Strain Name:
C57BL/6J-MtgxR1744Btlr/Mmmh
Stock Number:
039776-MU
Citation ID:
RRID:MMRRC_039776-MU
Other Names:
R1744 (G1), C57BL/6J-MtgxR1744Btlr
Major Collection:

Strain Information

Met
Name: met proto-oncogene
Synonyms: Par4, c-Met, HGF receptor
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 17295
HGNC: HGNC:7029
Homologene: 206
Macf1
Name: microtubule-actin crosslinking factor 1
Synonyms: Aclp7, trabeculin alpha, Acf7
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11426
Homologene: 136191
Cemip2
Name: cell migration inducing hyaluronidase 2
Synonyms: Tmem2, 3110012M15Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 83921
VEGA: 19
Homologene: 75008
Adgrl3
Name: adhesion G protein-coupled receptor L3
Synonyms: 5430402I23Rik, Lphn3, D130075K09Rik, LEC3, lectomedin 3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 319387
Homologene: 22878
Ociad1
Name: OCIA domain containing 1
Synonyms: Asrij, TPA018, B230209J16Rik, Imi2, 6030432N09Rik, Emi2, expressed during mesenchymal induction 2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 68095
Homologene: 9866
Ddx56
Name: DEAD box helicase 56
Synonyms: 2600001H07Rik, D11Ertd619e, NOH61, DEAD (Asp-Glu-Ala-Asp) box polypeptide 56
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 52513
Homologene: 6498
Snd1
Name: staphylococcal nuclease and tudor domain containing 1
Synonyms: Tudor-SN, p100 co-activator
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 56463
Homologene: 8665
Hars1
Name: histidyl-tRNA synthetase 1
Synonyms: MMHRS, Hars
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 15115
VEGA: 18
HGNC: HGNC:4816
Homologene: 1592
Sec16a
Name: SEC16 homolog A, endoplasmic reticulum export factor
Synonyms: C230052J16Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227648
Homologene: 10533
Zcchc8
Name: zinc finger, CCHC domain containing 8
Synonyms: 5730565F05Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 70650
Homologene: 32349
Csde1
Name: cold shock domain containing E1, RNA binding
Synonyms: unr, D3Jfr1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229663
Homologene: 5179
Trps1
Name: transcriptional repressor GATA binding 1
Synonyms: D15Ertd586e, trichorhinophalangeal syndrome I (human)
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 83925
Homologene: 8556
Rif1
Name: replication timing regulatory factor 1
Synonyms: D2Ertd145e, 5730435J01Rik, 6530403D07Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 51869
Homologene: 41231
Ptprm
Name: protein tyrosine phosphatase receptor type M
Synonyms: RPTPmu
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 19274
VEGA: 17
HGNC: HGNC:9675
Homologene: 37694
Dennd2a
Name: DENN domain containing 2A
Synonyms: B930096L08Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 209773
Homologene: 35238
Retsat
Name: retinol saturase (all trans retinol 13,14 reductase)
Synonyms: 0610039N19Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 67442
Homologene: 41195
Lcp2
Name: lymphocyte cytosolic protein 2
Synonyms: SLP76, m1Khoe, twm, SLP-76
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16822
HGNC: HGNC:6529
Homologene: 4065
Tnfsf13b
Name: tumor necrosis factor (ligand) superfamily, member 13b
Synonyms: BLyS, BAFF, D8Ertd387e, zTNF4, TALL-1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 24099
Homologene: 48443
Stxbp1
Name: syntaxin binding protein 1
Synonyms: Sxtbp1, Rb-sec1, N-sec1, Munc-18a, Unc18h, nsec1, Munc18-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20910
Homologene: 2382
Scn1a
Name: sodium channel, voltage-gated, type I, alpha
Synonyms: Nav1.1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20265
Homologene: 21375
Klf7
Name: Kruppel-like transcription factor 7 (ubiquitous)
Synonyms: 9830124P08Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 93691
HGNC: HGNC:6350
Homologene: 2751
Tspear
Name: thrombospondin type laminin G domain and EAR repeats
Synonyms: C330046G03Rik, ORF65
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 252974
HGNC: HGNC:1268
Homologene: 36972
Siglec1
Name: sialic acid binding Ig-like lectin 1, sialoadhesin
Synonyms: Sn, CD169, Siglec-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20612
Homologene: 124458
Pde5a
Name: phosphodiesterase 5A, cGMP-specific
Synonyms: PDE5A1, Pde5
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242202
HGNC: HGNC:8784
Homologene: 842
Ogfod2
Name: 2-oxoglutarate and iron-dependent oxygenase domain containing 2
Synonyms: 1300006G11Rik, 5730405M13Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 66627
Homologene: 32588
Slc25a30
Name: solute carrier family 25, member 30
Synonyms: KMCP1, 4933433D23Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 67554
VEGA: 14
Homologene: 57046
Ros1
Name: Ros1 proto-oncogene
Synonyms: c-ros, Ros-1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19886
Homologene: 2207
Sh2d4a
Name: SH2 domain containing 4A
Synonyms: SH2A, 2210402M20Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 72281
Homologene: 11117
Kmt2d
Name: lysine (K)-specific methyltransferase 2D
Synonyms: C430014K11Rik, Mll2, bapa, Mll4
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 381022
HGNC: HGNC:7133
Homologene: 86893
Or8g4
Name: olfactory receptor family 8 subfamily G member 4
Synonyms: Olfr967, GA_x6K02T2PVTD-33447884-33448816, MOR171-30P
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258086
VEGA: 9
HGNC: HGNC:8484
Homologene: 115535
Mcemp1
Name: mast cell expressed membrane protein 1
Synonyms: 1810033B17Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 69189
Homologene: 52162
Slc6a20a
Name: solute carrier family 6 (neurotransmitter transporter), member 20A
Synonyms: Xtrp3s1, A730081N20Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 102680
Homologene: 10625
L3hypdh
Name: L-3-hydroxyproline dehydratase (trans-)
Synonyms: 2810055F11Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 67217
Homologene: 12100
Clca3a1
Name: chloride channel accessory 3A1
Synonyms: Clca1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12722
HGNC: HGNC:2017
Homologene: 77224
Gabrp
Name: gamma-aminobutyric acid type A receptor subunit pi
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216643
HGNC: HGNC:4089
Homologene: 22798
Ces4a
Name: carboxylesterase 4A
Synonyms: Ces8
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234677
Homologene: 71949
Vmn2r68
Name: vomeronasal 2, receptor 68
Synonyms: EG620697, Vmn2r68-ps
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 620697
Homologene: 115466
Zfp618
Name: zinc finger protein 618
Synonyms: 2810031P15Rik, D430033D05Rik, 2810040O04Rik, Nedd10
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 72701
Homologene: 18975
Sphkap
Name: SPHK1 interactor, AKAP domain containing
Synonyms: 4930544G21Rik, A930009L15Rik, SKIP
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 77629
Homologene: 18172
D7Ertd443e
Name: DNA segment, Chr 7, ERATO Doi 443, expressed
Synonyms: Fats, 4933400E14Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71007
Homologene: 18998
Or6c69
Name: olfactory receptor family 6 subfamily C member 69
Synonyms: Olfr816, GA_x6K02T2PULF-11590830-11589892, MOR113-1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258667
Homologene: 133584
Vmn1r23
Name: vomeronasal 1 receptor 23
Synonyms: V1rc24
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 171197
Homologene: 110825
Tmem132b
Name: transmembrane protein 132B
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 208151
Homologene: 28135
Sp110
Name: Sp110 nuclear body protein
Synonyms: Ipr1, 5031415C07Rik, 52kDa, Ifi75, 5830484A20Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 109032
HGNC: HGNC:5401
Homologene: 82192
Cth
Name: cystathionine gamma lyase
Synonyms: 0610010I13Rik, CSE
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 107869
HGNC: HGNC:2501
Homologene: 1432
Gpam
Name: glycerol-3-phosphate acyltransferase, mitochondrial
Synonyms: GPAT1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 14732
Homologene: 7343
Mgat5
Name: mannoside acetylglucosaminyltransferase 5
Synonyms: beta1,6N-acetylglucosaminyltransferase V, GlcNAc-TV, 5330407H02Rik, 4930471A21Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 107895
HGNC: HGNC:7049
Homologene: 1808
Prr27
Name: proline rich 27
Synonyms: 4930432K09Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 73779
Homologene: 136277
Trappc6a
Name: trafficking protein particle complex 6A
Synonyms: TRS33, 4930519D19Rik, 1810073E21Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67091
Homologene: 69370
Otud3
Name: OTU domain containing 3
Synonyms: 3110030K17Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 73162
Homologene: 66103
Bcl2l15
Name: BCLl2-like 15
Synonyms: LOC229672, Bfk
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229672
Homologene: 19060
Psg29
Name: pregnancy-specific beta-1-glycoprotein 29
Synonyms: cea17
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 114872
Homologene: 83380
Lbx1
Name: ladybird homeobox 1
Synonyms: Lbx1h
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 16814
Homologene: 4784
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 64,079,213 bp
  • G to A, chromosome 1 at 83,277,515 bp
  • G to C, chromosome 1 at 85,594,372 bp
  • T to C, chromosome 1 at 127,479,469 bp
  • T to C, chromosome 2 at 26,439,186 bp
  • A to G, chromosome 2 at 32,806,719 bp
  • G to A, chromosome 2 at 52,112,392 bp
  • T to C, chromosome 2 at 66,322,276 bp
  • A to G, chromosome 2 at 131,081,299 bp
  • T to C, chromosome 3 at 86,546,904 bp
  • T to A, chromosome 3 at 103,050,315 bp
  • T to A, chromosome 3 at 103,838,540 bp
  • T to C, chromosome 3 at 122,747,897 bp
  • G to T, chromosome 3 at 144,746,835 bp
  • C to G, chromosome 3 at 157,906,268 bp
  • A to T, chromosome 4 at 63,086,634 bp
  • A to T, chromosome 4 at 123,475,853 bp
  • A to C, chromosome 4 at 138,895,748 bp
  • T to C, chromosome 5 at 73,300,719 bp
  • A to G, chromosome 5 at 81,794,420 bp
  • A to G, chromosome 5 at 87,843,047 bp
  • G to A, chromosome 5 at 123,700,373 bp
  • G to A, chromosome 5 at 124,114,156 bp
  • T to C, chromosome 5 at 125,778,844 bp
  • T to C, chromosome 6 at 17,540,646 bp
  • T to C, chromosome 6 at 28,527,746 bp
  • A to T, chromosome 6 at 39,480,251 bp
  • A to T, chromosome 6 at 57,925,925 bp
  • C to T, chromosome 6 at 72,606,575 bp
  • C to A, chromosome 6 at 124,307,028 bp
  • T to C, chromosome 7 at 17,210,353 bp
  • A to G, chromosome 7 at 19,514,229 bp
  • A to T, chromosome 7 at 85,231,989 bp
  • G to A, chromosome 7 at 121,127,776 bp
  • A to G, chromosome 7 at 134,349,413 bp
  • G to A, chromosome 8 at 3,666,054 bp
  • G to A, chromosome 8 at 10,031,661 bp
  • G to A, chromosome 8 at 68,331,155 bp
  • G to A, chromosome 8 at 105,138,097 bp
  • A to C, chromosome 9 at 39,750,415 bp
  • C to T, chromosome 9 at 123,662,993 bp
  • A to T, chromosome 10 at 52,123,379 bp
  • T to A, chromosome 10 at 77,864,884 bp
  • A to C, chromosome 10 at 129,911,393 bp
  • G to A, chromosome 11 at 6,266,396 bp
  • A to T, chromosome 11 at 33,572,462 bp
  • T to C, chromosome 11 at 34,069,911 bp
  • A to G, chromosome 12 at 72,077,349 bp
  • T to C, chromosome 13 at 50,469,354 bp
  • A to G, chromosome 14 at 75,763,330 bp
  • T to C, chromosome 15 at 50,661,213 bp
  • C to T, chromosome 15 at 76,186,218 bp
  • T to C, chromosome 15 at 98,865,047 bp
  • T to C, chromosome 17 at 66,689,366 bp
  • G to A, chromosome 18 at 36,770,832 bp
  • C to A, chromosome 19 at 21,832,137 bp
  • T to C, chromosome 19 at 45,234,213 bp
  • T to C, chromosome 19 at 55,074,591 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1744 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039776-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.