Strain Name:
C57BL/6J-MtgxR8319Btlr/Mmmh
Stock Number:
067856-MU
Citation ID:
RRID:MMRRC_067856-MU
Other Names:
R8319 (G1)
Major Collection:

Strain Information

Cryzl1
Name: crystallin zeta like 1
Synonyms: 2210407J23Rik, 2410006O11Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 66609
HGNC: HGNC:2420
Homologene: 3749
Zfp568
Name: zinc finger protein 568
Synonyms: chato, LOC381866
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243905
Homologene: 136307
Hnrnpul1
Name: heterogeneous nuclear ribonucleoprotein U-like 1
Synonyms: E1B-AP5, E1BAP5, E130317O14Rik, Hnrnpul, Hnrpul1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232989
Homologene: 31419
Cux1
Name: cut-like homeobox 1
Synonyms: CDP, Cutl1, Cux, Cux-1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 13047
HGNC: HGNC:2557
Scn10a
Name: sodium channel, voltage-gated, type X, alpha
Synonyms: Nav1.8
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20264
VEGA: 9
Homologene: 21300
Smurf2
Name: SMAD specific E3 ubiquitin protein ligase 2
Synonyms: 2810411E22Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 66313
Homologene: 41490
Zfp933
Name: zinc finger protein 933
Synonyms: 2810408P10Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242747
Homologene: 138474
Atl1
Name: atlastin GTPase 1
Synonyms: FSP1, AD-FSP, Spg3a, SPG3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 73991
VEGA: 12
Homologene: 9302
Dnajc13
Name: DnaJ heat shock protein family (Hsp40) member C13
Synonyms: LOC382100, D030002L11Rik, Rme8
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235567
Homologene: 13574
Bhlhe40
Name: basic helix-loop-helix family, member e40
Synonyms: eip1 (E47 interaction protein 1), DEC1, cytokine response gene 8, Stra13, CR8, Bhlhb2, Clast5, C130042M06Rik, Sharp2, Stra14
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 20893
HGNC: HGNC:1046
Homologene: 2722
Cacna1c
Name: calcium channel, voltage-dependent, L type, alpha 1C subunit
Synonyms: D930026N18Rik, (alpha)1 subunit, Cchl1a1, Cav1.2, L-type Cav1.2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12288
HGNC: HGNC:1390
Homologene: 55484
Klhl6
Name: kelch-like 6
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 239743
Homologene: 15603
Ttn
Name: titin
Synonyms: shru, L56, mdm, connectin, D330041I19Rik, 2310057K23Rik, 2310074I15Rik, 2310036G12Rik, D830007G01Rik, 1100001C23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Fig4
Name: FIG4 phosphoinositide 5-phosphatase
Synonyms: A530089I17Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 103199
VEGA: 10
Homologene: 6713
Rusc2
Name: RUN and SH3 domain containing 2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100213
Homologene: 18967
Col12a1
Name: collagen, type XII, alpha 1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12816
HGNC: HGNC:2188
Homologene: 3217
Naip5
Name: NLR family, apoptosis inhibitory protein 5
Synonyms: Naip-rs3, Lgn1, Birc1e
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17951
HGNC: HGNC:7634
Homologene: 113589
Intu
Name: inturned planar cell polarity protein
Synonyms: Pdzk6, 9230116I04Rik, 9430087H23Rik, Pdzd6
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 380614
Homologene: 41059
Cpne2
Name: copine II
Synonyms: 3322401K10Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234577
HGNC: HGNC:2315
Homologene: 27392
Ampd3
Name: adenosine monophosphate deaminase 3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 11717
HGNC: HGNC:470
Homologene: 408
Pwwp2b
Name: PWWP domain containing 2B
Synonyms: D930023J19Rik, D7Ertd517e, Pwwp2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101631
Homologene: 19056
Specc1
Name: sperm antigen with calponin homology and coiled-coil domains 1
Synonyms: Cytsb, 2810012G08Rik, B230396K10Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 432572
Homologene: 45157
Fbxw7
Name: F-box and WD-40 domain protein 7
Synonyms: AGO, 1110001A17Rik, Fbxo30, SEL-10, Fbxw6, Cdc4, Fbw7
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 50754
Homologene: 117451
Gbe1
Name: 1,4-alpha-glucan branching enzyme 1
Synonyms: D16Ertd536e, 2310045H19Rik, 2810426P10Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 74185
HGNC: HGNC:4180
Homologene: 129
Naip1
Name: NLR family, apoptosis inhibitory protein 1
Synonyms: Birc1a, D13Lsd1, Naip
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17940
VEGA: 13
HGNC: HGNC:7634
Homologene: 113589
Atg9a
Name: autophagy related 9A
Synonyms: Apg9l1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 245860
Homologene: 34495
Gtf3c5
Name: general transcription factor IIIC, polypeptide 5
Synonyms: TFiiiC2-63, TFIIIC63, 2700084A09Rik, TFIIICepsilon
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 70239
HGNC: HGNC:4668
Homologene: 40806
Otogl
Name: otogelin-like
Synonyms: Gm6924
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 628870
Homologene: 46008
Ddx60
Name: DExD/H box helicase 60
Synonyms: DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234311
Homologene: 23031
Il18
Name: interleukin 18
Synonyms: Il-18, Igif
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 16173
VEGA: 9
HGNC: HGNC:5986
Homologene: 1200
Mdga2
Name: MAM domain containing glycosylphosphatidylinositol anchor 2
Synonyms: 9330209L04Rik, Mamdc1, Adp, Mdga2, 6720489L24Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 320772
Homologene: 45659
Ninl
Name: ninein-like
Synonyms: 4930519N13Rik, LOC381388, LOC381387
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 78177
Homologene: 57024
Thumpd3
Name: THUMP domain containing 3
Synonyms: Gtrosa26as
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14911
Homologene: 7351
Otulin
Name: OTU deubiquitinase with linear linkage specificity
Synonyms: m7-1Sapc, gumby, m3Sapc, Fam105b
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 432940
VEGA: 15
Homologene: 106591
Or51b17
Name: olfactory receptor family 51 subfamily B member 17
Synonyms: MOR1-2, Olfr64, GA_x6K02T2PBJ9-6648196-6649143, 5'[b]2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18366
Homologene: 56593
Abcc1
Name: ATP-binding cassette, sub-family C member 1
Synonyms: Mrp1, Abcc1a, Mdrap, MRP, Abcc1b
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 17250
HGNC: HGNC:51
Homologene: 133779
Ift56
Name: intraflagellar transport 56
Synonyms: hydrocephalic-polydactyl, hop, hpy, Ttc26, 9430097H08Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 264134
Homologene: 11786
Prdm13
Name: PR domain containing 13
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230025
Homologene: 11000
Or4c12
Name: olfactory receptor family 4 subfamily C member 12
Synonyms: Olfr1259, GA_x6K02T2Q125-51376062-51375133, MOR232-9
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258338
Homologene: 128115
Hcfc2
Name: host cell factor C2
Synonyms: 1700129L13Rik, fkls
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 67933
Homologene: 8337
4921517D22Rik
Name: RIKEN cDNA 4921517D22 gene
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 70900
VEGA: 13
Homologene: 87278
Reep4
Name: receptor accessory protein 4
Synonyms: 2700029E10Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 72549
VEGA: 14
Homologene: 11888
Tas2r139
Name: taste receptor, type 2, member 139
Synonyms: Tas2r39, mt2r34
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 353148
Homologene: 52214
Gabra1
Name: gamma-aminobutyric acid type A receptor subunit alpha 1
Synonyms: GABAA alpha 1, GABAAR alpha1, Gabra-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14394
HGNC: HGNC:4075
Homologene: 629
Adamts14
Name: ADAM metallopeptidase with thrombospondin type 1 motif 14
Synonyms: Adamts-14, TS14
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237360
Homologene: 16383
Gm340
Name: predicted gene 340
Synonyms: LOC381224
Type: Gene
Species: Mouse
Chromosome: 19
Ndufaf1
Name: NADH:ubiquinone oxidoreductase complex assembly factor 1
Synonyms: CGI-65, 2410001M24Rik, CIA30
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 69702
Homologene: 32289
Phf11b
Name: PHD finger protein 11B
Synonyms: Gm4902
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 236451
Homologene: 87807
Sox12
Name: SRY (sex determining region Y)-box 12
Synonyms: 2010205A02Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20667
Homologene: 5057
Scgb1b3
Name: secretoglobin, family 1B, member 3
Synonyms: Gm5325, Abpa3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 384585
Homologene: 114479
Mcub
Name: mitochondrial calcium uniporter dominant negative beta subunit
Synonyms: 9030408N13Rik, Ccdc109b
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 66815
Homologene: 23056
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 75,185,698 bp
  • A to T, chromosome 2 at 28,570,494 bp
  • A to G, chromosome 2 at 76,706,954 bp
  • A to G, chromosome 2 at 89,943,680 bp
  • A to G, chromosome 2 at 119,660,087 bp
  • A to T, chromosome 2 at 150,959,907 bp
  • G to A, chromosome 2 at 152,397,272 bp
  • T to A, chromosome 3 at 40,653,772 bp
  • T to A, chromosome 3 at 84,974,552 bp
  • A to G, chromosome 3 at 129,933,679 bp
  • G to T, chromosome 4 at 21,679,327 bp
  • T to A, chromosome 4 at 43,425,378 bp
  • G to A, chromosome 4 at 147,828,453 bp
  • C to T, chromosome 5 at 136,565,397 bp
  • T to A, chromosome 6 at 38,405,945 bp
  • T to C, chromosome 6 at 42,141,786 bp
  • TG to TGG, chromosome 6 at 108,664,857 bp
  • T to A, chromosome 6 at 113,063,146 bp
  • T to C, chromosome 6 at 118,637,774 bp
  • A to T, chromosome 7 at 25,754,477 bp
  • T to C, chromosome 7 at 29,998,204 bp
  • G to A, chromosome 7 at 31,375,979 bp
  • A to G, chromosome 7 at 103,893,429 bp
  • T to A, chromosome 7 at 110,795,775 bp
  • T to C, chromosome 7 at 139,255,183 bp
  • T to C, chromosome 8 at 61,942,635 bp
  • A to G, chromosome 8 at 94,553,412 bp
  • A to T, chromosome 9 at 50,581,518 bp
  • C to T, chromosome 9 at 79,648,697 bp
  • G to A, chromosome 9 at 104,190,391 bp
  • G to T, chromosome 9 at 119,670,389 bp
  • C to A, chromosome 10 at 41,263,101 bp
  • T to G, chromosome 10 at 61,221,927 bp
  • T to A, chromosome 10 at 82,738,367 bp
  • C to T, chromosome 10 at 107,853,266 bp
  • C to T, chromosome 11 at 42,135,488 bp
  • C to T, chromosome 11 at 62,118,675 bp
  • A to G, chromosome 11 at 106,824,752 bp
  • T to C, chromosome 12 at 67,221,029 bp
  • A to T, chromosome 12 at 69,955,319 bp
  • A to T, chromosome 13 at 59,690,672 bp
  • A to G, chromosome 13 at 100,221,659 bp
  • C to A, chromosome 13 at 100,429,213 bp
  • A to C, chromosome 14 at 59,338,697 bp
  • T to A, chromosome 14 at 70,546,511 bp
  • AT to ATT, chromosome 15 at 27,606,318 bp
  • T to A, chromosome 16 at 14,396,451 bp
  • T to C, chromosome 16 at 19,957,190 bp
  • G to A, chromosome 16 at 70,488,076 bp
  • T to C, chromosome 16 at 91,692,363 bp
  • T to A, chromosome 19 at 41,582,904 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8319 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067856-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.