Strain Name:
C57BL/6J-MtgxR9057Btlr/Mmmh
Stock Number:
068883-MU
Citation ID:
RRID:MMRRC_068883-MU
Other Names:
R9057 (G1)
Major Collection:

Strain Information

B4galnt1
Name: beta-1,4-N-acetyl-galactosaminyl transferase 1
Synonyms: beta1,4GalNAC-T, GM2/GD2 synthase, GalNAcT, Gal-NAc-T, 4933429D13Rik, Ggm-2, Galgt1, GalNAc-T, Ggm2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14421
VEGA: 10
HGNC: HGNC:4117
Homologene: 1133
Hfe
Name: homeostatic iron regulator
Synonyms: MR2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 15216
HGNC: HGNC:4886
Homologene: 88330
Vps41
Name: VPS41 HOPS complex subunit
Synonyms: Vam2, mVam2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218035
VEGA: 13
Homologene: 69165
Tnrc6b
Name: trinucleotide repeat containing 6b
Synonyms: A730065C02Rik, D230019K20Rik, 2700090M07Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 213988
VEGA: 15
Homologene: 66194
Ints6
Name: integrator complex subunit 6
Synonyms: DICE1, 2900075H24Rik, Ddx26, Notch2l
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 18130
VEGA: 14
Homologene: 8121
Kpna4
Name: karyopherin subunit alpha 4
Synonyms: importin alpha 3, 1110058D08Rik, IPOA3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 16649
HGNC: HGNC:6397
Homologene: 20521
Igf1r
Name: insulin-like growth factor I receptor
Synonyms: IGF-1R, A330103N21Rik, hyft, CD221, line 186
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16001
HGNC: HGNC:5465
Homologene: 30997
Vps13c
Name: vacuolar protein sorting 13C
Synonyms: C230055H22Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320528
VEGA: 9
Homologene: 41188
Myh10
Name: myosin, heavy polypeptide 10, non-muscle
Synonyms: nonmuscle myosin heavy chain IIB, SMemb, NMHC-B, nonmuscle myosin heavy chain II-B, Myhn-2, 5730504C04Rik, myosin IIB, Fltn, Myhn2, Fltn, NMHC II-B, Myosin IIB, 9330167F11Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 77579
HGNC: HGNC:7568
Homologene: 55941
Mib1
Name: MIB E3 ubiquitin protein ligase 1
Synonyms: E430019M12Rik, mindbomb, Mib, mind bomb-1, skeletrophin
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225164
Homologene: 10810
Pan2
Name: PAN2 poly(A) specific ribonuclease subunit
Synonyms: Usp52, 1200014O24Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 103135
VEGA: 10
Homologene: 5918
Psmd12
Name: proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
Synonyms: P55, 1500002F15Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 66997
HGNC: HGNC:9557
Homologene: 2109
Heatr5a
Name: HEAT repeat containing 5A
Synonyms: D930036F22Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 320487
VEGA: 12
Homologene: 19635
Ints4
Name: integrator complex subunit 4
Synonyms: 2610034N24Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101861
Homologene: 69427
Bard1
Name: BRCA1 associated RING domain 1
Synonyms: ENSMUSG00000060893, ENSMUSG00000073653
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12021
HGNC: HGNC:952
Homologene: 400
Nif3l1
Name: Ngg1 interacting factor 3-like 1 (S. pombe)
Synonyms: 1110030G24Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 65102
Homologene: 5881
Golga3
Name: golgin A3
Synonyms: 5430416E01Rik, G1-499-14, repro27, Mea-2, Mea2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 269682
HGNC: HGNC:4426
Homologene: 4308
Alms1
Name: ALMS1, centrosome and basal body associated
Synonyms: Alstrom syndrome 1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 236266
HGNC: HGNC:428
Homologene: 49406
Nbeal2
Name: neurobeachin-like 2
Synonyms: 1110014F23Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235627
Homologene: 86422
Mpzl3
Name: myelin protein zero-like 3
Synonyms: A530065I17Rik, rc, ruf, 5430427F17Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 319742
Homologene: 18867
Htt
Name: huntingtin
Synonyms: HD, IT15, C430023I11Rik, htt, Hdh, huntingtin
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 15194
HGNC: HGNC:4851
Homologene: 1593
Aagab
Name: alpha- and gamma-adaptin binding protein
Synonyms: 2310007F21Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 66939
VEGA: 9
Homologene: 11648
Bcl9
Name: B cell CLL/lymphoma 9
Synonyms: 2610202E01Rik, 8030475K17Rik, A330041G23Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 77578
HGNC: HGNC:1008
Homologene: 3191
Tsc1
Name: TSC complex subunit 1
Synonyms: tuberous sclerosis 1, hamartin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 64930
Homologene: 314
Atad2b
Name: ATPase family, AAA domain containing 2B
Synonyms: D530031C13Rik, 1110014E10Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 320817
VEGA: 12
Homologene: 86351
Zfhx2
Name: zinc finger homeobox 2
Synonyms: zfh-5
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 239102
Homologene: 52657
Zfp870
Name: zinc finger protein 870
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240066
VEGA: 17
Homologene: 48189
Pgk2
Name: phosphoglycerate kinase 2
Synonyms: Pgk-2, Tcp-2, Tcp-2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 18663
VEGA: 17
HGNC: HGNC:8898
Homologene: 57138
Wnt16
Name: wingless-type MMTV integration site family, member 16
Synonyms: E130309I19Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 93735
Homologene: 62175
Sp9
Name: trans-acting transcription factor 9
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 381373
Homologene: 66935
Dnah5
Name: dynein, axonemal, heavy chain 5
Synonyms: Dnahc5, Mdnah5, b2b1134Clo, b2b1154Clo, b2b1537Clo, b2b1565Clo, b2b3491Clo
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 110082
HGNC: HGNC:2950
Homologene: 1048
Syne2
Name: spectrin repeat containing, nuclear envelope 2
Synonyms: nesprin-2, D12Ertd777e, diminished cone electroretinogram, Cpfl8, Nesp2g, dice, syne-2, 6820443O06Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 319565
Homologene: 56700
Trappc14
Name: trafficking protein particle complex 14
Synonyms: BC037034, Map11
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231807
Homologene: 10106
Col19a1
Name: collagen, type XIX, alpha 1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12823
HGNC: HGNC:2196
Homologene: 55608
Scd3
Name: stearoyl-coenzyme A desaturase 3
Synonyms: 4930513N16Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 30049
VEGA: 19
Homologene: 137370
B4gat1
Name: beta-1,4-glucuronyltransferase 1
Synonyms: B3gnt6, BETA3GNT1, 1500032M01Rik, iGNT, B3gnt1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 108902
VEGA: 19
Homologene: 38239
Slc8a1
Name: solute carrier family 8 (sodium/calcium exchanger), member 1
Synonyms: D930008O12Rik, Ncx1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 20541
VEGA: 17
Homologene: 69090
Serac1
Name: serine active site containing 1
Synonyms: 4930511N22Rik, D17Ertd141e
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 321007
Homologene: 41900
Ggt6
Name: gamma-glutamyltransferase 6
Synonyms: 9030405D14Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71522
Homologene: 51918
Cenpt
Name: centromere protein T
Synonyms: G630055P03Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 320394
Homologene: 41610
Abca2
Name: ATP-binding cassette, sub-family A member 2
Synonyms: Abc2, D2H0S1474E
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11305
HGNC: HGNC:32
Homologene: 55590
Spire2
Name: spire type actin nucleation factor 2
Synonyms: Spir-2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234857
Homologene: 72212
Or2ag17
Name: olfactory receptor family 2 subfamily AG member 17
Synonyms: MOR283-10P, GA_x6K02T2PBJ9-9168355-9167405, Olfr699
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258180
Homologene: 79391
Col17a1
Name: collagen, type XVII, alpha 1
Synonyms: Bpag, BP180, BPAg2, Bpag2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 12821
HGNC: HGNC:2194
Homologene: 7276
Ano5
Name: anoctamin 5
Synonyms: Tmem16e, Gdd1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233246
Homologene: 100071
Sh3bp1
Name: SH3-domain binding protein 1
Synonyms: 3BP-1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 20401
Homologene: 7534
Nacad
Name: NAC alpha domain containing
Synonyms: mKIAA0363
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 192950
Homologene: 135717
AI837181
Name: expressed sequence AI837181
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 107242
Homologene: 12869
Ankle1
Name: ankyrin repeat and LEM domain containing 1
Synonyms: 8430438L13Rik, Ankrd41
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234396
Homologene: 17562
Tcp11l1
Name: t-complex 11 like 1
Synonyms: C130096D04Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 320554
Homologene: 41260
Exo5
Name: exonuclease 5
Synonyms: Dem1, 3110037I16Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 73172
Homologene: 41497
Slc26a3
Name: solute carrier family 26, member 3
Synonyms: 9130013M11Rik, Dra, 9030623B18Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 13487
HGNC: HGNC:3018
Homologene: 55435
Asb7
Name: ankyrin repeat and SOCS box-containing 7
Synonyms: D030055C23Rik, Asb-7
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 117589
Homologene: 34130
Lactb
Name: lactamase, beta
Synonyms: Mrpl56
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 80907
VEGA: 9
Homologene: 12755
Ces2f
Name: carboxylesterase 2F
Synonyms: 2310038E17Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 71903
HGNC: HGNC:1864
Homologene: 135673
Acat1
Name: acetyl-Coenzyme A acetyltransferase 1
Synonyms: 6330585C21Rik, Acat
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 110446
HGNC: HGNC:93
Homologene: 6
Gm5592
Name: predicted gene 5592
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 434172
Homologene: 45597
Zfp61
Name: zinc finger protein 61
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22719
Homologene: 74923
Klrh1
Name: killer cell lectin-like receptor subfamily H, member 1
Synonyms: LOC232415, Gm156
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232415
Homologene: 16395
Sars2
Name: seryl-aminoacyl-tRNA synthetase 2
Synonyms: D7Ertd353e, 2410015F05Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71984
Homologene: 6073
Cyb5d2
Name: cytochrome b5 domain containing 2
Synonyms: neuferricin, 9330151E16Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 192986
Homologene: 14701
Or6e1
Name: olfactory receptor family 6 subfamily E member 1
Synonyms: IC6, GA_x6K02T2QVSB-39745261-39746202, Olfr49, MOR118-1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 18348
Homologene: 106373
Rpl23a
Name: ribosomal protein L23A
Synonyms: MDA20
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268449
Homologene: 110453
Mup12
Name: major urinary protein 12
Synonyms: Gm2024
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100039054
Homologene: 74304
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 24,510,881 bp
  • A to G, chromosome 1 at 58,450,489 bp
  • A to G, chromosome 1 at 71,030,648 bp
  • G to A, chromosome 2 at 25,441,572 bp
  • T to A, chromosome 2 at 28,685,862 bp
  • A to T, chromosome 2 at 73,273,269 bp
  • A to G, chromosome 2 at 104,697,681 bp
  • G to A, chromosome 3 at 69,094,685 bp
  • A to T, chromosome 3 at 97,204,990 bp
  • A to T, chromosome 4 at 60,740,780 bp
  • A to T, chromosome 4 at 120,921,989 bp
  • A to G, chromosome 5 at 34,852,110 bp
  • C to T, chromosome 5 at 110,184,599 bp
  • A to T, chromosome 5 at 138,262,687 bp
  • T to A, chromosome 6 at 22,288,824 bp
  • T to A, chromosome 6 at 85,609,832 bp
  • T to A, chromosome 6 at 129,775,840 bp
  • A to T, chromosome 7 at 24,291,277 bp
  • G to T, chromosome 7 at 28,746,821 bp
  • C to A, chromosome 7 at 41,289,463 bp
  • A to G, chromosome 7 at 51,553,906 bp
  • T to A, chromosome 7 at 66,659,647 bp
  • T to C, chromosome 7 at 68,183,438 bp
  • T to C, chromosome 7 at 97,509,780 bp
  • A to T, chromosome 7 at 106,790,089 bp
  • T to A, chromosome 8 at 71,406,317 bp
  • C to A, chromosome 8 at 104,948,112 bp
  • C to A, chromosome 8 at 105,849,773 bp
  • T to A, chromosome 8 at 123,368,808 bp
  • G to A, chromosome 9 at 45,068,294 bp
  • C to T, chromosome 9 at 53,592,000 bp
  • T to A, chromosome 9 at 63,617,500 bp
  • T to C, chromosome 9 at 66,967,695 bp
  • T to A, chromosome 9 at 67,920,927 bp
  • G to T, chromosome 9 at 110,627,150 bp
  • A to G, chromosome 10 at 127,171,130 bp
  • A to T, chromosome 10 at 128,320,272 bp
  • C to A, chromosome 11 at 6,600,876 bp
  • A to G, chromosome 11 at 68,765,185 bp
  • C to T, chromosome 11 at 72,437,241 bp
  • C to T, chromosome 11 at 72,789,098 bp
  • G to A, chromosome 11 at 78,181,195 bp
  • G to A, chromosome 11 at 107,486,502 bp
  • T to A, chromosome 12 at 5,018,102 bp
  • A to T, chromosome 12 at 31,470,959 bp
  • C to T, chromosome 12 at 51,939,637 bp
  • T to G, chromosome 12 at 75,890,393 bp
  • T to A, chromosome 13 at 18,843,532 bp
  • T to A, chromosome 13 at 23,705,675 bp
  • T to C, chromosome 14 at 54,282,691 bp
  • C to T, chromosome 14 at 55,072,570 bp
  • A to G, chromosome 14 at 62,714,291 bp
  • C to T, chromosome 15 at 28,390,868 bp
  • A to G, chromosome 15 at 78,910,009 bp
  • G to A, chromosome 15 at 80,879,148 bp
  • C to A, chromosome 17 at 6,061,615 bp
  • A to T, chromosome 17 at 32,883,819 bp
  • A to G, chromosome 17 at 40,207,844 bp
  • A to C, chromosome 17 at 81,648,050 bp
  • T to A, chromosome 18 at 10,795,728 bp
  • G to T, chromosome 19 at 5,039,028 bp
  • A to C, chromosome 19 at 5,426,702 bp
  • C to T, chromosome 19 at 44,235,901 bp
  • A to T, chromosome 19 at 47,649,083 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9057 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068883-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.