Strain Name:
C57BL/6J-MtgxR8504Btlr/Mmmh
Stock Number:
067840-MU
Citation ID:
RRID:MMRRC_067840-MU
Other Names:
R8504 (G1)
Major Collection:

Strain Information

Acvr1c
Name: activin A receptor, type IC
Synonyms: ALK7, Alk-7
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 269275
Homologene: 26724
Myh7
Name: myosin, heavy polypeptide 7, cardiac muscle, beta
Synonyms: MYH-beta/slow, Myhc-b, B-MHC, beta-MHC, betaMHC, MyHC-I, Myhcb
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 140781
HGNC: HGNC:7577
Homologene: 68044
H2-DMa
Name: histocompatibility 2, class II, locus DMa
Synonyms: H2-Ma, H2-M alpha, H-2Ma
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 14998
HGNC: HGNC:4934
Homologene: 4464
Rgs10
Name: regulator of G-protein signalling 10
Synonyms: 2310010N19Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67865
HGNC: HGNC:9992
Homologene: 37710
Elp3
Name: elongator acetyltransferase complex subunit 3
Synonyms: KAT9, 2610507P14Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 74195
VEGA: 14
Homologene: 7105
Zc3h7b
Name: zinc finger CCCH type containing 7B
Synonyms: Scrg3
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 20286
VEGA: 15
Homologene: 9735
Zfhx3
Name: zinc finger homeobox 3
Synonyms: A230102L03Rik, Atbf1, Sci, WBP9
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11906
HGNC: HGNC:777
Homologene: 21366
Birc6
Name: baculoviral IAP repeat-containing 6
Synonyms: D630005A10Rik, apollon, A430032G04Rik, A430040A19Rik, Bruce
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12211
Homologene: 7248
Chd9
Name: chromodomain helicase DNA binding protein 9
Synonyms: 1810014J18Rik, 9030205D12Rik, A330063D19Rik, AD013
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 109151
Homologene: 11844
Zeb1
Name: zinc finger E-box binding homeobox 1
Synonyms: Tw, Zfhx1a, Zfx1a, Zfhep, Tcf18, MEB1, Nil2, 3110032K11Rik, Tcf8, AREB6, ZEB, [delta]EF1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 21417
Homologene: 31779
Tut4
Name: terminal uridylyl transferase 4
Synonyms: Tent3a, 9230115F04Rik, Zcchc11, 6030404K05Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230594
Homologene: 35279
Top2a
Name: topoisomerase (DNA) II alpha
Synonyms: DNA Topoisomerase II alpha, Top-2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 21973
Homologene: 830
Scaper
Name: S phase cyclin A-associated protein in the ER
Synonyms: D530014O03Rik, Zfp291
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244891
VEGA: 9
Homologene: 32488
Ranbp3
Name: RAN binding protein 3
Synonyms: 2610024N24Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 71810
VEGA: 17
HGNC: HGNC:9850
Homologene: 136516
Zfp985
Name: zinc finger protein 985
Synonyms: Gm13154
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 433804
Homologene: 133076
Hk2
Name: hexokinase 2
Synonyms: HKII
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 15277
HGNC: HGNC:4923
Homologene: 37273
M6pr
Name: mannose-6-phosphate receptor, cation dependent
Synonyms: CD-MPR, Mpr46
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 17113
HGNC: HGNC:6752
Homologene: 31086
Lmbr1l
Name: limb region 1 like
Synonyms: 1110013E13Rik, D15Ertd735e
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 74775
Homologene: 10011
Ass1
Name: argininosuccinate synthetase 1
Synonyms: fold, ASS, Ass-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11898
HGNC: HGNC:758
Homologene: 6899
Pank2
Name: pantothenate kinase 2
Synonyms: 4933409I19Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74450
Homologene: 65126
Wdr25
Name: WD repeat domain 25
Synonyms: B930090D16Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 212198
VEGA: 12
Homologene: 56993
Selenot
Name: selenoprotein T
Synonyms: 2810407C02Rik, SelT, Selt, 5730408P04Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 69227
Homologene: 32304
Plekhm2
Name: pleckstrin homology domain containing, family M (with RUN domain) member 2
Synonyms: 2310034J19Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 69582
Homologene: 19575
Arhgdia
Name: Rho GDP dissociation inhibitor alpha
Synonyms: 5330430M07Rik, Rho GDIalpha, Rho-GDI
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 192662
HGNC: HGNC:678
Homologene: 908
Zfhx2
Name: zinc finger homeobox 2
Synonyms: zfh-5
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 239102
Homologene: 52657
Galr3
Name: galanin receptor 3
Synonyms: Galnr3
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 14429
VEGA: 15
HGNC: HGNC:4134
Homologene: 20798
Lct
Name: lactase
Synonyms: LOC226413, LPH, Lphl
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226413
HGNC: HGNC:6530
Homologene: 124204
Klhl8
Name: kelch-like 8
Synonyms: 2310001P09Rik, D5Ertd431e
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 246293
Homologene: 10819
Cacna1a
Name: calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
Synonyms: Cacnl1a4, nmf352, smrl, alpha1A, SCA6, Ccha1a
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12286
HGNC: HGNC:1388
Homologene: 56383
Cdh23
Name: cadherin related 23 (otocadherin)
Synonyms: nmf112, 4930542A03Rik, USH1D, sals, ahl, bob, mdfw, nmf252, nmf181
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 22295
Homologene: 11142
Muc5ac
Name: mucin 5, subtypes A and C, tracheobronchial/gastric
Synonyms: MGM, 2210005L13Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17833
HGNC: HGNC:7515
Homologene: 137237
Sycp2l
Name: synaptonemal complex protein 2-like
Synonyms: EG621792, Gm40956, LOC218175
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 637277
Homologene: 52882
Adgrf5
Name: adhesion G protein-coupled receptor F5
Synonyms: 8430401C09Rik, Gpr116
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224792
VEGA: 17
Homologene: 9065
Akap3
Name: A kinase anchor protein 3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 11642
HGNC: HGNC:373
Homologene: 4688
Pkhd1
Name: polycystic kidney and hepatic disease 1
Synonyms: tigmin, FPC
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 241035
HGNC: HGNC:9016
Homologene: 16336
Cercam
Name: cerebral endothelial cell adhesion molecule
Synonyms: CerCAM, Ceecam1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 99151
Homologene: 22954
Abca4
Name: ATP-binding cassette, sub-family A member 4
Synonyms: Rim protein, RmP, D430003I15Rik, Abc10
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 11304
HGNC: HGNC:34
Homologene: 298
Slc4a8
Name: solute carrier family 4 (anion exchanger), member 8
Synonyms: NDCBE, KNBC-3, sodium bicarbonate cotransporter isoform 3 kNBC-3
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 59033
Homologene: 68419
Cul9
Name: cullin 9
Synonyms: Parc, 1810035I07Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 78309
Homologene: 56696
Fyco1
Name: FYVE and coiled-coil domain containing 1
Synonyms: ZFYVE7, Mem2, 2810409M01Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 17281
Homologene: 11561
Nynrin
Name: NYN domain and retroviral integrase containing
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 277154
VEGA: 14
Homologene: 19483
Ap4b1
Name: adaptor-related protein complex AP-4, beta 1
Synonyms: AP-4 beta-4, 1810038H16Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 67489
HGNC: HGNC:572
Homologene: 38203
Unc13a
Name: unc-13 homolog A
Synonyms: Munc13-1, 2410078G03Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 382018
Homologene: 11279
Tektl1
Name: tektin like 1
Synonyms: 4931413A09Rik, Ccdc105
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70976
VEGA: 10
Homologene: 18299
Csmd2
Name: CUB and Sushi multiple domains 2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329942
Homologene: 89034
Efhd2
Name: EF hand domain containing 2
Synonyms: 2600015J22Rik, swiprosin 1, D4Wsu27e
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 27984
Homologene: 32580
Slc13a3
Name: solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3
Synonyms: NaDC-3, NaDC3, SDCT2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 114644
Homologene: 11266
Plch2
Name: phospholipase C, eta 2
Synonyms: A930027K05Rik, PLCeta2, Plcl4
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 269615
Homologene: 85172
Coil
Name: coilin
Synonyms: p80-coilin, Cln80
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12812
HGNC: HGNC:2184
Homologene: 3413
Ccng2
Name: cyclin G2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12452
HGNC: HGNC:1593
Homologene: 3208
Map9
Name: microtubule-associated protein 9
Synonyms: 5033421J10Rik, 5330427D05Rik, Mtap9, ASAP
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 213582
Homologene: 41591
Or5m3
Name: olfactory receptor family 5 subfamily M member 3
Synonyms: MOR199-1, GA_x6K02T2Q125-47485813-47486745, Olfr1032
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258572
Homologene: 17299
Zfp536
Name: zinc finger protein 536
Synonyms: 9630010P11Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243937
Homologene: 8813
Ano5
Name: anoctamin 5
Synonyms: Tmem16e, Gdd1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233246
Homologene: 100071
Zfp759
Name: zinc finger protein 759
Synonyms: Rslcan-8
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 268670
VEGA: 13
Ivl
Name: involucrin
Synonyms: 1110019C06Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 16447
HGNC: HGNC:6187
Homologene: 137207
Serpinb9e
Name: serine (or cysteine) peptidase inhibitor, clade B, member 9e
Synonyms: NK26, Spi14, ovalbumin
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20710
HGNC: HGNC:8955
Homologene: 69093
Ptprb
Name: protein tyrosine phosphatase receptor type B
Synonyms: VE-PTP, 3230402H02Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19263
VEGA: 10
HGNC: HGNC:9665
Homologene: 2125
Phkg2
Name: phosphorylase kinase, gamma 2 (testis)
Synonyms: 1500017I02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 68961
HGNC: HGNC:8931
Homologene: 47915
Atp8a2
Name: ATPase, aminophospholipid transporter-like, class I, type 8A, member 2
Synonyms: agil, Ib, wl
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 50769
Homologene: 4443
Gnal
Name: guanine nucleotide binding protein, alpha stimulating, olfactory type
Synonyms: Golf, 2610011C15Rik, Gna10, Galphaolf, G alpha 10, 9630020G10Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 14680
VEGA: 18
HGNC: HGNC:4388
Homologene: 68222
Exoc8
Name: exocyst complex component 8
Synonyms: EXO84, SEC84, Exo84p
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 102058
Homologene: 44545
Ccdc90b
Name: coiled-coil domain containing 90B
Synonyms: 2310015N07Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 66365
Homologene: 23328
Slco4a1
Name: solute carrier organic anion transporter family, member 4a1
Synonyms: OATP-E, Slc21a12
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 108115
Homologene: 9482
Or5d44
Name: olfactory receptor family 5 subfamily D member 44
Synonyms: Olfr1174-ps, GA_x6K02T2Q125-49796506-49795568, Olfr1174, MOR174-18
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 546769
HGNC: HGNC:8336
Homologene: 77381
Gm21190
Name: predicted gene, 21190
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100861755
Homologene: 69402
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 20,520,208 bp
  • A to T, chromosome 1 at 128,287,569 bp
  • T to C, chromosome 2 at 29,881,817 bp
  • T to C, chromosome 2 at 31,501,532 bp
  • C to T, chromosome 2 at 58,283,479 bp
  • T to G, chromosome 2 at 86,007,805 bp
  • C to T, chromosome 2 at 88,311,481 bp
  • A to G, chromosome 2 at 131,293,400 bp
  • G to T, chromosome 2 at 165,434,079 bp
  • T to C, chromosome 2 at 180,464,799 bp
  • A to G, chromosome 3 at 58,585,277 bp
  • T to C, chromosome 3 at 82,377,169 bp
  • T to C, chromosome 3 at 92,572,771 bp
  • T to A, chromosome 3 at 103,812,800 bp
  • T to C, chromosome 3 at 122,129,334 bp
  • T to C, chromosome 4 at 108,530,942 bp
  • A to C, chromosome 4 at 128,546,690 bp
  • A to T, chromosome 4 at 141,642,453 bp
  • G to A, chromosome 4 at 141,859,875 bp
  • A to T, chromosome 4 at 147,583,426 bp
  • G to T, chromosome 4 at 154,984,395 bp
  • A to G, chromosome 5 at 15,525,864 bp
  • C to G, chromosome 5 at 93,273,343 bp
  • G to A, chromosome 5 at 103,867,948 bp
  • T to C, chromosome 6 at 82,744,866 bp
  • T to C, chromosome 6 at 122,316,070 bp
  • T to A, chromosome 6 at 126,864,530 bp
  • C to A, chromosome 7 at 37,480,067 bp
  • A to T, chromosome 7 at 51,573,028 bp
  • T to A, chromosome 7 at 92,575,337 bp
  • G to T, chromosome 7 at 127,582,356 bp
  • A to T, chromosome 7 at 128,418,069 bp
  • A to T, chromosome 7 at 141,807,155 bp
  • A to C, chromosome 8 at 71,645,761 bp
  • A to G, chromosome 8 at 84,638,741 bp
  • A to G, chromosome 8 at 90,996,844 bp
  • A to G, chromosome 8 at 108,856,917 bp
  • T to G, chromosome 8 at 124,895,970 bp
  • A to T, chromosome 9 at 55,864,438 bp
  • C to A, chromosome 9 at 123,830,077 bp
  • T to A, chromosome 10 at 60,438,839 bp
  • T to C, chromosome 10 at 78,749,204 bp
  • T to C, chromosome 10 at 78,750,629 bp
  • A to G, chromosome 10 at 116,341,031 bp
  • A to T, chromosome 11 at 88,981,154 bp
  • C to T, chromosome 11 at 99,014,741 bp
  • T to C, chromosome 11 at 120,579,528 bp
  • C to T, chromosome 12 at 109,026,467 bp
  • T to A, chromosome 12 at 114,253,924 bp
  • T to A, chromosome 13 at 33,255,109 bp
  • T to G, chromosome 13 at 41,137,914 bp
  • T to A, chromosome 13 at 67,138,883 bp
  • A to G, chromosome 14 at 54,990,329 bp
  • A to C, chromosome 14 at 55,065,786 bp
  • G to C, chromosome 14 at 55,870,246 bp
  • A to C, chromosome 14 at 59,647,917 bp
  • A to T, chromosome 14 at 65,547,911 bp
  • T to A, chromosome 15 at 79,043,079 bp
  • T to G, chromosome 15 at 81,780,518 bp
  • T to A, chromosome 15 at 98,912,184 bp
  • T to A, chromosome 15 at 100,803,290 bp
  • A to G, chromosome 17 at 34,138,442 bp
  • A to G, chromosome 17 at 43,446,949 bp
  • T to C, chromosome 17 at 46,503,580 bp
  • T to C, chromosome 17 at 56,708,273 bp
  • T to A, chromosome 17 at 74,652,005 bp
  • C to A, chromosome 18 at 5,705,127 bp
  • T to A, chromosome 18 at 67,217,184 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8504 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067840-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.