Strain Name:
C57BL/6J-MtgxR8342Btlr/Mmmh
Stock Number:
067731-MU
Citation ID:
RRID:MMRRC_067731-MU
Other Names:
R8342 (G1)
Major Collection:

Strain Information

Eno1
Name: enolase 1, alpha non-neuron
Synonyms: Eno-1, 2-phospho-D-glycerate hydrolase, alpha-enolase, c-Myc promoter binding protein, MBP-1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 13806
HGNC: HGNC:3350
Homologene: 134343
Ppm1a
Name: protein phosphatase 1A, magnesium dependent, alpha isoform
Synonyms: Mpp alpha, MPPa-1, 2900017D14Rik, 2310003C21Rik, MMPa-2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 19042
VEGA: 12
HGNC: HGNC:9275
Homologene: 56428
Nrg1
Name: neuregulin 1
Synonyms: GGFII, HGL, Hgl, SMDF, GGF, HRG, D230005F13Rik, ARIA, HRGalpha, heregulin, 6030402G23Rik, NDF
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 211323
HGNC: HGNC:7997
Homologene: 138451
Ubr5
Name: ubiquitin protein ligase E3 component n-recognin 5
Synonyms: Edd1, Edd, 4432411E13Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 70790
VEGA: 15
Homologene: 9295
Ckap5
Name: cytoskeleton associated protein 5
Synonyms: 3110043H24Rik, D730027C18Rik, 4930432B04Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 75786
Homologene: 8844
Kif1b
Name: kinesin family member 1B
Synonyms: Kif1b beta, A530096N05Rik, N-3 kinesin, D4Mil1e, KIF1Bp204, KIF1Bp130, Kif1b alpha
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 16561
Homologene: 99835
Arrdc3
Name: arrestin domain containing 3
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 105171
Homologene: 69318
Ate1
Name: arginyltransferase 1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 11907
HGNC: HGNC:782
Homologene: 31420
Syne1
Name: spectrin repeat containing, nuclear envelope 1
Synonyms: enaptin165, nesprin-1, A330049M09Rik, C130039F11Rik, SYNE-1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 64009
VEGA: 10
Homologene: 52329
Syn3
Name: synapsin III
Synonyms: Synapsin IIIa
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 27204
Homologene: 68320
Atp6v1b2
Name: ATPase, H+ transporting, lysosomal V1 subunit B2
Synonyms: Atp6b2, HO57
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11966
HGNC: HGNC:854
Homologene: 1279
Numb
Name: NUMB endocytic adaptor protein
Synonyms: m-numb
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 18222
HGNC: HGNC:8060
Homologene: 2775
Prune2
Name: prune homolog 2
Synonyms: 6330414G02Rik, A330102H22Rik, Olfaxin, A230083H22Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 353211
VEGA: 19
Homologene: 18939
Chst15
Name: carbohydrate sulfotransferase 15
Synonyms: MAd5, GalNAcS-6ST, MAd5, 4631426J05Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 77590
Homologene: 8908
Muc16
Name: mucin 16
Synonyms: 1110008I14Rik, LOC385009, Gm21044
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 73732
Homologene: 141193
Aak1
Name: AP2 associated kinase 1
Synonyms: D6Ertd245e, 5530400K14Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 269774
Homologene: 128746
Slc12a7
Name: solute carrier family 12, member 7
Synonyms: Kcc4
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20499
VEGA: 13
Homologene: 21312
Marchf6
Name: membrane associated ring-CH-type finger 6
Synonyms: F830029L24Rik, March6
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223455
VEGA: 15
Homologene: 4301
Nr2e1
Name: nuclear receptor subfamily 2, group E, member 1
Synonyms: Nr2e1, tailless, Mtll, Tlx
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 21907
HGNC: HGNC:7973
Homologene: 37750
Sucnr1
Name: succinate receptor 1
Synonyms: Gpr91
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 84112
HGNC: HGNC:4542
Homologene: 41865
Cars2
Name: cysteinyl-tRNA synthetase 2, mitochondrial
Synonyms: D530030H10Rik, 2410044A07Rik, 2310051N18Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 71941
Homologene: 11575
Trpc1
Name: transient receptor potential cation channel, subfamily C, member 1
Synonyms: Mtrp1, Trp1, Trrp1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 22063
Homologene: 2478
Tmco5
Name: transmembrane and coiled-coil domains 5
Synonyms: 1700095F04Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 67356
Homologene: 41661
Ttn
Name: titin
Synonyms: shru, L56, mdm, connectin, D330041I19Rik, 2310057K23Rik, 2310074I15Rik, 2310036G12Rik, D830007G01Rik, 1100001C23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Myh15
Name: myosin, heavy chain 15
Synonyms: EG667772
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 667772
VEGA: 16
Homologene: 18929
Loxhd1
Name: lipoxygenase homology domains 1
Synonyms: 1700096C21Rik, sba
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240411
Dpyd
Name: dihydropyrimidine dehydrogenase
Synonyms: E330028L06Rik, DPD
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99586
HGNC: HGNC:3012
Homologene: 85
Col9a3
Name: collagen, type IX, alpha 3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12841
HGNC: HGNC:2219
Homologene: 20438
Lrp4
Name: low density lipoprotein receptor-related protein 4
Synonyms: mdig, 6430526J12Rik, Megf7
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228357
HGNC: HGNC:6696
Homologene: 17964
Scn9a
Name: sodium channel, voltage-gated, type IX, alpha
Synonyms: PN1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20274
Homologene: 2237
Adad1
Name: adenosine deaminase domain containing 1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 21744
Homologene: 7569
Muc5b
Name: mucin 5, subtype B, tracheobronchial
Synonyms: MUC5, 2300002I04Rik, MUC9
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 74180
HGNC: HGNC:7516
Homologene: 136756
Ankar
Name: ankyrin and armadillo repeat containing
Synonyms: 4932422E22Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 319695
Homologene: 85163
Steap1
Name: six transmembrane epithelial antigen of the prostate 1
Synonyms: 2410007B19Rik, Prss24
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 70358
Homologene: 8256
Dlec1
Name: deleted in lung and esophageal cancer 1
Synonyms: D630005C06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320256
HGNC: HGNC:2899
Homologene: 84733
Arl6
Name: ADP-ribosylation factor-like 6
Synonyms: 1110018H24Rik, BBS3, 2210411E14Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 56297
Homologene: 12960
Nrg3
Name: neuregulin 3
Synonyms: ska
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 18183
HGNC: HGNC:7999
Homologene: 32051
Cdkl1
Name: cyclin dependent kinase like 1
Synonyms: 4933411O17Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 71091
VEGA: 12
HGNC: HGNC:1781
Homologene: 55805
Pramel14
Name: PRAME like 14
Synonyms: Pramef17, Gm13107
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 626943
Homologene: 129642
Agbl4
Name: ATP/GTP binding protein-like 4
Synonyms: 4931433A01Rik, 4930578N11Rik, Ccp6
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 78933
Homologene: 84880
Vmn2r60
Name: vomeronasal 2, receptor 60
Synonyms: Casr-rs3, Gprc2a-rs3, EG637898
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 637898
Homologene: 129683
Slc23a1
Name: solute carrier family 23 (nucleobase transporters), member 1
Synonyms: D18Ucla2, SVCT1, YSPL3, Slc23a2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 20522
Homologene: 40769
Klk1b26
Name: kallikrein 1-related petidase b26
Synonyms: Klk26, Egfbp2, PRECE-2, mGK-26, EGF-BP type B
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16618
Homologene: 68141
Repin1
Name: replication initiator 1
Synonyms: AP4, E430037F08Rik, Zfp464
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 58887
Homologene: 22810
Ceacam5
Name: CEA cell adhesion molecule 5
Synonyms: 1600029H12Rik, Psg30
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 73250
HGNC: HGNC:1819
Homologene: 115938
Potegl
Name: POTE ankyrin domain family, member G like
Synonyms: 4931423N10Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 70981
Homologene: 86765
Sult3a1
Name: sulfotransferase family 3A, member 1
Synonyms: Sultx2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 57430
VEGA: 10
Homologene: 111031
Slc37a2
Name: solute carrier family 37 (glycerol-3-phosphate transporter), member 2
Synonyms: Slc37a1, cI-2, G3PP, ci2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 56857
Homologene: 41357
Gnat3
Name: G protein subunit alpha transducin 3
Synonyms: Gtn, alpha-gustducin, Ggust
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 242851
Homologene: 24284
Ahr
Name: aryl-hydrocarbon receptor
Synonyms: Ahh, Ah, In, Ahre, dioxin receptor, bHLHe76
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 11622
HGNC: HGNC:348
Homologene: 1224
Or1l4b
Name: olfactory receptor family 1 subfamily L member 4B
Synonyms: MOR138-7, MOR138-4P, Olfr364, GA_x6K02T2NLDC-33831282-33832243
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227794
HGNC: HGNC:8216
AI987944
Name: expressed sequence AI987944
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233168
Mcpt2
Name: mast cell protease 2
Synonyms: MMCP-2, Mcp-2, MMCP-2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 17225
VEGA: 14
Pdlim2
Name: PDZ and LIM domain 2
Synonyms: mystique, SLIM, 4732462F18Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 213019
Homologene: 11006
Nemp1
Name: nuclear envelope integral membrane protein 1
Synonyms: Tmem194
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 210035
Homologene: 18346
Or8g2b
Name: olfactory receptor family 8 subfamily G member 2B
Synonyms: MOR171-13, Olfr971, GA_x6K02T2PVTD-33539896-33540819
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258607
VEGA: 9
Homologene: 133635
Bin1
Name: bridging integrator 1
Synonyms: Amphl, Amphiphysin 2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 30948
VEGA: 18
HGNC: HGNC:1052
Homologene: 113707
Ugt1a7c
Name: UDP glucuronosyltransferase 1 family, polypeptide A7C
Synonyms: A10'
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 394432
Homologene: 136043
Cyp4f15
Name: cytochrome P450, family 4, subfamily f, polypeptide 15
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106648
Homologene: 80199
Camk2b
Name: calcium/calmodulin-dependent protein kinase II, beta
Synonyms: CaMK II
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12323
HGNC: HGNC:1461
Homologene: 111050
Ankrd49
Name: ankyrin repeat domain 49
Synonyms: Gbif
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 56503
VEGA: 9
Homologene: 9787
Malrd1
Name: MAM and LDL receptor class A domain containing 1
Synonyms: Gm13364, Gm13318, Diet1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 102635496
Homologene: 136214
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 72,652,460 bp
  • T to C, chromosome 1 at 88,095,251 bp
  • G to T, chromosome 2 at 15,633,224 bp
  • T to A, chromosome 2 at 23,257,005 bp
  • T to C, chromosome 2 at 37,146,766 bp
  • G to T, chromosome 2 at 66,536,282 bp
  • T to C, chromosome 2 at 76,889,441 bp
  • A to G, chromosome 2 at 91,488,445 bp
  • T to A, chromosome 2 at 91,606,362 bp
  • T to C, chromosome 2 at 116,880,253 bp
  • A to T, chromosome 2 at 180,603,390 bp
  • T to C, chromosome 3 at 37,079,901 bp
  • C to T, chromosome 3 at 60,086,734 bp
  • A to G, chromosome 3 at 119,314,803 bp
  • A to T, chromosome 4 at 101,910,384 bp
  • C to T, chromosome 4 at 111,119,027 bp
  • T to A, chromosome 4 at 143,994,239 bp
  • T to C, chromosome 4 at 149,222,348 bp
  • A to G, chromosome 4 at 150,245,236 bp
  • G to A, chromosome 5 at 5,740,816 bp
  • A to G, chromosome 5 at 18,003,840 bp
  • G to T, chromosome 6 at 48,597,345 bp
  • A to G, chromosome 6 at 86,986,339 bp
  • A to T, chromosome 7 at 17,752,246 bp
  • A to T, chromosome 7 at 41,374,886 bp
  • A to T, chromosome 7 at 42,141,070 bp
  • A to T, chromosome 7 at 44,016,084 bp
  • A to T, chromosome 7 at 130,503,765 bp
  • T to C, chromosome 7 at 132,247,886 bp
  • A to T, chromosome 7 at 141,860,865 bp
  • A to C, chromosome 8 at 11,529,706 bp
  • C to A, chromosome 8 at 31,822,306 bp
  • A to G, chromosome 8 at 69,101,383 bp
  • C to A, chromosome 9 at 14,781,527 bp
  • A to G, chromosome 9 at 18,658,685 bp
  • A to T, chromosome 9 at 37,238,214 bp
  • A to C, chromosome 9 at 39,840,316 bp
  • A to G, chromosome 9 at 95,726,548 bp
  • A to G, chromosome 9 at 119,139,389 bp
  • T to C, chromosome 10 at 5,108,622 bp
  • G to A, chromosome 10 at 33,866,521 bp
  • A to T, chromosome 10 at 42,568,429 bp
  • A to T, chromosome 10 at 86,467,027 bp
  • G to A, chromosome 10 at 127,693,029 bp
  • C to T, chromosome 11 at 5,990,383 bp
  • C to T, chromosome 12 at 35,508,272 bp
  • A to T, chromosome 12 at 69,754,178 bp
  • G to A, chromosome 12 at 72,784,135 bp
  • T to C, chromosome 12 at 83,808,216 bp
  • T to C, chromosome 13 at 73,785,162 bp
  • A to G, chromosome 13 at 80,883,671 bp
  • T to A, chromosome 14 at 39,012,096 bp
  • T to C, chromosome 14 at 56,042,793 bp
  • C to A, chromosome 14 at 70,166,114 bp
  • A to T, chromosome 15 at 31,494,116 bp
  • A to G, chromosome 15 at 38,024,837 bp
  • T to C, chromosome 16 at 49,092,757 bp
  • C to T, chromosome 16 at 59,622,439 bp
  • A to T, chromosome 17 at 32,690,759 bp
  • A to G, chromosome 18 at 32,413,113 bp
  • C to T, chromosome 18 at 35,622,535 bp
  • G to A, chromosome 18 at 77,405,985 bp
  • C to A, chromosome 19 at 17,125,663 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8342 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067731-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.