Strain Name:
C57BL/6J-MtgxR8949Btlr/Mmmh
Stock Number:
068787-MU
Citation ID:
RRID:MMRRC_068787-MU
Other Names:
R8949 (G1)
Major Collection:

Strain Information

Top1
Name: topoisomerase (DNA) I
Synonyms: D130064I21Rik, Top-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 21969
Homologene: 2467
Wfs1
Name: wolframin ER transmembrane glycoprotein
Synonyms: Wolfram syndrome 1 homolog (human), wolframin
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22393
Homologene: 4380
Sirt1
Name: sirtuin 1
Synonyms: Sir2, Sir2alpha
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 93759
Homologene: 56556
Spcs2
Name: signal peptidase complex subunit 2 homolog (S. cerevisiae)
Synonyms: 5730406I15Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 66624
Homologene: 8842
Atxn2l
Name: ataxin 2-like
Synonyms: A2D, A2LG, A2RP, A2lp
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233871
Homologene: 16513
Mettl25
Name: methyltransferase like 25
Synonyms: BC067068
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216292
Homologene: 32774
Eef2
Name: eukaryotic translation elongation factor 2
Synonyms: Ef-2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 13629
VEGA: 10
HGNC: HGNC:3214
Homologene: 134867
Ttll4
Name: tubulin tyrosine ligase-like family, member 4
Synonyms: 4632407P03Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 67534
Homologene: 8764
Bmpr2
Name: bone morphogenetic protein receptor type 2
Synonyms: BMPR-II, BMPRII, BMP-2, 2610024H22Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12168
HGNC: HGNC:1078
Homologene: 929
Hr
Name: lysine demethylase and nuclear receptor corepressor
Synonyms: N, rh, bldy, rh-bmh, ba
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 15460
HGNC: HGNC:5172
Homologene: 3774
Dhx32
Name: DEAH-box helicase 32 (putative)
Synonyms: Ddx32, DEAH (Asp-Glu-Ala-His) box polypeptide 32
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101437
Homologene: 56798
Syt17
Name: synaptotagmin XVII
Synonyms: Bk
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 110058
Homologene: 9553
Tnc
Name: tenascin C
Synonyms: C130033P17Rik, TN, hexabrachion, Hxb, cytotactin, tenascin-C, TN-C
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 21923
HGNC: HGNC:5318
Homologene: 55636
Muc16
Name: mucin 16
Synonyms: 1110008I14Rik, LOC385009, Gm21044
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 73732
Homologene: 141193
Baz1a
Name: bromodomain adjacent to zinc finger domain 1A
Synonyms: Wcrf180, Acf1, Gtl5
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217578
HGNC: HGNC:960
Homologene: 45654
Zfp949
Name: zinc finger protein 949
Synonyms: 4930422I07Rik, Nczf
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 71640
Homologene: 129930
Phaf1
Name: phagosome assembly factor 1
Synonyms: Lin10, D230025D16Rik, Mytho
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234678
Homologene: 11864
Lct
Name: lactase
Synonyms: LOC226413, LPH, Lphl
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226413
HGNC: HGNC:6530
Homologene: 124204
Ksr2
Name: kinase suppressor of ras 2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 333050
Homologene: 45469
Agpat3
Name: 1-acylglycerol-3-phosphate O-acyltransferase 3
Synonyms: LPAAT3, D10Jhu12e
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 28169
HGNC: HGNC:326
Homologene: 10591
Lrp1
Name: low density lipoprotein receptor-related protein 1
Synonyms: b2b1554Clo, A2mr, CD91
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16971
HGNC: HGNC:6692
Homologene: 1744
Col12a1
Name: collagen, type XII, alpha 1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12816
HGNC: HGNC:2188
Homologene: 3217
Svep1
Name: sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
Synonyms: 4833413O10Rik, D430029O09Rik, 1110021D17Rik, Polydom
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 64817
Homologene: 23386
Afm
Name: afamin
Synonyms: Alf, alpha albumin
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 280662
HGNC: HGNC:316
Homologene: 881
Dnah9
Name: dynein, axonemal, heavy chain 9
Synonyms: Dnahc9, D11Ertd686e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237806
HGNC: HGNC:2953
Homologene: 20357
Bmpr1b
Name: bone morphogenetic protein receptor, type 1B
Synonyms: Alk6, CFK-43a, BMPR-IB, Acvrlk6
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12167
HGNC: HGNC:1077
Homologene: 20322
Atg4b
Name: autophagy related 4B, cysteine peptidase
Synonyms: Apg4b, autophagin 1, 2510009N07Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 66615
Homologene: 100868
Skint6
Name: selection and upkeep of intraepithelial T cells 6
Synonyms: OTTMUSG00000008519
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230622
Homologene: 135888
Zfp607a
Name: zinc finger protein 607A
Synonyms: Zfp607, 4732475C15Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 545938
Homologene: 134321
Col6a5
Name: collagen, type VI, alpha 5
Synonyms: Gm7455, Col6a5
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 665033
Homologene: 122792
Map3k13
Name: mitogen-activated protein kinase kinase kinase 13
Synonyms: C130026N12Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 71751
VEGA: 16
HGNC: HGNC:6852
Homologene: 37958
Steap1
Name: six transmembrane epithelial antigen of the prostate 1
Synonyms: 2410007B19Rik, Prss24
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 70358
Homologene: 8256
Tecrl
Name: trans-2,3-enoyl-CoA reductase-like
Synonyms: Srd5a2l2, D330017N19Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 243078
Homologene: 27549
Spata31h1
Name: SPATA31 subfamily H member 1
Synonyms: 4932415D10Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 102635990
VEGA: 10
Homologene: 82476
Sgsm3
Name: small G protein signaling modulator 3
Synonyms: CIP85, 1810012I01Rik, Rutbc3
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 105835
Homologene: 9249
Vmn1r193
Name: vomeronasal 1 receptor 193
Synonyms: V1ri9
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 171259
Homologene: 110880
Cfh
Name: complement component factor h
Synonyms: Mud-1, Sas-1, Sas1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12628
HGNC: HGNC:4883
Homologene: 20086
Tdpoz3
Name: TD and POZ domain containing 3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 399674
Homologene: 128308
Or4g16
Name: olfactory receptor family 4 subfamily G member 16
Synonyms: MOR245-12, GA_x6K02T2Q125-72357646-72358581, Olfr1279
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258388
Homologene: 121520
Smpdl3b
Name: sphingomyelin phosphodiesterase, acid-like 3B
Synonyms: 1110054A24Rik, Asml3b
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100340
Homologene: 8708
Nudcd1
Name: NudC domain containing 1
Synonyms: 4921532K09Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 67429
VEGA: 15
Homologene: 12128
Bfsp2
Name: beaded filament structural protein 2, phakinin
Synonyms: CP49
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 107993
HGNC: HGNC:1041
Homologene: 20791
Gzmg
Name: granzyme G
Synonyms: Ctla-7, Ctla7
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 14944
VEGA: 14
Homologene: 133275
Eef2k
Name: eukaryotic elongation factor-2 kinase
Synonyms: eEF-2K
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13631
Homologene: 7299
Hs3st2
Name: heparan sulfate (glucosamine) 3-O-sulfotransferase 2
Synonyms: A830061E14Rik, 6430516N12Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 195646
HGNC: HGNC:5195
Homologene: 21220
Or5b104
Name: olfactory receptor family 5 subfamily B member 104
Synonyms: MOR202-20, Olfr1457, GA_x6K02T2RE5P-3423041-3422097
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258568
HGNC: HGNC:8324
Homologene: 133676
Speer4e2
Name: spermatogenesis associated glutamate (E)-rich protein 4E2
Synonyms: Gm10354
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100503549
Homologene: 69402
Cndp2
Name: CNDP dipeptidase 2
Synonyms: Dip-2, Pep1, 0610010E05Rik, Cn2, Pep-1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 66054
VEGA: 18
Homologene: 10085
Tmem184a
Name: transmembrane protein 184a
Synonyms: Sdmg1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231832
Homologene: 64815
Krtap6-2
Name: keratin associated protein 6-2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 16701
Ndufv3
Name: NADH:ubiquinone oxidoreductase core subunit V3
Synonyms: 1500032D16Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 78330
HGNC: HGNC:7719
Homologene: 10885
Or52a33
Name: olfactory receptor family 52 subfamily A member 33
Synonyms: Olfr622, MOR26-1, GA_x6K02T2PBJ9-6362863-6361910
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259087
Homologene: 100540
Ighv1-31
Name: immunoglobulin heavy variable 1-31
Synonyms: Gm16965
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 629893
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 59,867,701 bp
  • T to C, chromosome 1 at 74,681,816 bp
  • T to A, chromosome 1 at 93,787,757 bp
  • A to T, chromosome 1 at 128,294,192 bp
  • G to T, chromosome 1 at 140,098,967 bp
  • T to A, chromosome 2 at 111,307,034 bp
  • A to G, chromosome 2 at 160,705,262 bp
  • T to C, chromosome 3 at 93,827,092 bp
  • T to G, chromosome 3 at 141,880,442 bp
  • T to C, chromosome 4 at 58,054,604 bp
  • T to C, chromosome 4 at 64,008,850 bp
  • T to A, chromosome 4 at 113,074,099 bp
  • T to C, chromosome 4 at 132,746,503 bp
  • A to T, chromosome 5 at 5,739,940 bp
  • C to T, chromosome 5 at 14,976,198 bp
  • C to T, chromosome 5 at 36,966,943 bp
  • C to T, chromosome 5 at 83,313,307 bp
  • T to A, chromosome 5 at 90,531,515 bp
  • T to C, chromosome 5 at 117,685,495 bp
  • C to A, chromosome 5 at 139,805,556 bp
  • A to G, chromosome 7 at 27,878,519 bp
  • A to G, chromosome 7 at 99,844,716 bp
  • A to T, chromosome 7 at 103,639,495 bp
  • A to G, chromosome 7 at 118,433,831 bp
  • A to T, chromosome 7 at 120,891,988 bp
  • A to G, chromosome 7 at 121,500,794 bp
  • A to T, chromosome 7 at 126,492,205 bp
  • A to T, chromosome 7 at 133,742,741 bp
  • T to A, chromosome 8 at 105,249,443 bp
  • A to G, chromosome 9 at 18,520,925 bp
  • C to A, chromosome 9 at 79,674,688 bp
  • C to T, chromosome 9 at 88,568,718 bp
  • T to C, chromosome 9 at 103,449,953 bp
  • C to T, chromosome 9 at 105,945,634 bp
  • T to C, chromosome 10 at 63,326,185 bp
  • A to G, chromosome 10 at 78,283,155 bp
  • T to A, chromosome 10 at 81,178,684 bp
  • A to G, chromosome 10 at 82,287,919 bp
  • A to G, chromosome 10 at 105,832,853 bp
  • T to A, chromosome 10 at 127,589,536 bp
  • A to G, chromosome 11 at 66,168,400 bp
  • T to C, chromosome 12 at 54,894,453 bp
  • T to C, chromosome 12 at 114,829,416 bp
  • T to C, chromosome 13 at 22,219,750 bp
  • C to T, chromosome 14 at 56,159,469 bp
  • T to C, chromosome 14 at 70,557,888 bp
  • T to C, chromosome 15 at 44,388,575 bp
  • A to G, chromosome 15 at 81,010,411 bp
  • A to G, chromosome 16 at 21,905,132 bp
  • T to C, chromosome 16 at 89,419,815 bp
  • A to G, chromosome 17 at 31,527,768 bp
  • A to G, chromosome 18 at 84,675,005 bp
  • A to T, chromosome 19 at 13,095,126 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8949 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068787-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.