Strain Name:
C57BL/6J-MtgxR8270Btlr/Mmmh
Stock Number:
067694-MU
Citation ID:
RRID:MMRRC_067694-MU
Other Names:
R8270 (G1)
Major Collection:

Strain Information

D630045J12Rik
Name: RIKEN cDNA D630045J12 gene
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330286
Homologene: 19782
Gtf2h3
Name: general transcription factor IIH, polypeptide 3
Synonyms: 34kDa, 5033417D07Rik, D5Ertd679e, BTF2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 209357
HGNC: HGNC:4657
Homologene: 1160
Iqgap1
Name: IQ motif containing GTPase activating protein 1
Synonyms: D7Ertd237e, D7Ertd257e
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 29875
HGNC: HGNC:6110
Homologene: 74514
Arhgef12
Name: Rho guanine nucleotide exchange factor 12
Synonyms: 2310014B11Rik, LARG
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 69632
VEGA: 9
Homologene: 9088
Prdm5
Name: PR domain containing 5
Synonyms: E130112L17Rik, PFM2, 4432417F03Rik, 6530401I24Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 70779
HGNC: HGNC:9349
Homologene: 10274
Tnrc6a
Name: trinucleotide repeat containing 6a
Synonyms: CAGH26, D130023A07Rik, 3110054G10Rik, Tnrc6, 2010321I05Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233833
Homologene: 41399
Sec24d
Name: SEC24 homolog D, COPII coat complex component
Synonyms: LOC383951, 2310020L09Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 69608
Homologene: 40986
Nckap1
Name: NCK-associated protein 1
Synonyms: Hem2, Hem-2, mh19, Nap1, H19
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 50884
HGNC: HGNC:7666
Homologene: 8384
Csde1
Name: cold shock domain containing E1, RNA binding
Synonyms: D3Jfr1, unr
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229663
Homologene: 5179
Esf1
Name: ESF1 nucleolar pre-rRNA processing protein homolog
Synonyms: 2610101J03Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66580
Homologene: 5717
Herc1
Name: HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
Synonyms: 2810449H11Rik, D130015N03Rik, tbl
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235439
HGNC: HGNC:4867
Homologene: 31207
Atp5pd
Name: ATP synthase peripheral stalk subunit d
Synonyms: 0610009D10Rik, Atp5h
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71679
HGNC: HGNC:845
Homologene: 130552
Bicc1
Name: BicC family RNA binding protein 1
Synonyms: Bic-C, jcpk
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 83675
Homologene: 12856
Dnah8
Name: dynein, axonemal, heavy chain 8
Synonyms: Hst6.7b, Dnahc8, P1-Loop
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 13417
VEGA: 17
HGNC: HGNC:2952
Homologene: 1049
Arhgap44
Name: Rho GTPase activating protein 44
Synonyms: AU040829
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216831
Homologene: 65284
Piezo1
Name: piezo-type mechanosensitive ion channel component 1
Synonyms: Fam38a, Piezo1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234839
Homologene: 124356
Ppp1r12b
Name: protein phosphatase 1, regulatory subunit 12B
Synonyms: 9530009M10Rik, 1810037O03Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329251
HGNC: HGNC:7619
Homologene: 135710
Atp6v0a4
Name: ATPase, H+ transporting, lysosomal V0 subunit A4
Synonyms: Atp6n1b, V-ATPase alpha 4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 140494
HGNC: HGNC:866
Homologene: 39904
Ush2a
Name: usherin
Synonyms: MUSH2A, LOC269160, Ush2a, A930037M10Rik, A930011D15Rik, LOC381317, Ushrn
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22283
Homologene: 66151
Cdh5
Name: cadherin 5
Synonyms: 7B4/cadherin-5, VE-Cad, VEcad, VE-cadherin, CD144, VECD, VEC
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12562
HGNC: HGNC:1764
Homologene: 1359
Adgrv1
Name: adhesion G protein-coupled receptor V1
Synonyms: Mgr1, Mass1, Gpr98, VLGR1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 110789
Homologene: 19815
Capn7
Name: calpain 7
Synonyms: PalBH
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 12339
HGNC: HGNC:1484
Homologene: 7651
Tcaf2
Name: TRPM8 channel-associated factor 2
Synonyms: Fam115c
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232748
Homologene: 17147
Cass4
Name: Cas scaffolding protein family member 4
Synonyms: F730031O20Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 320664
Homologene: 75128
Lrrc37
Name: leucine rich repeat containing 37
Synonyms: Gm884, LOC380730
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380730
Homologene: 134511
Usp35
Name: ubiquitin specific peptidase 35
Synonyms: LOC244144, LOC381901
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244144
Homologene: 35459
Ctse
Name: cathepsin E
Synonyms: A430072O03Rik, C920004C08Rik, CatE, CE
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13034
HGNC: HGNC:2530
Homologene: 37551
Cacna1i
Name: calcium channel, voltage-dependent, alpha 1I subunit
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239556
HGNC: HGNC:1396
Homologene: 69331
Serac1
Name: serine active site containing 1
Synonyms: 4930511N22Rik, D17Ertd141e
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 321007
Homologene: 41900
Dclre1a
Name: DNA cross-link repair 1A
Synonyms: SNM1, 2810043H12Rik, mSNM1, SMN1a
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 55947
Homologene: 8920
Serpina1f
Name: serine (or cysteine) peptidase inhibitor, clade A, member 1F
Synonyms: Serpina2, 0610012A11Rik, epserin
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 68348
HGNC: HGNC:8985
Homologene: 87037
Sspo
Name: SCO-spondin
Synonyms: Scospondin, C79529
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243369
Homologene: 45453
Mfap5
Name: microfibrillar associated protein 5
Synonyms: MAGP-2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 50530
Homologene: 2599
Map1a
Name: microtubule-associated protein 1 A
Synonyms: Mtap1a, Mtap-1, Mtap1, 6330416M19Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17754
HGNC: HGNC:6835
Homologene: 1778
Or8b46
Name: olfactory receptor family 8 subfamily B member 46
Synonyms: Olfr910, GA_x6K02T2PVTD-32239063-32239995, MOR165-3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258807
VEGA: 9
Homologene: 115510
Dmc1
Name: DNA meiotic recombinase 1
Synonyms: Mei11, sgdp, Dmc1h, Dmc1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 13404
VEGA: 15
HGNC: HGNC:2927
Homologene: 5135
Gm4922
Name: predicted gene 4922
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237300
VEGA: 10
Homologene: 50497
Krtap5-1
Name: keratin associated protein 5-1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 50774
Smr2l
Name: submaxillary gland androgen regulated protein 2 like
Synonyms: Gm7714
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 665615
Or5p78
Name: olfactory receptor family 5 subfamily P member 78
Synonyms: GA_x6K02T2PBJ9-10942040-10942984, Olfr506, MOR204-23
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258215
Homologene: 133672
Fbxl12
Name: F-box and leucine-rich repeat protein 12
Synonyms: 3110048D16Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 30843
Homologene: 32198
Rbks
Name: ribokinase
Synonyms: 5230400M11Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71336
Homologene: 5482
Hapln2
Name: hyaluronan and proteoglycan link protein 2
Synonyms: 4930401E20Rik, Bral1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 73940
Homologene: 11045
Apbb1ip
Name: amyloid beta precursor protein binding family B member 1 interacting protein
Synonyms: proline-rich protein 48, Prp48, 9930118P07Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 54519
Homologene: 32434
Klk1b26
Name: kallikrein 1-related petidase b26
Synonyms: Klk26, Egfbp2, PRECE-2, mGK-26, EGF-BP type B
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16618
Homologene: 68141
Kcnk10
Name: potassium channel, subfamily K, member 10
Synonyms: 3010005K24Rik, Trek2, 1700024D23Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 72258
VEGA: 12
HGNC: HGNC:6273
Homologene: 11321
Prr27
Name: proline rich 27
Synonyms: 4930432K09Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 73779
Homologene: 136277
Cyp2d34
Name: cytochrome P450, family 2, subfamily d, polypeptide 34
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223706
VEGA: 15
Homologene: 86099
Optc
Name: opticin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 269120
HGNC: HGNC:8158
Homologene: 8652
Klhl3
Name: kelch-like 3
Synonyms: EG627648, 7530408C15Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 100503085
HGNC: HGNC:6354
Homologene: 79542
Prr30
Name: proline rich 30
Synonyms: 1700110M21Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 76627
Homologene: 130773
Fxyd5
Name: FXYD domain-containing ion transport regulator 5
Synonyms: dysadherin, EF-8, Oit2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18301
HGNC: HGNC:4029
Homologene: 7458
Crisp3
Name: cysteine-rich secretory protein 3
Synonyms: Aeg2, CRISP-3, SGP28, CRS3
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 11572
Homologene: 135665
Fn3k
Name: fructosamine 3 kinase
Synonyms: 2310074G21Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 63828
Homologene: 23336
Krtap5-3
Name: keratin associated protein 5-3
Synonyms: A030007E19Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 77215
Gm21958
Name: predicted gene, 21958
Type: Gene
Species: Mouse
Chromosome: 3
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 131,668,139 bp
  • C to T, chromosome 1 at 133,905,072 bp
  • G to T, chromosome 1 at 134,876,148 bp
  • T to C, chromosome 1 at 188,444,641 bp
  • C to T, chromosome 2 at 22,874,992 bp
  • T to A, chromosome 2 at 80,524,664 bp
  • T to C, chromosome 2 at 121,299,020 bp
  • A to T, chromosome 2 at 140,155,113 bp
  • T to A, chromosome 2 at 172,427,669 bp
  • G to A, chromosome 3 at 54,714,212 bp
  • G to A, chromosome 3 at 88,023,544 bp
  • G to A, chromosome 3 at 103,038,755 bp
  • T to C, chromosome 3 at 123,305,886 bp
  • A to T, chromosome 5 at 31,650,466 bp
  • A to C, chromosome 5 at 87,846,312 bp
  • T to C, chromosome 5 at 88,282,524 bp
  • A to G, chromosome 5 at 124,595,987 bp
  • A to G, chromosome 6 at 38,074,229 bp
  • A to T, chromosome 6 at 38,190,723 bp
  • A to T, chromosome 6 at 42,630,024 bp
  • A to T, chromosome 6 at 48,449,963 bp
  • T to A, chromosome 6 at 65,936,074 bp
  • T to C, chromosome 6 at 122,521,930 bp
  • A to G, chromosome 7 at 31,041,429 bp
  • A to T, chromosome 7 at 44,016,120 bp
  • A to G, chromosome 7 at 80,730,127 bp
  • T to C, chromosome 7 at 97,312,344 bp
  • T to A, chromosome 7 at 108,612,943 bp
  • T to A, chromosome 7 at 123,170,071 bp
  • T to A, chromosome 7 at 142,201,956 bp
  • C to A, chromosome 7 at 142,296,462 bp
  • A to G, chromosome 8 at 104,113,040 bp
  • A to G, chromosome 8 at 122,501,559 bp
  • C to A, chromosome 9 at 20,638,864 bp
  • T to G, chromosome 9 at 38,539,348 bp
  • T to C, chromosome 9 at 42,971,058 bp
  • T to G, chromosome 9 at 66,487,950 bp
  • G to T, chromosome 9 at 89,085,405 bp
  • C to T, chromosome 10 at 18,784,012 bp
  • T to A, chromosome 10 at 70,932,108 bp
  • A to G, chromosome 11 at 65,022,034 bp
  • T to C, chromosome 11 at 103,543,315 bp
  • T to C, chromosome 11 at 115,416,872 bp
  • A to T, chromosome 11 at 121,439,311 bp
  • T to C, chromosome 12 at 98,435,099 bp
  • A to G, chromosome 12 at 103,693,498 bp
  • A to T, chromosome 13 at 58,113,154 bp
  • G to A, chromosome 13 at 81,503,044 bp
  • A to G, chromosome 14 at 31,358,679 bp
  • A to G, chromosome 14 at 101,198,386 bp
  • T to C, chromosome 15 at 79,601,545 bp
  • T to A, chromosome 15 at 80,373,634 bp
  • T to A, chromosome 15 at 82,620,787 bp
  • A to T, chromosome 17 at 6,050,758 bp
  • C to T, chromosome 17 at 30,840,713 bp
  • T to C, chromosome 17 at 40,235,922 bp
  • G to A, chromosome 19 at 56,544,950 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8270 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067694-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.