Strain Name:
C57BL/6J-MtgxR8255Btlr/Mmmh
Stock Number:
067681-MU
Citation ID:
RRID:MMRRC_067681-MU
Other Names:
R8255 (G1)
Major Collection:

Strain Information

Ank2
Name: ankyrin 2, brain
Synonyms: ankyrin B, Gm4392, Ankyrin-B, Ank-2, Ankyrin-2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 109676
HGNC: HGNC:493
Abca12
Name: ATP-binding cassette, sub-family A member 12
Synonyms: 4833417A11Rik, 4832428G11Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74591
Homologene: 45441
Thbs3
Name: thrombospondin 3
Synonyms: Thbs-3, TSP3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 21827
Homologene: 5159
Birc6
Name: baculoviral IAP repeat-containing 6
Synonyms: D630005A10Rik, apollon, A430032G04Rik, A430040A19Rik, Bruce
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12211
Homologene: 7248
Hmmr
Name: hyaluronan mediated motility receptor (RHAMM)
Synonyms: CD168, Rhamm
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 15366
HGNC: HGNC:5012
Homologene: 8271
Med27
Name: mediator complex subunit 27
Synonyms: 1500015J03Rik, 2310042P07Rik, D2Ertd434e, Crsp8
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68975
HGNC: HGNC:2377
Homologene: 3152
Hat1
Name: histone aminotransferase 1
Synonyms: 2410071B14Rik, KAT1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 107435
HGNC: HGNC:4821
Homologene: 2701
Tmem161b
Name: transmembrane protein 161B
Synonyms: 2810446P07Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 72745
Homologene: 14519
Nol6
Name: nucleolar protein family 6 (RNA-associated)
Synonyms: Nrap
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230082
Homologene: 41505
Zzef1
Name: zinc finger, ZZ-type with EF hand domain 1
Synonyms: 8430405D05Rik, C130099L13Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 195018
Homologene: 9027
Son
Name: Son DNA binding protein
Synonyms: 2900011L12Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 20658
Homologene: 10551
Zfp30
Name: zinc finger protein 30
Synonyms: Zfp-30, 2610306P15Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22693
Homologene: 84799
Smc5
Name: structural maintenance of chromosomes 5
Synonyms: Smc5l1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226026
VEGA: 19
Homologene: 41009
Dhx32
Name: DEAH-box helicase 32 (putative)
Synonyms: Ddx32, DEAH (Asp-Glu-Ala-His) box polypeptide 32
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101437
Homologene: 56798
Sult1a1
Name: sulfotransferase family 1A, phenol-preferring, member 1
Synonyms: Stp1, PST
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20887
Homologene: 128224
Zbtb18
Name: zinc finger and BTB domain containing 18
Synonyms: Zfp238, RP58
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 30928
Homologene: 21276
Moxd1
Name: monooxygenase, DBH-like 1
Synonyms: 3230402N08Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 59012
Homologene: 22904
Skor2
Name: SKI family transcriptional corepressor 2
Synonyms: Fussel18, Corl2, Gm7348
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 664805
VEGA: 18
Homologene: 64797
Fat2
Name: FAT atypical cadherin 2
Synonyms: EMI2, mKIAA0811, LOC245827, Fath2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 245827
HGNC: HGNC:3596
Homologene: 1110
Abca4
Name: ATP-binding cassette, sub-family A member 4
Synonyms: Rim protein, RmP, D430003I15Rik, Abc10
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 11304
HGNC: HGNC:34
Homologene: 298
Ipcef1
Name: interaction protein for cytohesin exchange factors 1
Synonyms: A130090K04Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 320495
Homologene: 32271
Sult3a2
Name: sulfotransferase family 3A, member 2
Synonyms: Gm4794
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 215895
VEGA: 10
Homologene: 111031
Rnf135
Name: ring finger protein 135
Synonyms: 0610037N03Rik, 2410006N06Rik, MGC13061, U 2-3-0
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71956
Homologene: 12427
Vmn1r179
Name: vomeronasal 1 receptor 179
Synonyms: V1rd17
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 404286
Homologene: 134022
Hcrtr2
Name: hypocretin (orexin) receptor 2
Synonyms: mOX2aR, OX2r, mOXR2, mOX2bR
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 387285
HGNC: HGNC:4849
Homologene: 1168
Wdr31
Name: WD repeat domain 31
Synonyms: 5430402I10Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 71354
Homologene: 11360
Myh3
Name: myosin, heavy polypeptide 3, skeletal muscle, embryonic
Synonyms: Myhse, MyHC-emb, Myhs-e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17883
HGNC: HGNC:7573
Homologene: 20553
Or5p51
Name: olfactory receptor family 5 subfamily P member 51
Synonyms: Olfr470, GA_x6K02T2PBJ9-10175273-10174329, MOR204-22
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258417
Chd5
Name: chromodomain helicase DNA binding protein 5
Synonyms: B230399N07Rik, 4930532L22Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 269610
Homologene: 56712
Il1rl2
Name: interleukin 1 receptor-like 2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 107527
HGNC: HGNC:5999
Homologene: 2860
Tnfrsf8
Name: tumor necrosis factor receptor superfamily, member 8
Synonyms: CD30
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 21941
Homologene: 949
Or2z8
Name: olfactory receptor family 2 subfamily Z member 8
Synonyms: Olfr372, GA_x6K02T2NUPS-191522-192466, MOR282-1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 404315
Homologene: 17287
Gpaa1
Name: GPI anchor attachment protein 1
Synonyms: mGAA1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 14731
HGNC: HGNC:4446
Homologene: 37852
Sdr42e1
Name: short chain dehydrogenase/reductase family 42E, member 1
Synonyms: 4632417N05Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 74032
Homologene: 23654
Or2v1
Name: olfactory receptor family 2 subfamily V member 1
Synonyms: GA_x6K02T2QP88-6300500-6299553, Olfr56, IF7, MOR276-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18356
HGNC: HGNC:8280
Homologene: 22608
Ifi44
Name: interferon-induced protein 44
Synonyms: MTAP44, p44, A430056A10Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99899
Homologene: 4683
2210408I21Rik
Name: RIKEN cDNA 2210408I21 gene
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 72371
Homologene: 89234
Vmn1r121
Name: vomeronasal 1 receptor 121
Synonyms: Gm8533
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 667240
Homologene: 104166
Ifi35
Name: interferon-induced protein 35
Synonyms: IFP35, 2010008K16Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 70110
HGNC: HGNC:5399
Homologene: 4040
Tlcd3b
Name: TLC domain containing 3B
Synonyms: A330104J06Rik, 1500016O10Rik, Fam57b
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 68952
Homologene: 69491
Gzmg
Name: granzyme G
Synonyms: Ctla-7, Ctla7
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 14944
VEGA: 14
Homologene: 133275
Slc7a11
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 11
Synonyms: System xc, 9930009M05Rik, sut, xc, xCT
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 26570
Homologene: 22684
Or4k15c
Name: olfactory receptor family 4 subfamily K member 15C
Synonyms: MOR246-4, GA_x6K02T2PMLR-5775299-5774334, Olfr726
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 258313
Homologene: 44957
Med31
Name: mediator complex subunit 31
Synonyms: 3110004H13Rik, l11Jus15
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67279
Homologene: 9368
Dnah7c
Name: dynein, axonemal, heavy chain 7C
Synonyms: Dnahc7c
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 100101919
Homologene: 41287
Nkx2-4
Name: NK2 homeobox 4
Synonyms: 1700001P03Rik, Nkx-2.4, tinman
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228731
HGNC: HGNC:7837
Homologene: 41526
Tas1r1
Name: taste receptor, type 1, member 1
Synonyms: T1R1, TR1, Gpr70, T1r1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 110326
Homologene: 12888
Gm12888
Name: predicted gene 12888
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 545677
Homologene: 111034
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 40,365,311 bp
  • T to C, chromosome 1 at 46,659,429 bp
  • T to A, chromosome 1 at 71,319,899 bp
  • T to C, chromosome 1 at 177,447,437 bp
  • C to A, chromosome 2 at 29,524,364 bp
  • A to G, chromosome 2 at 71,409,003 bp
  • C to A, chromosome 2 at 147,084,004 bp
  • A to T, chromosome 3 at 50,427,728 bp
  • A to C, chromosome 3 at 89,225,258 bp
  • A to T, chromosome 3 at 122,155,277 bp
  • A to G, chromosome 3 at 126,946,749 bp
  • A to T, chromosome 3 at 151,745,982 bp
  • G to T, chromosome 4 at 41,120,168 bp
  • A to T, chromosome 4 at 62,463,397 bp
  • A to G, chromosome 4 at 121,324,797 bp
  • A to T, chromosome 4 at 145,315,083 bp
  • A to T, chromosome 4 at 152,032,317 bp
  • A to G, chromosome 4 at 152,379,423 bp
  • T to G, chromosome 7 at 21,097,754 bp
  • C to T, chromosome 7 at 23,929,011 bp
  • T to A, chromosome 7 at 29,789,401 bp
  • A to G, chromosome 7 at 107,845,161 bp
  • T to A, chromosome 7 at 126,675,108 bp
  • G to A, chromosome 7 at 126,824,103 bp
  • T to C, chromosome 7 at 133,737,391 bp
  • T to A, chromosome 8 at 72,057,763 bp
  • G to T, chromosome 8 at 117,663,763 bp
  • T to A, chromosome 9 at 76,232,921 bp
  • T to G, chromosome 10 at 6,920,007 bp
  • A to G, chromosome 10 at 24,223,802 bp
  • T to C, chromosome 10 at 33,779,751 bp
  • T to C, chromosome 11 at 40,707,435 bp
  • C to A, chromosome 11 at 49,134,480 bp
  • T to A, chromosome 11 at 55,270,275 bp
  • A to G, chromosome 11 at 67,095,022 bp
  • G to A, chromosome 11 at 72,215,468 bp
  • A to G, chromosome 11 at 72,875,129 bp
  • A to G, chromosome 11 at 80,193,887 bp
  • A to T, chromosome 11 at 101,457,782 bp
  • A to T, chromosome 13 at 77,267,731 bp
  • C to A, chromosome 13 at 84,222,418 bp
  • C to T, chromosome 14 at 50,083,872 bp
  • T to A, chromosome 14 at 56,158,296 bp
  • T to C, chromosome 15 at 76,333,238 bp
  • A to T, chromosome 16 at 91,664,936 bp
  • G to A, chromosome 17 at 74,662,780 bp
  • T to C, chromosome 18 at 76,858,969 bp
  • A to T, chromosome 19 at 23,208,926 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8255 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067681-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.