Strain Name:
C57BL/6J-MtgxR1596Btlr/Mmmh
Stock Number:
039633-MU
Citation ID:
RRID:MMRRC_039633-MU
Other Names:
R1596 (G1), C57BL/6J-MtgxR1596Btlr
Major Collection:

Strain Information

Arhgap10
Name: Rho GTPase activating protein 10
Synonyms: A930033B01Rik, PSGAP-s, PSGAP-m
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 78514
Homologene: 12695
Lrig2
Name: leucine-rich repeats and immunoglobulin-like domains 2
Synonyms: 4632419I10Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 269473
Homologene: 8882
Casp8
Name: caspase 8
Synonyms: MACH, FLICE, Caspase-8, Mch5
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12370
HGNC: HGNC:1509
Homologene: 7657
Frrs1
Name: ferric-chelate reductase 1
Synonyms: Sdfr2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20321
Homologene: 40653
Ep400
Name: E1A binding protein p400
Synonyms: 1700020J09Rik, p400, mDomino
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 75560
Homologene: 38779
Atm
Name: ataxia telangiectasia mutated
Synonyms: C030026E19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 11920
HGNC: HGNC:795
Homologene: 30952
Hdac5
Name: histone deacetylase 5
Synonyms: mHDA1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 15184
Homologene: 3995
Ptpra
Name: protein tyrosine phosphatase receptor type A
Synonyms: PTP[a], Ptpa, RPTPalpha, PTPalpha, RPTRalpha
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19262
HGNC: HGNC:9664
Homologene: 20621
Mbd2
Name: methyl-CpG binding domain protein 2
Synonyms: MBD2a
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 17191
HGNC: HGNC:6917
Homologene: 2918
Clcn6
Name: chloride channel, voltage-sensitive 6
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 26372
HGNC: HGNC:2024
Homologene: 985
Lrba
Name: LPS-responsive beige-like anchor
Synonyms: Lba, D3Ertd775e
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 80877
HGNC: HGNC:1742
Homologene: 36205
Ncapg2
Name: non-SMC condensin II complex, subunit G2
Synonyms: Luzp5, Mtb, 5830426I05Rik, mCAP-G2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 76044
VEGA: 12
Homologene: 9820
Cnot1
Name: CCR4-NOT transcription complex, subunit 1
Synonyms: 6030411K04Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234594
HGNC: HGNC:7877
Homologene: 9453
Abl1
Name: c-abl oncogene 1, non-receptor tyrosine kinase
Synonyms: E430008G22Rik, c-Abl
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11350
HGNC: HGNC:76
Homologene: 3783
Robo3
Name: roundabout guidance receptor 3
Synonyms: Robo3a, Rbig1, Rig1, Rig-1, Robo3b
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 19649
Homologene: 32119
Prcp
Name: prolylcarboxypeptidase (angiotensinase C)
Synonyms: 2510048K03Rik, 2610104A14Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 72461
HGNC: HGNC:9344
Homologene: 55867
Unkl
Name: unkempt family like zinc finger
Synonyms: 1300004G08Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 74154
Homologene: 62673
Ice1
Name: interactor of little elongation complex ELL subunit 1
Synonyms: BC018507
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218333
VEGA: 13
Homologene: 18902
Tnrc6c
Name: trinucleotide repeat containing 6C
Synonyms: 9930033H14Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217351
Homologene: 23137
Nptx1
Name: neuronal pentraxin 1
Synonyms: Np1, D11Bwg1004e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18164
HGNC: HGNC:7952
Homologene: 1891
Fgd2
Name: FYVE, RhoGEF and PH domain containing 2
Synonyms: Tcd-2, tcs-2, Tcd2, tcs2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 26382
HGNC: HGNC:3664
Homologene: 8438
Ramp1
Name: receptor (calcitonin) activity modifying protein 1
Synonyms: 9130218E19Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 51801
HGNC: HGNC:9843
Homologene: 4275
Egln3
Name: egl-9 family hypoxia-inducible factor 3
Synonyms: Hif-p4h-3, 2610021G09Rik, SM-20, Phd3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 112407
Homologene: 32531
Prkaa2
Name: protein kinase, AMP-activated, alpha 2 catalytic subunit
Synonyms: AMPKalpha2, 2310008I11Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 108079
HGNC: HGNC:9377
Homologene: 4551
Vax1
Name: ventral anterior homeobox 1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 22326
Homologene: 7593
Sdk2
Name: sidekick cell adhesion molecule 2
Synonyms: 4632412F08Rik, 5330435L01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237979
Homologene: 10406
Mrc1
Name: mannose receptor, C type 1
Synonyms: MR, CD206
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17533
HGNC: HGNC:7228
Homologene: 37622
Brinp3
Name: bone morphogenetic protein/retinoic acid inducible neural specific 3
Synonyms: Fam5c, B830045N13Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 215378
Homologene: 17786
Mink1
Name: misshapen-like kinase 1 (zebrafish)
Synonyms: Map4k6, MINK, Misshapen/NIKs-related kinase, Ysk2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 50932
Homologene: 56762
Irak3
Name: interleukin-1 receptor-associated kinase 3
Synonyms: IRAK-M, 4833428C18Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 73914
Homologene: 36215
Trank1
Name: tetratricopeptide repeat and ankyrin repeat containing 1
Synonyms: C030048J01Rik, LOC235639, A230061D21Rik, Lba1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320429
Homologene: 45845
Atp10b
Name: ATPase, class V, type 10B
Synonyms: 9030605H24Rik, 5930426O13Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 319767
Homologene: 70969
Or6z5
Name: olfactory receptor family 6 subfamily Z member 5
Synonyms: MOR103-6, Olfr1346, GA_x6K02T2QGBW-3203957-3204898
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258918
Homologene: 74134
Abca8a
Name: ATP-binding cassette, sub-family A member 8a
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217258
HGNC: HGNC:38
Homologene: 131160
Trim67
Name: tripartite motif-containing 67
Synonyms: D130049O21Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 330863
Homologene: 45699
Serpinb9c
Name: serine (or cysteine) peptidase inhibitor, clade B, member 9c
Synonyms: ovalbumin, 3830421J05Rik, NK9, Spi11
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20707
HGNC: HGNC:8955
Map1a
Name: microtubule-associated protein 1 A
Synonyms: Mtap1a, Mtap-1, Mtap1, 6330416M19Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17754
HGNC: HGNC:6835
Homologene: 1778
Col11a1
Name: collagen, type XI, alpha 1
Synonyms: C530001D20Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12814
HGNC: HGNC:2186
Homologene: 56389
Pdzrn3
Name: PDZ domain containing RING finger 3
Synonyms: Semcap3, LNX3, 1110020C07Rik, semaphorin cytoplasmic domain-associated protein 3A
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 55983
Homologene: 10328
Gli3
Name: GLI-Kruppel family member GLI3
Synonyms: brachyphalangy, Bph
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 14634
HGNC: HGNC:4319
Homologene: 139
Ccdc178
Name: coiled coil domain containing 178
Synonyms: 4921528I01Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 70950
VEGA: 18
Homologene: 12373
Slc45a3
Name: solute carrier family 45, member 3
Synonyms: 2210413P12Rik, IPCA-6, Pcanap6
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 212980
HGNC: HGNC:8642
Homologene: 23813
Dsg1c
Name: desmoglein 1 gamma
Synonyms: Dsg6
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 211924
HGNC: HGNC:3048
Cttnbp2
Name: cortactin binding protein 2
Synonyms: ORF4, 4732477G22Rik, 3010022N24Rik, Cortbp2, 9130022E09Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 30785
Homologene: 14125
Adam6b
Name: a disintegrin and metallopeptidase domain 6B
Synonyms: 4930523C11Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238405
Homologene: 128362
Fam83c
Name: family with sequence similarity 83, member C
Synonyms: 5530400B04Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71405
Homologene: 18669
Cfap43
Name: cilia and flagella associated protein 43
Synonyms: 4632415N18Rik, D19Ertd652e, 4930428C11Rik, Wdr96, 4930463G05Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 100048534
Homologene: 36425
Ncf4
Name: neutrophil cytosolic factor 4
Synonyms: p40phox
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 17972
HGNC: HGNC:7662
Homologene: 525
Mrgprg
Name: MAS-related GPR, member G
Synonyms: MrgG, LOC381974
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 381974
Homologene: 28580
Serpinb3a
Name: serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3A
Synonyms: Sqn5
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20248
Homologene: 76659
Nlrp4c
Name: NLR family, pyrin domain containing 4C
Synonyms: Nalp4c, Rnh2, Nalp-alpha
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 83564
Homologene: 75315
Ackr2
Name: atypical chemokine receptor 2
Synonyms: Ccbp2, chemokine decoy receptor D6, D6
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 59289
VEGA: 9
HGNC: HGNC:1565
Homologene: 992
Klhl31
Name: kelch-like 31
Synonyms: 9830147P19Rik, D930047P17Rik, Kbtbd1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244923
Homologene: 27819
Cst5
Name: cystatin D
Synonyms: DD72, Cst10
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 58214
HGNC: HGNC:2477
Homologene: 55615
Or52n4b
Name: olfactory receptor family 52 subfamily N member 4B
Synonyms: MOR34-9, MOR34-8P, MOR34-12, Olfr1548, GA_x6K02T2PBJ9-10874315-10875286, Olfr503, MOR34-9
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259143
Homologene: 121509
Ubash3b
Name: ubiquitin associated and SH3 domain containing, B
Synonyms: TULA-2, Sts-1, 2810457I06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 72828
Homologene: 13152
4930447A16Rik
Name: RIKEN cDNA 4930447A16 gene
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 74892
Nxpe4
Name: neurexophilin and PC-esterase domain family, member 4
Synonyms: D930028F11Rik, Fam55d
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244853
VEGA: 9
Homologene: 83471
Fbxw20
Name: F-box and WD-40 domain protein 20
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 434440
Homologene: 110776
Dlg2
Name: discs large MAGUK scaffold protein 2
Synonyms: Gm21505, A330103J02Rik, PSD93, Chapsyn-110, B330007M19Rik, B230218P12Rik, Dlgh2, LOC382816
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 23859
HGNC: HGNC:2901
Homologene: 1046
Or10a3n
Name: olfactory receptor family 10 subfamily A member 3N
Synonyms: Olfr519, MOR268-6, GA_x6K02T2PBJ9-11224559-11223615
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 277935
Homologene: 17186
Sapcd2
Name: suppressor APC domain containing 2
Synonyms: ang, 6030458L21Rik, 2010317E24Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 72080
Homologene: 18664
Csn1s2b
Name: casein alpha s2-like B
Synonyms: Csnd, Csne
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12992
Homologene: 49221
Reep1
Name: receptor accessory protein 1
Synonyms: D6Ertd253e
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 52250
Homologene: 41504
Prl3a1
Name: prolactin family 3, subfamily a, member 1
Synonyms: 1600016E11Rik, PLP-I, Plpi, Prlpi, PLP-H
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 67000
Homologene: 49844
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 58,831,674 bp
  • T to C, chromosome 1 at 91,223,300 bp
  • T to C, chromosome 1 at 107,047,174 bp
  • T to A, chromosome 1 at 131,981,529 bp
  • T to C, chromosome 1 at 146,514,782 bp
  • C to T, chromosome 2 at 14,248,890 bp
  • T to A, chromosome 2 at 25,376,410 bp
  • A to G, chromosome 2 at 31,790,338 bp
  • C to T, chromosome 2 at 121,289,765 bp
  • T to A, chromosome 2 at 130,544,952 bp
  • T to C, chromosome 2 at 149,405,409 bp
  • C to T, chromosome 2 at 155,831,062 bp
  • C to T, chromosome 3 at 86,350,304 bp
  • A to G, chromosome 3 at 104,491,026 bp
  • C to T, chromosome 3 at 114,152,613 bp
  • A to G, chromosome 3 at 116,883,199 bp
  • A to T, chromosome 4 at 105,036,329 bp
  • T to A, chromosome 4 at 148,023,379 bp
  • T to A, chromosome 5 at 87,819,058 bp
  • A to T, chromosome 5 at 110,708,861 bp
  • A to G, chromosome 6 at 18,408,592 bp
  • G to T, chromosome 6 at 71,756,437 bp
  • A to G, chromosome 6 at 101,151,005 bp
  • C to A, chromosome 7 at 6,066,778 bp
  • T to C, chromosome 7 at 6,474,515 bp
  • T to C, chromosome 7 at 92,431,051 bp
  • T to C, chromosome 7 at 92,917,834 bp
  • T to A, chromosome 7 at 108,545,083 bp
  • T to A, chromosome 7 at 108,893,879 bp
  • A to G, chromosome 7 at 143,764,694 bp
  • A to G, chromosome 8 at 77,450,697 bp
  • A to T, chromosome 8 at 95,751,832 bp
  • T to C, chromosome 8 at 124,826,139 bp
  • C to T, chromosome 9 at 37,424,632 bp
  • A to G, chromosome 9 at 41,031,497 bp
  • T to A, chromosome 9 at 48,396,555 bp
  • A to G, chromosome 9 at 53,453,378 bp
  • A to G, chromosome 9 at 77,650,074 bp
  • C to T, chromosome 9 at 109,221,300 bp
  • T to A, chromosome 9 at 111,366,290 bp
  • T to C, chromosome 9 at 121,909,212 bp
  • A to T, chromosome 10 at 120,182,546 bp
  • A to G, chromosome 11 at 43,235,767 bp
  • T to C, chromosome 11 at 70,608,328 bp
  • G to T, chromosome 11 at 102,204,656 bp
  • T to A, chromosome 11 at 110,068,060 bp
  • T to A, chromosome 11 at 113,838,609 bp
  • C to T, chromosome 11 at 117,758,041 bp
  • C to A, chromosome 11 at 119,544,582 bp
  • C to T, chromosome 12 at 54,203,195 bp
  • T to A, chromosome 12 at 113,491,026 bp
  • T to A, chromosome 12 at 116,419,236 bp
  • C to A, chromosome 13 at 15,725,471 bp
  • A to G, chromosome 13 at 27,259,617 bp
  • A to G, chromosome 13 at 33,154,390 bp
  • C to T, chromosome 13 at 70,604,895 bp
  • A to G, chromosome 15 at 37,425,774 bp
  • G to A, chromosome 15 at 78,250,437 bp
  • A to G, chromosome 17 at 25,205,733 bp
  • G to A, chromosome 17 at 29,376,930 bp
  • A to G, chromosome 18 at 20,282,047 bp
  • T to A, chromosome 18 at 22,020,873 bp
  • T to A, chromosome 18 at 70,616,632 bp
  • A to G, chromosome 19 at 47,795,761 bp
  • T to A, chromosome 19 at 59,166,424 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1596 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039633-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.