Strain Name:
C57BL/6J-MtgxR8359Btlr/Mmmh
Stock Number:
067872-MU
Citation ID:
RRID:MMRRC_067872-MU
Other Names:
R8359 (G1)
Major Collection:

Strain Information

Ide
Name: insulin degrading enzyme
Synonyms: 4833415K22Rik, 1300012G03Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 15925
HGNC: HGNC:5381
Homologene: 3645
Sema3c
Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
Synonyms: 1110036B02Rik, Semae
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20348
Homologene: 36201
Htr3b
Name: 5-hydroxytryptamine (serotonin) receptor 3B
Synonyms: 5-HT3 receptor subunit B, 5-HT3B
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 57014
VEGA: 9
HGNC: HGNC:5298
Homologene: 38131
Ppp1r16b
Name: protein phosphatase 1, regulatory subunit 16B
Synonyms: ANKRD4, Wdt4, C130078N17Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228852
Homologene: 9194
Pkp4
Name: plakophilin 4
Synonyms: Armrp, 5031422I09Rik, 9430019K17Rik, p0071
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227937
HGNC: HGNC:9026
Homologene: 2689
Fryl
Name: FRY like transcription coactivator
Synonyms: 2310004H21Rik, 9030227G01Rik, 2510002A14Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 72313
Homologene: 103956
Wnk1
Name: WNK lysine deficient protein kinase 1
Synonyms: Hsn2, Prkwnk1, 6430573H23Rik, EG406236
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232341
Homologene: 14253
Kif16b
Name: kinesin family member 16B
Synonyms: N-3 kinesin, 8430434E15Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16558
Homologene: 135708
Hspbap1
Name: Hspb associated protein 1
Synonyms: 3830421G21Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 66667
VEGA: 16
Homologene: 11617
Dynlrb1
Name: dynein light chain roadblock-type 1
Synonyms: km23-1, 2010320M17Rik, 2010012N15Rik, Dncl2a, DNLC2A
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 67068
Homologene: 69161
Brwd1
Name: bromodomain and WD repeat domain containing 1
Synonyms: Wdr9, D530019K20Rik, G1-403-16, 5330419I02Rik, repro5
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 93871
Homologene: 23130
Smchd1
Name: SMC hinge domain containing 1
Synonyms: MommeD1, 4931400A14Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 74355
Homologene: 23665
Cit
Name: citron
Synonyms: citron kinase, Cit-k, CRIK-SK, C030025P15Rik, citron-N
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12704
HGNC: HGNC:1985
Homologene: 21404
Zfp180
Name: zinc finger protein 180
Synonyms: HHZ168, D130011P11, 2310040I01Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 210135
Homologene: 8306
Smc5
Name: structural maintenance of chromosomes 5
Synonyms: Smc5l1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226026
VEGA: 19
Homologene: 41009
Slc6a3
Name: solute carrier family 6 (neurotransmitter transporter, dopamine), member 3
Synonyms: Dat1, DAT
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 13162
VEGA: 13
Homologene: 55547
Ckmt1
Name: creatine kinase, mitochondrial 1, ubiquitous
Synonyms: UbCKmit, Mt-CK, mi-CK
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12716
Homologene: 69058
Cenpw
Name: centromere protein W
Synonyms: 2610036L11Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 66311
VEGA: 10
Homologene: 84642
Igf2r
Name: insulin-like growth factor 2 receptor
Synonyms: M6P/IGF2R, mannose-6-phosphate receptor, cation independent, CD222, CI-MPR, Mpr300, IGF-II/CI-MPR
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 16004
HGNC: HGNC:5467
Homologene: 676
Carm1
Name: coactivator-associated arginine methyltransferase 1
Synonyms: m9Bei, Prmt4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 59035
Homologene: 10990
Katnip
Name: katanin interacting protein
Synonyms: D430042O09Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233865
Homologene: 45841
Golm2
Name: golgi membrane protein 2
Synonyms: D130060C09Rik, Casc4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 319996
Homologene: 16310
Slc9a1
Name: solute carrier family 9 (sodium/hydrogen exchanger), member 1
Synonyms: antiporter, Apnh, Nhe-1, Nhe1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 20544
Homologene: 20660
Dhodh
Name: dihydroorotate dehydrogenase
Synonyms: 2810417D19Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 56749
HGNC: HGNC:2867
Homologene: 1043
Mccc1
Name: methylcrotonoyl-Coenzyme A carboxylase 1 (alpha)
Synonyms: 2310058B18Rik, 1810045E08Rik, MCCalpha, MCCA
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 72039
HGNC: HGNC:6936
Homologene: 10603
Myh11
Name: myosin, heavy polypeptide 11, smooth muscle
Synonyms: SM2, SM1, smMHC
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 17880
VEGA: 16
HGNC: HGNC:7569
Homologene: 128512
Sycp1
Name: synaptonemal complex protein 1
Synonyms: SCP1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20957
Homologene: 2389
Cacna1s
Name: calcium channel, voltage-dependent, L type, alpha 1S subunit
Synonyms: Cchl1a3, Cav1.1, muscle dysgenesis, DHPR alpha1s, mdg, sj, fmd
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12292
HGNC: HGNC:1397
Homologene: 37257
Synpo2l
Name: synaptopodin 2-like
Synonyms: Chap, 1110054M18Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 68760
Homologene: 23499
Edem1
Name: ER degradation enhancer, mannosidase alpha-like 1
Synonyms: A130059K23Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 192193
Homologene: 33836
Rmdn2
Name: regulator of microtubule dynamics 2
Synonyms: Fam82a1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 381110
VEGA: 17
Homologene: 71930
Crybg1
Name: crystallin beta-gamma domain containing 1
Synonyms: Aim1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 11630
HGNC: HGNC:356
Homologene: 18168
Adam5
Name: a disintegrin and metallopeptidase domain 5
Synonyms: tMDCII
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11499
HGNC: HGNC:212
Homologene: 49138
Col6a4
Name: collagen, type VI, alpha 4
Synonyms: Dvwa, EG235580, Vwa6, 1110001D15Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 68553
Homologene: 130754
Or5p81
Name: olfactory receptor family 5 subfamily P member 81
Synonyms: Olfr510, MOR204-34, GA_x6K02T2PBJ9-10997715-10998659
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258308
Pla2r1
Name: phospholipase A2 receptor 1
Synonyms: PLA2-I receptor, Pla2g1br, M-type receptor
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18779
HGNC: HGNC:9042
Homologene: 32016
Enthd1
Name: ENTH domain containing 1
Synonyms: LOC383075
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 383075
VEGA: 15
Homologene: 45131
Adgrf1
Name: adhesion G protein-coupled receptor F1
Synonyms: Gpr110, 5031409J19Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 77596
Homologene: 124643
Zkscan16
Name: zinc finger with KRAB and SCAN domains 16
Synonyms: Zfp483
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100041581
Homologene: 26419
Pla2g6
Name: phospholipase A2, group VI
Synonyms: iPLA2, iPLA2beta
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 53357
HGNC: HGNC:9039
Homologene: 2635
Zfr2
Name: zinc finger RNA binding protein 2
Synonyms: 9130206N08Rik, 2010013I23Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 103406
Homologene: 88124
Slc22a20
Name: solute carrier family 22 (organic anion transporter), member 20
Synonyms: LOC381203, mOAT6
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 381203
Homologene: 87203
Prss50
Name: serine protease 50
Synonyms: Tsp50
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235631
Homologene: 8314
Nexn
Name: nexilin
Synonyms: 1110046H09Rik, nF actin binding protein
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 68810
Homologene: 44892
Or10h1b
Name: olfactory receptor family 10 subfamily H member 1B
Synonyms: MOR267-17, GA_x6K02T2MG8L-16493-15546, IF6, MOR267-20, Olfr55
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 100038859
Homologene: 110515
Sh2d1b1
Name: SH2 domain containing 1B1
Synonyms: Eat2, Sh2d1b, Eat2a, EAT-2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 26904
Homologene: 8070
Fam170a
Name: family with sequence similarity 170, member A
Synonyms: Znfd, LOC225497
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225497
VEGA: 18
Homologene: 86702
Cyp21a1
Name: cytochrome P450, family 21, subfamily a, polypeptide 1
Synonyms: 21-hydroxylase, Oh21-1, 21OH, Cyp21, 21OHA, Oh21-1, 21-OH
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 13079
Homologene: 68063
Or2t47
Name: olfactory receptor family 2 subfamily T member 47
Synonyms: Olfr328, MOR275-2, GA_x6K02T2NKPP-873285-874217
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258495
Homologene: 133015
Upp2
Name: uridine phosphorylase 2
Synonyms: 1700124F02Rik, UPASE2, UDRPASE2, UP2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 76654
Homologene: 12654
Dnali1
Name: dynein, axonemal, light intermediate polypeptide 1
Synonyms: 1700023A09Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 75563
Homologene: 2586
Mos
Name: Moloney sarcoma oncogene
Synonyms: c-mos
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 17451
HGNC: HGNC:7199
Homologene: 3919
Atpaf2
Name: ATP synthase mitochondrial F1 complex assembly factor 2
Synonyms: ATP12p, ATP12
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 246782
Homologene: 34602
Slpi
Name: secretory leukocyte peptidase inhibitor
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20568
Homologene: 2305
Plekha2
Name: pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 2
Synonyms: TAPP2, 6430512N22Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 83436
Homologene: 41822
Slc30a2
Name: solute carrier family 30 (zinc transporter), member 2
Synonyms: Znt2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230810
Homologene: 40855
Or4p4
Name: olfactory receptor family 4 subfamily P member 4
Synonyms: GA_x6K02T2Q125-50131417-50131917, Olfr1192, MOR225-11
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 257937
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 136,116,061 bp
  • T to A, chromosome 1 at 170,283,124 bp
  • A to G, chromosome 2 at 58,777,943 bp
  • A to G, chromosome 2 at 59,350,551 bp
  • T to A, chromosome 2 at 60,443,283 bp
  • A to T, chromosome 2 at 88,652,988 bp
  • A to T, chromosome 2 at 121,363,050 bp
  • A to T, chromosome 2 at 121,867,151 bp
  • G to A, chromosome 2 at 142,711,857 bp
  • A to G, chromosome 2 at 155,249,950 bp
  • G to T, chromosome 2 at 158,761,375 bp
  • A to T, chromosome 2 at 164,356,055 bp
  • C to T, chromosome 3 at 35,964,344 bp
  • T to A, chromosome 3 at 102,820,593 bp
  • T to A, chromosome 3 at 152,248,361 bp
  • A to G, chromosome 4 at 3,871,097 bp
  • C to T, chromosome 4 at 58,957,230 bp
  • T to A, chromosome 4 at 125,063,667 bp
  • A to T, chromosome 4 at 133,420,616 bp
  • T to C, chromosome 4 at 134,349,379 bp
  • T to C, chromosome 5 at 17,653,728 bp
  • A to G, chromosome 5 at 73,075,933 bp
  • T to A, chromosome 5 at 115,984,544 bp
  • C to T, chromosome 6 at 108,846,813 bp
  • T to C, chromosome 6 at 119,992,447 bp
  • C to T, chromosome 7 at 24,104,912 bp
  • T to A, chromosome 7 at 108,668,311 bp
  • T to C, chromosome 7 at 125,868,851 bp
  • A to T, chromosome 8 at 24,806,486 bp
  • A to G, chromosome 8 at 25,088,391 bp
  • A to C, chromosome 8 at 109,606,406 bp
  • G to A, chromosome 9 at 21,569,469 bp
  • A to C, chromosome 9 at 48,947,296 bp
  • T to C, chromosome 9 at 106,068,384 bp
  • A to G, chromosome 9 at 110,862,302 bp
  • T to A, chromosome 10 at 30,198,488 bp
  • T to C, chromosome 10 at 43,992,542 bp
  • C to T, chromosome 10 at 81,242,819 bp
  • G to T, chromosome 11 at 58,552,203 bp
  • T to C, chromosome 11 at 60,407,303 bp
  • T to A, chromosome 13 at 73,544,883 bp
  • T to A, chromosome 14 at 20,666,140 bp
  • T to C, chromosome 15 at 79,287,170 bp
  • T to C, chromosome 15 at 80,474,155 bp
  • C to T, chromosome 16 at 14,208,231 bp
  • C to A, chromosome 16 at 35,824,996 bp
  • T to C, chromosome 16 at 96,016,209 bp
  • A to G, chromosome 17 at 12,683,861 bp
  • G to A, chromosome 17 at 33,176,921 bp
  • A to G, chromosome 17 at 34,802,131 bp
  • A to T, chromosome 17 at 43,310,395 bp
  • A to T, chromosome 17 at 71,431,243 bp
  • A to T, chromosome 17 at 79,628,151 bp
  • A to G, chromosome 18 at 50,281,610 bp
  • T to C, chromosome 19 at 5,971,526 bp
  • A to C, chromosome 19 at 23,234,079 bp
  • A to T, chromosome 19 at 37,330,487 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8359 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067872-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.