Strain Name:
C57BL/6J-MtgxR8731Btlr/Mmmh
Stock Number:
068579-MU
Citation ID:
RRID:MMRRC_068579-MU
Other Names:
R8731 (G1)
Major Collection:

Strain Information

Scn3a
Name: sodium channel, voltage-gated, type III, alpha
Synonyms: LOC381367, Nav1.3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20269
Homologene: 56005
Tanc1
Name: tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
Synonyms: 1200003E16Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66860
Homologene: 18946
Scrib
Name: scribbled planar cell polarity
Synonyms: Crc, Scrb1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 105782
Homologene: 44228
Llgl2
Name: LLGL2 scribble cell polarity complex component
Synonyms: 9130006H11Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217325
HGNC: HGNC:6629
Homologene: 3323
Abcc8
Name: ATP-binding cassette, sub-family C member 8
Synonyms: Sur, D930031B21Rik, SUR1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20927
HGNC: HGNC:59
Homologene: 68048
Cdk5rap2
Name: CDK5 regulatory subunit associated protein 2
Synonyms: an, 2900018K03Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 214444
Homologene: 49533
Myo1b
Name: myosin IB
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17912
HGNC: HGNC:7596
Homologene: 7856
Myo9b
Name: myosin IXb
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 17925
HGNC: HGNC:7609
Homologene: 3058
Dync1h1
Name: dynein cytoplasmic 1 heavy chain 1
Synonyms: Swl, Dnchc1, 9930018I23Rik, Dnec1, dynein heavy chain, retrograde transport, MAP1C, Loa
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 13424
HGNC: HGNC:2961
Homologene: 1053
Cc2d2a
Name: coiled-coil and C2 domain containing 2A
Synonyms: b2b1035Clo, 5730509K17Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231214
Homologene: 18159
Dgkd
Name: diacylglycerol kinase, delta
Synonyms: dgkd-2, DGKdelta
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227333
HGNC: HGNC:2851
Homologene: 100054
Uhrf1
Name: ubiquitin-like, containing PHD and RING finger domains, 1
Synonyms: ICBP90, Np95
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 18140
Homologene: 7866
Vps11
Name: VPS11, CORVET/HOPS core subunit
Synonyms: 1200011A11Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 71732
VEGA: 9
Homologene: 6673
Rab9
Name: RAB9, member RAS oncogene family
Synonyms: 2410064E05Rik, SID 99
Type: Gene
Species: Mouse
Chromosome: X
NCBI: 56382
HGNC: HGNC:9792
Homologene: 20900
Nsl1
Name: NSL1, MIS12 kinetochore complex component
Synonyms: LOC381318, 4833432M17Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 381318
Homologene: 22898
Apeh
Name: acylpeptide hydrolase
Synonyms: N-acylaminoacyl peptide hydrolase
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235606
HGNC: HGNC:586
Homologene: 1240
Dpysl3
Name: dihydropyrimidinase-like 3
Synonyms: Ulip, CRMP-4, Ulip1, CRMP4, TUC4, 9430041P20Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 22240
HGNC: HGNC:3015
Homologene: 20361
Mylk3
Name: myosin light chain kinase 3
Synonyms: D830007F02Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 213435
Homologene: 35278
Stk31
Name: serine threonine kinase 31
Synonyms: C330007K24Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 77485
Homologene: 12677
Nalcn
Name: sodium leak channel, non-selective
Synonyms: Vgcnl1, A530023G15Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 338370
VEGA: 14
Homologene: 21832
Vmn2r2
Name: vomeronasal 2, receptor 2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 100125586
Homologene: 129753
Gpr179
Name: G protein-coupled receptor 179
Synonyms: 5330439C02Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217143
Homologene: 34917
Cap2
Name: cyclase associated actin cytoskeleton regulatory protein 2
Synonyms: 2810452G09Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 67252
Homologene: 101397
Fam227b
Name: family with sequence similarity 227, member B
Synonyms: 4930525F21Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 75823
Homologene: 27384
Cracr2a
Name: calcium release activated channel regulator 2A
Synonyms: LOC243645, Efcab4b, LOC381812
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 381812
Homologene: 41883
Igfn1
Name: immunoglobulin-like and fibronectin type III domain containing 1
Synonyms: 9830123M21Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226438
Homologene: 130054
Dcaf7
Name: DDB1 and CUL4 associated factor 7
Synonyms: Wdr68, 2610037L01Rik, 1700012F10Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71833
Homologene: 55930
Spata7
Name: spermatogenesis associated 7
Synonyms: B230306G18Rik, HSD3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 104871
Homologene: 10189
Tspan33
Name: tetraspanin 33
Synonyms: 1300010A20Rik, Pen, Penumbra
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232670
Homologene: 8213
Dffb
Name: DNA fragmentation factor, beta subunit
Synonyms: Didff, CPAN, 40kDa, CAD, 5730477D02Rik, DFF40, caspase-activated DNase
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 13368
HGNC: HGNC:2773
Homologene: 3241
Clip1
Name: CAP-GLY domain containing linker protein 1
Synonyms: 4631429H07Rik, Clip50, cytoplasmic linker protein 50, restin, Rsn, 1110007I12Rik, Clip 170, CLIP-170
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 56430
Homologene: 74455
Otulin
Name: OTU deubiquitinase with linear linkage specificity
Synonyms: Fam105b, m3Sapc, gumby, m7-1Sapc
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 432940
VEGA: 15
Homologene: 106591
Vmn2r65
Name: vomeronasal 2, receptor 65
Synonyms: ENSMUSG00000070600
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100009609
Plch1
Name: phospholipase C, eta 1
Synonyms: PLCeta1, Plcl3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 269437
Homologene: 88833
Gm57858
Name: gene model 57858
Synonyms: Ccdc144b
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 241943
Homologene: 87263
Aadacl2
Name: arylacetamide deacetylase like 2
Synonyms: EG639634
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 639634
Homologene: 28634
Repin1
Name: replication initiator 1
Synonyms: Zfp464, E430037F08Rik, AP4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 58887
Homologene: 22810
Ace
Name: angiotensin I converting enzyme
Synonyms: CD143
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11421
HGNC: HGNC:2707
Homologene: 37351
Slc36a4
Name: solute carrier family 36 (proton/amino acid symporter), member 4
Synonyms: 6330573I15Rik, PAT4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 234967
Homologene: 56300
Or5af1
Name: olfactory receptor family 5 subfamily AF member 1
Synonyms: GA_x6K02T2NKPP-575829-574903, Olfr312, MOR222-4P
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258065
Homologene: 77375
Cox10
Name: heme A:farnesyltransferase cytochrome c oxidase assembly factor 10
Synonyms: 2410004F01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 70383
HGNC: HGNC:2260
Homologene: 80170
Gnas
Name: GNAS complex locus
Synonyms: neuroendocrine-specific Golgi protein p55 isoform 1, Gs-alpha, SCG6, XLalphas, P2, Gnas1, Gs alpha, P3, P1, Nesp, Galphas, Oedsml, G alpha s, Gsa, Gnasxl, Nespl, Nesp55
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14683
HGNC: HGNC:4392
Homologene: 55534
Bod1
Name: biorientation of chromosomes in cell division 1
Synonyms: 2310022M17Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69556
Homologene: 16300
Disp1
Name: dispatched RND transporter family member 1
Synonyms: 1190008H24Rik, DispA
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 68897
Homologene: 14133
Myl10
Name: myosin, light chain 10, regulatory
Synonyms: Mylc2pl, PLRLC-A, 1700027I08Rik, PLRLC, PLRLC-B, PLRLC-C
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 59310
Homologene: 69341
Gm21680
Name: predicted gene, 21680
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100862368
Homologene: 69402
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to C, chromosome 1 at 51,760,411 bp
  • A to G, chromosome 1 at 87,916,813 bp
  • A to G, chromosome 1 at 135,997,836 bp
  • A to T, chromosome 1 at 183,087,508 bp
  • A to G, chromosome 1 at 191,082,412 bp
  • T to C, chromosome 2 at 59,843,252 bp
  • A to T, chromosome 2 at 65,468,163 bp
  • A to T, chromosome 2 at 126,126,978 bp
  • T to C, chromosome 2 at 174,284,906 bp
  • A to T, chromosome 3 at 36,035,285 bp
  • A to T, chromosome 3 at 60,024,946 bp
  • A to T, chromosome 3 at 63,697,638 bp
  • A to G, chromosome 3 at 64,116,983 bp
  • A to T, chromosome 4 at 70,245,510 bp
  • T to C, chromosome 4 at 153,974,644 bp
  • A to T, chromosome 5 at 25,968,232 bp
  • A to T, chromosome 5 at 43,735,446 bp
  • A to C, chromosome 5 at 123,614,693 bp
  • G to C, chromosome 5 at 136,697,971 bp
  • T to C, chromosome 6 at 29,717,311 bp
  • G to T, chromosome 6 at 48,597,345 bp
  • T to A, chromosome 6 at 49,438,501 bp
  • T to G, chromosome 6 at 127,625,927 bp
  • T to G, chromosome 7 at 46,154,562 bp
  • A to T, chromosome 7 at 84,940,239 bp
  • T to C, chromosome 8 at 71,353,842 bp
  • T to G, chromosome 8 at 85,359,005 bp
  • A to G, chromosome 9 at 15,719,752 bp
  • T to C, chromosome 9 at 44,354,459 bp
  • A to G, chromosome 9 at 108,087,223 bp
  • A to G, chromosome 11 at 31,669,242 bp
  • C to T, chromosome 11 at 58,831,442 bp
  • A to G, chromosome 11 at 63,964,219 bp
  • T to C, chromosome 11 at 97,343,729 bp
  • T to A, chromosome 11 at 105,970,600 bp
  • T to A, chromosome 11 at 106,054,722 bp
  • A to G, chromosome 11 at 115,851,190 bp
  • T to A, chromosome 12 at 98,658,282 bp
  • T to A, chromosome 12 at 110,640,584 bp
  • T to C, chromosome 13 at 46,646,530 bp
  • T to C, chromosome 14 at 123,599,854 bp
  • A to G, chromosome 15 at 27,608,842 bp
  • A to T, chromosome 15 at 76,063,639 bp
  • T to A, chromosome 17 at 56,322,363 bp
  • C to T, chromosome 18 at 43,438,092 bp
  • C to T, chromosome X at 166,457,758 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8731 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068579-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.