx, Ankrd32
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 105377
Homologene: 13000
Ecpas
Name: Ecm29 proteasome adaptor and scaffold
Synonyms: AI314180
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230249
Homologene: 6056
Ehmt2
Name: euchromatic histone lysine N-methyltransferase 2
Synonyms: G9a, NG36, Bat8, D17Ertd710e, KMT1C
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 110147
Homologene: 48460
Zbtb20
Name: zinc finger and BTB domain containing 20
Synonyms: A930017C21Rik, 7330412A13Rik, HOF, D16Wsu73e, 1300017A20Rik, Zfp288
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 56490
Homologene: 9226
Gas1
Name: growth arrest specific 1
Synonyms: Gas-1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 14451
HGNC: HGNC:4165
Homologene: 1548
D5Ertd579e
Name: DNA segment, Chr 5, ERATO Doi 579, expressed
Synonyms: 9030221A05Rik, A930018H20Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 320661
Homologene: 19716
Setd1a
Name: SET domain containing 1A
Synonyms: KMT2F
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233904
Homologene: 52251
Eng
Name: endoglin
Synonyms: CD105, Endo
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 13805
HGNC: HGNC:3349
Homologene: 92
Lifr
Name: LIF receptor alpha
Synonyms: A230075M04Rik, soluble differentiation-stimulating factor receptor
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 16880
VEGA: 15
HGNC: HGNC:6597
Homologene: 1735
Ighmbp2
Name: immunoglobulin mu DNA binding protein 2
Synonyms: Smbp2, Catf1, Smubp2, p110 subunit, RIPE3b1, Smbp-2, sma, AEP
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 20589
HGNC: HGNC:5542
Homologene: 1642
Nelfa
Name: negative elongation factor complex member A, Whsc2
Synonyms: Whsc2h, Nelf-A, Whsc2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 24116
Homologene: 68478
Cpsf3
Name: cleavage and polyadenylation specificity factor 3
Synonyms: 73 kDa
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 54451
VEGA: 12
HGNC: HGNC:2326
Homologene: 6499
Lap3
Name: leucine aminopeptidase 3
Synonyms: Pep-S, LAP, peptidase S, Pep-7, Pep7
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 66988
Homologene: 41072
Btbd10
Name: BTB domain containing 10
Synonyms: Gmrp1, 1110056N09Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 68815
Homologene: 13009
F5
Name: coagulation factor V
Synonyms: Cf-5, Cf5
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14067
HGNC: HGNC:3542
Homologene: 104
Fsip2
Name: fibrous sheath-interacting protein 2
Synonyms: OTTMUSG00000013335
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241516
Homologene: 110349
Zfp790
Name: zinc finger protein 790
Synonyms: 6330581L23Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233056
Homologene: 51695
Fcgbpl1
Name: Fc fragment of IgG binding protein like 1
Synonyms: 9530053A07Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 319482
Homologene: 130055
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: OTTMUSG00000005786, LOC380698
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380698
Homologene: 70869
Krt4
Name: keratin 4
Synonyms: K4, Krt2-4, Krt-2.4
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 16682
VEGA: 15
HGNC: HGNC:6441
Homologene: 20523
Egflam
Name: EGF-like, fibronectin type III and laminin G domains
Synonyms: nectican, pikachurin
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 268780
Homologene: 65044
Traf6
Name: TNF receptor-associated factor 6
Synonyms: C630032O20Rik, 2310003F17Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22034
Homologene: 3395
Unc5d
Name: unc-5 netrin receptor D
Synonyms: D930029E11Rik, Unc5h4
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 210801
Homologene: 15450
Arhgef4
Name: Rho guanine nucleotide exchange factor 4
Synonyms: 9330140K16Rik, C230030N03Rik, Asef
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226970
HGNC: HGNC:684
Homologene: 49414
Fam227a
Name: family with sequence similarity 227, member A
Synonyms: 4933432B09Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 75729
Homologene: 123434
Megf6
Name: multiple EGF-like-domains 6
Synonyms: Egfl3, 2600001P17Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230971
HGNC: HGNC:3232
Homologene: 45412
Adamts15
Name: ADAM metallopeptidase with thrombospondin type 1 motif 15
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235130
VEGA: 9
Homologene: 8610
Ndufb10
Name: NADH:ubiquinone oxidoreductase subunit B10
Synonyms: 22kDa, 0610011B04Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 68342
HGNC: HGNC:7696
Homologene: 3343
Dcbld2
Name: discoidin, CUB and LCCL domain containing 2
Synonyms: CLCP1, 1700055P21Rik, Esdn
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 73379
Homologene: 12499
Aim2
Name: absent in melanoma 2
Synonyms: Ifi210, LOC383619
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 383619
HGNC: HGNC:357
Homologene: 83226
Ren1
Name: renin 1 structural
Synonyms: Rnr, Ren, Ren-1, Ren-A, Ren1c, Rn-1, Ren1d
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 19701
HGNC: HGNC:9958
Homologene: 20151
Cobll1
Name: Cobl-like 1
Synonyms: Coblr1, D430044D16Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 319876
Homologene: 8933
Fam50b
Name: family with sequence similarity 50, member B
Synonyms: D0H6S2654E, X5L, XAP-5-like
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 108161
VEGA: 13
Homologene: 101669
Vmn2r12
Name: vomeronasal 2, receptor 12
Synonyms: Gm6769
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 627569
Homologene: 129606
Igsf21
Name: immunoglobulin superfamily, member 21
Synonyms: LOC230868
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230868
Homologene: 13153
Tgfbr2
Name: transforming growth factor, beta receptor II
Synonyms: TBR-II, TbetaRII, TbetaR-II, 1110020H15Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 21813
VEGA: 9
Homologene: 2435
Hus1b
Name: HUS1 checkpoint clamp component B
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 210554
Homologene: 51833
Taf10
Name: TATA-box binding protein associated factor 10
Synonyms: Taf2h, 30kDa, TAFII30
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 24075
Homologene: 86923
Smoc1
Name: SPARC related modular calcium binding 1
Synonyms: SRG, SPARC-related protein, 2600002F22Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 64075
Homologene: 56943
Pxdc1
Name: PX domain containing 1
Synonyms: 1300014I06Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 66895
Homologene: 12051
Tmem181a
Name: transmembrane protein 181A
Synonyms: Tmem181, Gpr178, 5930418K15Rik, C76977
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 77106
Homologene: 44787
Tssc1
Name:
Type: Gene
Species: Mouse
Chromosome: 12
Fam65c
Name:
Type: Gene
Species: Mouse
Chromosome: 2
Hmha1
Name:
Type: Gene
Species: Mouse
Chromosome: 10
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 34,810,374 bp
  • A to G, chromosome 1 at 71,599,665 bp
  • T to C, chromosome 1 at 133,354,269 bp
  • A to T, chromosome 1 at 164,192,265 bp
  • A to T, chromosome 1 at 173,455,354 bp
  • C to A, chromosome 2 at 32,678,922 bp
  • T to C, chromosome 2 at 65,099,231 bp
  • A to G, chromosome 2 at 79,658,152 bp
  • T to A, chromosome 2 at 82,984,744 bp
  • A to T, chromosome 2 at 82,987,677 bp
  • C to T, chromosome 2 at 101,691,480 bp
  • T to A, chromosome 2 at 166,943,208 bp
  • T to C, chromosome 2 at 167,983,759 bp
  • G to T, chromosome 3 at 41,613,288 bp
  • A to G, chromosome 3 at 101,584,854 bp
  • C to T, chromosome 4 at 58,872,756 bp
  • A to T, chromosome 4 at 140,028,231 bp
  • T to C, chromosome 4 at 149,351,516 bp
  • T to A, chromosome 4 at 154,268,619 bp
  • T to C, chromosome 5 at 33,922,013 bp
  • T to C, chromosome 5 at 36,615,470 bp
  • T to C, chromosome 5 at 45,509,491 bp
  • T to A, chromosome 5 at 109,090,483 bp
  • T to A, chromosome 5 at 113,850,815 bp
  • T to A, chromosome 5 at 122,319,819 bp
  • G to A, chromosome 6 at 17,665,382 bp
  • T to C, chromosome 6 at 113,114,913 bp
  • T to A, chromosome 7 at 28,164,448 bp
  • T to G, chromosome 7 at 29,829,780 bp
  • T to C, chromosome 7 at 105,743,927 bp
  • T to A, chromosome 7 at 113,322,792 bp
  • A to G, chromosome 7 at 127,796,243 bp
  • T to A, chromosome 8 at 28,844,827 bp
  • T to C, chromosome 8 at 77,310,842 bp
  • A to T, chromosome 9 at 20,897,730 bp
  • C to T, chromosome 9 at 30,904,656 bp
  • G to A, chromosome 9 at 108,500,178 bp
  • G to A, chromosome 9 at 116,109,955 bp
  • T to C, chromosome 10 at 69,893,509 bp
  • G to A, chromosome 10 at 80,027,872 bp
  • C to T, chromosome 11 at 58,995,960 bp
  • T to A, chromosome 11 at 70,884,929 bp
  • T to C, chromosome 12 at 21,300,177 bp
  • A to G, chromosome 12 at 28,863,107 bp
  • A to G, chromosome 12 at 81,167,666 bp
  • A to G, chromosome 13 at 30,947,232 bp
  • A to G, chromosome 13 at 34,628,815 bp
  • G to A, chromosome 13 at 34,746,864 bp
  • T to C, chromosome 13 at 60,176,118 bp
  • A to T, chromosome 13 at 77,112,671 bp
  • A to G, chromosome 15 at 7,187,015 bp
  • C to A, chromosome 15 at 7,212,152 bp
  • A to G, chromosome 15 at 79,640,660 bp
  • A to G, chromosome 15 at 101,920,549 bp
  • A to T, chromosome 16 at 43,577,080 bp
  • T to C, chromosome 16 at 58,433,347 bp
  • A to G, chromosome 17 at 6,295,800 bp
  • A to T, chromosome 17 at 24,724,192 bp
  • A to G, chromosome 17 at 34,911,420 bp
  • T to C, chromosome 17 at 69,210,366 bp
  • A to G, chromosome 19 at 3,266,365 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8175 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067600-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.