Strain Name:
C57BL/6J-MtgxR8483Btlr/Mmmh
Stock Number:
067927-MU
Citation ID:
RRID:MMRRC_067927-MU
Other Names:
R8483 (G1)
Major Collection:

Strain Information

Chd7
Name: chromodomain helicase DNA binding protein 7
Synonyms: Todo, Gena 52, GENA 60, Dz, Cycn, Cyn, Obt, Mt, Whi, GENA 47, A730019I05Rik, Lda, Flo, Edy, WBE1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 320790
Homologene: 19067
Esco2
Name: establishment of sister chromatid cohesion N-acetyltransferase 2
Synonyms: 2410004I17Rik, D030072L07Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 71988
Homologene: 12432
Nucks1
Name: nuclear casein kinase and cyclin-dependent kinase substrate 1
Synonyms: Nucks, 8430423A01Rik, 2700010L10Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98415
Homologene: 23377
Zic1
Name: zinc finger protein of the cerebellum 1
Synonyms: odd-paired homolog
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 22771
Homologene: 2562
Cwc27
Name: CWC27 spliceosome-associated protein
Synonyms: NY-CO-10, Sdccag10, 3110009E13Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 67285
Homologene: 21192
Cyp39a1
Name: cytochrome P450, family 39, subfamily a, polypeptide 1
Synonyms: oxysterol 7-alpha-hydroxylase
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 56050
VEGA: 17
Homologene: 9580
Patj
Name: PATJ, crumbs cell polarity complex component
Synonyms: Inadl, Cipp
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12695
Homologene: 72199
Dnmt3b
Name: DNA methyltransferase 3B
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 13436
HGNC: HGNC:2979
Homologene: 56000
Stk38l
Name: serine/threonine kinase 38 like
Synonyms: 4930473A22Rik, Ndr2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232533
Homologene: 56299
Kat6b
Name: K(lysine) acetyltransferase 6B
Synonyms: Myst4, Morf, monocytic leukemia, qkf, querkopf, B130044K16Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 54169
Homologene: 136480
Cux1
Name: cut-like homeobox 1
Synonyms: CDP, Cutl1, Cux, Cux-1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 13047
HGNC: HGNC:2557
Brca1
Name: breast cancer 1, early onset
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12189
HGNC: HGNC:1100
Homologene: 5276
Ipo5
Name: importin 5
Synonyms: IMB3, RanBP5, Kpnb3, 1110011C18Rik, importin beta 3, 5730478E03Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 70572
VEGA: 14
HGNC: HGNC:6402
Homologene: 1710
Usp24
Name: ubiquitin specific peptidase 24
Synonyms: 2810030C21Rik, 2700066K03Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329908
Homologene: 35420
Ankrd28
Name: ankyrin repeat domain 28
Synonyms: E430019N21Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 105522
VEGA: 14
Homologene: 35374
Vps8
Name: VPS8 CORVET complex subunit
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 209018
Homologene: 44592
Lbhd2
Name: LBH domain containing 2
Synonyms: LOC380787, A230065H16Rik, Lbh2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 380787
Homologene: 78587
Pdp1
Name: pyruvate dehydrogenase phosphatase catalytic subunit 1
Synonyms: LOC381511, Ppm2c
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 381511
HGNC: HGNC:9279
Homologene: 31928
Ark2c
Name: arkadia (RNF111) C-terminal like ring finger ubiquitin ligase 2C
Synonyms: Ark2c, Rnf165, G630064H08Rik, 2900024M11Rik, LOC225743
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225743
Homologene: 79757
Kank4
Name: KN motif and ankyrin repeat domains 4
Synonyms: Ankrd38
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242553
Homologene: 18244
Lrrc55
Name: leucine rich repeat containing 55
Synonyms: LOC241528, A330097E02Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241528
VEGA: 2
Homologene: 19385
Hsd17b13
Name: hydroxysteroid (17-beta) dehydrogenase 13
Synonyms: Pan1b
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 243168
Homologene: 71549
Zfyve28
Name: zinc finger, FYVE domain containing 28
Synonyms: 9630058O20Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231125
Homologene: 15119
Lrp1
Name: low density lipoprotein receptor-related protein 1
Synonyms: b2b1554Clo, A2mr, CD91
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16971
HGNC: HGNC:6692
Homologene: 1744
Klhl1
Name: kelch-like 1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 93688
HGNC: HGNC:6352
Homologene: 56903
Dnah3
Name: dynein, axonemal, heavy chain 3
Synonyms: Dnahc3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 381917
HGNC: HGNC:2949
Homologene: 19674
Unc80
Name: unc-80, NALCN activator
Synonyms: C230061B10Rik, C030018G13Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329178
Homologene: 122243
Gcnt3
Name: glucosaminyl (N-acetyl) transferase 3, mucin type
Synonyms: 2210401J11Rik, 2210021I22Rik, 2010013H22Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 72077
VEGA: 9
HGNC: HGNC:4205
Homologene: 20993
Vmn2r88
Name: vomeronasal 2, receptor 88
Synonyms: V2r13, V2r3
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 669149
Homologene: 129606
Prmt8
Name: protein arginine N-methyltransferase 8
Synonyms: Hrmt1l3, Hrmt1l4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 381813
HGNC: HGNC:5188
Homologene: 76124
Tent5c
Name: terminal nucleotidyltransferase 5C
Synonyms: Fam46c, 4930431B09Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 74645
Homologene: 56783
Nprl3
Name: nitrogen permease regulator-like 3
Synonyms: HS-40, Mare, m(alpha)RE, -14 gene, Phg, HS-26, Prox1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17168
Homologene: 8091
Or14j3
Name: olfactory receptor family 14 subfamily J member 3
Synonyms: Olfr114, GA_x6K02T2PSCP-2049802-2048870, MOR218-10
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258284
Homologene: 133642
Drc1
Name: dynein regulatory complex subunit 1
Synonyms: b2b1654Clo, Ccdc164, Gm1060, LOC381738
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 381738
Homologene: 35977
Oxa1l
Name: oxidase assembly 1-like
Synonyms: 1810020M02Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 69089
HGNC: HGNC:8526
Homologene: 31281
Pde3b
Name: phosphodiesterase 3B, cGMP-inhibited
Synonyms: 9830102A01Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18576
HGNC: HGNC:8779
Homologene: 709
Cdhr4
Name: cadherin-related family member 4
Synonyms: Cdh29, 1700021K14Rik, D330022A01Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 69398
Homologene: 82362
Pcdhb12
Name: protocadherin beta 12
Synonyms: PcdhbL, Pcdh3, Pcdhb5F
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93883
HGNC: HGNC:8690
Homologene: 87126
Ovgp1
Name: oviductal glycoprotein 1
Synonyms: oviductin, OGP, MOGP, muc9, mucin 9, Chit5
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12659
HGNC: HGNC:8524
Homologene: 74442
Aurkc
Name: aurora kinase C
Synonyms: IAK3, Stk13, AIE1, AIK3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20871
Homologene: 68302
Gsta3
Name: glutathione S-transferase, alpha 3
Synonyms: Gst2-3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14859
Homologene: 37355
V1ra8
Name: vomeronasal 1 receptor, A8
Synonyms: Vmn1r-ps33
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 113850
Prb1a
Name: proline-rich protein BstNI subfamily 1A
Synonyms: Prb1, proline-rich proteoglycan 2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 381833
Slc35f2
Name: solute carrier family 35, member F2
Synonyms: 1500009K05Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 72022
VEGA: 9
Homologene: 36363
Gpam
Name: glycerol-3-phosphate acyltransferase, mitochondrial
Synonyms: GPAT1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 14732
Homologene: 7343
Cd200l1
Name: CD200 molecule like 1
Synonyms: LOC385647, Gm609, iSEC1, LOC208166
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 208166
Homologene: 86707
Ighe
Name: Immunoglobulin heavy constant epsilon
Synonyms: Gm900, LOC380792
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 380792
HGNC: HGNC:5522
Semp2l2a
Name: SUMO/sentrin specific peptidase 2-like 2A
Synonyms: AF366264
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 231201
Homologene: 130042
Or6c219
Name: olfactory receptor family 6 subfamily C member 219
Synonyms: GA_x6K02T2PULF-11624146-11623190, Olfr818, MOR110-2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258773
Homologene: 74100
Sra1
Name: steroid receptor RNA activator 1
Synonyms: Srap
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 24068
Homologene: 11906
Smok2b
Name: sperm motility kinase 2B
Synonyms: LOC236574
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 236574
Homologene: 128738
Mtres1
Name: mitochondrial transcription rescue factor 1
Synonyms: 1700021F05Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 67851
Homologene: 41137
Zbed4
Name: zinc finger, BED type containing 4
Synonyms: 1700009F06Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223773
Homologene: 138455
Pcdha9
Name: protocadherin alpha 9
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 192161
HGNC: HGNC:8664
Homologene: 130700
Ang6
Name: angiogenin, ribonuclease A family, member 6
Synonyms: EG630952
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 630952
HGNC: HGNC:483
Homologene: 134083
Wdr54
Name: WD repeat domain 54
Synonyms: 1700030E05Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 75659
Homologene: 11382
Or4s2
Name: olfactory receptor family 4 subfamily S member 2
Synonyms: Olfr526-ps1, GA_x6K02T2Q125-50121628-50122030, GA_x6K02T2PRF0-44595-45531, MOR230-9, Olfr1191
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 404399
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 21,262,839 bp
  • T to C, chromosome 1 at 66,693,710 bp
  • A to G, chromosome 1 at 131,928,091 bp
  • A to T, chromosome 2 at 85,191,951 bp
  • A to G, chromosome 2 at 88,643,334 bp
  • A to G, chromosome 2 at 153,674,386 bp
  • T to A, chromosome 3 at 100,472,468 bp
  • T to A, chromosome 3 at 105,986,995 bp
  • A to G, chromosome 4 at 8,822,412 bp
  • T to C, chromosome 4 at 11,961,982 bp
  • C to A, chromosome 4 at 98,424,302 bp
  • T to A, chromosome 4 at 98,771,378 bp
  • T to C, chromosome 4 at 106,373,756 bp
  • A to T, chromosome 5 at 30,350,441 bp
  • T to C, chromosome 5 at 34,236,136 bp
  • C to T, chromosome 5 at 103,977,183 bp
  • C to A, chromosome 5 at 136,275,090 bp
  • A to G, chromosome 6 at 83,153,610 bp
  • A to T, chromosome 6 at 90,202,934 bp
  • A to C, chromosome 6 at 127,704,013 bp
  • T to G, chromosome 6 at 132,208,435 bp
  • T to A, chromosome 6 at 146,758,519 bp
  • T to A, chromosome 7 at 6,996,665 bp
  • A to G, chromosome 7 at 114,519,568 bp
  • T to C, chromosome 7 at 119,937,030 bp
  • T to A, chromosome 8 at 13,838,229 bp
  • T to A, chromosome 9 at 53,809,701 bp
  • A to T, chromosome 9 at 70,034,677 bp
  • T to C, chromosome 9 at 91,364,371 bp
  • T to C, chromosome 9 at 107,994,999 bp
  • T to C, chromosome 10 at 43,532,919 bp
  • G to A, chromosome 10 at 127,558,650 bp
  • T to A, chromosome 10 at 129,945,129 bp
  • T to A, chromosome 11 at 32,263,083 bp
  • T to C, chromosome 11 at 101,525,976 bp
  • G to A, chromosome 12 at 111,411,756 bp
  • T to C, chromosome 12 at 113,272,188 bp
  • G to T, chromosome 13 at 104,804,264 bp
  • C to A, chromosome 13 at 104,804,268 bp
  • G to T, chromosome 14 at 21,669,393 bp
  • A to T, chromosome 14 at 31,735,091 bp
  • A to G, chromosome 14 at 44,001,828 bp
  • T to A, chromosome 14 at 51,413,073 bp
  • G to A, chromosome 14 at 54,368,544 bp
  • T to C, chromosome 14 at 65,831,669 bp
  • A to G, chromosome 14 at 96,381,934 bp
  • A to G, chromosome 14 at 120,946,148 bp
  • A to G, chromosome 15 at 88,781,787 bp
  • T to C, chromosome 16 at 21,575,013 bp
  • T to A, chromosome 16 at 45,419,872 bp
  • A to C, chromosome 17 at 13,235,021 bp
  • A to G, chromosome 17 at 37,589,975 bp
  • A to G, chromosome 17 at 43,683,007 bp
  • A to G, chromosome 18 at 36,667,826 bp
  • A to G, chromosome 18 at 36,998,583 bp
  • A to T, chromosome 18 at 37,437,537 bp
  • G to A, chromosome 18 at 77,468,338 bp
  • A to C, chromosome 19 at 55,088,942 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8483 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067927-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.