Strain Name:
C57BL/6J-MtgxR8931Btlr/Mmmh
Stock Number:
068775-MU
Citation ID:
RRID:MMRRC_068775-MU
Other Names:
R8931 (G1)
Major Collection:

Strain Information

Sod2
Name: superoxide dismutase 2, mitochondrial
Synonyms: manganese SOD, manganese superoxide dismutase, Sod-2, MnSOD
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 20656
VEGA: 17
Homologene: 530
Mc3r
Name: melanocortin 3 receptor
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17201
HGNC: HGNC:6931
Homologene: 7412
Cemip2
Name: cell migration inducing hyaluronidase 2
Synonyms: 3110012M15Rik, Tmem2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 83921
VEGA: 19
Homologene: 75008
Ephx2
Name: epoxide hydrolase 2, cytoplasmic
Synonyms: Eph2, sEH, sEP
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 13850
VEGA: 14
HGNC: HGNC:3402
Homologene: 37558
Wdfy3
Name: WD repeat and FYVE domain containing 3
Synonyms: D5Ertd66e, Bwf1, 2610509D04Rik, Bchs, Ggtb3, Alfy
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 72145
Homologene: 22855
Carmil1
Name: capping protein regulator and myosin 1 linker 1
Synonyms: Lrrc16, 1110037D04Rik, Carmil, Lrrc16a
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 68732
Homologene: 9757
Kat6b
Name: K(lysine) acetyltransferase 6B
Synonyms: Myst4, Morf, monocytic leukemia, qkf, querkopf, B130044K16Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 54169
Homologene: 136480
Nop58
Name: NOP58 ribonucleoprotein
Synonyms: SIK similar protein, MSSP, Nol5
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 55989
Homologene: 7024
Ankrd11
Name: ankyrin repeat domain 11
Synonyms: 9530048I21Rik, Yod, 3010027A04Rik, 2410104C19Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 77087
Homologene: 69134
Bzw2
Name: basic leucine zipper and W2 domains 2
Synonyms: HSPC028, 1110001I24Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 66912
VEGA: 12
Homologene: 8530
Cep170
Name: centrosomal protein 170
Synonyms: 4933426L22Rik, A330004A13Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 545389
Homologene: 22844
Hip1
Name: huntingtin interacting protein 1
Synonyms: E130315I21Rik, HIP-1, 2610109B09Rik, A930014B11Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 215114
HGNC: HGNC:4913
Homologene: 68463
Cyp7a1
Name: cytochrome P450, family 7, subfamily a, polypeptide 1
Synonyms: cholesterol 7 alpha hydroxylase
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 13122
HGNC: HGNC:2651
Homologene: 30987
Naa16
Name: N(alpha)-acetyltransferase 16, NatA auxiliary subunit
Synonyms: 1300019C06Rik, Narg1l
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 66897
Homologene: 134838
Tfcp2
Name: transcription factor CP2
Synonyms: LBP-1c, Tcfcp2, D230015P20Rik, UBP-1, CP-2, LBP-1d, LSF, LBP1, CP2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 21422
VEGA: 15
Homologene: 4134
Ldlr
Name: low density lipoprotein receptor
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 16835
VEGA: 9
HGNC: HGNC:6547
Homologene: 55469
Clhc1
Name: clathrin heavy chain linker domain containing 1
Synonyms: 1700034F02Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 73324
Homologene: 17569
Prokr2
Name: prokineticin receptor 2
Synonyms: Gpr73l1, EG-VEGRF2, Gpcr73l1, PKR2, B830005M06Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 246313
Homologene: 16368
Tenm3
Name: teneurin transmembrane protein 3
Synonyms: 2610100B16Rik, Odz3, Ten-m3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 23965
Homologene: 22673
Arap1
Name: ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
Synonyms: 2410002L19Rik, Centd2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 69710
Homologene: 12326
Zng1
Name: Zn regulated GTPase metalloprotein activator 1
Synonyms: Cbwd1, Zng1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226043
VEGA: 19
Homologene: 6843
Myo15a
Name: myosin XVA
Synonyms: Myo15
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17910
HGNC: HGNC:7594
Homologene: 56504
Ern2
Name: endoplasmic reticulum to nucleus signalling 2
Synonyms: Ire1b
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 26918
Homologene: 22687
Aldh3b1
Name: aldehyde dehydrogenase 3 family, member B1
Synonyms: ALDH4, ALDH7, 1700001N19Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 67689
VEGA: 19
HGNC: HGNC:410
Homologene: 73890
Fbn1
Name: fibrillin 1
Synonyms: Fib-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14118
HGNC: HGNC:3603
Homologene: 30958
Trpm3
Name: transient receptor potential cation channel, subfamily M, member 3
Synonyms: MLSN2, melastatin 2, 6330504P12Rik, LTRPC3, B930001P07Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226025
VEGA: 19
Homologene: 62287
Pik3c2g
Name: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 18705
HGNC: HGNC:8973
Homologene: 3362
Tsbp1
Name: testis expressed basic protein 1
Synonyms: BC051142
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 407788
Homologene: 128168
Sgcz
Name: sarcoglycan zeta
Synonyms: C230085N17Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244431
Homologene: 26726
Slc28a2b
Name: solute carrier family 28 member 2b
Synonyms: Gm14085
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 381417
Pcdh8
Name: protocadherin 8
Synonyms: 1700080P15Rik, Papc
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 18530
HGNC: HGNC:8660
Homologene: 1943
Mug1
Name: murinoglobulin 1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 17836
HGNC: HGNC:9750
Homologene: 136663
Fbln2
Name: fibulin 2
Synonyms: 5730577E14Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14115
HGNC: HGNC:3601
Homologene: 1514
Cttnbp2
Name: cortactin binding protein 2
Synonyms: ORF4, 4732477G22Rik, 3010022N24Rik, Cortbp2, 9130022E09Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 30785
Homologene: 14125
Zfp536
Name: zinc finger protein 536
Synonyms: 9630010P11Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243937
Homologene: 8813
Arhgef19
Name: Rho guanine nucleotide exchange factor 19
Synonyms: 6430573B13Rik, WGEF
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 213649
Homologene: 17710
Prb1c
Name: proline-rich protein BstNI subfamily 1C
Synonyms: Gm8882
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 667929
Or6c33
Name: olfactory receptor family 6 subfamily C member 33
Synonyms: MOR116-1, GA_x6K02T2PULF-11688441-11689379, Olfr820
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258670
Homologene: 17337
Rnf148
Name: ring finger protein 148
Synonyms: 4933432M07Rik, Greul3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 71300
Homologene: 82404
BC051019
Name: cDNA sequence BC051019
Synonyms: D7H11orf16, ICRFP703N2430Q5.5
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 57355
HGNC: HGNC:1169
Homologene: 49631
Or7g19
Name: olfactory receptor family 7 subfamily G member 19
Synonyms: GA_x6K02T2PVTD-12687800-12688738, MOR153-1, Olfr832
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258075
HGNC: HGNC:8467
Homologene: 128143
Ndufaf7
Name: NADH:ubiquinone oxidoreductase complex assembly factor 7
Synonyms: 2410091C18Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 73694
VEGA: 17
Homologene: 12508
Glis1
Name: GLIS family zinc finger 1
Synonyms: GliH1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230587
Homologene: 77390
Hmgcs2
Name: 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2
Synonyms: mHS
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 15360
HGNC: HGNC:5008
Homologene: 38066
Ddx25
Name: DEAD box helicase 25
Synonyms: GRTH, DEAD (Asp-Glu-Ala-Asp) box polypeptide 25
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 30959
Homologene: 8310
Poc1b
Name: POC1 centriolar protein B
Synonyms: Wdr51b, 4933430F16Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 382406
Homologene: 41728
Tbc1d12
Name: TBC1D12: TBC1 domain family, member 12
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 209478
VEGA: 19
Homologene: 50835
Gpr61
Name: G protein-coupled receptor 61
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229714
Homologene: 12910
Setbp1
Name: SET binding protein 1
Synonyms: Seb
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240427
Homologene: 9192
Acat3
Name: acetyl-Coenzyme A acetyltransferase 3
Synonyms: ACTL
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224530
HGNC: HGNC:94
Homologene: 55855
Uox
Name: urate oxidase
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 22262
Homologene: 7584
Zfp511
Name: zinc finger protein 511
Synonyms: 2410004P19Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 69752
Homologene: 42950
Or6c88
Name: olfactory receptor family 6 subfamily C member 88
Synonyms: MOR114-11, GA_x6K02T2PULF-11248702-11249664, Olfr794
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258375
Homologene: 45066
Tcte2
Name: t-complex-associated testis expressed 2
Synonyms: Tcte-2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 21646
Slc25a2
Name: solute carrier family 25 (mitochondrial carrier, ornithine transporter) member 2
Synonyms: Ornt2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 83885
Homologene: 129775
Rce1
Name: Ras converting CAAX endopeptidase 1
Synonyms: D19Ertd98e, D19Ertd283e
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 19671
VEGA: 19
Homologene: 3769
Trbv14
Name: T cell receptor beta, variable 14
Synonyms: Gm16910, BV13S1, Tcrb-V13
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 100124678
Trav14-3
Name: T cell receptor alpha variable 14-3
Synonyms: Gm13933
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 547330
Calm3
Name: calmodulin 3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 12315
HGNC: HGNC:1449
Homologene: 116117
H4c11
Name: H4 clustered histone 11
Synonyms: Hist1h4j
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 319159
Homologene: 134474
Gm13283
Name: predicted gene 13283
Synonyms: EG545645
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 545645
Homologene: 45671
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 59,692,390 bp
  • A to T, chromosome 1 at 176,769,811 bp
  • C to A, chromosome 2 at 122,518,502 bp
  • T to C, chromosome 2 at 125,360,175 bp
  • A to G, chromosome 2 at 132,374,076 bp
  • A to T, chromosome 2 at 172,249,595 bp
  • C to T, chromosome 3 at 98,296,241 bp
  • A to G, chromosome 3 at 108,150,154 bp
  • A to T, chromosome 3 at 146,612,292 bp
  • T to C, chromosome 4 at 6,271,238 bp
  • G to A, chromosome 4 at 88,683,475 bp
  • A to C, chromosome 4 at 88,761,279 bp
  • A to G, chromosome 4 at 107,563,863 bp
  • T to C, chromosome 4 at 141,249,292 bp
  • A to G, chromosome 5 at 101,917,555 bp
  • A to T, chromosome 5 at 135,431,443 bp
  • A to G, chromosome 6 at 18,434,809 bp
  • A to T, chromosome 6 at 23,654,705 bp
  • T to C, chromosome 6 at 41,135,430 bp
  • A to T, chromosome 6 at 91,269,090 bp
  • G to C, chromosome 6 at 121,884,337 bp
  • G to A, chromosome 6 at 132,361,934 bp
  • A to G, chromosome 6 at 139,875,367 bp
  • G to C, chromosome 7 at 16,917,473 bp
  • G to T, chromosome 7 at 37,569,296 bp
  • G to A, chromosome 7 at 101,408,117 bp
  • T to C, chromosome 7 at 109,716,079 bp
  • C to T, chromosome 7 at 122,170,140 bp
  • T to C, chromosome 7 at 140,037,281 bp
  • A to G, chromosome 8 at 37,639,986 bp
  • T to C, chromosome 8 at 48,235,602 bp
  • C to T, chromosome 8 at 122,895,979 bp
  • T to A, chromosome 9 at 18,944,624 bp
  • G to A, chromosome 9 at 21,731,812 bp
  • T to C, chromosome 9 at 35,554,568 bp
  • T to C, chromosome 10 at 99,192,999 bp
  • A to T, chromosome 10 at 129,570,681 bp
  • A to T, chromosome 10 at 130,017,900 bp
  • C to T, chromosome 11 at 29,560,533 bp
  • A to G, chromosome 11 at 60,477,194 bp
  • T to C, chromosome 12 at 36,134,944 bp
  • T to A, chromosome 13 at 21,735,199 bp
  • T to A, chromosome 13 at 24,154,721 bp
  • T to C, chromosome 14 at 21,624,927 bp
  • C to A, chromosome 14 at 53,763,655 bp
  • G to T, chromosome 14 at 66,084,992 bp
  • A to G, chromosome 14 at 79,344,955 bp
  • G to A, chromosome 14 at 79,769,531 bp
  • T to C, chromosome 15 at 100,504,417 bp
  • G to C, chromosome 17 at 12,928,518 bp
  • T to C, chromosome 17 at 13,008,306 bp
  • C to A, chromosome 17 at 13,713,148 bp
  • T to C, chromosome 17 at 34,440,354 bp
  • A to G, chromosome 17 at 78,937,521 bp
  • C to A, chromosome 18 at 37,638,036 bp
  • A to G, chromosome 18 at 78,856,508 bp
  • A to G, chromosome 19 at 3,918,803 bp
  • C to T, chromosome 19 at 4,624,066 bp
  • T to A, chromosome 19 at 21,792,959 bp
  • T to A, chromosome 19 at 22,766,670 bp
  • T to G, chromosome 19 at 24,955,416 bp
  • T to C, chromosome 19 at 38,865,654 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8931 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068775-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.